• The Korea Journal of Herbology
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• v.26 no.1
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• pp.103-110
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• 2011

Objective : For the standardization and quality control of eleutheroside E in Eleutherococcus species, HPLC analysis was performed and eleutherosdie E content was compared in 23 kinds of Eleutherococcus species collected from Korea and China. Methods : The content of eleutheroside E in stem bark of Eleutherococcus species collected from Korea and China were analyzed by HPLC. 0.5% phosphoric acid and acetonitrile was used as mobile solvent. Validation of HPLC analysis method was confirmed by analyzing specificity, linearity, precision and accuracy following ICH guideline. Results : Content of eleutheroside E was determined to be 1.0-1.6% and 0.5-0.8% in Korean and Chinese E. senticosus, respectively. Content of eleutheroside E in E. sessiliflorus was 0.7-1.1% and 0.2-0.4% respectively in Korean and Chinese origin. All calibration curves showed good linear regression. The method showed good precision and accuracy with intra-day and inter-day variations of 0.880-3.442% (RSD) and 0.606-3.328% (RSD), respectively, and average recovery was of 0.141-1.363% (RSD), for the eleutheroside E analyzed. Conclusion : These results might be used to establish a criterion of eleutheroside E in Eleutherococcus species.

• International Journal of Contents
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• v.7 no.4
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• pp.108-115
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• 2011

The current study aims to analyze the acceptance of International Standard Terminology (IST) related to herbs and formulas used in Korea. It also intends to examine limitations of each term source by linking texts for herbal medicine research and formula research used in schools of oriental medicine with medicinal substance-formula classification names within the IST framework. This study examined 64 medicinal classification names of IST, including synonyms, 41 formula classification names, 65 classification names of "Herbal Medicine Study," 89 medicinal classification names of "Shin's Clinical Herbal Medicine Study," and lastly 83 formula classification names of "Formula Study." Data on their chief virtue, efficacy and characteristics as medicinal substances were extracted from their definitions, and such data were used to perform Chinese character-English mapping using the IST. The outcomes of the mapping were then analyzed in terms of both lexical matching and semantic matching. In terms of classification names for medicinal substances, "Herbal Medicine Study" had 60.0% lexical matching, whereas "Shin's Clinical Herbal Medicine Study" had 48.3% lexical matching. When semantic matching was also applied, "Herbal Medicine Study" showed a value of 87.7% and "Shin's Clinical Herbal Medicine Study" 74.2%. In terms of formula classification names, lexical matching was 28.9% of 83 subjects, and when semantic matching was also considered, the value was 30.1%. When the conceptual elements of this study were applied, some IST terms that are classified with other codes were found to be conceptually consistent, and some terms were not accepted due to different depths in the classification systems of each source.

• Korean Journal of Medicinal Crop Science
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• v.17 no.2
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• pp.109-114
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• 2009

Rhubarb is the well-known and frequently used herbal medicine for the treatment of constipation, inflammation, and cancer. As described in the Korea and Chinese Pharmacopoeia, rhubarb consists of the roots and rhizomes of Rheum palmatum, R. officinale, and R. tanguticum. However, the pharmacological differences among rhubarb have not been scientifically established. In the present study, we investigated and compared the inhibitory effects of 70% ethanolic extracts from R. palmatum (RPE), R. officinale (ROE), R. nobile (RNE), and R. franzenbachii (RFE) on the production of inflammatory mediators, nitric oxide (NO), prostaglandin $E_2$ ($PGE_2$), interlukin-1beta ($IL-1{\beta}$), and tumor necrosis factor-alpha ($TNF-{\alpha}$) in RAW 264.7 macrophage cells. ROE, RNE, and RFE significantly inhibited the release of NO, $PGE_2$, $IL-1{\beta}$, and $TNF-{\alpha}$. RPE significantly reduced the release of $IL-1{\beta}$, but not NO, $PGE_2$, and $TNF-{\alpha}$. Overall, RFE was found to inhibit the release of $PGE_2$ and $IL-1{\beta}$, to a far greater degree than RPE, ROE, and RNE. Our results indicate that RFE possess the strongest anti-inflammatory activity among 4 tested rhubarb.

