• Clinical and Experimental Pediatrics
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• v.57 no.10
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• pp.445-450
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• 2014

Purpose: Familial hypokalemic periodic paralysis (HOKPP) is an autosomal dominant channelopathy characterized by episodic attacks of muscle weakness and hypokalemia. Mutations in the calcium channel gene, CACNA1S, or the sodium channel gene, SCN4A, have been found to be responsible for HOKPP; however, the mechanism that causes hypokalemia remains to be determined. The aim of this study was to improve the understanding of this mechanism by investigating the expression of calcium-activated potassium ($K_{Ca}$) channel genes in HOKPP patients. Methods: We measured the intracellular calcium concentration with fura-2-acetoxymethyl ester in skeletal muscle cells of HOKPP patients and healthy individuals. We examined the mRNA and protein expression of KCa channel genes (KCNMA1, KCNN1, KCNN2, KCNN3, and KCNN4) in both cell types. Results: Patient cells exhibited higher cytosolic calcium levels than normal cells. Quantitative reverse transcription polymerase chain reaction analysis showed that the mRNA levels of the $K_{Ca}$ channel genes did not significantly differ between patient and normal cells. However, western blot analysis showed that protein levels of the KCNMA1 gene, which encodes $K_{Ca}$1.1 channels (also called big potassium channels), were significantly lower in the membrane fraction and higher in the cytosolic fraction of patient cells than normal cells. When patient cells were exposed to 50 mM potassium buffer, which was used to induce depolarization, the altered subcellular distribution of BK channels remained unchanged. Conclusion: These findings suggest a novel mechanism for the development of hypokalemia and paralysis in HOKPP and demonstrate a connection between disease-associated mutations in calcium/sodium channels and pathogenic changes in nonmutant potassium channels.

• Fashion & Textile Research Journal
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• v.18 no.6
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• pp.800-811
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• 2016

This study aims to extract the multi-channel attributes of Dongdaemun-based fashion brands and consider the effects of these attributes on customer equity, customer satisfaction and re-purchase intention. In total, 493 samples of those who have purchased Dongdaemun-based fashion brand products using multi-channels were collected for the final data analysis, which was performed using SPSS 21.0 and AMOS 18.0. The findings of study are as follows. Among the multi-channel attributes of Dongdaemun-based fashion brands, entertainment and informativeness had a significant effect on all customer equity drivers. In terms of the effects of customer equity drivers on customer satisfaction and re-purchase intention, all customer equity drivers significantly influenced customer satisfaction, while brand equity significantly influenced re-purchase intention. Also, customer satisfaction significantly affected re-purchase intention. In the effective relationship between customer equity drivers and CLV, brand equity causes a significant influence on CLV amongst the customer equity drivers. There were significant differences among groups following the multi-channel shopping orientation of consumers. This study is significant for its scientific focus on the distribution channels of Dongdaemun, and in terms of the practical aspect of identifying the multi-channel attributes considered to be important to consumers. Measuring customer equity will suggest implications about the long-term direction of the development of Dongdaemun-based fashion brands.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.16 no.7
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• pp.1463-1469
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• 2012

This paper has presented the influence of scaling theory on short channel effects of double gate(DG) MOSFET in subthreshold region. In the case of conventional MOSFET, to preserve constantly output characteristics,current and switching frequency have been analyzed based on scaling theory. To analyze the results of application of scaling theory for short channel effects of DGMOSFET, the changes of threshold voltage, drain induced barrier height and subthreshold swing have been observed according to scaling factor. The analytical potential distribution of Poisson equation already verified has been used. As a result, it has been observed that threshold voltage among short channel effects is grealty changed according to scaling factor. The best scaling theory for DGMOSFET has been explained as using modified scaling theory, applying weighting factor reflected the influence of two gates when scaling theory has been applied for channel length.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.17 no.3
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• pp.672-677
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• 2013

This paper have analyzed the change of breakdown voltage for channel dimension of double gate(DG) MOSFET. The breakdown voltage to have the small value among the short channel effects of DGMOSFET to be next-generation devices have to be precisely analyzed. The analytical solution of Poisson's equation have been used to analyze the breakdown voltage, and Gaussian function been used as carrier distribution to analyze closely for experimental results. The breakdown voltages have been analyzed for device parameters such as channel thickness and doping concentration, and projected range and standard projected deviation of Gaussian function. Since this potential model has been verified in the previous papers, we have used this model to analyze the breakdown voltage. As a result, we know the breakdown voltage is influenced on Gaussian function and device parameters for DGMOSFET.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2012.10a
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• pp.811-814
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• 2012

This paper have analyzed the change of breakdown voltage for channel dimension of double gate(DG) MOSFET. The breakdown voltage to have the small value among the short channel effects of DGMOSFET to be next-generation devices have to be precisely analyzed. The analytical solution of Poisson's equation have been used to analyze the breakdown voltage, and Gaussian function been used as carrier distribution to analyze closely for experimental results. The breakdown voltages have been analyzed for device parameters such as channel thickness and doping concentration, and projected range and standard projected deviation of Gaussian function. Since this potential model has been verified in the previous papers, we have used this model to analyze the breakdown voltage. Resultly, we know the breakdown voltage is influenced on Gaussian function and device parameters for DGMOSFET.

