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Vascular endothelial dysfunction after anthracyclines treatment in children with acute lymphoblastic leukemia

  • Jang, Woo Jung;Choi, Duk Yong;Jeon, In-Sang
    • Clinical and Experimental Pediatrics
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    • v.56 no.3
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    • pp.130-134
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    • 2013
  • Purpose: Anthracyclines have been utilized in the treatment of children with acute lymphoblastic leukemia (ALL). Recent studies have shown that anthracyclines may induce toxicity in the vascular endothelium. This study was performed using brachial artery reactivity (BAR) to evaluate vascular endothelial function in ALL patients who were treated with anthracycline chemotherapy. Methods: We included 21 children with ALL who received anthracycline chemotherapy and 20 healthy children. The cumulative dose of anthracyclines in the ALL patients was $142.5{\pm}18.2/m^2$. The last anthracycline dose was administered to the patients 2 to 85 months prior to their examination using BAR. The diameter of the brachial artery was measured in both groups using echocardiography, and BAR was calculated as the percentage change in the arterial diameter after release of the cuff relative to the baseline vessel diameter. Results: In the anthracycline-treated group, BAR was observed to be $3.4%{\pm}3.9%$, which was significantly lower than that observed in the control group ($12.1%{\pm}8.0%$, P<0.05). The time elapsed after the last anthracycline treatment and the age at the time of treatment did not affect the change in BAR (P =0.06 and P =0.13, respectively). Conclusion: These results provided evidence that treatment of ALL patients with anthracycline results in endothelial dysfunction. A larger cohort study and a longer follow-up period will be required to clarify the relationship between endothelial dysfunction resulting from anthracycline treatment for childhood ALL and occurrence of cardiovascular diseases later in life.

The associations between marital satisfaction and life satisfaction among retirees in later life: a longitudinal comparison (은퇴 노인의 부부관계 만족도와 삶 만족도의 관계에 대한 종단적 비교)

  • Choi, Bomi;Jun, Hey Jung;Joo, Susanna
    • Journal of Family Relations
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    • v.21 no.2
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    • pp.77-96
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    • 2016
  • Objectives: The aims of this study are to examine the associations between marital satisfaction and life satisfaction among Korean retirees in later life and to test whether the degrees of associations increased over time. Method: Nationally representative Korean Longitudinal Study of Ageing data from wave 1 (in 2006) to wave 4 (in 2012) was utilized and retirees in later life (65-89 years old, N=402) were analyzed. Latent growth modeling (LGM) and model constraint were applied using Mplus 7.3. Age, sex, household income, subjective health, depressive symptoms and elapsed time after retirement were included as control variables. Results: Linear unconditional LGM fitted the data well and showed gradual decrease in life satisfaction. Conditional LGM revealed significant associations between marital satisfaction and life satisfaction from time 1 to time 4. According to model constraint test, the size of associations between marital satisfaction and life satisfaction did not change with time. Conclusions: To sum up these results, the associations between marital satisfaction and life satisfaction were significant and relatively stable over time among retirees in later life. This study suggests one's spouse is a fundamental component of social convoy among Korean retirees in later life. Therefore, intervention programs targeted toward enhancing marital relationships among retirees' couples will help them to live a better life.

Physico-chemical Properties of Disturbed Plastic Film House Soils under Cucumber and Grape Cultivation as Affected by Artificial Accumulation History

