• 한국동물위생학회지
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• 제44권4호
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• pp.185-194
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• 2021

Polyglutamine extension in the coding sequence of mutant huntingtin causes neuronal degeneration associated with the formation of insoluble polyglutamine aggregates in Huntington's disease (HD). Mutant huntingtin can form aggregates within the nucleus and processes of neurons possibly due to misfolding of the proteins. To better understand the mechanism by which an elongated polyglutamine causes aggregates, we have developed an in vitro binding assay system of polyglutamine tract from truncated huntingtin. We made GST-HD exon1 fusion proteins which have expanded polyglutamine epitopes (e.g., 17, 23, 32, 46, 60, 78, 81, and 94 CAG repeats). In the present emergence of new study adjusted nanotechnology on protein chip such as surface plasmon resonance strategy which used to determine the substance which protein binds in drug discovery platform is worth to understand better neurodegenerative diseases (i.e., Alzheimer disease, Parkinson disease and Huntington disease) and its pathogenesis along with development of therapeutic measures. Hence, we used strengths of surface plasmon resonance (SPR) technology which is enabled to examine binding specificity and explore targeted molecular epitope using its electron charged wave pattern in HD pathogenesis utilize conjugated mutant epitope of HD protein and its interaction whether wild type GST-HD interacts with mutant GST-HD with maximum binding affinity at pH 6.85. We found that the maximum binding affinity of GST-HD17 with GST-HD81 was higher than the binding affinities of GST-HD17 with other mutant GST-HD constructs. Furthermore, our finding illustrated that the mutant form of GST-HD60 showed a stronger binding to GST-HD23 or GST-HD17 than GST-HD60 or GST-HD81. These results indicate that the binding affinity of mutant huntingtin does not correlate with the length of polyglutamine. It suggests that the aggregation of an expanded polyglutamine might have easily occurred in the presence of wild type form of huntingtin.

• 정보보호학회논문지
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• 제20권6호
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• pp.97-109
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• 2010

온라인상 저작권 침해와 관련, 1차적인 책임은 불법 저작물을 복제 전송하여 유통시킨 개인에게 있겠지만, 불법저작물 유통에 대한 장을 제공한 온라인서비스제공자(Online Service Provider, OSP)의 간섭책임의 문제가 대두되었고, 현재 대부분의 OSP는 저작권 간접침해의 책임을 회피하고, 이미지 훼손을 방지하기 위하여 자율적으로 필터링 기술을 적용하고 있으며, 특히 우리나라의 경우는 P2P나 웹하드 서비스제공자 등과 같은 특수한 유형의 OSP에게는 저작권법상 필터링 의무가 발생하고, 이를 위반하면 과태료 처분까지 받도록 규정하고 있다. 하지만 OSP의 필터링에 대해서는 그 필요성에도 불구하고 효율성과 타당성에 대해 많은 논란이 제기되고 있다. 이에 따라 이 글에서는 먼저 인터넷이 태동하고 인터넷 기술발전을 선도해 온 미국의 OSP의 책임이론과 우리 저작권법상 OSP의 책임제한 규정 및 필터링 관련 규정을 살펴보고 이어서 국내 OSP의 필터링 적용현황과 적용상의 한계를 살펴보았다. 그리고 국내 OSP의 필터링 개선방안으로 OSP의 책임제한 요건의 명확화, 저작권자와 OSP의 협력방안 모색, 상이한 필터링 기술간의 호환성을 제공하기 위한 표준 적용, 기타 고려사항 등 4가지를 제시하였다.

• 응용통계연구
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• 제26권1호
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• pp.151-162
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• 2013

중고제품 특히 고가인 중고품에 대한 점증하는 수요로 인하여 그러한 제품에 대한 보증과 보전정책이 최근 제품의 신뢰성을 향상시키기 위해 연구되고 있다. 이 논문에서는 사용한 년 수 x에서 고객에 의해서 구입된 중고제품에 대한 주기적인 유지보수모형을 연구하였다. 구입할 때 판매자는 제품의 고장율을 줄이기 위해서 그리고 각각의 유지보수가 수행되고 난 이후에 신뢰성을 향상시키기 위해서 정해진 보증기간을 제공한다. 만일 연속적인 유지보수 사이에서 고장이 일어난다면 단지 최소수리가 행해진다. 보증정책에 대해서 보증기간동안에 주기적인 유지보수 점검과 더불어 각 고장에 관해서는 무상 비재생수리를 한다. 따라서 이러한 보증정책 하에서 보증기간에 일어난 모든 유지보수와 수리비용은 판매자에게 부과된다. 제안된 주기적인 유비보수 계획에 대해서 보증기간 동안에 판매자에게 부과된 기대 총비용을 계산하기 위한 모형과 판매자의 측면에서 총기대보증비용을 최소화하기 위한 각 유지보수에서 고장율의 최적향상수준을 유도한다. 또한 제안된 방법들에 근거해서 최적향상수준에 대한 수치적인 결과를 제시한다.

