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Simultaneous Determination of the Novel Neuroprotective Agent KR-31378 and its Metabolite KR-31612 Using High Performance Liquid Chromatography with Tandem Mass Spectrometry in Human Plasma

  • Kim, John;Ji, Hye-Young;Yoo, Sung-Eun;Kim, Sun-Ok;Lee, Dong-Ha;Lim, Hong;Lee, Hye-Suk
    • Archives of Pharmacal Research
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    • 제25권5호
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    • pp.647-651
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    • 2002
  • An LC/MS/MS method for the simultaneous determination of a neuroprotective agent for ischemia-reperfusion damage, KR-31378 and its N-acetyl metabolite KR-31612 in human plasma was developed. KR-31378, KR-31612 and the internal standard. KR-31543 were extracted from human plasma by liquid-liquid extraction. A reverse-phase HPLC separation was performed on Luna phenylhexyl column with the mixture of acetonitrile-5 mM ammonium formate (55:45, v/v) as mobile phase. The detection of analytes was performed using an electrospray ionization tandem mass spectrometry in the multiple reaction monitoring mode. The lower limits of quantification for KR-31378 and KR-31612 were 2.0 ng/ml. The method showed a satisfactory sensitivity, precision, accuracy, recovery and selectivity.

A Kinetic Monte Carlo Simulation of Individual Site Type of Ethylene and α-Olefins Polymerization

  • Zarand, S.M. Ghafelebashi;Shahsavar, S.;Jozaghkar, M.R.
    • 대한화학회지
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    • 제62권3호
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    • pp.191-202
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    • 2018
  • The aim of this work is to study Monte Carlo simulation of ethylene (co)polymerization over Ziegler-Natta catalyst as investigated by Chen et al. The results revealed that the Monte Carlo simulation was similar to sum square error (SSE) model to prediction of stage II and III of polymerization. In the case of activation stage (stage I) both model had slightly deviation from experimental results. The modeling results demonstrated that in homopolymerization, SSE was superior to predict polymerization rate in current stage while for copolymerization, Monte Carlo had preferable prediction. The Monte Carlo simulation approved the SSE results to determine role of each site in total polymerization rate and revealed that homopolymerization rate changed from site to site and order of center was different compared to copolymerization. The polymer yield was reduced by addition of hydrogen amount however there was no specific effect on uptake curve which was predicted by Monte Carlo simulation with good accuracy. In the case of copolymerization it was evolved that monomer chain length and monomer concentration influenced the rate of polymerization as rate of polymerization reduced from 1-hexene to 1-octene and increased when monomer concentration proliferate.

고려인삼 ( Panax ginseng. C.A. Meyer)전분의 이화학적 특성에 관한 연구 제 2보 전분의 화학적 특성 (Physico Chemical Properties of Korean Ginseng (Panax ginseng C.A. Meyer) Root Starch II. Chemical Properties of the Starch)

  • 김해중;조재선;유영진
    • Journal of Ginseng Research
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    • 제8권2호
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    • pp.124-134
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    • 1984
  • Ginseng root starch, prepared by conventional method, contained crude lipid of 0.5%, crude protein of 0.4%, crude mineral of 0.17% and phosphorous of 12.5mg% as noncarbohydrate constituents. The amylose content of ginseng root starch picked in Summer (May to August) and Winter (November to March) was 32-35% and 15-20%, respectively, and it was decreased with a growing preiod of ginseng. The blue value, alkali number and ferricyanide number of the starch were 0.14-0.17, 8.50 and 0.781, respectively. The molecular weight of amylose in the starch was estimated to be 1.27-7.95${\times}$105 by means of periodate oxidation, and the degree of branching and glucose unit per segment of amylopectin were 3.50-3.53% and 28.3-28.5, respectively, The starch content of ginseng root was decreased when dried under sunlight and stored at 5$^{\circ}C$ for twenty days. In contrast, sucrose content in the root was increased from 3.8% in fresh state to 11.5% during storage at the above condition. In the other hand, starch was converted to maltose by heating at temperature above 70$^{\circ}C$.

