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Comparative Drug Evaluation of Atorvastatin versus Rosuvastatin in Pharmacotherapy of Korean Patients with Dyslipidemia

  • Park, Seon-Young;Lee, Myung-Koo;Lim, Sung-Cil
    • Biomolecules & Therapeutics
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    • v.16 no.1
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    • pp.54-60
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    • 2008
  • Dyslipidemia is the multiple lipid metabolic disorders which is one of the high risk factors for the atherosclerotic diseases. It increases the morbidity and mortality and therefore, must be treated with antilipidemic agents. HMG-Co A reductase inhibitors (statins), one of many antidyslipidemic agents, have shown to be significant improvement from the various cholesterol levels. Especially, data from many comparative trials suggest that rosuvastatin is more effective than atorvastatin among many other statins. The aims of this study were to evaluate the efficacy and safety between rosuvastatin and atorvastatin in the treatment of Korean patients with dyslipidemia. Currently the Korean Society of Lipidology and Atherosclerosis based on the Korean health screening data suggests that Korean patients with dyslipidemia should be treated by the target cholesterol levels according to the Adult Treatment Panel III guidelines of the US National Cholesterol Education Program (NCEP-ATP III). We reviewed retrospectively all medical histories of the total 392 dyslipidemic patients with atorvastatin or rosuvastatin from June 1st, 2004 to August 31st, 2006 in Chungbuk National University Medical Center. Patients were classified as total 4 groups by the NCEP-ATP III Guidelines. The numbers of enrolled patients were each 5 mg atorvastatin (n=34), 10 mg atorvastatin (n=148), 5 mg rosuvastatin (n=94) and 10 mg rosuvastatin (n=82). In comparison between groups, rosuvastatin groups in the lowering LDL-C had better efficacies, and the results were each 22% (5 mg atorvastatin), 33.3% (10 mg atorvastatin), 35% (5 mg rosuvastatin) and 41.3% (10 mg rosuvastatin) with the dose relationship (P=0.000). Rosuvastatin groups also have shown to be more significantly reducing Total Cholesterol levels compared to atorvastatin groups with the no dose relationship (P=0.000). In the lowering of non-HDL cholesteroles, rosuvastatin groups showed significantly better efficacies than atorvastatin with the dose-relationship (P=0.000). Each medication groups did not demonstrate the differences in the changing of HDL cholesterol and triglyceride levels (P=0.096, 0.309, respectively). In conclusion, rosuvastatin was better efficacious than atrovastatin in reducing LDL-C Total Chol, and Tg. Therefore, rosuvastatin is a good antilipidemic agents for Korean patients with dyslipidemia and it can use to minimize the morbidity and mortality related to the cardiovascular diseases in Korean.

The Present Situation of the University Mathematics Education and the Efficient Methods of Mathematics Education for the 7th Curriculum Generation (대학수학교육의 현황과 7차교육과정세대의 효율적인 수학교육방안)

  • Kim, Kwang-Hwan;Kim, Byung-Hak;Kim, Kyung-Suk;Park, Eun-Ah
    • Communications of Mathematical Education
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    • v.23 no.2
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    • pp.255-277
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    • 2009
  • Currently Science and technology are changing so fast these days, educating competent and creative person, majoring in natural sciences, including mathematics., becoming more and more important. But, in Korea, there are many problems in high school and university education program, so performance level in mathematics is decreasing and avoiding mathematics and natural sciences is increasing. Naturally the numbers of science oritented students in high school are decreasing and ability in mathematics, in particular calculus, is decreasing. Hence, the above situation leads to a reduction of scientific manpower. In this point of a view, we analyse the situation of the downturn of the ability of the science, especially calculus, among engineering majored freshmen. We also study many data reported by Ministry of Education and Science, Korea and scholar societies. From this study we conclude that the essential rerasons for the above situations are curriculum and the system of the entrance examination of the university, and we give suggestions for solutions of such a situation.

