• Journal of the Korean Society of Food Science and Nutrition
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• v.32 no.5
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• pp.758-763
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• 2003

Amino acid transporters play an important role in supplying nutrients to normal and cancer cells for cell proliferation. System L is a major transport system responsible for the N $a^{＋}$-independent, large neutral amino acids including several essential amino acids. L-type amino acid transporter 1 (LAT1), an isoform of system L amino acid transporter, is highly expressed presumably to support their continuous growth and proliferation in malignant tumors. 2-Aminobicyclo- (2,2,1) -heptane-2-carboxylic acid (BCH) is a model compound for study of amino acid transporter as a system L selective inhibitor. In the present study, we examined whether BCH induced growth inhibition in KB human oral squamous carcinoma cell line or not. The uptake of L-［$^{14}$ C］leucine by KB cells is inhibited by BCH in a concentration dependent manner with a Ι $C_{50}$ value of 75.3$\pm$6.2 ${\mu}{\textrm}{m}$ and a $K_{i}$ value of 98.7$\pm$ 4.1 ${\mu}{\textrm}{m}$. The growth of KB cells is inhibited by BCH in time dependent manner and concentration dependent manner with a Ι $C_{50}$ value of 11.1 $\pm$0.8 mM. In the DNA of KB cells treated with the various concentrations and various periods of BCH, the characteristic ladders associated with DNA fragmentation were not observed. These results suggest that BCH inhibits the growth of KB oral epidermoid carcinoma cells through the inhibition of transport of neutral amino acids into cells without DNA break down. This phenomenon will be a new rationale for anti-cancer therapy.y.

• Journal of the Korean earth science society
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• v.28 no.7
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• pp.914-924
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• 2007

This study is to compare differences in the depositional environments of natural beaches with those of beaches developed with artificial structures in the East Coast of Korea. Naksan-Osan beaches were selected for the examination of natural beaches and Anmok-Yumjun beaches for that of developed beaches. The study was performed on the foreshores and backshores of the selected beaches, and was based on the field research during the flood period of year 2004 and the dry period of year 2005. In Naksan-Osan beaches, pain size is fuel and sorting is better from northern coast to southern coast. Furthermore, sediment undergoes changes regularly and seasonal variations are small. But in Anmok-Yumjun beaches, grain size is coarser and sorting is worse than in Naksan-Osan beaches, showing irregular tendencies. The characteristic features of the two beaches would be effected by longshore currents which change along the type of coast line and have an effect on sediment. Especially, long shore currents interrupted by artificial structures in Anmok-Yumjun beaches may cause sedimental environment changes. In Anmok-Yumjun beaches, harbor expansions will be continued, and thus more changes are expected to occur in the beaches.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.36 no.1
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• pp.105-114
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• 2016

With approximately 20 million transportation card data entries of the metropolitan districts being generated per day, application of the data to management and policy interventions is becoming an issue of interest. The research herein attempts a model of the possibility of dynamic demand change predictions and its purpose is thereby to construct a Dynamic Passengers Trip Assignment Model. The model and algorithm created are targeted at city rail lines operated by seven different transport facilities with the exclusion of travel by bus, as passenger movements by this mode can be minutely disaggregated through card tagging. The model created has been constructed in continuous time as is fitting to the big data characteristic of transport card data, while passenger path choice behavior is effectively represented using a perception parameter as a function of increasing number of transfers. Running the model on 800 pairs of metropolitan city rail data has proven its capability in determining dynamic demand at any moment in time, in line with the typical advantages expected of a continuous time-based model. Comparison against data measured by the eye of existing rail operating facilities to assess changes in congestion intensity shows that the model closely approximates the values and trends of the existing data with high levels of confidence. Future research efforts should be directed toward continued examination into construction of an integrated bus-city rail system model.

• Journal of the Korean Institute of Gas
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• v.24 no.5
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• pp.29-38
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• 2020

It is practically difficult to accurately measure the temperature and concentration of a large combustion systems at industrial sites in real time. Temperature measurement using thermocouple, which are mainly used, is a point-measuring method that is less accurate and less reliable to analyze the wide area range of inner combustion system, and has limitations to internal accessibility. In terms of concentration analysis, most measurement methods use sampling method, which are limited by the difficulty of real-time measurement. As a way to overcome these limitations, laser-based measurement methods have been developed continuously. Laser-based measurement are line-average measurement methods with high representation and precision, which are beneficial for the application of large combustion systems. In this study the temperature and concentration were measured in real time by water vapor and oxygen generated during combustion using Tunable Diode Laser Absorption Spectroscopy (TDLAS). The results showed that the average temperature inside the combustion system was 1330℃ and the mean oxygen concentration was 3.3 %, which showed similar tendency with plant monitoring data.