• 대한방사선기술학회지:방사선기술과학
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• 제19권1호
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• pp.55-74
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• 1996

This study was carried out to improve service efficiency and to cope with a emergency situation in emergency radiography, through analysis of the radiographic distribution and literature cited about emergency care. Data collection of radiographic distribution was surveyed for 761 emergency outpatients who visit during JAN, 1994 at ER of the general hospital in Pusan city. The results is as follows: Emergency radiography rate of simple radiography was 61.1 %, special radiography 2.5 %, CT 12.6 %, and ultrasonography 6.7 %. In simple radiography rate, a high rate was distributed on male(63.6 %), thoracicsurgery part(90.0%), admission patient(74.9 %), and long stayed patient at ER. In special raiography rate, a high rate was observed in urologic part(28.6%), and in CT rate, observed neurosurgery part(49.2 %) and neurologic part(36.7%). Ultrasonography rate was high for female(8.8 %) and internal medicine part(15.9 %). There are distributed regional radiography rate in radiographic type that chest(55.3 %) is high in the simple radiography, urinary system(1.2%) in the special study, and brain(40.0 %) in the CT. Regional radiography rate according to diagnostic department also was showed highly for head(64.6%) in neurosurgery, chest(90.0%) in thoracic-surgery, abdomen(58.0%) in general-surgery, spine (40.0% ) in neuro-surgery, and pelvis(15.9%), upper extrimity(20.5%), and lower extrimity(31.8%) in orthopedic-surgery each. Mean radiographic case number per patient of simple radiography was sinificant on sex, age, transfer relation in both total and radiographic patients(p<0.05). Mean radiographic case number was highly distributed on male(2.2 case number) in sex, on thirties(2.7) in age, transfered patient(2.7) in patient type, and on neurosurgery(3.4) in diagnostic charged part. Total radiographic case number in regional part was highly distributed on chest(499 case number). Considering the above results, emergency radiographer should take care of the elder patient in emergency radiography and get hold of injury mechanism to decrease possible secondary injury during radiography. Because of high radiography rate of urinary system in special study, radiographer should know well about dealing with contrastmedia administration and related instrument. All radiographer who take charge emergency patient should cope with a emergency situation during radiography, Because head trauma patients is very important in patient care, especilly in CT at night, charged doctor should be always silted with CT room and monitoring-patient. Radiography was reqested by many diagnostic department in ER. Considering that rate of simple radiography is high, special room for emergency radiography should be established in ER area, and the radiographer of this room should be stationed radiologic technician who is career and can implement emergency patient care.

• 한국보건간호학회지
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• 제3권2호
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• pp.5-46
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• 1989

