• Journal of Chest Surgery
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• 제47권4호
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• pp.333-343
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• 2014

Background: A preclinical study was conducted for evaluating a valved conduit manufactured with a glutaraldehyde (GA)-fixed bovine pericardium treated using an anticalcification protocol. Methods: Bovine pericardia were decellularized, fixed with GA in an organic solvent, and detoxified. We prepared a valved conduit using these bovine pericardia and a specially designed mold. The valved conduit was placed under in vitro circulation by using a mock circulation model, and the durability under mechanical stress was evaluated for 2 months. The valved conduit was implanted into the right ventricular outflow tract of a goat, and the hemodynamic, radiologic, histopathologic, and biochemical results were obtained for 6 months after the implantation. Results: The in vitro mock circulation demonstrated that valve motion was good and that the valved conduit had good gross and microscopic findings. The evaluation of echocardiography and cardiac catheterization demonstrated the good hemodynamic status and function of the pulmonary xenograft valve 6 months after the implantation. According to specimen radiography and a histopathologic examination, the durability of the xenografts was well preserved without calcification at 6 months after the implantation. The calcium and inorganic phosphorus concentrations of the explanted xenografts were low at 6 months after the implantation. Conclusion: This study demonstrated that our synergistic employment of multiple anticalcification therapies has promising safety and efficacy in the future clinical study.

• Tuberculosis and Respiratory Diseases
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• 제67권4호
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• pp.359-363
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• 2009

Immunoglobulin G4 (IgG4) related autoimmune diseases are characterized by high serum IgG4 concentrations, sclerosing inflammation of numerous IgG4-positive lymphoplasma cells of varying origin, and a positive response to steroid treatment. Autoimmune pancreatitis, sclerosing cholangitis, and retroperitoneal fibrosis are representative presentations of IgG4 related autoimmune disease. Herein, we describe 2 patients (40-years-old woman and 47-years-old man) diagnosed with pulmonary involvement of IgG4-related autoimmune disease. The patients were admitted for an evaluation of the lung mass or multiple lung nodules found on chest radiography. Surgical lung biopsies were performed and pathologic finding revealed lymphoplasmacytic sclerosing inflammation with numerous IgG4 positive cells. The patients had elevated serum total IgG and IgG4 levels. Treatment consisted of high dose methylpredinisolone (1 mg/kg/day) and demonstrated good responsiveness. However, one patient experienced 2 relapses while being tapered off of steroid treatment.

• Tuberculosis and Respiratory Diseases
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• 제77권4호
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• pp.193-196
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• 2014

Acute airway obstruction after hemoptysis occurs due to the presence of blood clots. These conditions may result in lifethreatening ventilation impairment. We report a case of obstruction of the large airway by endobronchial blood clots which were removed using bronchoscopic cryotherapy at the bedside of intensive care unit. A 66-year-old female with endometrial cancer who had undergone chemotherapy, was admitted to the intensive care unit due to neutropenic fever. During mechanical ventilation, the minute ventilation dropped to inadequately low levels and chest radiography showed complete opacification of the left hemithorax. Flexible bronchoscopy revealed large blood clots obstructing the proximal left main bronchus. After unsuccessful attempts to remove the clots with bronchial lavage and forceps extraction, blood clots were removed using bronchoscopic cryotherapy. This report shows that cryotherapy via flexible bronchoscopy at the bedside in the intensive of intensive care unit is a simple and effective alternative for the removal of endobronchial blood clots.