• Transactions of the KSME C: Technology and Education
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• v.1 no.1
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• pp.107-113
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• 2013

This paper presents the process of turbine development for Organic Rankine Cycle(ORC) system. Development of turbine for ORC system is hot issue in the electric generation market due to the characteristic of organic refrigerant which the evaporate temperature is lower than general refrigerant. Recently, the industry have an interest about ORC turbine development in Korea, and they presented numerous research results. In developing the turbine, several processes can be considered. However, there was few document about ORC turbine development because of the trade secret. This paper can be used as a reference in developing ORC turbine.

• Magazine of the Korean Society of Agricultural Engineers
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• v.18 no.2
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• pp.4116-4120
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• 1976

With the use of many rivers increased nearly to the capacity, the need for information concerning daily quantities of water and the total annual or seasonal runoff has became increased. A systematic record of the flow of a river is commonly made in terms of the mean daily discharge Since. a single observation of stage is converted into discharge by means of rating curve, it is essential that the stage discharge relations shall be accurately established. All rating curves have the looping effect due chiefly to channel storage and variation in surface slope. Loop rating curves are most characteristic on streams with somewhat flatter gradients and more constricted channels. The great majority of gauge readings are taken by unskilled observers once a day without any indication of whether the stage is rising or falling. Therefore, normal rating curves shall show one discharge for one gauge height, regardless of falling or rising stage. The above reasons call for the correction of the discharge measurements taken on either side of flood waves to the theoretical steady-state condition. The correction of the discharge measurement is to consider channel storage and variation in surface slope. (1) Channel storage As the surface elevation of a river rises, water is temporarily stored in the river channel. There fore, the actual discharge at the control section can be attained by substracting the rate of change of storage from the measured discharge. (2) Variation in surface slope From the Manning equation, the steady state discharge Q in a channel of given roughness and cross-section, is given as {{{{Q PROPTO SQRT { 1} }}}} When the slope is not equal, the actual discharge will be {{{{ { Q}_{r CDOT f } PROPTO SQRT { 1 +- TRIANGLE I} CDOT TRIANGLE I }}}} may be expressed in the form of {{{{ TRIANGLE I= { dh/dt} over {c } }}}} and the celerity is approximately equal to 1.3 times the mean watrr velocity. Therefore, The steady-state discharge can be estimated from the following equation. {{{{Q= { { Q}_{r CDOT f } } over { SQRT { (1 +- { A CDOT dh/dt} over {1.3 { Q}_{r CDOT f }I } )} } }}}} If a sufficient number of observations are available, an alternative procedure can be applied. A rating curve may be drawn as a median line through the uncorrected values. The values of {{{{ { 1} over {cI } }}}} can be yielded from the measured quantities of Qr$.$f and dh/dt by use of Eq. (7) and (8). From the 1/cI v. stage relationship, new vlues of 1/cI are obtained and inserted in Eq. (7) and (8) to yield the steady-state discharge Q. The new values of Q are then plotted against stage as the corrected steadystate curve.

• The Korean Journal of Physiology and Pharmacology
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• v.13 no.4
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• pp.273-279
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• 2009

