• The Journal of Asian Finance, Economics and Business
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• 제8권2호
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• pp.583-593
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• 2021

The purpose of this study was to examine the relationship between transformational leadership and organizational performance with readiness to change and empower knowledge sharing quality as mediating variables. The survey was conducted by collecting the respondents' data by filling up forms which were designed using the google form application and collecting it using WhatsApp. This was performed on 400 respondents, encompassing employees from the National Agency of Drug and Food Control in Indonesia. The research model adopted was validated using Structural Equation Modeling technique with AMOS tool. The findings showed transformational leadership as a significant predictor of readiness to change and it proved relevant in empowering knowledge sharing quality, which in turn affects organizational performance. Furthermore, the effects of both two mediating variables was also examined, and only readiness to change significantly influenced the relationship between predictors of transformational leadership and organizational performance. The findings of this study showed the need for transformational leaders as the research focused on understanding the differences in employee character. This is required to encourage better performance by empowering quality knowledge dissemination mechanisms, with continuous in-house training activities. Therefore, the model adopted in this research and the hypotheses prove the direct effect of transformational leadership on organizational performance, achievable through the mediating role of readiness to change.

• 가정과삶의질연구
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• 제34권3호
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• pp.65-84
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• 2016

This study examined the factors that were associated with longitudinal changes for ten years from 2004 to 2014 in time spent on housework by married couples who had a preschooler as their first-born child. It also sought to figure out how much of such temporal changes were attributable to differences in the means on associated factors as well as to differences in the influence or slope of such factors. A total of 9,668 time diaries from the Korean Time Use Survey were used to analyze the influence of couple's weekly work hours, wife's relative income, couple's education and gender role attitudes on the time spent on housework of husbands and wives. Results from descriptive statistics, regression and decomposition analysis were as follows. First, women decreased, while men increased their time doing housework. Second, weekly work hours of husband and wife were related to their time doing housework in every year surveyed. Third, wife's relative earnings and couple's gender role attitudes affected wife's time doing housework more than husbands', whereas couple's education had stronger effects on husbands than wives. However, such influence was apparent on a certain survey year, and then disappeared in another, or became stronger or weaker longitudinally. Fourth, the temporal decrease in wife's housework time and increase in husband's housework time were attributable to social and cultural changes such as reduced working hours, rising female income, higher educational background, and prevalence of egalitarian gender role attitudes. Findings suggest that the trend in spending time on housework is expected to continue, and provide a timely policy implications to facilitate the change.

• Molecules and Cells
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• 제43권9호
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• pp.784-792
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• 2020

Arginine kinase (AK), a bioenergy-related enzyme, is distributed widely in invertebrates. The role of highly conserved histidines in AKs is still unascertained. In this study, the highly conserved histidine 284 (H284) in AK of Daphnia magna (DmAK) was replaced with alanine to elucidate the role of H284. We examined the alteration of catalytic activity and structural changes of H284A in DmAK. The catalytic activity of H284A was reduced dramatically compared to that in wild type (WT). Thus the crystal structure of H284A displayed several structural changes, including the alteration of D324, a hydrogen-bonding network around H284, and the disruption of π-stacking between the imidazole group of the H284 residue and the adenine ring of ATP. These findings suggest that such alterations might affect a conformational change of the specific loop consisting of G310-V322 at the antiparallel β-sheet region. Thus, we speculated that the H284 residue might play an important role in the conformational change of the specific loop when ATP binds to the substrate-binding site of DmAK.

• IMMUNE NETWORK
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• 제9권6호
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• pp.255-264
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• 2009

Background: Chronic low grade inflammation is closely linked to type II diabetes, obesity, and atherosclerosis. Macrophages play a key role in the regulation of pro- or anti-inflammatory actions at the lesion sites of disease. Components of cordyceps militaris, cordycepin and adenosine, have been used for the modulation of inflammatory diseases. The effects of cordycepin in the modulation of macrophages have yet to be be elucidated. We investigated the effects of cordycepin and adenosine on the morphological changes of macrophages under the inflammatory condition of LPS and an anti-inflammatory condition involving high concentrations of adenosine. Methods: We confirmed the mRNA levels of the M1/M2 cytokine genes through RT-PCR and morphological change. Results: LPS-activated macrophages returned to their inactivated original shape, i.e., they looked like naive macrophages, through the treatment with high concentrations of cordycepin ($40{\mu}g/ml$). LPS and adenosine activated macrophages also returned to their original inactivated shapes after cordycepin treatment; however, at relatively higher levels of cordycepin than adenosine. This change did not occur with relatively low concentrations of cordycepin. Adenosine down-regulated the gene expression of M1 cytokines (IL-$1{\beta}$, TNF-${\alpha}$) and chemokines (CX3CR1, RANTES), such as cordycepin. Additionally, M2 cytokines (IL-10, IL-1ra, TGF-${\beta}$) were up-regulated by both cordycepin and adenosine. Conclusion: Based on these observations, both cordycepin and adenosine regulated the phenotypic switch on macrophages and suggested that cordycepin and adenosine may potentially be used as immunomodulatory agents in the treatment of inflammatory disease.