  • Han, Kyung-Hwa;Ibrahim, Muhammad;Zhang, Yong-Seon;Jung, Kang-Ho;Cho, Hee-Rae;Hur, Seung-Oh;Sonn, Yeon-Kyu
    • Korean Journal of Soil Science and Fertilizer
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    • v.48 no.2
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    • pp.105-118
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    • 2015
  • This study was carried out to investigate the effects of profile disturbance with different artificial accumulation history on physico-chemical properties of soil under plastic film house. The investigations included soil profile description using soil column cylinder auger F10cm x h110cm, in situ and laboratory measurements of soil properties at five sites each at the cucumber (Site Ic ~ Vc) and grape (Site Ig ~ Vg) plastic film houses with artificial soil accumulation. The sites except sites Ic, IVc, IVg and Vg, belong to ex-paddy area. The types of accumulates around root zone included sandy loam soil for 3 sites, loam soil for 1 site, saprolite for 2 sites, and multi-layer with different accumulates for 3 sites. Especially, Site IIg has mixed plow zone (Ap horizon) with original soil and saprolite, whereas disturbed soil layers of the other sites are composed of only external accumulates. The soil depth disturbed by artificial accumulation ranged from 20 cm, for Site IIg, to whole measured depth of 110 cm, for Site IVc, Vc, and Site IVg. Elapsed time from artificially accumulation to investigation time ranged from 3 months, Site IIc, to more than 20 years, Site Vg, paddy-soil covering over well-drained upland soil during land leveling in 1980s. Disturbed top layer in all sites except Site Vg had no structure, indicating low structural stability. In situ infiltration rate had no correlation with texture or organic matter content, but highest value with highest variability in Site IIIc, the shortest elapsed time since sandy loam soil accumulation. Relatively low infiltration rate was observed in sites accumulated by saprolite with coarse texture, presumably because its low structural stability in the way of weathering process could result in relatively high compaction in agro-machine work or irrigation. In all cucumber sites, there were water-transport limited zone with very low permeable or impermeability within 50 cm under soil surface, but Site IIg, IIIg, and Vg, with relatively weak disturbance or structured soil, were the reverse. We observed the big change in texture and re-increase of organic matter content, available phosphate, and exchangeable cations between disturbed layer and original soil layer. This study, therefore, suggest that the accumulation of coarse material such as saprolite for cultivating cash crop under plastic film house might not improve soil drainage and structural stability, inversely showing weaker disturbance of original soil profile with higher drainage.

Remodeling Process Model Applying Service Life and Functionality Evaluation for Military Facilities (내용연수와 기능성 평가를 활용한 군 시설물 리모델링 대상 선정 프로세스 모델)

  • Cho, Jongwoo;Lee, Hyun-Soo;Park, Moonseo;Kim, Jaegon;Moon, Hyo-Soo
    • Korean Journal of Construction Engineering and Management
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    • v.16 no.6
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    • pp.41-52
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    • 2015
  • The number of military facilities has been rapidly increased due to growing requirement of modernization and military welfare. However, adequate maintenance has not implemented to these facilities. As a result, they are deteriorated quickly and require performance enhancement treatments. There are two ways of performance enhancement, reconstruction and remodeling. Despite the research result that remodeling within the standard remodeling range is more economical, remodeling of military facilities is not considered equivalent to reconstruction as an option of performance improvement. Therefore, derived from the relationship between performance change during life cycle of building and range of remodeling needs, this study tries to propose Remodeling Process Model(RPM) which uses a method to choose remodeling in a Specific Point of Time(SPT) when remodeling is considered more economical than reconstruction. In addition, this study suggests practical service life and functionality evaluation standard together which require to realize the RPM. This RPM make it possible to avoid the cases that facilities which do not have any problem on structural reliability but have low level of functionality miss appropriate remodeling timing and inevitably choose reconstruction as a performance improvement option. It also present the possibility of simple reconstruction / remodeling decision-making for facility managers who administrate building having various type, compilation and elapsed time. Consequently, this process model focusing on remodeling more may contribute to reduce resource waste caused by reconstruction.