The accumulation of ${\beta}$-amyloid (A${\beta}$) aggregates is a characteristic of Alzheimer's disease (AD). Furthermore, these aggregates have neurotoxic effects on cells, and thus, molecules that inhibit A${\beta}$ aggregate formation could be valuable therapeutics for AD. It is well known that aggregation of A${\beta}$ depends on its hydrophobicity, and thus, in order to increase the hydrophilicity of A${\beta}$, we considered using citrate, an anionic surfactant with three carboxylic acid groups. We hypothesized that citrate could reduce hydrophobicity and increase hydrophilicity of A${\beta}_{1-40}$ molecules via hydrophilic/electrostatic interactions. We found that citrate significantly inhibited A${\beta}_{1-40}$ aggregation and significantly protected SH-SY5Y cell line against A${\beta}_{1-40}$ aggregates-induced neurotoxicity. In details, we examined the effects of citrate on A${\beta}_{1-40}$ aggregation and on A${\beta}_{1-40}$ aggregates-induced cytotoxicity, cell viability, and apoptosis. Th-T assays showed that citrate significantly inhibited A${\beta}_{1-40}$ aggregation in a concentration-dependent manner (Th-T intensity: from 91.3% in 0.01 mM citrate to 82.1% in 1.0 mM citrate vs. 100.0% in A${\beta}_{1-40}$ alone). In cytotoxicity and viability assays, citrate reduced the toxicity of A${\beta}_{1-40}$ in a concentration-dependent manner, in which the cytotoxicity decreased from 107.5 to 102.3% as compared with A${\beta}_{1-40}$ aggregates alone treated cells (127.3%) and the cell viability increased from 84.6 to 93.8% as compared with the A${\beta}_{1-40}$ aggregates alone treated cells (65.3%). Furthermore, Hoechst 33342 staining showed that citrate (1.0 mM) suppressed A${\beta}_{1-40}$ aggregates-induced apoptosis in the cells. This study suggests that citrate can inhibit A${\beta}_{1-40}$ aggregation and protect neurons from the apoptotic effects of A${\beta}_{1-40}$ aggregates. Accordingly, our findings suggest that citrate administration should be viewed as a novel neuroprotective strategy for AD.

• The Journal of the Korea Contents Association
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• v.8 no.6
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• pp.1-7
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• 2008

The paper is to solve the problem of existing sound system, which has difficulties of system organization and the increase of additional install cost and unfriendly interior. To solve the existing system, we drew the new sound system based on PLC and studied it. A transmitter and a receiver were designed using the PLC chip INT5500CS. Sound system was configured with a CD player that sound signals are sent from the transmitter and a speaker connected to the receiver. For analysis of characteristics of this system, a USBPre external sound card and Smaart Live 5 which is a PC-based sound measuring program were added. As a result of our experiment, the measured signal level is $2{\sim}3$[dB] lower than reference signal, latency is 16.69[ms] and the specific character of coherency is bad in high frequency band. Otherwise, this system transmits and receives signals over 90[%] in good condition as a result of measuring pink noise, frequency(1kHz), and phase, magnitude. In view of the result so far achieved, the system designed our team has excellent performance, it resolves defect of existing audio signal transmition system.

• Cartoon and Animation Studies
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• s.21
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• pp.1-17
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• 2010

As animation emerged as a high value-added content business, more studies are conducted focusing on the fact that the key to the success of animation is not a story but a character. This study aims to examine the characters of , the globally loved animation, and figure out its interactive way of attracting viewers based on Spectatorship Theory, so that it can help set the nation's TV animation series to be made on the right track. To achieve this goal, it will explore various aspects including the concept of animation character, the relations between ideology and character, and the changes in design according to a social phenomenon, then based on Spectatorship Theory will analyze and suggest how the characters of fulfill the required conditions to attract viewers. In addition, it will examine the wide application of the characters of . In conclusion, unlike theatrical animation, TV animation has a characteristic that it can easily and repeatedly deliver messages to viewers over a long time, however, domestic TV animation turned out to fail to utilize the advantage. In other words, while its character has distinct individuality, it is not supported by creative and solid story line, and the character is not attractive as much as the characters of which successfully evoke sympathy from viewers. In animation, arousing sympathy from its viewers or audiences is very important, so a character that well reflects social discourse is an integral part of it. Therefore, in-depth and specialized study on animation's character is highly required for the sustainable success and growth of domestic animation.

• Journal of the Korean Society for Marine Environment & Energy
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• v.19 no.3
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• pp.173-184
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• 2016

This study was carried out to understand the characteristic distributions of water temperature and salinity in accordance with seasons atound the Tongyeong and Geoje, based on a cluster analysis. Water temperatures in coastal areas were $1-2^{\circ}C$ higher than those in open seas when in the spring, autumn and winter. In particular, a south-northward isothermal line was established at the bottom layer in the winter of 2014, unlikely to the surface layer. In addition, a south-northward isohaline was also established at the bottom layer in the winter of 2013. Therefore, we recognized that a moving pattern of water masses has also a difference since forming directions of those lines were not equivalent with each other between the surface and bottom layers. In contrast, stratification appeared in the summer with a roughly difference of water temperature of $10^{\circ}C$ and a salinity of 2-10 psu between the layers. A cluster analysis indicated that the southeastern coastal waters have three distinct water masses, even though some complicated situations exist due to the seawater inflow from the outside. However, the result of a cluster analysis turned out quite reasonable because the result of a regression analysis proved that it is appropriate, just except for the timing of a south-northward front formation.