The current medical payment Insurance Rates in Korea stipulate charges for medical treatment by the doctor, pharmaceutist, medical technician and maternity nurse. But unfortunately didn't specify those charges for nursing done by the professional nurse. Only basic nursing fee is accounted insufficiently in current medical insurance fee schedule. therefore, Being face with covering entire people by medical insurance by 1991, It seems that the problems pertaining to operating the hospital and medical insurance system would be incessantly expanded in that no mention is made of medical charges rendered by major medical producer service in the current system, For that reason, this study made an attempt to clarify the importance the professional nursing puts of the current medical payment. The purpose of this study was to accounting nursing fee which diveded into the current medical fee schedule. (Method) 1. Data collection; Importance and difficulties in nursing activities was conducted in 'S' National University Hospital. Total nursing activities were selected 72 items which included direct care and indirect care. This study was conducted to evaluating the degree of importance and difficulties according to nursing activities through questionnaire to 204 RN. and so relative difficulties (acuity) were computered because the nursing cost level of each nursing service was differently established by the equivalent coefficient according to degree of relative difficulty and time required. 2. Calculation of cost according to nursing activities; After 47 nursing activities were selected in General surgery nursing units, calculation of nursing cost was as follows Cost of Nursing activity = (relative difficulty X Average hourly wage and benefits of nurse) + material cost of nursing -t- Average nursing administration cost So, Calculated cost by nursing activities was compared to current non-insured and insurance rate. 3. Calculation of nursing cost by K - DRG ; Total of 578 patients who were hospitalized in General Surgery units from January to March 1988 ware classified by K - DRG After estimation of total nursing cost based on the K-DRG, verified the appropriateness of basic nursing fee in medical insurance rate (Results) 1. Analysis of degree of importance and difficulties were 4.16 and 3.67 based on 5 point scale. This score were judged that it is worthy specifying the nursing fee 2. The nursing cost of 47 nursing service items in general surgery patients showed that the average cost of nursing activity was \1374.5 and The lowest cost was \217 of 'oral administration nursing' item, The highest cost was \11,025 of 'saline enematill clear' item 3. The result of comparison between the calculated cost by nursing activities against the current non-insured and insurance rate showed that 13 items(27.7%) involved to payment of insurance rate, 9 items(19.1%) involved to non-insured rate, remainder 25 items (53.2%) were not charged anywhere of total 47 nursing activities 4. When calculated cost by nursing activities was 100. current insurance rate was 62.3, non-insured rate was 176.6. Therefore this showed that most of non-insured rate were higher than calculated nursing cost. The insurance rate, however, were lower than it. Reim-bursement was imputed to non-insured patients. So the current rate system became estrainged from cost system. When Remainder 25 items of nursing activities compared' to \1390 of daily basic nursing fee per patient belonged to payment as a insurance fee schedule, basic nursing fee schedule was 1-2% of calculated cost of nursing activities. Therefore it showed that nursing fee was not counted adequately in it. 5. Nursing cost by K-DRG estimated in chart review based on counting number of nursing activities and length of stay The result showed that average amount of total nursing cost was \183828.1 Comparison of nursing cost calculated by K- DRG and basic nursing fee schedule showed that only 12.3% of nursing cost was charged (Conclusion) From the above research result, It is fact that nursing prime cost should be estimated more accurately and included adequately in current medical payment system. The payment system of nursing activities should be introduced not only nursing activities of drug administration and injection fee belonged to insurance fee schedule but also most nursing activities belonged not to mekical fee schedule. Even if introducing payment system of nursing activities, It should be estimated scientific method of Accounting nursing cost So nurses could offer nursing care of good quality, thereby they could make a great contribution not merely to the convalescence of the patient but to the promotion of the people's health.

• 한국보건간호학회지
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• 제10권1호
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• pp.118-138
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• 1996

