• 건축역사연구
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• 제9권2호
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• pp.65-84
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• 2000

The region of Southeast Asia had already experienced rapid urbanization and cultural change before the East Asia region did. None the less, nowadays shophouses and rowhouses still form the major portion of streets in Chinese town in Southeast Asia countries. The purpose of this study is to examine the adaptation process of shophouse and rowhouse in the Southeast Asia region and the architectural characteristics between the middle of 18th and the early of 20th, which Chinese people of the region inherit and develop, for more thorough understanding of cultural adaptability and regionalism of Chinese architecture in Southeast Asia. The common fact found in the Southeast Asia region is that Chinese people in countries of this region gradually started to live densely as a group in a certain zone in city area since they got to play important roles in commerce, trade and service works related with cities, due to European countries' advance into Southeast Asia and their construction of colonial cities in the region. Chinese people in the region utilized residential rowhouse and special shophouse, which is a kind of shop adapted from rowhouses' sitting room or storage, for their commercial and industrial activities in urban areas, which had problems of limited space. They also realized high densities through vertical expansion of space in order to adjust to changing urban structure under execution of urban planning in cities of colonial area and rapid urbanization. Even though residence of Chinese in Southeast Asia was influenced by new political, social, economic and cultural rules of European colonies in Southeast Asia, it has continuously succeeded to the cultural tradition of China, their home country, in terms of planning principle which puts air well in the middle and hierarchial spacial construction method. Appearance of the open connected verandah, designed by Stamford Raffles, the founder of Singapore, can be regarded as one of the architectural characters. Hence, Chinese residence in cities of Southeast Asia can be understood as a new regional architectural culture in the context of European countries' urban planning and urbanization of colonial areas, Immigrants from southern China and their role, their adjustment to urban areas by utilizing mixed type houses of residence and business, cultural tradition of Chinese home country.

• BMB Reports
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• 제41권3호
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• pp.230-235
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• 2008

LRP15 is a novel gene cloned from lymphocytic cells, and its function is still unknown. Bioinformatic data showed that LRP15 might be regulated by DNA methylation and had an important role in DNA repair. In this study, we investigate whether the expression of LRP15 is regulated by DNA methylation, and whether overexpression of LRP15 increases efficiency of DNA repair of UV-induced DNA damage in HeLa cells. The results showed (1) the promoter of LRP15 was hypermethylated in HeLa cells, resulting a silence of its expression. Gene expression was restored by a demethylating agent, 5-aza-2'-deoxycytidine, but not by a histone deacetylase inhibitor, trichostatin A; (2) overexpression of LRP15 inhibited HeLa cell proliferation, and the numbers of cells in the G2/M phase of the cell cycle in cells transfected with LRP15 increased about 10% compared with controls; (3) cyclin B1 level was much lower in cells overexpressing LRP15 than in control cells; and (4) after exposure to UV radiation, the LRP15-positive cells showed shorter comet tails compared with the LRP15-negative cells. From these results we conclude that the expression of LRP15 is controlled by methylation in its promoter in HeLa cells, and LRP15 confers resistance to UV damage and accelerates the DNA repair rate.

• Journal of Information Processing Systems
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• 제13권5호
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• pp.1243-1258
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• 2017

A new medical materials scheduling system and its modeling method for the complex rescue are presented. Different from other similar system, first both the BeiDou Satellite Communication System (BSCS) and the Special Fiber-optic Communication Network (SFCN) are used to collect the rescue requirements and the location information of disaster areas. Then all these messages will be displayed in a special medical software terminal. After that the bipartite graph models are utilized to compute the optimal scheduling of medical materials. Finally, all these results will be transmitted back by the BSCS and the SFCN again to implement a fast guidance of medical rescue. The sole drug scheduling issue, the multiple drugs scheduling issue, and the backup-scheme selection issue are all utilized: the Kuhn-Munkres algorithm is used to realize the optimal matching of sole drug scheduling issue, the spectral clustering-based method is employed to calculate the optimal distribution of multiple drugs scheduling issue, and the similarity metric of neighboring matrix is utilized to realize the estimation of backup-scheme selection issue of medical materials. Many simulation analysis experiments and applications have proved the correctness of proposed technique and system.