• Journal of Physiology & Pathology in Korean Medicine
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• v.24 no.5
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• pp.770-778
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• 2010

To establish the fundament for EBM of Traditional Korean Medicine, the papers on Pyeongwi-san (Pingwei-san) frequently used in medical institutions of Traditional Korean Medicine were analyzed through researching domestic and international papers. The papers were classified by the registration of domestic or international journals, the year of publishment, experimental fields and the kinds of studies on biological activities. Of total 518 papers on Pyeongwi-san (Pingwei-san), 32 volumes were selected according to selection creteria. 20 volumes were published in domestic journals, 11 in Chinese journal and 1 in Japanese journal. The papers on instrumental analyses reported the quantification of standard compounds of herbal medicines in Pyeongwi-san (Pingwei-san) using HPLC, GC-MS. The papers on biological activities of Pyeongwi-san (Pingwei-san) showed improvement of gastrointestinal activity and water-electrolyte metabolism, immune regulation, anti-oxidant, anti-inflammatory, analgesic, anti-convulsant activities, hypnotic duration, blood pressure regulation, hepatic protection, congestive heart failure, anti-cancer activities. Further studies including gastrointestinal activity need to be preceeded to establish the fundament for EBM of Pyeongwi-san (Pingwei-san).

• The Journal of Internal Korean Medicine
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• v.40 no.3
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• pp.312-330
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• 2019

Objectives: The present study aimed to provide clinical evidence on the effect of herbal medicine on the treatment of hepatitis C using a systematic review and meta-analysis of randomized controlled trials (RCTs). Methods: This study included RCTs that verified the effects of herbal medicine for the treatment of hepatitis C. A literature search of English, Chinese, and Korean databases was performed, and the selected literature was assessed to investigate the risk of bias. Results: The analysis included 14 RCTs. The total effective rate was the most commonly used outcome measure. The meta-analysis revealed that the total effective rate and total bilirubin difference were higher and that the recurrent rate was lower in the herbal medicine group than in the western medicine group (RR: 1.20, 95% CI: 1.06-1.35, p=0.003, I2=52; MD: 0.52, 95% CI: -0.62 to 1.66, p=0.37, I2=0; RR: 0.35, 95% CI: 0.11-1.09, p=0.07, I2=0). The included RCTs had relatively poor quality and a small sample size. Conclusion: Treatment with herbal medicine was found to be partially effective in treating hepatitis C. The included RCTs had relatively poor quality and a small sample size. This study can serve as a foundation for further clinical studies on the development of treatment methods for hepatitis C based on herbal medicine.

• The Journal of Pediatrics of Korean Medicine
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• v.35 no.1
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• pp.48-62
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• 2021

Objectives The purpose of this study is to obtain knowledge from clinical studies conducted in China to examine the effectiveness of herb medicine in childhood acute leukemia. Methods We searched the randomized controlled trials (RCTs) with herbal medicine treatment on childhood acute leukemia from the 'CAJ', Chinese Academic Journal from China National Knowledge Infrastructure (CNKI). And then, demographic data, duration of illness, intervention, treatment period, outcome, adverse events, and composition of herbal medicine were analyzed for this study. Result 10 RCT studies were selected and analyzed. The control group were given western medicine therapy, the treatment group was given herbal medicine on the basis of the control group. The most commonly used herbal medicine were 淸熱解毒藥, 補氣藥, 補陰藥, 活血祛瘀藥 in 'boosting vital force and driving out evil spirit (扶正祛邪)' way to 'relieve heat (熱毒)' and 'assist the vital force (正氣)'. In the treatment group, complete remission was significantly higher than control group and the decrease in TCM syndrome scores also showed significant effects. Adverse events were significantly lower in the treatment group. Conclusions Herbal medicine treatment on childhood acute leukemia can be suggested as a new treatment for children who have less response to the conventional therapy, and can supplement the limitations of the western medicine by increasing complete remission and reducing adverse events.