• 한국임상수의학회지
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• 제25권3호
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• pp.187-191
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• 2008

A 7-year-old, intact female Yorkshire terrier dog was presented for coughing, anorexia, chest pain and dyspnea. Right lateral thoracic radiograph demonstrated a large mass shape on the heart base with decreased cardiac silhouette and severe right deviation of the trachea with the heart shifted to the left thoracic wall was observed on the ventrodorsal thoracic projection. Echocardiographic examination revealed a large rounded mass compressing left atrium around the heart base without signs of pericardial effusion. On computed tomographic (CT) findings, sagittal CT images depicted the possibility of cranial vena caval invasion and heart base involvement of the mass associated with biatrial compression. Dorsal CT image revealed the right deviation of trachea due to the heart base mass and markedly shrunk lung space was detected on the transverse CT image. Because the dog suddenly had died during the recovery from anesthesia after finishing CT scan, necropsy was performed. On gross findings, a large and lobulated mass was located at the base of the heart. A poorly-demarcated, infiltrative, multilobulated tumor composed of polyhedral cells in solid cellular sheets was confirmed based on histopathologic examination. This dog was diagnosed as a chemodectoma. This case report describes the clinical findings, diagnostic consistency of thoracic radiography, echocardiography and CT, and histopathologic confirmation in a spontaneously occurring chemodectoma with a Yorkshire terrier dog.

• 동의신경정신과학회지
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• 제16권2호
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• pp.35-42
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• 2005

Objective : The relations of the heart size and seven emotions were described in Dong Yi Bo Gam, and we aimed to identify the correlations of the patients with anxiety disorder and their heart sizes. Methods : The subjects were 15 patients with anxiety disorder and 20 control groups. Chest radiography were performed. We measured patients' heart sizes and compared with control groups. Results : 1. The signigicant difference of somatization, anxiety, depression scale and Panic anxiety scale in SCL-90-R in patients with anxiety disorder from controls was confirmed. 2. The difference of thoracic sizes in patients with anxiety disorder and controls had no correlations. 3. The difference of heart sizes in patients with anxiety disorder and controls had no correlations. 4. The difference of cardiothoracic ratio in patients with anxiety disorder and controls had negative correlations. Conclusions : Based on these results, the patients with anxiety disorders and their heart sizes had no correlations. But in cardiothoracic ratio had negative correlations. So heart size and seven emotions have significant correlation.

• Tuberculosis and Respiratory Diseases
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• 제45권3호
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• pp.636-642
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• 1998

저자들은 항마이코플라스마 항체와 한냉 응집소 검사로 진단된 마이코플라스마 폐렴에서 급성 호흡곤란 증후군과 한냉 응집소용혈성 빈혈, 그리고 간염이 발생된 전격성 M. þneumoniae 감염이 스테로이드 투여로 임상 증상 및 X-선 소견 그리고 한냉 응집소 용혈성 빈혈이 호전되었던 1예를 치험하였기에 문헌 고찰과 함께 보고하는 바이다.

• 대한방사선기술학회지:방사선기술과학
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• 제1권1호
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• pp.44-54
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• 1978

This study was carried out with statistical materials during the last two years of period from Jan. 1975 to Dec. 1976 which presented at radiologic department of 5 hospitals in Seoul City. The primary purpose of this study was to obtained more detailed informations related to the activities of radiologic technologists in diagnostic X-Ray examinations part and to provide some basic materials for managements in activities of then and manpower managements of their organization and practice. From the results of this study, the following conclusions were obtained [1] During two year from the January of 1975 to the December of 1976, total number of case in X-ray examinations were 464,830 case and 22,029 case in 1975 and 24,461 in 1976. And ratio of icreased in X-Ray examinations by year was 11.09 per cent. [2] Regarding the examined portion of X-Ray examination, a great propotion was chest examination as 56.88 per cent. [3] An average, the required time per case in X-Ray exam. was 9.28 minutes and make used of 1.94 sheets of X-Ray film per case in radiography. [4] An average, ratio of increased in X-Ray film by year was 12.71 per cent and ratio of failed film in it was 2.23 per cent. [5] The frequency rate of film size showed the highest distribution of $8"{\times}10"$(28.17%) and the highest distribution of X-Ray film by month was July(8.93%). [6] An average, the amount of activities per a diagnostic X-Ray equipment was 34.92 case and make used of 67.81 sheets of X-Ray film in a day. [7] The mean number of case in X-Ray examinations by radiologic technologists was 29.29 cases and make used of 56.87 sheets of X-Ray film in a day. Also, the average number of case was reading by radiologists was 32.42 case and 62.97 sheets of X-Ray film in a day.