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NaOH 활성화법으로 제조한 폐감귤박 활성탄의 흡착특성 (Adsorption Characteristics of Activated Carbon Prepared From Waste Citrus Peels by NaOH Activation)

  • 강경호;감상규;이송우;이민규
    • 한국환경과학회지
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    • 제16권11호
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    • pp.1279-1285
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    • 2007
  • The activated carbon was prepared from waste citrus peels using NaOH. With the increase of NaOH ratio, iodine adsorptivity and specific surface area of the activated carbon prepared were increased, but activation yield was decreased. The optimal condition of activation was at 300% NaOH and $700^{\circ}C$ for 1.5 hr. For the activated carbon produced under optimal condition, iodine adsorptivity was 1,006 mg/g, specific surface area was $1,356 m^2/g$, and average pore diameter was $20{\sim}25{\AA}$. From the adsorption experiment for benzene vapor in fixed bed reactor, it was found that the adsorption capacity of activated carbon prepared from waste citrus peel was higher than that of activated carbon purchased from Calgon company. This result implied that the activated carbon prepared from waste citrus peel could be used for gas phase adsorption.

기상합성법을 이용하여 합성한 단일 실리콘 나노선에 대한 광전류 측정 (Photocurrent of Single Silicon Nanowire Synthesized by Themical Chemical Vapor Deposition)

  • 김경환;김기현;강정민;윤창준;정동영;민병돈;조경아;김상식;서민철
    • 한국전기전자재료학회:학술대회논문집
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    • 한국전기전자재료학회 2005년도 하계학술대회 논문집 Vol.6
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    • pp.7-8
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    • 2005
  • Silicon(Si) nanowires have been grown by thermal chemical vapor deposition using the 20h ball-milled SiO powders under controlled conditions without the catalyst. For the synthesis of Si nanowires, $Al_2O_3$ substrates were used. Current-Voltage(I-V) and photoresponses were measured for the single Si nanowire in vacuum at room temperature. The light sources for these measurements were the 325 nm wavelength line from a He-Cd laser and the 633 nm wavelength line from a He-Ne laser. The intensity of the photoresponse is independent of the illumination time. And rise and decay times of the photoresponses are shorter than 1 sec.

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Research on Value Creativity of Taiwan's Small and Medium-sized Enterprises

  • Tien, Shiaw-Wen;Chung, Yi-Chan;Tsai, Chih-Hung;Hsieh, Chia-Hsiang;Chen, Hung-Hsi
    • International Journal of Quality Innovation
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    • 제8권1호
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    • pp.99-119
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    • 2007
  • This research probes into the execution of small and medium-sized enterprises' value creativities by a difference analysis with different classifications, different capital, different turnover, different employees, and different established years. This study develop a questionnaire about value creativity with five dimensions and thirty-five items according to "Valuation" by McKinsey and Company, Inc. and Copeland et al., such as: "Aspiration and target," "Portfolio management," "Organization design," "Process management," and "Business and individual performance management." The results are as follows: (1) Most small and medium-sized enterprises (SMEs) have executed value creativities; (2) There is a difference in the execution of value creativities between the livelihood industry and the chemical industry; the execution of value creativities by livelihood industry is better than the chemical industry; (3) For value creativities of the execution of different capital and turnover for SMEs, bigger entities are better than smaller ones; (4) For the value creativities of the execution of different numbers of staff in SMEs, those with more staff are better than those with fewer staff; (5) For the value creativities of the execution of different established years for SMEs, those established longer are better than those established shorter.

VRLA 배터리의 충/방전 거동과 노화 예측 모델링 (Prediction of Charge/Discharge Behaviors and Aging of the VRLA Battery)

  • 이명규;조재성;신치범;류기선
    • Korean Chemical Engineering Research
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    • 제56권6호
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    • pp.779-783
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    • 2018
  • 본 연구에서는 차량용 12 V 납축전지로 주로 사용되는 VRLA (Valve regulated lead acid) 배터리의 충/방전 특성과 노화에 따른 이의 변화를 수학적으로 모델링하였다. 기존에 리튬 이온 배터리의 거동 예측에 주로 이용되어 왔던 수학적 모델링 기법을 상용 70 Ah VRLA 배터리에 적용하였다. 정전류 충/방전에 따른 전압의 변화를 모델링 결과와 비교하였다. 비교 결과로부터 사용된 수학적 모델이 납축전지에도 높은 정확도로 적용될 수 있음을 알 수 있었다. 또한 이를 이용하여 납축전지의 노화를 예측할 수 있음을 확인하였다.