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Analysis of Mathematics Textbooks Before and After the Curriculum Revision in 2012 of the North Korea : Focused on the 1st Grade of Middle School (북한의 2012년 교육과정 개정 전후 수학교과서 분석 : 초급중학교 1학년을 중심으로)

  • Jung, Hye Yun;Lee, Kyeong-Hwa
    • School Mathematics
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    • v.18 no.1
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    • pp.143-157
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    • 2016
  • North Korea had been reorganized its educational curriculum and new contexts were authored in 2013. In this study, mathematics contexts of North Korean secondary school's first grade in 2009 and 2013 were investigated. And the changes of content structure, content development, and content composition were analyzed. Results were as follows: First, with respect to the content structure, 1 chapter decreased, while lesson number was intact and 4 subunits increased. Second, with respect to the content development, considerable changes were presented. The tendencies that encouraged student and pursued a student friendly form were investigated. Third, with respect to the content composition, obvious changes were presented. It was investigated that the ratio of numbers and number operations, letters and expressions decreased nearly half. And new contents were supplemented in the areas of patterns, geometry, functions, probability and statics, equation of figures, set and statement. This changes suggests that differences between contexts of South and North Korea is narrowing compared to the past. In conclusion, the direction of North Korean mathematical education is changing for the general direction of South Korean mathematical education.

Characteristics of Silicon Rich Oxide by PECVD (PECVD에 의한 Sirich 산화막의 특성)

  • Gang, Seon-Hwa;Lee, Sang-Gyu;Park, Hong-Rak;Go, Cheol-Gi;Choe, Su-Han
    • Korean Journal of Materials Research
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    • v.3 no.5
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    • pp.459-465
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    • 1993
  • By making the inter-metal PECVD $SiO_2$ as a Si rich oxide under the SOG, the hydrogen and water related diffusants could be captured a t SI dangling bonds. This gettering process was known to prevent the device characteristics degradations related to the H, $H_20$. The basic characteristics of Si rich oxide have been studied according to changing high/low frequency power and $SiH_4/N_2O$ gas flow ratio in PECVD. As increase in low frequency power, deposition rate decreased but K.I. and compressive stress increased. Decrease of the water peaks of FTIR spectra at the wave number range of 3300~3800$\textrm{cm}^{-1}$' also indicated that intensty the films were densified. As increase in SiH, gas flow rate, deposition rate, R.I. and etch rate increased while compressive stress decreased. F'TIK spectra showed that peak intensity corresponding to Si-0-Si stretching vibration decreased and shifted to the lower wave numbers. But AES showed that Si dangl~ng bonds were increased as a result of lower Si:O(l: 1.23) ratlo inthe Si rich oxide as compared to Si : O(1 : 1.98) ratio of usual oxide.

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A Result of Field Survey for Ergonomic Work Risk Factors in General Hospital (의료업종의 작업위험요인에 대한 실태조사 결과)

  • Kim, Jin-Young;Kim, Yeong-Mee;Kim, Day-Sung;Im, Heung-Jae;Kim, Jeung-Ho;Kang, Seong-Kyu
    • Journal of the Ergonomics Society of Korea
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    • v.26 no.3
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    • pp.91-100
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    • 2007
  • The purposes of this research are to survey work-related risk factors of musculoskeletal disorders(MSDs) in various departments and tasks at general hospitals in non-manufacturing sectors, and to use basic data derived from the survey results in preventing work-related MSDs in hospital workers. Investigation started in March of 2006 and continued for 6 months in 220 general hospitals at Seoul, Incheon, Kyeongi, and Kangwon area. Investigators visited and interviewed workers in hospitals to identify the presence of tasks of musculoskeletal burden, the investigation results of ergonomic risk factors required by the Occupational Safety and Health Law, statistical analysis from questionnaire for musculoskeletal symptoms, and major departments and tasks that have such risk factors. Twenty-seven percents of hospitals finished the investigation of ergonomic risk factors, and 69% did not do the investigation while remained 4% did not have such factors in their hospitals. The rank order of major departments that had such musculoskeletal burdens was kitchen rooms of 143, managing departments/computer rooms/dispensaries of 137, physical treatment rooms of 109, nursing departments of 96, radiological and clinical laboratories of 63. Eighteen hospitals that did not hold legal duties by the section 148 of labor minister decree practiced prevention programs of MSDs according to the labor-management cooperation. Nursing departments ranked in the first place for the numbers of musculoskeletal symptoms of 438. Managing departments/computer rooms/dispensaries, kitchen rooms, and medical treatment departments held 127, 52 and 45 symptoms, respectively. The magnitude order of physical symptom areas followed shoulder of 185, backs and waist of 166, hand wrists of 120, necks of 110, and legs/feet of 106. The departments and jobs that had major work-related ergonomic risks were patient transporting, central supplying, patient nursing (moving patients into wheel-chairs, changing of patient posture and sheet alteration), manual transporting, operation, and managing/computer departments.