Analysis of Debris Flow of Chun-cheon Landslide Area using Numerical Methods (수치해석을 통한 춘천 산사태지역 토석류 거동 분석)

  • Choi, Junghae
    • The Journal of Engineering Geology
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    • v.27 no.1
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    • pp.59-66
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    • 2017
  • The characteristic of recent rainfall pattern in Korea is concentrated in summer season and it is very different compare with former characteristic. In 2011, there was heavy rainfall in Chuncheon city of northern part of Korea. Because of rainfall in short time, many landslides were occurred in narrow area and many people were killed by these landslides at that time. The purpose of this study is to calculate run-out distance of debris flow and analyze the movement properties of debris flow according to the elapsed time using numerical analysis method at that time. The debris 2D program, which is developed by prof. Liu in National Taiwan University, was used in this study. Run-out distance of debris flow was calculated under different yield strength conditions which were controlled by rainfall amount. The results reveal that absolute maximum velocity of the debris flow is about 8.1 m/s and maximum depth of debris flow is about 7 m when debris flow was occurred. The run-out distance after 500 sec is about 300 m from end of the valley. It is very well similar with actual debris flow run-out distance. From these results, we can presume the maximum velocity and depth of debris flow at that time.

Global Carbon Cycle Under the IPCC Emissions Scenarios (IPCC 배출시나리오에 따른 지구 규모의 탄소 이동 연구)

  • Kwon, O-Yul
    • Journal of Environmental Science International
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    • v.16 no.3
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    • pp.287-297
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    • 2007
  • Increasing carbon dioxide emissions from fossil fuel use and land-use change has been perturbing the balanced global carbon cycle and changing the carbon distribution among the atmosphere, the terrestrial biosphere, the soil, and the ocean. SGCM(Simple Global Carbon Model) was used to simulate global carbon cycle for the IPCC emissions scenarios, which was six future carbon dioxide emissions from fossil fuel use and land-use change set by IPCC(Intergovernmental Panel on Climate Change). Atmospheric $CO_2$ concentrations for four scenarios were simulated to continuously increase to $600{\sim}1050ppm$ by the year 2100, while those for the other two scenarios to stabilize at $400{\sim}600ppm$. The characteristics of these two $CO_2$-stabilized scenarios are to suppress emissions below $12{\sim}13$ Gt C/yr by tile year 2050 and then to decrease emissions up to 5 Gt C/yr by the year 2100, which is lower than the current emissions of $6.3{\pm}0.4$ Gt C/yr. The amount of carbon in the atmosphere was simulated to continuously increase for four scenarios, while to increase by the year $2050{\sim}2070$ and then decrease by the year 2100 for the other two scenarios which were $CO_2$-stabilized scenarios. Even though the six emission scenarios showed different simulation results, overall patterns were such similar that the amount of carbon was in the terrestrial biosphere to decrease first several decades and then increase, while in the soil and the ocean to continuously increase. The ratio of carbon partitioning to tile atmosphere for the accumulated total emissions was higher for tile emission scenario having higher atmospheric $CO_2$, however that was decreasing as time elapsed. The terrestrial biosphere and the soil showed reverse pattern to the atmosphere.

Design of Distributed Processing Framework Based on H-RTGL One-class Classifier for Big Data (빅데이터를 위한 H-RTGL 기반 단일 분류기 분산 처리 프레임워크 설계)

  • Kim, Do Gyun;Choi, Jin Young
    • Journal of Korean Society for Quality Management
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    • v.48 no.4
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    • pp.553-566
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    • 2020
  • Purpose: The purpose of this study was to design a framework for generating one-class classification algorithm based on Hyper-Rectangle(H-RTGL) in a distributed environment connected by network. Methods: At first, we devised one-class classifier based on H-RTGL which can be performed by distributed computing nodes considering model and data parallelism. Then, we also designed facilitating components for execution of distributed processing. In the end, we validate both effectiveness and efficiency of the classifier obtained from the proposed framework by a numerical experiment using data set obtained from UCI machine learning repository. Results: We designed distributed processing framework capable of one-class classification based on H-RTGL in distributed environment consisting of physically separated computing nodes. It includes components for implementation of model and data parallelism, which enables distributed generation of classifier. From a numerical experiment, we could observe that there was no significant change of classification performance assessed by statistical test and elapsed time was reduced due to application of distributed processing in dataset with considerable size. Conclusion: Based on such result, we can conclude that application of distributed processing for generating classifier can preserve classification performance and it can improve the efficiency of classification algorithms. In addition, we suggested an idea for future research directions of this paper as well as limitation of our work.

