• The Journal of Pediatrics of Korean Medicine
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• v.27 no.4
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• pp.87-98
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• 2013

Objectives The purpose of this study is to find a literature study of infantile anorexia clinical cases with Traditional Chinese Medicine (TCM) to utilize with Korean medicine treatment methods. Methods 5 TCM journals with the highest impact factors were searched and selected among the journals listed in www.cnki.net. The search keywords were, "Children's Anorexia", "Infantile Apositia", "Infantile Anorexia", "Anorexia Nervosa", and "child of anorexia". he search was limited to the publication date from 2000 to 2012. Results Total 20 studies were selected: Acupuncture (5), Herbal medicine (9), Complex Treatment (3), External Application (2) and Moxibustion (1). Among the Acupuncture related studies, 1 study tested the effect of Sifeng (EX-UE10, 四縫), 3 studies tested the effect of Sifeng (EX-UE10, 四縫) and other acupoints treatment together, and 1 study tested the effect of combination of other acupoints. In all these studies, the study groups showed better therapeutic effects compared to the control groups. The Herbal medicine related studies showed the improvement in appetite and weight as a result of Herbal Medicines treatment. Among the Complex Treatment related studies, 2 studies tested the effect of Acupuncture and Chiropractic co-treatment, 1 study tested the effect of Moxibustion and Herbal medicine co-treatment. In all these studies, symptoms of Infantile anorexia showed significantly improved. Other papers related to External Application and Moxibustion treatment were reported improving in appetite and had other the clinical effects as well. Conclusions Clinical studies testing the effect of TCM for the treatment of Infantile Anorexia have been conducted in small scales, and all the studies showed a certain level of symptom improvement of the patients in the study groups. These results implicate that the methods in Korean medicine can be highly potential treatment options for the treatment of Infantile Anorexia. Accurate and well-controlled studies in large scale would be required to prove the effect of Korean medicine for the treatment of patients with Infantile Anorexia.

• Journal of Oriental Neuropsychiatry
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• v.31 no.1
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• pp.49-61
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• 2020

Objectives: The objective of this study is to analyze clinical reports of treatment of menopausal depression in traditional Chinese medicine (TCM). Methods: This study included randomized controlled trials (RCT) in treating menopausal depression. Literature studies of Chinese National Knowledge Infrastructure Database(CNKI) were performed. Clinical reports on menopausal depression treatment were searched using the following key words in the CNKI: 'menopausal depression' and 'postmenopausal depression'. Results and Conclusions: A total of 24 RCT articles on menopausal depression were selected. The most widely used diagnostic tool for menopausal depression was CCMD-3. Effective rate and HAMD were the most commonly used assessment tools. Bosinhaeultang-gagam (Bushenjieyu-tang jiajian) and Gami-gammaegdaejotang(Jiawei ganmaidazao-tang) were used much more than other prescriptions, while Bupleuri Radix was the most used single medicine herb. Additionally, the Chinese medicine treatment group showed less adverse reactions than the control group. As a result, we could know frequently used herbal prescription and single medicinal herbs and this can be helpful in developing more advanced studies in future.

• The Journal of Korean Obstetrics and Gynecology
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• v.30 no.1
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• pp.16-28
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• 2017

Objectives: This study was performed to review the research trends in the periodic therapy of dysmenorrhea in traditional Chinese medicine (TCM). Methods: We searched articles in Chinese Academic journal (CAJ). Search key words were 'dysmenorrhea' and 'periodic therapy or cyclic treatment'. Results: We selected 6 studies except unrelated studies. According to study design, study was classified into 1 single group before after study and 5 randomized controlled trials. According to dysmenorrheal type, study was classified into 4 studies on primary dysmenorrhea and 2 studies on secondary dysmenorrhea. In the selected studies, there were four studies in which the menstrual cycle was divided into 2 periods, one study divided into 3 periods, and one study divided into 4 periods. The most used herb was "Angelicae Gigantis Radix", "Cinnamomi Cortex Spissus". All studies showed effective results on dysmenorrhea. Conclusions: In TCM, Research on periodic therapy of dysmenorrhea was being conducted more actively than Korean medicine. The periodic therapy seems to be effective on dysmenorrhea from this research. It would be necessary to fulfill further clinical study with periodic therapy on dysmenorrhea in Korean medicine to establish standard evidence of them.

