• Title/Summary/Keyword: Change Factor

Search Result 4,724, Processing Time 0.101 seconds

Anti-inflammatory Effect of Eleutherococcus senticosus Extracts from Gangwon-do by Plant parts or Solvents (강원도 가시오갈피의 식물 부위 또는 추출 용매 조건에 따른 항염증 효과)

  • Junkyu Park;Mina Boo;Soojin An;Sujin Shin;Jinbong Park;Ho-Young Choi;Kyungjin Lee
    • The Korea Journal of Herbology
    • /
    • v.38 no.4
    • /
    • pp.21-29
    • /
    • 2023
  • Background : The purpose of this study was to investigate the anti-inflammatory properties of stems and leaves of Eleutherococcus senticosus (Rupr. & Maxim.) Maxim. (ES) from Gangwon-do. Methods and Results : Stems and leaves of ES were collected from two areas in Gangwon-do: Cheorwon-gun and Samcheok-si. Samples were extracted with water by using the pressurized liquid extraction method and with 70% prethanol A by using the heat reflux extraction method. The anti-inflammatory effects of ES were evaluated through the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazoliumbromide(MTT), lactate dehydrogenase(LDH) assay, nitric oxide(NO) assay, enzyme-linked immunosorbent assay(ELISA), and Western blot analysis in RAW 264.7 macrophages stimulated with lipopolysaccharide (LPS). 1) Results showed that ES leaf extractions were not cytotoxic at a concentration of up to 30 ㎍/㎖. The leaves of 70% prethanol A extractions of ES(30 ㎍/㎖) inhibited NO, interleukin-6(IL-6), and tumor necrosis factor-α(TNF-α) production and decreased the protein level of cyclooxygenase 2(COX-2). There was no significant change in the protein level of inducible nitric oxide synthase(iNOS). The stem extractions of ES did not exhibit anti-inflammatory effects. Conclusions : In this study, the leaves of 70% prethanol A extractions of ES demonstrated anti-inflammatory effect on RAW 264.7 macrophages. The 70% prethanol A extractions have a relatively higher anti-inflammatory effect on RAW 264.7 macrophages than water extractions.

Influence of Water-Cement Ratios and Curing Conditions on the Diffusion Characteristics of Chloride Ion in Concrete (콘크리트의 염소이온 확산특성에 미치는 물-시멘트비 및 양생조건의 영향)

  • Bae, Su-Ho;Lee, Kwang-Myong;Kim, Jee-Sang;Jung, Sang-Hwa
    • KSCE Journal of Civil and Environmental Engineering Research
    • /
    • v.26 no.4A
    • /
    • pp.753-759
    • /
    • 2006
  • To predict service life of concrete structures exposed to chloride attack, surface chloride concentration, diffusion coefficient of chloride ion, and chloride corrosion threshold value in concrete, are used as important factors. Of these, as the diffusion coefficient of chloride ion for concrete is strongly influenced by concrete quality and environmental conditions of structures and may significantly change the service life of structures, it is considered as the most important factor for service life prediction. The qualitative factors affecting the penetration and diffusion of chloride ion into concrete are water-cement (W/C) ratio, age, curing conditions, chloride ion concentration of given environment, wet and dry conditions, etc. In this paper the influence of W/C ratio and curing conditions on the diffusion characteristics of chloride ion in concrete was investigated through the chloride ion diffusion test. In the test, the voltages passing through the diffusion cell were measured by accelerated test method using potential difference, and then with the consideration of IR drop ratio the diffusion coefficient of chloride ion for concrete with different W/C ratios were estimated by Andrade's model. Furthermore, under different curing conditions formulas for the estimation of the diffusion coefficient of chloride ion have been proposed by the regression analysis considering the effect of W/C ratio and age.

An Experimental Study on a Characteristics of Flow around Groynes for Groyne Spacing (수제 설치간격에 따른 수제주변 흐름특성에 관한 실험 연구)

  • Kang, Joon Gu;Yeo, Hong Koo;Roh, Young Sin
    • KSCE Journal of Civil and Environmental Engineering Research
    • /
    • v.26 no.3B
    • /
    • pp.271-278
    • /
    • 2006
  • In design of groyne series, groyne spacing is a important factor and have an effect on not only the characteristics of backward and recirculation flow in groyne zone but also flow field in main channel. It is necessary study about flow pattern of recirculation zone and main channel that is a cause of bad change, local scour and bank erosion by groyne spacing. In this study, flow variation of groyne zone and main chanel for spacing of groynes were analyzed from the experiment results in order to offer a fundamental data that can be used to decide the proper groyne spacing. Experiments were conducted 12 cases for groyne spacing(L) by groyne length(l) rate and the velocity profile was measured using LSPIV and ADV. From the results, two vortex flows developed in recirculation zone for L/l=3~9 and three vortex flows developed over L/l=10. The velocity of backward flow in recirculation zone was decreased up to 20% over L/l=4. The velocity of main channel flow was increased from 1.3 to 2.0 times by groyne spacing and the rate of velocity increased by increasing groyne spacing. The maximum velocity occurred in 0.7~0.8 times of groyne spacing downstream of upper groyne.