Because of accelerated urbanization public body visiting nursing project that started according as matter of health on urban class in the lower brackets of income was concentrated on Social interests has a unsatisfied points to propel project efficiently from the lack of rating materials. Therefore centering around written contents in documentary literature of citizen health by household in five years from starting year of project to now. visiting frequency by medical manpower was evaluated quantitatively and qualitatively in aspect of management hereupon. for the sake of giving a basic materials for public health project of this field. This research presents documentary literature of citizen health which become materials is that as one person's charged region of nurse in duty scale. district is Kang-Buck Gu. the object is resident in the lower brackets of income grounded livelihood protection law and who is admitted by the head of organ~chief of health care). and the number of material centering around the head of a household is 415 copy. The result of research is summarized. as follow. 1. Average visiting frequency examinated by medical manpower show difference according to valuables of supervision characteristics namely average visiting. Frequency of nurse has long term residence in case registration season is early and supervision season is the first year and is high incase a kind of house is unlicdnsed mountain town. Average visiting frequency with doctor is high incase supervision season is the first year and the medical insurance system is admitted by chief of health care. That shows that a man of discomfort behavior left alone are yet many in local society. The meaning of this result shows that the continuity of official relation about class in the lowest brackets of income of long term residence goes well between househole who is a user of visiting nursing service of the object according to midway income under management influences a given duty of nurse s and so causes quantitative decrease. 2. In case behavier and condition of health that nurse diagnoses are bad. as the type matter is a lack of health and the number of patient is large. the average visiting frequency of nurse is high. because average visiting frequency with doctor is high as the condition of health is bad and the number of patient is large. That is similar with that of nurse. CD Average visiting frequency of nurse s seen by matter of disease is very high only in apoplexy by 39.50 and is confined within limits from 7.63 to 11.36 in other disease. But average visiting frequency with doctor is double as many as that of nurse but defined in apoplexy hypertension and articulate. (1) Average visiting frequency of nurse by existence in inoculation of hepatitis is low by 6.73 in unidentified group and very high by 26.89 in group of non-inoculation and the case of the antigenic positive man of B type hepatitis or epileptic who can't be inoculated shows 13.00 and that even family nursing service is needed to them. That result shows that though one person nurse of local charge has a large scale of duty. as visting nursing service is given a class who has a large demand preferentially by respectively accurate nursing diagnosis. the number of diagnosis service is similar with it. 3. During five years. average visiting frequency of nurse is 10.84 and average visiting frequency with doctor is 76.50 seeing from the official scale of nurse. visiting by household is performed two more per year to the average. Seeing this by type of service. average visiting frequency of nurse is higher in indirectly nursing than in directly nursing and that suggests that at the time of visiting household nurse performs education of protection lively save patient but at the time of contrastedly visiting with doctor. directly nursing is more contents of service show no difference by man power and medication dressing by demand is 14.3 and 18.6 the aid of hardship term of doctor and nurse is high by 18.7 and 17.00 in the request of hospitalization when seeing by demands. 4. Action by turns exemplified 1994 is well in sequence of 2/4 turn. 3/4 turn. 1/4 turn. 4/4 turn. When seen by average visiting frequency of nurse but gradually is even. Without difference by turns. average visiting frequency of doctor is much higher in 1/4 turn than other turns. Type of service by turns is all even but directly nursing is inactive in 4/4 and indirectly nursing. Very increases in 4/4 and so. Nurse's quantity of duty is plentiful that shows that by evaluation of last turn and plan of project. Contents of service follows that medication and dressing is the highest by' 5.57 in 1/4turn. goes down gradually by turn. becomes 3.57 in 3/4 turn. and increases again by 4.83 in 4/4 turn. the rest service is higher in 2/4 turn than other turns. 5. Total visiting frequency of nurse is explained to total $37.5\%$ by six valuables of visiting frequency of doctor. nursing demand. demand of diagnosis. condition of behavior. year. Special terms and magnitude of influential power is the same as sequence of enumerated valuables. Namely. the higher the visiting frequency of doctor. the bigger nursing and demand of diagnosis is. the worse the condition of behavior is. the older the object is and the more the household of special terms is. the high total visiting frequency of nurse is.

• 대한장애인치과학회지
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• 제14권1호
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• pp.11-16
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• 2018

In order to increase the accessibility of dental care for people with disabilities, National Health Insurance Service has implemented an additional point system of National Dental Insurance for dental treatment of patients with a special health care need (AID). The purpose of this study is to investigate the types and status of AID in Korea using data of the Health Insurance Review and Assessment Service from 2011 to 2017. The basic consultation fee is increased by 9.03 points (713 won) for brain disorder, intellectual disability, mental disability, or autistic disorder. From 2011 to 2015, the number of claims with a basic consultation fee increased from 90,456 to 141,179. Dental treatment and surgical treatment fee is increased by 100% of the defined insurance score for each of the 15 items. During the five years from 2012 to 2016, the number and amount of claims for each item increased steadily. Of the total claims for 5 years, endodontic treatment was highest, with 107,477 cases, followed by 51,641 cases of scaling. There are two types of dental safety observation fee, simple and complex. The simple safety observation fee is 10,370 won per day, and the complex safety observation fee is 20,750 won per day. Dental safety observation fees were charged 34 times in 2015, 14 times in 2016, and 41 times through May 2017. From 2011 to 2017, the number and amount of claims using AID for dental care for people with disabilities increased. However, considering that the number of registered dental users with disability was about 560,000 in 2016, the number of claims using AID is 1-20,000, which is less than 2% of registered dental users with disability. Therefore, it is necessary to expand dental services for people with disabilities including AID.