• Korean Journal of Oriental Medicine
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• v.17 no.2
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• pp.135-167
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• 2011

Objective : To establish the fundament for EBM of Traditional Korean Medicine, the papers on Bojungikgitang(Buzhongyiqi-tang) frequently used in medical institutions of Traditional Korean Medicine were analyzed through researching domestic and international papers. Methods : The papers were classified by the registration of domestic or international journals, the year of publishment, experimental fields and the kinds of studies on biological activities. Results : Among 2005 volumes of papers on Bojungikgi-tang(Buzhongyiqi-tang), 219 volumes were selected according to selective criteria. 71 volumes were published in domestic journals, 52 volumes were in Chinese journal, 96 volumes were in Japanese journal. The papers on instrumental analyses reported the quantification of standard compounds of herbal medicines in Bojungikgi-tang(Buzhongyiqi-tang) using HPLC method. The papers on biological activities of Bojungikgi-tang(Buzhongyiqi-tang) showed mainly immune regulation, anti-infection, anti-cancer, gastrointestinal activity, neuropsychiatric regulation, anti-inflammation, hepatoprotection, musculoskeletal regulation. Among biological activities, papers on immume regulation were reported mostly. Conclusions : The efficacy of Bojungikgi-tang(Buzhongyiqi-tang) could be related to immune regulation, gastrointestinal activity, anti-fatigue and further study need to be preceeded to establish the fundament for EBM of Bojungikgitang(Buzhongyiqi-tang).

• Korean Journal of Pharmacognosy
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• v.46 no.3
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• pp.260-267
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• 2015

Advanced glycation end products (AGEs) have been postulated to play a central role in the development of diabetic complications. A variety of different agents that inhibit AGEs have been under investigation. In this study, 111 herbal medicines from China have been investigated with an in vitro evaluation system using AGEs formation inhibitory activity. Of these, 9 herbal medicines (IC₅₀: <5 μg/ml) were found to have significant AGEs formation inhibitory activity. Particularly, herbal medicines Barleria cristata (leaves), Calotropis gigantea (stems), Ardisia virens (leaves), Dalbergia yunnanensis (leaves) Pittosporum runcatum (leaves), Ardisia japonica (leaves), Rhododendron racemosum (twigs), Oxyria sinensiss (aerial parts), Pyrrosia calvata (whole plants), showed more potent inhibitory activity (approximately 15-40 fold) than the positive control aminoguanidine (IC₅₀: 76.47 μg/ml).

• The Journal of Internal Korean Medicine
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• v.43 no.4
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• pp.559-566
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• 2022

Introduction: The aim of this systematic review is to provide evidence confirming the efficacy and safety of herbal medicines used in the treatment of liver cancer. Methods: The review will include randomized clinical trials that compared herbal medicines used as treatments for liver cancer with other therapies, such as placebos and Western medicine. Only randomized controlled trials will be included in this review, and all types of herbal medicine will be evaluated. Eleven electronic databases will be searched from the inception date: the Cochrane Database of Systematic Reviews, MEDLINE, EMBASE, AMED, CINAHL, one Chinese database (CNKI), and five Korean databases (OASIS, DBpia, RISS, KISS, and NDSL). The selection of studies, data extraction, and management will be performed independently by four researchers. Methodological quality, including the risk of bias, will be assessed using the Cochrane risk-of-bias assessment tool. Results: The review of current evidence for the effectiveness of herbal medicine for liver cancer will be summarized and quantitatively analyzed. Conclusions: Our systematic review will provide evidence of the efficacy of herbal medicines as treatments for liver cancer. This evidence will provide useful information for practitioners and patients in the fields of oncology and complementary medicine.

• The Journal of Internal Korean Medicine
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• v.38 no.1
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• pp.48-63
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• 2017

Objectives: This study was performed to review the recent clinical research trends of the effects of herbal medicine treatment on chronic pancreatitis in China. Methods: We searched for clinical studies about chronic pancreatitis from the China Academic Journal (CAJ) of the China National Knowledge Infrastructure (CNKI) from January 1, 2005, to August 1, 2016. Results: Thirty-seven papers were selected from 126 studies. The most commonly used herbal prescriptions included Bupleuri Radix (柴胡), Paeoniae Radix Alba (白芍藥), Glycyrrhizae Radix (甘草), Scutellariae Radix (黃芩), Aucklandiae Radix (木香), and Rhei Rhizoma (大黃). Qingyi-tang (淸胰湯) was the most frequently used herbal prescription. Clinical symptoms, physicochemical examination, radiological examination, and relapse were used to evaluate the treatments. The effective treatment rate was 77.5-100%, and effectiveness in the experimental group was significantly higher than in the control group in 15 papers (p<0.05). Conclusions: Herbal medicine treatment has been shown as an effective treatment for chronic pancreatitis. In the future, more scientifically designed clinical studies should be performed to prove the effectiveness of herbal medicine treatment on chronic pancreatitis. These research results can be utilized in other clinical studies and in the treatment of chronic pancreatitis.