A Load Emulator for Low-power Embedded Systems and Its Application (저전력 내장형 시스템을 위한 부하의 전력 소모 에뮬레이션 시스템과 응용)

  • Kim, Kwan-Ho;Chang, Nae-Hyuck
    • Journal of the Institute of Electronics Engineers of Korea SC
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    • v.42 no.6
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    • pp.37-48
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    • 2005
  • The efficiency of power supply circuits such as DC-DC converters and batteries varies on the trend of the power consumption because their efficiencies are not fixed. To analyze the efficiency of power supply circuits, we need the temporal behavior of the power consumption of the loads, which is dependent on the activity factors of the devices during the operation. Since it is not easy to model every detail of those factors, one of the most accurate power consumption analyses of power supply circuits is measurement of a real system, which is expensive and time consuming. In this paper, we introduce an active load emulator for embedded systems which is capable of power measurement, logging, replaying and synthesis. We adopt a pattern recognition technique for data compression in that long-term behaviors of power consumption consist of numbers of repetitions of short-term behaviors, and the number of short-term behaviors is generally limited to a small number. We also devise a heterogeneous structure of active load elements so that low-speed, high-current active load elements and high-speed, low-current active load elements may emulate large amount and fast changing power consumption of digital systems. For the performance evaluation of our load emulator, we demonstrate power measurement and emulation of a hard drive. As an application of our load emulator, it is used for the analysis of a DC-DC converter efficiency and for the verification of a low-power frequency scaling policy for a real-time task.

Fabrication and Evaluation of NMOS Devices (NMOS 소자의 제작 및 평가)

  • 이종덕
    • Journal of the Korean Institute of Telematics and Electronics
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    • v.16 no.4
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    • pp.36-46
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    • 1979
  • Using N_ Ch silicon gate technology . the capacitors and transistors with various dimenssion were fabricated. Although the applied process was somewhat standard the conditions of ion implantation for the gate were varied by changing the implant energies from 30keV to 60keV for B and from 100 keV to 175keV for P . The doses of the implant also changed from 3 $\times$ 10 /$\textrm{cm}^2$ to 5 $\times$ 10 /$\textrm{cm}^2$ for B and from 4$\times$ 10 /$\textrm{cm}^2$ to 7 $\times$ 10 /$\textrm{cm}^2$ for P . The D. C. parameters such as threshold voltage. substrate doping level, the degree of inversion, capacitance. flat band voltage, depletion layer width, gate oxide thickless, surface states, motile charge density, electron mobility. leakage current were evaluated and also compared with the corresponing theoretical values and / or good numbers for application. The threshold voltages measured using curve tracer and C-V plot gave good agreements with the values calculated from SUPREM II which has been developed by Stanford University process group. The threshold vol tapes with back gate bias were used to calculate the change of the substrate doping level. The measured subthreshold slope enabled the prediction of the degree of inversion The D. C. testing results suggest the realized capacitors and transistors are suited for the memory applications.

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Dynamic ontology construction algorithm from Wikipedia and its application toward real-time nation image analysis (국가이미지 분석을 위한 위키피디아 실시간 동적 온톨로지 구축 알고리즘 및 적용)

  • Lee, Youngwhan
    • Journal of the Korean Data and Information Science Society
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    • v.27 no.4
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    • pp.979-991
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    • 2016
  • Measuring nation images was a challenging task when employing offline surveys was the only option. It was not only prohibitively expensive, but too much time-consuming and therefore unfitted to this rapidly changing world. Although demands for monitoring real-time nation images were ever-increasing, an affordable and reliable solution to measure nation images has not been available up to this date. The researcher in this study developed a semi-automatic ontology construction algorithm, named "double-crossing double keyword collection (or DCDKC)" to measure nation images from Wikipedia in real-time. The ontology, WikiOnto, can be used to reflect dynamic image changes. In this study, an instance of WikiOnto was constructed by applying the algorithm to the big-three exporting countries in East Asia, Korea, Japan, and China. Then, the numbers of page views for words in the instance of WikiOnto were counted. A collection of the counting for each country was compared to each other to inspect the possibility to use for dynamic nation images. As for the conclusion, the result shows how the images of the three countries have changed for the period the study was performed. It confirms that DCDKC can very well be used for a real-time nation-image monitoring system.