• 마케팅과학연구
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• 제18권2호
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• pp.223-252
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• 2008

본 연구에서 우리는 시장 자료가 부족한 상황에서 개인레벨과 총량레벨 모두에서 신상품들과 기존 상품들 간의 동태적 대체, 경쟁을 예측하는데 적합하도록 전환비용 요소가 포함된 신 구상품간 대체 경쟁 예측 선택기반 확산 모형을 제안하고자 한다. 추가적으로, 우리는 제안된 모형을 디지털 케이블 TV, IPTV 등이 포함된 신규 유료 양방향 방송서비스들과 기존의 아날로그 케이블 TV가 대표하는 구 유료 방송 서비스간에 벌어지는 대체 및 경쟁 예측 사례에 적용하여 본 모형의 의의를 밝히며, 또한 관련된 실증적 시사점을 도출하고자 한다. 실증 적용 결과, 유료 방송서비스 시장에 있어선 기존 상품과 전환 비용을 고려하지 않고 신상품 수요 예측을 하는 경우, 초기 확산 속도를 과대 추정하거나 왜곡된 예측 경향이 존재하여, 보다 현실적이고 보수적인 신상품 수요 예측을 위해 이들의 반영이 필요함을 밝혀, 본 연구에서 제안된 모형의 의의를 확인할 수 있었다. 또한, 제안된 모형이 S자 곡선을 미리 가정하기보다, 실증 대상의 속성이 소비자의 상태전환에 미치는 영향의 정도에 따라 유연한 형태의 총량시장 성장 곡선을 도출함을 확인하였다. 실증적으로는 여러 가격 조합에 대해 IPTV가 디지털 케이블 TV에 비해 더 선호되어 가입자 확보 면에서 우위에 있을 것임을 확인할 수 있었다. 한편, 기존 상품인 아날로그케이블 TV의 경우 열위의 서비스 속성에도 불구하고, 가격에서의 우위와 높은 전환비용의 존재로 인해 급격한 대체보다 점진적인 대체가 이루어질 가능성이 큼을 알 수 있었다.

• 한국언론정보학보
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• 제19권
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• pp.265-294
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• 2002

이 연구의 목적은 <여인천하> 시청자 게시론 분석을 통해서 인터넷 수용자가 어떻게 사이버 공간에 참여해서 그들만의 사이버 문화공간을 만들어나가는가를 분석하는 데 있다. 인터넷게시판 수용자는 '드라마 공동체의 참여', '평가와 해석적 참여', '개인적 참여', '방송사에 대한 비판', '공동작가의 참여' 방식을 통해서 사이버 공동체를 형성해나가고 있었다. 사이버 공동체는 보편적 의미공유보다 국면적 의미공유를 향하는 의미공동체를 지향하고 있었다. 게시판의 참여자들은 소속감이나 동질감이 약하고, 글쓰기의 즐거움이나 타자와의 커뮤니케이션을 하는 재미 등과 같은 정서적 욕구에 지나치게 기대어 있었다. 동시에 방송사에 대한 비판이나 공동 작가적 참여를 통해서 적극적으로 운영방식이나 프로그램에 참여하고 있었다. 이것은 게시판 공간이 개인적이면서 공적이고 참여적이면서도 소극적인 이중적 사이버 공간이라는 것을 의미한다.

• 한국정보전자통신기술학회논문지
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• 제13권2호
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• pp.159-168
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• 2020

소비패턴과 무관하게 부과되는 현행 주택용 전기요금은 소비자선택권을 제약하는 문제가 있다. 이의 개선을 위하여 정부는 2019년 9월부터 주택용 계시별 요금제 기반의 실증 사업을 개시하였으나 그 효과에 대한 분석은 아직 제한적이다. 본 연구에서는 우선 기존 누진요금 대비 주택용 계시별 요금의 변화와 한계를 분석하였다. 분석을 위하여 두 개 단지의 아파트 전기사용량 데이터를 사용하였다. 주택용 계시별 요금제 적용 결과 전기사용량이 많은 경우 요금이 최대 33.8 % 까지 감소하는 반면 전기사용량이 적은경우 최대 117.7 % 증가한 것으로 나타났다, 이는 사회적 관점에서 전기요금의 수용성 문제를 야기할 수 있다. 이를 극복하기 위하여 본 연구에서는 누진제기반 계시별요금제를 제시하였다. 분석 결과 누진제 대비 계시별 요금제는 사용자의 전력소비 패턴에 따라 요금의 변동을 보이면서도 요금변동률 평균은 32%에서 -1.9 %로 감소한 것으로 나타났다. 이는 제안된 전기요금이 기존 누진제의 틀을 유지하면서도 계시별요금제의 효과를 지원할 수 있음을 의미한다.