Degradation characteristics of the FRP material for using as a PCB substrate (PCB 기판용 FRP 재료의 열화특성)

  • Park Jong Kwan
    • Journal of the Institute of Electronics Engineers of Korea SD
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    • v.41 no.12
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    • pp.1-6
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    • 2004
  • In this study, heat and discharge treatments are arbitrary simulated for finding out the initiations and processes of surface degradation on the surface of polymer for using as a PCB substrate. Thermal-treatment changed the surface to the hydrophobic one with the increase of contact angle and surface potential decay, respectively. The XPS spectrum showed that the increased hydrophobicity in thermal treatment was originated from the continuous decrease of side-chains caused by secessions of oxygen groups and the increase of unsaturated double bond in carbon chains. Also, thermal-treatment caused the discoloration on the point of treated surface. These phenomena were attributed to the generation of ether group. In the chemical change by discharge treatment, a lot of side-chains occurred on the treated surface, and so the hydrophilicity increased as time elapsed.

A Study on the Spontaneous Ignition Possibility of Shredded Waste Thermoplastic Elastomer (폐 열가소성 플라스틱 탄성체 분쇄물의 자연발화가능성에 관한 연구)

  • Park, Young Ju;Lee, Hae Pyeong;Goh, Kyoung Chun;Eom, Young Sup
    • Journal of the Korean Society of Safety
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    • v.31 no.1
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    • pp.61-65
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    • 2016
  • In this study, we considered the ignition possibility for the shredded thermoplastic elastomer at the fire ground loaded the waste TPE. The average moisture content of the TPE sample was almost 0.33 wt.% at $110^{\circ}C$ and the range of ignition point was $461.9{\sim}491.9^{\circ}C$ approximately. In addition, we analyzed the change of weight and calorie the TPE sample according to temperature variations using the TG-DTA analyzer. As a result, the weight loss occurred twice in $250{\sim}420^{\circ}C$ and $420{\sim}473^{\circ}C$, and we found the second weight loss temperature range was the ignition point of TPE. Also, we conducted the spontaneous ignition tests of TPE for the wet and dry samples and we confirmed that the possibility of spontaneous ignition of TPE was very low. The elapsed time and humidity had little influence on the spontaneous ignition of TPE in this experimental conditions. In conclusion, the spontaneous of the shredded waste TPE in this study.

The Effect of Melamine Sulphonate High-Range Water Reducing Agent to the Fluidity of High-Flowability Paste (고유동페이스트의 유동특성에 미치는 멜라민계 고성능가수제의 영향)

  • Nam Ji-Hyun;Cho Eun-Young;Oh Sang-Gyun;Kim Jung-Kil
    • Proceedings of the Korean Institute of Building Construction Conference
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    • 2005.11a
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    • pp.71-74
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    • 2005
  • The viscosity of high-flowability paste is very high compared to normal concrete for the low water-binder ratio(W/B). Therefore, high-flowability concrete is positively necessary to high-range water reducing agent. High-Flowability paste can make much higher fluidity with no occurrence of segregation, by its higher viscosity and lower yield value than normal concrete. The flowability of high-flowability paste must be evaluated not only by convention consistency test such as slump test but also by the base of the rheological properties of the fresh concrete. The purpose of this study is to analyze the fluidity of high-flowability paste according to the addition ratio of the Melamine Sulphonate high-range water reducing agent.; high-flowability paste is considered as Bingham plastic fluid with the rheology parameters of the plaste viscosity and yield value.

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