• 대한방사선기술학회지:방사선기술과학
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• 제32권2호
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• pp.147-151
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• 2009

ROC에 의한 의료영상을 평가하는 방법으로 지금까지는 5단계로 평가하는 평정확신도법이 일반적으로 사용되었다. 이 평정확신도법에서는 TPF나 FPF의 산출을 쉽게 구하는 것이 가능하나, 실험에 있어서 부드럽게 ROC곡선의 추정을 하기 위해서 관찰자에 대해 적당한 카테고리 배분이 요구되거나 또 짜여진 카테고리 배분을 위해 그 데이터가 무효해지는 경우가 많다. 이러한 문제를 해결하기 위해 또는 관찰실험 이외의 데이터에도 ROC해석의 응용이 가능해지도록 카테고리 분류가 되어 있지 않은 연속적으로 분포된 실험결과를 이용 ROC 해석을 행하는 방법인 연속확신도법이 보고 되었다. 하지만 국내에서는 의료영상의 평가에 연속확신도법을 적용한 예가 거의 없어서 흉부 디지털영상의 평가에 적용해 보았다. 그 결과 상용화된 프로그램에 의하여 부드러운 ROC곡선을 그릴 수 있었으며, 특성값을 쉽게 측정할 수 있어 디지털 의료영상의 평가에 적절히 사용될 수 있으리라 사료된다.

• Tuberculosis and Respiratory Diseases
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• 제70권3호
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• pp.257-260
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• 2011

A 65-year-old woman was admitted due to poor oral intake and a dry cough over the previous 3 months. The physical examination was remarkable for bibasilar crackles, and plain chest radiography showed reticulation in both lower lung fields. A pulmonary function test demonstrated a restrictive pattern with a reduced diffusing capacity of the lung for carbon monoxide. High resolution computed tomography showed reticulation and honey-combing in both peripheral lung zones, which was consistent with usual interstitial pneumonia pattern. Her skin showed livedo reticularis. The erythrocyte sedimentation rate and C-reactive protein level were elevated, and hematuria was noted on urinary analysis. A serologic test for auto-antibodies showed seropositivity for Myeloperoxidase-Anti-neutrophil cytoplasmic antibody (MPO-ANCA). A kidney biopsy was performed and showed focal segmental glomerulosclerosis. She was diagnosed as having pulmonary fibrosis with microscopic polyangiitis (MPA) and treated with high dose steroids. Here we report a case of pulmonary fibrosis coexistent with microscopic polyangiitis.

• Tuberculosis and Respiratory Diseases
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• 제69권5호
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• pp.375-380
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• 2010

Lymphoid interstitial pneumonia (LIP) is a rare benign lymphoproliferative interstitial lung disease. LIP has been associated with autoimmune disorders, HIV, viral infections, and so on. Once underlying systemic diseases have been excluded, a diagnosis of idiopathic LIP can be made. Although 6 cases of pathologically confirmed LIP have occurred in Korea, thus far none has been associated with primary Sjogren's syndrome. A 44-year-old man was admitted to hospital due to a dry cough and dypsnea on exertion that had been ongoing for 2 months. A chest radiography showed multiple and variable-sized cystic lesions, on both lungs and both interstitial infiltration and consolidation in both lower lung fields. Tests for autoantibody showed positive results of anti-nuclear antibody and anti-Ro/La antibody. The patient underwent a video assisted thoracoscopic surgery biopsy and pathologically confirmed LIP. We report the first known case of LIP-associated with primary Sjogren's syndrome in Korea.