• 대한예방한의학회지
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• 제17권1호
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• pp.1-11
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• 2013

Objectives : The aim of this research is to produce information by gathering up the data on the interaction between medicinal herbs which lie scattered in oriental medical books, and to provide people with easy access to the information by visualizing it. Methods : For this purpose, this study established the fundamental data by organizing the patterns of interaction into some kinds after selecting a part of Bonchogangmok(本草綱目) and extracting its text. In addition, in an effort to visualize the data, the study converted the data into 'net' file and visualized the interaction between medicinal herbs on Pajek. The visualization was done targeting a total of three patterns, such as 1 medicinal herb, 2 medicinal herbs, and 1 prescription. With the data on 'Chinese Lacquer(乾漆)' for 1 medicinal herb, data on 'Licorice(甘草)' and 'Chinese Lacquer(乾漆)' for 2 medicinal herbs, and data on 'Iijin-tang(二陳湯)' for prescription, the research conducted the analysis of the network using 'Kamada-Kawaii Algorithm' on Pajek. Results : As a result of the analysis, it was possible to see the meanings at a single glance as the scattered and fractional meanings were integrated with focus on medicinal herbs, but the increasing number of analyzed medicinal herbs tended to more and more complicate their relationships, thus, requiring additional work like filtering. Conclusions : Such results are fairly applicable in on-line database, and it is judged that if further research expands its scope to include systematic classification of medicinal herbs or cover other medical books than Bonchogangmok, it will create more objective, abundant information.

• 대한한의학원전학회지
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• 제27권2호
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• pp.25-48
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• 2014

Objectives : This study aims to analyze the terms describing anti-aging effects in Dongeuibogam, and to propose the methodology for selecting medicinal herbs related to anti-aging effects. Methods : We considered aging or anti-aging theories by reviewing the major literature in korean medicine or traditional chinese medicine, and then we deduced the concepts describing anti-aging effects and the medicinal herbs for anti-aging effects. We investigated the medicinal herbs based on the terms describing anti-aging effects in Dongeuibogam and drew the methodology for selecting and classifying the medicinal herbs related to anti-aging. Results & Conclusions : The following conclusions could be drawn. 1. A set of causes and signs of aging in Dongeuibogam and a set of therapies for alleviating the aging signs in Chengumikbang, Yanglobongchinseo, and Nolohangeon was found. 2. Anti-aging effects should not be confused with disease treatments. Therefore, we defined the medical terms of anti-aging effects as "the terms expressing the effect of delaying or alleviating the subjective or objective signs of aging concretely". Based upon the terms of anti-aging effects, we defined the medicinal herbs for anti-aging effects as "the medicinal herbs whose effects are described in medical terms expressing the effects of delaying or alleviating the subjective or objective signs of aging concretely". 3. We considered Lycii Fructus, Asparagi Tuber in Dongeuibogam as examples of medicinal herbs whose effects are described in medical terms expressing anti-aging effects. It shows that we can select medicinal herbs for anti-aging effects by comparing the effects of 937 single therapies in Dongeuibogam to the terms describing anti-aging effects defined in this study. Futhermore, the results could be utilized as the basic materials of experimental study on anti-aging.

• Journal of Ginseng Research
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• 제47권4호
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• pp.493-505
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• 2023

In recent years, an increasing number of reports have explored the wound healing mechanism of these two traditional Chinese herbal medicines- Panax ginseng and Panax notoginseng, but there is no systematic research on the related core functions and different mechanisms in the treatment of wound healing up to now. Based on network pharmacology and meta-analysis, the present work aimed to comprehensively review the commonality and diversity of P. ginseng and P. notoginseng in wound healing. In this study, a wound healing-related "ingredients-targets" network of two herbs was constructed. Thereafter, meta-analysis of the multiple target lists by Metascape showed that these two medicines significantly regulated blood vessel development, responses to cytokines and growth factors and oxygen levels, cell death, cell proliferation and differentiation, and cell adhesion. To better understand the discrepancy between these two herbs, it was found that common signaling pathways including Rap1, PI3K/AKT, MAPK, HIF-1 and Focal adhesion regulated the functions listed above. In parallel, the different pathways including renin-angiotensin system, RNA transport and circadian rhythm, autophagy, and the different metabolic pathways may also explained the discrepancies in the regulation of the above-mentioned functions, consistent with the Traditional Chinese Medicine theory about the effects of P. ginseng and P. notoginseng.

• 한국식품위생안전성학회지
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• 제12권3호
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• pp.217-227
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• 1997

These experiments were performed to investigate the safety of the three medicinal herbs- Curcuma longa Linne, Paeonia japonica Miyabe, Scutellaria baikalensis George-irradiated with gamma rays in respect of genotoxicity. The methanol-soluble and water-soluble fractions of the methanol-water extracts of the 10 kGy gamma-irradiated herbs were examined in two short-term in vitro tests : (1) Salmonella typhimurium reversion assay (Ames test) in strain TA 98, TA 100 and TA 012 (2) Micronucleus test in cultured Chinese hamster ovary (CHO) cells. No mutagenicity was detected in the assays with or without metabolic activation. From these results, the safety of the herbs irradiated with gamma rays at practical doses could be revealed in further tests of genotoxicity in vivo, chronic and reproductive toxiceity.