• Asia pacific journal of information systems
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• 제23권2호
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• pp.87-109
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• 2013

While many surveys show very positive attitudes on the part of consumers towards eco-friendly products, the market share actually reflecting green IT purchases remains low in most countries. The motivations behind green IT purchase behavior are still obscure. Several studies have addressed the question of green IT diffusion from economic and normative viewpoints in an attempt to interpret IT adoption behavior. This study comes at the question from a different angle, namely negative frame, examining threat and coping behaviors using the Ordered Protection Motivation (OPM) model and threat appraisal theory. The results show that attitudes toward fairness and positive change, which are precedents of threat appraisal, play an important role in determining threat appraisal. Perceived threats in the green IT arena include habit change and ecological change. Appraisal for coping with these threats directly affects initial adoption behaviors regarding available green IT, and then indirectly encourages the purchase of new green IT products.

• 디지털융복합연구
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• 제7권1호
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• pp.19-29
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• 2009

This article is concerned to investigate the changing nature of the role of the state in relation to industrial policy to foster the IT industry in the Republic of Korea. In doing this, it has started with economic globalization introduced to the Korean political economy since the late 1980s. It has identified in what ways the state responded to the change, and to what extent the role of the state has fundamentally been changed in the context of policy mechanism in the process towards facilitating the IT industry in Korea. In addition, it presented how the state played a role in skill formation in relation to the industrial policy. In consequence, the role of the Korean state in fostering the IT industry has fundamentally changed from that as the developmental state in the industrialization process. In the process, that the strategic co-ordination role of the state and relations between the state and private capitals and societies are very significant to achieve the economic goal is presented as results, as well as some future tensions that would encounter in the way of charting the current policies.

• Asian Pacific Journal of Cancer Prevention
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• 제13권9호
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• pp.4311-4314
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• 2012

Posttraumatic growth (PTG) is the experience of positive change that occurs as a result of the struggle with highly challenging life crises. The need to understand PTG in relation to actual changes in an individual's life has recently been raised. Little is known about the role of social support in the experience of positive outcomes. The purpose of this study is to investigate the role of perceived social support in enhancing PTG in cancer patients. This study involved 105 cancer patients. The data were collected using a questionnaire that determined the socio-demographic features, posttraumatic growth inventory (PTGI) and perceived social support. Participants reported relatively high levels of PTG and social support. Total perceived social support, support from family, and friends were significantly positive associated with the development of PTG among cancer patients. Accordingly, the social surroundings of the patient should be informed about the importance of social support and how it helps the patient; they should be made aware of necessity of social support.

• BMB Reports
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• 제29권2호
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• pp.99-104
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• 1996

Site-directed substitutions were made to change the Ile91 of restriction endonuclease EcoRV to either Val, Ala or Gly to identify the role of Ile91 in recognition and catalysis, since substitution of Ile91 with Leu afforded dramatic effects on the activity and properties of restriction endonuclease EcoRV. These changes alter the size of the hydrophobic side chain at position 91 and thus might have revealed the reason for the altered phenotype of Ile91Leu. However, the properties of Ile91Val and Ile91Ala mutants were much like wild type EcoRV, in both activity and metal ion preference. Ile91Gly had very little activity with either $Mg^{2+}$ or $Mn^{2+}$ as cofactors. To try to understand the unusual $Mn^{2+}$ profile of the Ile91Leu mutant, two double mutants, Ile91Leu;Asp90Asn and Ile91Leu;Glu45Met were created. Both double mutants were seriously disabled by the second amino acid change. Ile91Leu;Glu45Met had some residual activity in the $Mn^{2+}$ reaction buffer, whereas the Ile91Leu;Asp90Asn displayed no detectable activity.

• Journal of Ginseng Research
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• 제35권1호
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• pp.86-91
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• 2011

Ginsenoside (G)-F1 is an enzymatic metabolite generated from G-Rg1. Although this metabolite has been reported to suppress platelet aggregation and to reduce gap junction-mediated intercellular communication, the modulatory activity of G-F1 on the functional role of skin-derived cells has not yet been elucidated. In this study, we evaluated the regulatory role of G-F1 on the cellular responses of B16 melanoma cells. G-F1 strongly suppressed the proliferation of B16 cells up to 60% at 200 ${\mu}g/mL$, while only diminishing the viability of HEK293 cells up to 30%. Furthermore, G-F1 remarkably induced morphological change and clustering of B16 melanoma cells. The melanin production of B16 cells was also significantly blocked by G-F1 up to 70%. Interestingly, intracellular signaling events involved in cell proliferation, migration, and morphological change were up-regulated at 1 h incubation but down-regulated at 12 h. Therefore, our results suggest that G-F1 can be applied as a novel anti-skin cancer drug with anti-proliferative and anti-migration features.

• 한국수자원학회:학술대회논문집
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• 한국수자원학회 2016년도 학술발표회
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• pp.200-200
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• 2016

Climate changes have impacted to many sectors including water resources in Vietnam. Vietnam is agricultural development country having a lot of reservoirs. These reservoirs play a very important role in flow regulation for water supply to economic sectors. In the context of undesirable impacts of climate change such as increasing temparature, evaporation, changing rainfall and rainfall pattern, water demands and inflow to reservoirs also are being influenced. This leads to changes of resevoir exploitation effects that needs to be assessed for adaptation solutions. This arcticle summaries the development of a tool for quick assessement of climate change impacts on exploitation effect of reservoir in central provinces of Vietnam.