중소 바이오연료 기업의 물류 문제 해결을 위한 진화적 알고리즘 기반 배송 방법론 (An Evolutionary Algorithm based Distribution Methodology for Small-scale Biofuel Energy Companies)

  • 김수환;류준형
    • Korean Chemical Engineering Research
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    • 제56권6호
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    • pp.804-810
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    • 2018
  • 본 논문은 중소 바이오 연료 기업의 공급 사슬 망이 기존 화석연료업체와 경쟁하기 위해, 최소의 비용으로 수요에 대응할 수 있는 공급 계획을 수립할 수 있는방법론을 제안한다. 최소비용으로 공급하기 위해 수요처들 사이의 최적 경로와 공급량을 동시에 고려하여 공급 계획을 수립하였다. 이렇게 수립된 모델의 해를계산하기 위해 진화론적 방법을 이용하였다. 제안된 방법론을 이용할 때 중소기업의 어려움을 고려하여 과도한 투자비의 부담이 큰 상용 소프트웨어 대신 문제고유의 특성을 고려하여 최적 경로를 계산할 수 있다. 서울의 각 지역별로 바이오 연료를 공급하는 사례를 통해 제안된 방법을 수치적으로 설명하였다.

POSITION RECOGNITION AND QUALITY EVALUATION OF TOBACCO LEAVES VIA COLOR COMPUTER VISION

  • Lee, C. H.;H. Hwang
    • 한국농업기계학회:학술대회논문집
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    • 한국농업기계학회 2000년도 THE THIRD INTERNATIONAL CONFERENCE ON AGRICULTURAL MACHINERY ENGINEERING. V.III
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    • pp.569-577
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    • 2000
  • The position of tobacco leaves is affluence to the quality. To evaluate its quality, sample leaves was collected according to the position of attachment. In Korea, the position was divided into four classes such as high, middle, low and inside positioned leaves. Until now, the grade of standard sample was determined by human expert from korea ginseng and tobacco company. Many research were done by the chemical and spectrum analysis using NIR and computer vision. The grade of tobacco leaves mainly classified into 5 grades according to the attached position and its chemical composition. In high and low positioned leaves shows a low level grade under grade 3. Generally, inside and medium positioned leaf has a high level grade. This is the basic research to develop a real time tobacco leaves grading system combined with portable NIR spectrum analysis system. However, this research just deals with position recognition and grading using the color machine vision. The RGB color information was converted to HSI image format and the sample was all investigated using the bundle of tobacco leaves. Quality grade and position recognition was performed through well known general error back propagation neural network. Finally, the relationship about attached leaf position and its grade was analyzed.

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기술 및 시장을 고려한 최적 탄소자원화 기술 선정방법 (Optimal Carbon Upcycling Technology Selection Method Considering Technology and Market)

  • 이지현;제갈성;조지은
    • 신재생에너지
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    • 제19권1호
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    • pp.41-52
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    • 2023
  • Various carbon upcycling technologies have been proposed and are under development to achieve Korea's carbon neutrality target. Many chemical reactions are under development through various chemical reaction pathways, and different technological maturity levels are shown for each country and company. In this situation, it is essential to establish investment decisions such as research funds and human resources allocation through technological and economic analysis for close commercialization technologies and basic technologies with low technology readiness levels (TRL). Therefore, in this study, the technology development priority for developing carbon upcycling items was selected according to the domestic Carbon Capture & Utilization (CCU) technology roadmap using the stakeholder selection tool released by EU CarbonNext. As a result of the analysis, the TRL level of Korea's major carbon upcycling technologies was analyzed to be lower than that of other carbon resource technologies, and it was considered desirable to invest in mineral carbonization technologies among various candidate technologies.