• Preventive Nutrition and Food Science
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• 제19권3호
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• pp.178-186
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• 2014

Many recent studies have focused on maintaining a healthy life by preventing and/or postponing the aging process. Numerous studies have reported that continuous exposure to reactive oxygen species can stimulate skin aging and that excessive accumulation of fat can cause an impaired skin barrier and tissue structure alterations. Thus, the maintenance of antioxidant homeostasis and the suppression of adipose accumulation are important strategies for skin anti-aging. Here, we prepared three types of extracts [whole juice, acetone-perchloric acid (PCA), and ethanol] from 20 fruits and medicinal herbs native to the Gyeongnam area of Korea. The total phenolic content of each extract was analyzed, and we observed higher total phenolic contents in the medicinal herbs. Consistent with this, the results of the oxygen radical absorbance activity capacity assay indicated that the in vitro antioxidant activities of the medicinal herb extracts were stronger than those of the fruit extracts. The fruits and medicinal herbs had strong effects on cell-based systems, including $H_2O_2$-induced oxidative stress in human keratinocytes and 3T3-L1 lipid accumulation. Nishimura Wase persimmon, Taishu persimmon, wrinkled giant hyssop, sweet wormwood, Chinese cedar, red perilla, tan shen, hiyodori-jogo, and cramp bark may be natural anti-aging materials with effective antioxidant and anti-adipogenic activities. Taken together, our findings may provide scientific evidence supporting the development of functional foods and nutraceuticals from fruits and medicinal herbs.

• 한국자원식물학회:학술대회논문집
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• 한국자원식물학회 2001년도 추계정기 학술발표회 초록집
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• pp.98-98
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• 2001

• 한국식품영양과학회지
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• 제26권5호
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• pp.952-957
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• 1997

The three medicinal herbs-Curcuman longa Linne, Paeonia japonica Miyabe, Scutellaria baikalensis George-irradiated with gamma rays were tested for their possible genotoxicity. The methanol-soluble and water-soluble fractions of the 10kGy gamma-irradiated herbs were examined in cultured Chinese hamster ovary(CHO) cells for their ability to induce micronuclei. No mutagenicity of each test material was detected in the assay with or without metabolic activation. The safety of the herbs irradiated with gamma rays at practical doses needs further investigations using in vivo genotoxicity and chronic and reproductive toxicity tests.

• 한국산림과학회지
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• 제104권3호
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• pp.495-502
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• 2015

본 연구는 주요 약초류(8개 품목) 재배에 투입된 비용과 수입 등을 파악하여 소득분석을 실시함으로써 향후 단기소득임산물 손실에 대한 보상 기준 및 임업경영환경 개선을 위한 정책수립에 필요한 기초자료 제공을 목적으로 수행하였다. 약초류 재배에 대한 소득분석(10a 기준) 결과, 단위면적당 연평균소득은 잔대가 14,233천원으로 가장 높았고, 다음으로 하수오 4,121천원, 천마 3,766천원, 삼지구엽초 3,537천원, 삽주 2,655천원, 독활 1,048천원, 작약 1,025천원, 시호 919천원 등으로 나타났다. 이는 2014년에 분석한 주요 수실류 소득과 비교하면 약초류의 단위면적당 연평균소득이 비교적 높은 것으로 나타났다. 특히, 잔대와 독활의 경우 새순은 식용으로 뿌리는 약용으로 이용되고 있어 향후 농산촌지역의 새로운 소득원으로 부상할 수 있을 것으로 판단된다. 한편, 작약은 중국산으로 인한 판매 가격하락을 보이고 있어 향후 한-중 FTA가 시행되면 타 약초류에도 중국산으로 인한 소득손실 피해가 예상된다.

• 생약학회지
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• 제45권3호
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• pp.187-193
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• 2014

To identify potential gastrointestinal prokinetic agents, water and 70% ethanol extracts and isolated compounds from 41 different traditional medicinal herbs were evaluated for the stimulation of gastrointestinal (GI) motility in vivo. Of the 41 water and 70% ethanol extracts, 12 extracts were found to enhance GI motility activity in mice by more than 10%. The 12 extracts are as follows: Atractylodes japonica (root), Crataegus pinnatifida (flower), Aucklandia lappa (root), Inula helenium (root), Cynanchum wilfordii (root), Chinese Liriope platyphylla (root), Codonopsis pilosula (root), Glehnia littoralis (root), Pinellia ternate (tuber), Agastache rugosa (aerial part), Angelica decursiva (whole plant), and Peucedanum praeruptorum (whole plant). In particular, the extracts from Atractylodes japonica (root), Cynanchum wilfordii (root) and Angelica decursiva (whole plant) have demonstrated the highest GI motility activity. In addition, 26 isolated compounds from the medicinal herbs were tested, and 8 isolated compounds were found to be active. They are ${\alpha}$-ionone, ${\beta}$-ionone, trans-caryophyllene, cedrol, methyl-3,5-di-O-E-caffeoyl-quinate, lobetyolin, oleoyllinoleoylolein and cis-jasmone. ${\beta}$-ionone from Aucklandia lappa (root) showed the most potent GI motility activity. The active traditional medicinal herbs and isolated compounds might be therapeutically advantageous in the treatment of GI motility disorders.

• 한국식품저장유통학회:학술대회논문집
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• 한국식품저장유통학회 2003년도 제23차 추계총회 및 국제학술심포지움
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• pp.136.1-136
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• 2003

Aristolochic acid has been known to be a carcinogenic compound and to cause Chinese herbs nephrophathy. To determine the content of aristolochic acid in various medicinal herbs marketed domestically, samples of Aristolochia fangchi, Aristolochia fructus, Aristolochia radix, Asiasari radix, Saussureae radix, and Akebia caulis were analyzed using TLC and HPLC. The optimal conditions for TLC and HPLC were established for the quantitative analysis of aristolochic acid. This study showed that Aristolochia fangchi and Aristolochia fructus examined in this study contain aristolochic acid of 3.9 and 2.3 mg/g sample, respectively. In contrast, aristolochic acid was not detected in other samples.