Dietary Culture for Sacrificial Rituals and Foods in Andong Area(II) -Village Sacrificial Rituals and Foods- (안동지역의 제례에 따른 음식문화(II) -동제(洞祭)와 제물(祭物)-)

  • Yoon, Suk-Kyung
    • Journal of the Korean Society of Food Culture
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    • v.11 no.5
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    • pp.699-710
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    • 1996
  • The sacrificial foods using at 88 villages in Andong area where the village sacrificial rituals are performed, were investigated in 1994. The finding are as follows; 1. Since the village sacrificial rituals keep ancientry, white Baeksulki without any ingredients is used as Ddock (a steamed rice cake) in 74 villages, and in 5 villages the Baeksulki was served just in Siru (a tool used to prepare Ddock). The type of meat serving in rituals has been changing from large animal to small animal and the type of light from bowl-light to candle. 2. Though the ritual observes Confucianism style, memorial address was offered in 34 villages and only in 8 villages, liquor was served 3 times and the address was offered. In 60 villages, liquor was served only once, and calling village god, bowing twice, and burning memorial address paper were performed in order. Burning paper has been meaningful in rituals. 3. Tang (a stew) was served in 21 villages, and in 18 villages even Gook (a soup) was not used. The numbers of village which do not use cooked rice and Ddock are 14, respectively. 4. Fruits are essential in rituals foods. In 63 villages, 3 kinds of fruits are served and this is contrasted with even number of fruits in Bul-Chun-Wi Rituals. 5. In 25 villages, fish and meat are not served. As meat, chicken in 19 village are served. Meat Sikhae (a fermented rice beverage) prepared with meats or fish are served in 5 villages. Slice of dried meat is served in 73 villages commonly. 6. In gender of god for village shrine, woman in 43 villages, couple in 17 villages, man in 9 villages, mountain god in 2 villages, villages tree, etc were enshrined. In 52 villages liquor is served in rituals (liquor is used in 58 villages including serving god), in 28 villages sweet liquor (Gamju) is served for god (sweet liquor is used in 46 villages), and liquor, water, or sweet liquor is just displayed on table but not served in 8 villages. Incensing is found to be not common in village ritual, only in two villages it is performed. The most appropriate rituals food is thought to be pig for mountain god. Home dishes can not be used in village ritual and spoon is not used and chopstick is prepared from wild plant. Meat and fish are used in the raw.

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Prediction of Estimated Sales Amount through New Open of Department Store (대형백화점의 신규출점에 따른 예상매출액 추정)

  • Park, Chul-ju;Ko, Youn-bae;Youn, Myoung-kil;Kim, Won-kyum
    • Journal of Distribution Science
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    • v.4 no.2
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    • pp.5-20
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    • 2006
  • Retail is called location business because it is one of the most important factors to estimate management of stores for retailers who are going to sell products directly to customers. Retailers' management achievements are shown in sale in general. Therefore, retailers tend to focus on ways to increase the numbers of customers in order to raise sales. First of all, in this research, I am going to examine the most fundamental models such as Reilly's retail gravitation, converse model, huff probability model and multiful losit model in selecting stores. Secondly, I am going to provide the process and analyzing ways to predict estimated sales amount with the previous theory model. Also I am going to predict estimated sales amount of the department store L which is located in D metorpolitan city. Lastly, I am going to argue about the problem of this research and the next research subject. Our main goal is to provide ways to complement and inspect sales estimation models, which can be used in fields after taking characters of high class structure of Korea into consideration on the base of previous researches. According to the result of the research, my conclusion is that if the process of analysis and changing factors are complemented, revise model, which can reflect reality of Korea, will be provided. Therefore, in the future study, we have to build up theory models to suit for our retail market through critic reviews about the existing high class structure of Korea.

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