• The Korean Journal of Physiology and Pharmacology
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• 제25권4호
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• pp.281-296
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• 2021

The beneficial effects of hypoxic preconditioning are abolished in the diabetes. The present study was designed to investigate the protective effects and mechanisms of repeated episodes of whole body hypoxic preconditioning (WBHP) in db/db mice. The protective effects of preconditioning were explored on diabetes-induced vascular dysfunction, cognitive impairment and ischemia-reperfusion (IR)-induced increase in myocardial injury. Sixteen-week old db/db (diabetic) and C57BL/6 (non-diabetic) mice were employed. There was a significant impairment in cognitive function (Morris Water Maze test), endothelial function (acetylcholine-induced relaxation in aortic rings) and a significant increase in IR-induced heart injury (Langendorff apparatus) in db/db mice. WBHP stimulus was given by exposing mice to four alternate cycles of low (8%) and normal air O₂ for 10 min each. A single episode of WBHP failed to produce protection; however, two and three episodes of WBHP significantly produced beneficial effects on the heart, brain and blood vessels. There was a significant increase in the levels of brain-derived neurotrophic factor (BDNF) and nitric oxide (NO) in response to 3 episodes of WBHP. Moreover, pretreatment with the BDNF receptor, TrkB antagonist (ANA-12) and NO synthase inhibitor (L-NAME) attenuated the protective effects imparted by three episodes of WBHP. These pharmacological agents abolished WBHP-induced restoration of p-GSK-3β/GSK-3β ratio and Nrf2 levels in IR-subjected hearts. It is concluded that repeated episodes of WHBP attenuate cognitive impairment, vascular dysfunction and enhancement in IR-induced myocardial injury in diabetic mice be due to increase in NO and BDNF levels that may eventually activate GSK-3β and Nrf2 signaling pathway to confer protection.

• Asian Journal for Public Opinion Research
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• 제2권3호
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• pp.140-171
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• 2015

As China's economic development brings the country out of poverty and into modernity, a long-lasting debate concerns whether the Chinese public's value system is also changing toward the so-called "modern values," or whether some distinctly traditional Chinese values remain unchanged. Using empirical data collected at three points in time during the 1990s and the first two decades of the 21st Century (1993, 2002, and 2011), I found that Chinese citizens who benefitted from urbanization, rising levels of education and employment in non-farm, knowledge-based industries displayed stronger modern values. People with stronger modern values are more likely to emphasize individual autonomy, competition, gender equality, and market transaction, among others. Some characteristics of the Chinese people, most importantly family values, however, seem to remain stable amidst rapid social changes.

• International Journal of Costume and Fashion
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• 제9권1호
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• pp.1-14
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• 2009

This study is intended to examine the modernization of Chinese costumes through historical events, and to analyze the characteristics of the costume modernization process. The modernization of Chinese costumes appears to have begun with the Opium Wars, and the Nanjing Treaty(1842), the Beijing Treaty(1860) and the official residence of western people in Chinese territory. Afterwards, in order to initiate change, the Chinese people themselves implemented the Westernization movement(1861-94), placing an emphasis on the westernization of external elements such as technology and form, but aspects such as costume, deeply saturated in their traditions, do not appear to have changed significantly. Despite self-empowering movements such as these, as western forces diffused deeper into the Chinese mainland, neo-intellectuals formed the axis of a revolutionary movement. A major example can be found in the Xinhai Revolution(1911) revolution, which forbade the binding of feet and shaving of frontal hair and partially implemented western formal dress. Through these factors, the modernization process of Chinese costume demonstrates characteristics of an adherence to traditional dress and partial acceptance of western attire. Through this, we may understand the modern costumes of China, which adhered more to tradition than Japan, which pursued western costumes actively within a similar period, and Korea, which rushed modernization due to Japanese authority.

• 보건교육건강증진학회지
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• 제16권2호
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• pp.41-54
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• 1999

Health behaviors determine people's health status and the Quality of their life. Health education is the most effective method to change people's health behaviors in modem life. Therefore health education for adolescents is essencial to form desirable health behaviors and improve the Quality of their life. This study was administered to analyze important needs for the health education among Chinese, Korean -Chinese adolescents in Gilin, China and Korean adolescents in Seoul. Korea. The data were collected from 387 chinese and 74 Korean-Chinese boys and girls of 3 high schools in Gilin, China and 359 boys and girls of 3 high schools in Seoul, Korea. The results were as follow: 1. Forty percent of Korean students were sick during the past 4 weeks, but only 10.8％ of Korean-Chinese students and 9％ of Chinese students were sick. More than 70％ of Chinese and Korean-Chinese students had health concern, but only 26.6％ of Korean students were interested in health. 2. Korean-Chinese and Chinese students had higher health education needs than the Korean. They were not interested in sex education. On the other hand, Korean students were interested in mental health and not interested in consumer health education. 3. Korean-Chinese students had more health education needs than Chinese or Korean adolescents and the difference was statistically significant (p〈0.05). 4. In Korean-Chinese students, family income and academic grades were significantly related to their health education needs (p〈0.05). Among Chinese students, recent illness was related to their health education needs. In Korean students, the better health status and the more family income. the higher health education needs.

