• 제목/요약/키워드: Chemical library

검색결과 195건 처리시간 0.024초

Ranganathan의 문헌분류에 관한 규범적 원칙-특히 분류의 3단꼐와 분류규준을 중심으로 -

  • 오동근
    • 한국도서관정보학회지
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    • 제21권
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    • pp.195-229
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    • 1994

  • This article investigates the normative principles suggested by Rangannathan as the guiding principles for his theories, consisting of basic laws, fundamental laws, canons, principles and postulates. His five basic laws and five laws of library science are re-interpreted from the view point of library classification. And three planes of idea plane, verbal plane and notational plane, one of the core ideas in his analytico-synthetic theory of library classification, are analyzed. This article also suggests the demonstration model for this three planes using the ideas from chemistry ad chemical equation. In the last part, it analyzes the canons for library classification of three planes. These normative principles are basically guiding principles for so-called analytico-synthetic or faceted classification. But they can be a n.0, pplied to most of modern classification. But they can be a n.0, pplied to most of modern classification schemes, especially to semi-enumerative schemes including DDC, KDC, etc. so that they can improve the schemes. From this regard, these principles can also be helpful to the KDC, on the verge of the revision of its fourth edition.

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Property-based Design of Ion-Channel-Targeted Library

  • Ahn, Ji-Young;Nam, Ky-Youb;Chang, Byung-Ha;Yoon, Jeong-Hyeok;Cho, Seung-Joo;Koh, Hun-Yeong;No, Kyoung-Tai
    • 한국생물정보학회:학술대회논문집
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    • 한국생물정보시스템생물학회 2005년도 BIOINFO 2005
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    • pp.134-138
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    • 2005

  • The design of ion channel targeted library is a valuable methodology that can aid in the selection and prioritization of potential ion channel-likeness for ion-channel-targeted bio-screening from large commercial available chemical pool. The differences of property profiling between the 93 ion-channel active compounds from MDDR and CMC database and the ACDSC compounds were classified by suitable descriptors calculated with preADME software. Through the PCA, clustering, and similarity analysis, the compounds capable of ion channel activity were defined in ACDSC compounds pool. The designed library showed a tendency to follow the property profile of ion-channel active compounds and can be implemented with great time and economical efficiencies of ligand-based drug design or virtual high throughput screening from an enormous small molecule space.

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An Efficient Solid-phase Parallel Synthesis of 2-Amino and 2-Amidobenzo[d]oxazole Derivatives via Cyclization Reactions of 2-Hydroxyphenylthiourea Resin

  • Jung, Se-Lin;Kim, Seul-Gi;Lee, Gee-Hyung;Gong, Young-Dae
    • Bulletin of the Korean Chemical Society
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    • 제33권12호
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    • pp.4109-4116
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    • 2012

  • An efficient solid-phase methodology has been developed for the synthesis of 2-amino and 2-amidobenzo[d]-oxazole derivatives. The key step in this procedure involves the preparation of polymer-bound 2-aminobenzo-[d]oxazole resins 4 by cyclization reaction of 2-hydroxy-phenylthiourea resin 3. The resin-bound 2-hydroxyphenylthiourea 3 is produced by the addition of 2-aminophenol to the isothiocyanate-terminated resin 2 and serve as a key intermediate for the linker resin. This core skeleton 2-aminobenzo[d]oxazole resin 4 undergoes functionalization reaction with various electrophiles, such as alkylhalides and acid chlorides to generate 2-amino and 2-amidobenzo[d]oxazole resins 5 and 6 respectively. Finally, 2-amino and 2-amidobenzo[d]oxazole derivatives 7 and 8 are then generated in good yields and purities by cleavage of the respective resins 5 and 6 under trifluoroacetic acid (TFA) in dichloromethane ($CH_2Cl_2$).

  • https://doi.org/10.5012/bkcs.2012.33.12.4109 인용 PDF KSCI

도서관자료(圖書館資料) 보존(保存)에 관한 연구(硏究) (A Study on the Conservation of Library Materials)

  • 권기원
    • 한국비블리아학회지
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    • 제6권1호
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    • pp.179-213
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    • 1984

  • The history of recording and conserving for maintenance the human's memory from ancient times to modern's has brought about a lot of changing process of the recorded information media with developing in culture, and each society has made important recorded materials in his library as essentially the social apparatus. But most of them that were damaged by factors of the natural disaster, humidity, temperature, light, fungi and insects in the library, and were resulted in deterioration and losing the numerous materials. For removing the inevitable phases repeated, there are studying for counterplan of the fundamental environment factors about preservation, restoration and chemical research of materials in advanced countries, but I get a few researches about protecting the cultural properties. Therefore I research the survey of the actual conditions on 72 university libraries centering around them, and then I have researched the collection rate 81 percent, 58 university libraries. (local : 35, in seoul : 23) As the result of this research, I propose the model of the environment factors of conserving the library materials. 1) To apply the equipment of processing the radiant energy to the new construction and buildings. 2) To remove factors that occur fungi and insects by facilities being controlled relative humility, temperature, and to equip the ventilation arrangement in the library. 3) To shelve all acquired and bound materials after proceeding the vacuum fumigator. 4) Those who want to enter into the library stack were surely taken in sterilzing their hands and shoes, and must put on the gown. 5) To use the vacuum dusting thing (machine) for removing the dust without spreading out the floor of the library at any time. 6) To set up the gas automatic fire extinguisher worked by smoke sensor. 7) To assist the research into the preservation, natures and environment of recorded materials, and to supply financial funds for librarian. 8) To hold regularly the workshop be able to educate the methods of preservation materials by the constant system. (Library Association) 9) To add to responsibilities on certification of preservation materials for librarian. 10) To hold the constant committee system in each library. 11) To keep up with the ideal environment (humidity, temperature, light, ventilation, etc.) of preservation materials in the arrangement room, and to put on the gown.

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