• Journal of Oriental Neuropsychiatry
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• v.27 no.1
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• pp.11-21
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• 2016

Objectives: This study was performed to review the research trends in the treatment of eating disorder in traditional Chinese medicine (TCM). Methods: The CNKI database (China National Knowledge Infrastructure) was searched under the key words ‘Eating Disorder’, ‘Anorexia Nervosa’, and ‘Bulimia Nervosa’. Results: Thirteen articles were selected. These included 2 studies on bulimia nervosa, and 11 studies on anorexia nervosa. According to study design, studies were classified into 1 randomized controlled trial, 2 single group before-and-after studies, and 8 case reports. According to therapy method, they included 11 herbal medicine studies, and 2 complex treatment studies. The most common pattern identification was ‘liver qi depression’ (肝氣鬱結), and the most used herb was ‘Root of Bupleurum falcatum’ (柴胡). Most of the studies showed effective results. Conclusions: The results of our study indicated that TCM clinical studies on eating disorder were being conducted more actively than in Korean medicine. Korean medical treatment might be effective to relieve eating disorder symptoms. In the future, more scientifically designed clinical studies should be performed to prove the effectiveness of traditional Korean medicine treatment on eating disorder.

• Journal of TMJ Balancing Medicine
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• v.13 no.1
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• pp.1-12
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• 2023

Objectives: This study was performed to review the research trends in the treatment of anorexia nervosa (AN) in Traditional Chinese Medicine (TCM). Methods: Studies were searched through The China National Knowledge Infrastructure (CNKI) database. The search term for the subject were 'Eating Disorder', and 'Anorexia Nervosa'. Clinical research that conducted TCM treatment for AN patients were included. Studies were analyze according to study design, therapy method, diagnostic criteria, population and intervention. Results: 23 articles were selected. According to study design, studies were classified into two randomized controlled trial (RCT), three single group before-and-after studies, and 18 case reports. According to therapy method, they included 19 herbal medicine studies, two acupuncture treatment studies, and two complex treatment studies. The most common pattern identification was 'liver depression with spleen deficiency' (肝鬱脾虛), and the most used herb was 'Root of Bupleurum falcatum' (柴胡). Most of the studies showed effective results in increasing appetite and weight. Conclusions: The results of our study demonstrate that TCM treatments for AN has been effective in alleviating chief symptoms. However, in terms of evidence-based medicine, lack of RCT on TCM treatments for AN and absence of objective diagnostic criteria in case reports are limitations. Therefore well-designed further clinical studies should be performed based on the results of this study are recommended.

• The Journal of Korean Medicine
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• v.32 no.1
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• pp.67-83
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• 2011

Objectives: The purpose of this study was to examine the single dose toxicity with oral administration and genotoxicities of Ssanghwa-tang fermented with Lactobacillus acidophyllus. Materials and Methods: Clinical signs, weight changes, lethal doses$(LD_{50})$, and postmortem evaluation were determined by Globally Harmonized Classification System(GHCS) in a single-dose oral toxicity study. In vitro mammalian chromosomal aberration test was conducted with Ames test by cell proliferation suppression assessment using the cultivated CHO-K1(Chinese hamster ovary fibroblast) origins. Bacterial reversion assay was performed using Salmonella typhimurium (TA98, TA100, TA1535, and TA1537) and Escherichia coli (WP2uvrA). In vivo micronucleus test was performed using ICR mouse bone marrow. Results: No clinical sign was observed and none of the groups with doses up to 2000 mg/kg showed significant acute oral toxicity in the single dose oral administration. None of the sample doses taken during the 6 to 18 hour groups showed significant aberrant metaphases comparing to the negative control group in the in vitro mammalian chromosomal aberration test. No evidence of mutagenicity was seen for Escherichia coli (WP2uvrA) or Salmonella typhimurium (TA98, TA100, TA1535, and TA1537). No significant increase in the frequency of micronuclei was seen in the micronucleus test. Conclusion: These results indicate that the $LD_{50}$ value of Ssanghwa-Tang fermented with Lactobacillus acidophyllus may be over 2000 mg/kg and it have no acute oral toxicity and genotoxicity.

• The Journal of Korean Obstetrics and Gynecology
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• v.34 no.3
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• pp.137-156
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• 2021

Objectives: The purpose of this study is to assess the effect of taking herbal medicine for the postpartum lactation. Methods: We searched 9 databases for recent three years, that contained four english, two chinese, one japanese and two korean database from September 17, 2016 to December 31, 2020. Randomized controlled trials (RCTs) were eligible. Measurement of outcome included total curative effective rate, volume of lactation, volume of milk supplement, and serum prolactin concentration. The risk of bias was assessed by two independent authors using the Cochrane risk of bias tool. Results: Total 725 of studies was screened, 11 RCTs were finally selected. Number of participants per study ranged from 60 to 257. The treatment group of taking a herbal medicine is effective for improving total curative effective rate, volume of lactation, volume of milk supplement, and serum prolactin concentration compared with control group. Because most of the studies had considerable heterogeneity in terms of type of intervention and comparison for outcome measurement, meta analysis for quantitative analysis was impossible. Conclusions: This studies showed that taking a herbal medicine is effective on increasing volume of lactation and speeding up the start of the first breastfeeding. However, included studies suffered from incomplete reporting, high or unclear risk of bias and substantial heterogeneity between studies. In the Future, further high-quality RCTs are needed to prove effectiveness of herbal medicine for breastfeeding and reduce the risk of bias.