• The Transactions of The Korean Institute of Electrical Engineers
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• v.60 no.1
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• pp.205-213
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• 2011

The Long Term Evolution (LTE) system is designed to provide a high quality data service for fast moving mobile users. It is based on the Orthogonal Frequency Division Multiplexing (OFDM) and relies its channel estimation on the training samples which are systematically built within the transmitting data. Either a preamble or a lattice type is used for the distribution of training samples and the latter suits better for the multipath fading channel environment whose channel frequency response (CFR) fluctuates rapidly with time. In the lattice-type structure, the estimation of the CFR makes use of the least squares estimate (LSE) for each pilot samples, followed by an interpolation both in time-and in frequency-domain to fill up the channel estimates for subcarriers corresponding to data samples. All interpolation schemes should rely on the pilot estimates only, and thus, their performances are bounded by the quality of pilot estimates. However, the additive noise give rise to high fluctuation on the pilot estimates, especially in a communication environment with low signal-to-noise ratio. These high fluctuations could be monitored in the alternating high values of the first forward differences (FFD) between pilot estimates. In this paper, we analyzed statistically those FFD values and propose a postprocessing algorithm to suppress high fluctuations in the noisy pilot estimates. The proposed method is based on a localized adaptive moving-average filtering. The performance of the proposed technique is verified on a multipath environment suggested on a 3GPP LTE specification. It is shown that the mean-squared error (MSE) between the actual CFR and pilot estimates could be reduced up to 68% from the noisy pilot estimates.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.35 no.8
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• pp.815-823
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• 2011

Combustion phenomena in porous media combustors are widely used in industrial fields for the combustion of lowgrade fuels and the regeneration of combustion heat. However, studies of combustion phenomena in porous media have been limited, because these phenomena are difficult to observe, and the configurations of porous media are complex. We propose a simple model combustor: a multi-channel combustor that consists of many layers of combustion channels made of quartz plates. We conducted an experimental observation of the flames in the multi-channel combustor and obtained experimental results for the flame stabilization limits. Flames formulated in the multi-channel combustor showed variation in the spatial distribution depending on the heat transfer between neighboring channels. A simple analytical model was developed and the variation in the flammability limits of the multi-channel combustor was discussed. This study will enhance our understanding of flame behavior in a porous-media combustor.

• The Transactions of the Korea Information Processing Society
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• v.6 no.2
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• pp.408-414
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• 1999

In this paper, we propose the method using coherent detection with time division multiple pilot signal for each users I reverse CDMA channel as the structure of reverse CDMA channel to apply CDMA to upstream channel of bidirectional LMDS. By using coherent detection with pilot signal in reverse CDMA channel, capacity can be improved when compared with noncoherent detection, but it is required to allocate pilot signal for all user. And then interference is increased due to allocate continuously the pilot signals. In this case channel capacity is decreased. The method f pilot allocation is needed that reduce this interference and keep synchronization effect using coherent detection, In the reverse link, the pilot allocated to each users at different time and not overlapped is possible solution for it. this pilot is proposed and analyzed its performance and capacity. The result is that proposed method has more increased capacity compared wit others.

• Journal of the Korea Safety Management & Science
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• v.17 no.1
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• pp.203-213
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• 2015

Recently, online grocery shopping has been increasing with the development of internet, mobile, and IT technology due to the proportion of consumers changes like increasing single households and double-income couples. Therefore, online sales from distributors with offline stores have also increased, and the offline retailers are facing their limits in dealing with store-based online channel they have carried out. Domestic offline retailers benchmarked overseas advanced retailers to solve this problem by reviewing about developing the online-only distribution center. However, much investment is needed in order to operate the distribution center with the new concept from abroad. In this study, we have reviewed the current online grocery market trend and the theory related to developing distribution system of the online mall. For offline retailers, we have reviewed the case which developed the distribution center applied to the nation's first online-only distribution center. The purpose of this study is reducing trial and error for local retailers in developing online-only distribution centers and suggesting ways to improve investment effect.

• Korean journal of food and cookery science
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• v.22 no.2 s.92
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• pp.250-257
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• 2006

Foodservice industry and distribution business could make mutual prpgress when they join forces in responding to environmental uncertainty in an efficient manner. The purpose of this study was to examine the relational characteristics of domestic food service businesses and distribution firms in conjunction with the distribution channels and ensuing conflicts between them, to present possible alternatives on and how they should communicate with each other to achieve a satisfactory result. The relational characteristics and ensuing conflicts of food service businesses and distribution firms appeared to be significantly characterized by incongruities of target, role and perception. The types of relational characteristics that were triggered by the disagreement of roles and perception combined to decrease the intensity of the relational commitment. A satisfactory transactional relationship served to ease their conflicts caused by perceptual disagreement, and the soos of conflicts that were rooted in the discord of roles and of perception that increased the degree of relational commitment. As for relational performance, relational commitment, satisfaction with distribution channel and satisfaction with suppliers allowed them to maintain their relationship on a long-term basis.