• 한국경제지리학회지
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• 제19권2호
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• pp.225-241
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• 2016

본 연구는 서울시 광진구 자양동이 중국인 밀집 거주지역으로 변모하는 과정에서 지역주민과 이주민과의 갈등 및 소통, 그에 따른 관계변화에 대하여 문화적응의 관점에서 살펴본 것이다. 이를 위하여 연구자들은 중국인 이주민과 한국인 원주민을 대상으로 심층 인터뷰를 진행하였다. 조사결과 자양동에서의 원주민과 중국인 이주민의 관계는 타 지역에 비하여 긍정적인 것으로 나타났다. 중국인 유입초기에는 원주민과 이주민이 서로에 대한 부정적인 인식을 가지고 있었으나, 시간이 경과함에 따라 이해와 배려를 바탕으로 한 상호교류를 통해 갈등을 해소하고 서로를 수용하려는 문화적응의 양상이 나타났다. 이러한 변화는 자동의 공간적인 특징 때문에 나타난 것으로 보인다. 자양동의 생활권역은 타 지역보다 개방적이며, 원주민과 이주민의 생활공간이 명확히 구분되어 있지 않아 상호간 교류가 활발해질 수 있었다. 이에 더하여 중국인 이주민은 자양동에서 오랫동안 살고자 하는 정주의식을 바탕으로 주류사회에 융화되는 형태의 문화적응 양상을 보였다. 본 연구는 한국에 정주(定住)하려는 외국인 이주민과 지역주민의 문화적응 과정에 대한 다각적인 분석을 시도하였다는 데 의의가 있다. 또한 외국인 이주민과 지역 원주민의 소통이 서로에 대한 편견과 오해를 경감시키고 공생할 수 있는 가능성을 제시하고 있다.

• Asian Pacific Journal of Cancer Prevention
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• 제14권7호
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• pp.4239-4242
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• 2013

It is reported that the expression level of MLL3 in gastric cancer tissue highly correlates with tumor progression. However, whether MLL3 genetic variants are associated with the risk of gastric cancer remains unclear. In this study, we conducted a genotyping analysis for MLL3 in 314 cases of gastric cancer and 322 controls from the Chinese Han population. 4 SNPs (rs6943984, rs4725443, rs3800836, rs6464211) were selected for the present analysis. We found 2 SNPs (rs6943984, rs4725443) of MLL3 gene were significantly associated with the risk of gastric cancer : the rs6943984 with the minor allele A and rs4725443 with the minor allele C revealed strong associations with increased gastric cancer risk [P < 0.001, OR=1.97, 95% CI=1.48~2.64 and P <0.001, OR=2.23, 95% CI=1.54~3.24]. Haplotype analysis of the four SNPs showed that haplotype A-T-A-C, G-T-G-C, and G-C-A-C increased the risk of gastric cancer (P <0.001, P=0.18, and P<0.001, respectively), while haplotype G-T-A-C significantly reduced the risk of gastric cancer (P <0.001). We concluded that MLL3 variants are significantly associated with gastric cancer risk. Our results for the first time provided new insight into susceptibility factors of MLL3 gene variants in carcinogenesis of gastric cancer of the Chinese Han population.

• 한국의류학회지
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• 제13권3호
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• pp.268-285
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• 1989

The purpose of this thesis is to understand the concrete forms of the traditional Chinese trousers and finally to compare the forms and cuts of the Chinese, Japanese and Korean trousers, which shared the same form in the beginning. The literature survey helps to draw the following conclusions: 1. The first trousers of ancient China were adapted from the nomadic people of the North Asia. 2. The ancient Chinese had both forms of trousers consited of(a) I-letter typed crotch line and (b)$\lambda$-letter typed crotch-line. 3. The folk trousers of China consist mainly of $\lambda$-letter typed seamline which is the trouser form shared among some of the North-Eastern Asiatic people. 4. The open trousers are worn over the closed crotch trousers. 5. The open crotch trousers seems to be developed from the leggings of the nomadic people.