• Journal of Korean Medicine Rehabilitation
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• v.34 no.3
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• pp.13-26
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• 2024

Objectives This study aimed to examine the efficacy of Korean traditional medicine treatments for recurrent lumbar disc herniation by analyzing randomized controlled trials (RCTs). Methods The following 6 databases were used Korean studies Information Service System, Oriental Medicine Advanced Searching Integrated System, Research Information Sharing Service, ScienceON, PubMed, and China National Knowledge Infrastructure. Only RCTs were selected. The risk of bias was assessed by Cochrane's risk of bias tool. Results A total of 10 RCTs were analyzed, which utilized 8 types of interventions, including acupuncture, moxibustion, warm needling, electroacupuncture, herbal medicine, cupping, and chuna manual therapy. Acupuncture and moxibustion were the most frequently used treatments. There were 7 outcome measures, including the effective rate, visual analog scale, Japanese Orthopedic Association. The effective rate was assessed in all studies. Meta-analysis results indicated that warm needling therapy and traditional Chinese medicine interventions were more effective compared with the control. Conclusions In this study, warm needling therapy and herbal medicine interventions demonstrated beneficial effects. As the meta-analysis was conducted with only a subset of RCT studies, further large-scale, systematic RCT studies are needed.

• The Journal of Korean Medicine
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• v.40 no.1
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• pp.124-152
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• 2019

Objectives: This study aimed to ascertain what should be considered in the "Guideline for Clinical Trials with Herbal Medicinal Products for Colorectal Cancer" by analyzing the existing guidelines and clinical trials. Methods: The development committee searched guidelines for herbal medicinal products for colorectal cancer that have already been developed. Then, clinical trials for colorectal cancer using herbal medicine were searched. The searched trials were analyzed in terms of inclusion and exclusion of participants, intervention, comparator, outcomes and trial design. Then, we compared the results of our analysis with the regulations and guidelines of the Ministry of Food and Drug Safety in order to identify the issues we will have to consider when making the "Guideline for Clinical Trials with Herbal Medicinal Products for Colorectal Cancer". Several guidelines for anti-tumor agents and clinical trials with herbal medicinal products were searched on the national institution homepage. In addition, 12 articles were searched using a combination of the following search terms: 'colorectal neoplasms', 'herbal medicine', 'Medicine, Korean traditional', 'Medicine, Chinese Traditional', 'medicine, East Asian medicine', 'medicine, Kampo', etc. Results: The characteristics of participants were various, such as people with medical histories of surgeries or recurrent cancers or who complained of chemotherapy-induced side effects. The types of interventions were also various and included decoctions, powders, intravenous fluids, intraperitoneal injections and gargles. Comparators used included placebos and conventional treatments. The outcome measurements used in the studies were quality of life, symptom score, tumor response, and survival duration, etc. Safety was evaluated by recording adverse events. Conclusions: Findings were made by reviewing existing guidelines and comparing them with clinical trials for colorectal cancer and herbal medicinal products. These results will be utilized in the development of the "Guideline for Clinical Trials with Herbal Medicinal Products for Colorectal Cancer".

• Journal of Acupuncture Research
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• v.18 no.1
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• pp.29-39
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• 2001

Purpose : It has been reported that Oyo-Tang has an effect on allergic asthma clinically. In order to investigate the herbal acupuncture solution of the Oyo-Tang on allergic asthma, the Oyo-Tang herbal-acupuncture(OTHA) was applied on BL13 and ST36 of allergic asthma model of the rats. Methods : Then the concentration of serum IgE and the ratio of CD4+ and CD8+ T-cells in peripheral blood were measured and compared with control group. Results : The results obtained as follows; 1. The concentration of serum IgE was decreased significantly in both of the OTHA on BL13 group and on ST36 group as compared to control group. 2. The ratio of CD4+ and CD8+ T-cells in peripheral blood was not different statistically between the normal, the control, the OTHA on BL13 and the OTHA on ST36 group.