The Influence of Positive Thought about Social Capital on Social Participation of the Elderly Koreans (사회 자본에 대한 긍정적인 생각이 한국노인의 사회 참여에 미치는 영향)

  • Lee, Hyo Young;Jeon, Gyeong Suk
    • 한국노년학
    • /
    • v.29 no.3
    • /
    • pp.789-803
    • /
    • 2009
  • We investigated the influences of positive thought about social capital on social participation of the elderly Koreans. The study design was cross-sectional analysis of the National Statistic Office Study of Korean Society Statistics Survey 2003. Participants were total of 8,586 representative samples. Two types of social participation were investigated: meeting attendance and volunteer obligations. The base model included five thoughts about social capital that must be settled as a priority in Korea, i.e., reducing the differences between the rich and the poor, reducing the crime rate, reducing regulations and corruption, improving the moral level, eliminating environmental pollution. Social participation was influenced by positive thoughts about social capital, and different kinds of thoughts had different influences on different types of social participation. The elderly who responded positively to 'reducing the differences between the rich and the poor' attended all two types of social participation more. Along with education and health status, positive thought about social capital is another important factor that influences increased social participation. It may also compensate for deteriorating health with increasing age by promoting social participation. Encouraging social participation is a good way to improve the health of the elderly, as are efforts to change thought about social capital positively.

Altitude training as a powerful corrective intervention in correctin insulin resistance

  • Chen, Shu-Man;Kuo, Chia-Hua
    • Korean Journal of Exercise Nutrition
    • /
    • v.16 no.2
    • /
    • pp.65-71
    • /
    • 2012
  • Oxygen is the final acceptor of electron transport from fat and carbohydrate oxidation, which is the rate-limiting factor for cellular ATP production. Under altitude hypoxia condition, energy reliance on anaerobic glycolysis increases to compensate for the shortfall caused by reduced fatty acid oxidation [1]. Therefore, training at altitude is expected to strongly influence the human metabolic system, and has the potential to be designed as a non-pharmacological or recreational intervention regimen for correcting diabetes or related metabolic problems. However, most people cannot accommodate high altitude exposure above 4500 M due to acute mountain sickness (AMS) and insulin resistance corresponding to a increased levels of the stress hormones cortisol and catecholamine [2]. Thus, less stringent conditions were evaluated to determine whether glucose tolerance and insulin sensitivity could be improved by moderate altitude exposure (below 4000 M). In 2003, we and another group in Austria reported that short-term moderate altitude exposure plus endurance-related physical activity significantly improves glucose tolerance (not fasting glucose) in humans [3,4], which is associated with the improvement in the whole-body insulin sensitivity [5]. With daily hiking at an altitude of approximately 4000 M, glucose tolerance can still be improved but fasting glucose was slightly elevated. Individuals vary widely in their response to altitude challenge. In particular, the improvement in glucose tolerance and insulin sensitivity by prolonged altitude hiking activity is not apparent in those individuals with low baseline DHEA-S concentration [6]. In addition, hematopoietic adaptation against altitude hypoxia can also be impaired in individuals with low DHEA-S. In short-lived mammals like rodents, the DHEA-S level is barely detectable since their adrenal cortex does not appear to produce this steroid [7]. In this model, exercise training recovery under prolonged hypoxia exposure (14-15% oxygen, 8 h per day for 6 weeks) can still improve insulin sensitivity, secondary to an effective suppression of adiposity [8]. Genetically obese rats exhibit hyperinsulinemia (sign of insulin resistance) with up-regulated baseline levels of AMP-activated protein kinase and AS160 phosphorylation in skeletal muscle compared to lean rats. After prolonged hypoxia training, this abnormality can be reversed concomitant with an approximately 50% increase in GLUT4 protein expression. Additionally, prolonged moderate hypoxia training results in decreased diffusion distance of muscle fiber (reduced cross-sectional area) without affecting muscle weight. In humans, moderate hypoxia increases postprandial blood distribution towards skeletal muscle during a training recovery. This physiological response plays a role in the redistribution of fuel storage among important energy storage sites and may explain its potent effect on changing body composition. Conclusion: Prolonged moderate altitude hypoxia (rangingfrom 1700 to 2400 M), but not acute high attitude hypoxia (above 4000 M), can effectively improve insulin sensitivity and glucose tolerance for humans and antagonizes the obese phenotype in animals with a genetic defect. In humans, the magnitude of the improvementvaries widely and correlates with baseline plasma DHEA-S levels. Compared to training at sea-level, training at altitude effectively decreases fat mass in parallel with increased muscle mass. This change may be associated with increased perfusion of insulin and fuel towards skeletal muscle that favors muscle competing postprandial fuel in circulation against adipose tissues.

The North Korean Female Refugees' Personality and Psychological Adaptation (여성 새터민의 성격유형에 따른 심리적응)

  • Young Mi Sohn;Sook Jung Kang;Cheong Yeul Park
    • Korean Journal of Culture and Social Issue
    • /
    • v.20 no.1
    • /
    • pp.19-44
    • /
    • 2014
  • This study was conducted to investigate the types of personality of North Korean female refugees, which were extracted from the T-scores of SPFQ(scales of the Sixteen Personality Factor Questionnaire) and psychological adaptation. For this, The data of 158 North Korean female refugees located in Seoul Yangchun-Gu and Gayang-Gu was analyzed. The results were as follows. Firstly, the ratio of over 65T in ego-strength, self-control, social-boldness, anxiety scales and under 34T in abstractedness and openness to change scales was higher than in other scales. Secondly, there were statistically significant differences in personality characteristics based on the demographic variables especially age and the term of residence in South Korea. Thirdly, three distinct groups were extracted from the K-means cluster analysis. The first group was characterized with emotional-unstability and negative emotionality. And the North Korean female refugees in the second group hesitated to enter into and maintain proper relationships with south korean, while they were unlikely to accept norms and rules in South Korea. The third group, characterized by higher emotional stability, ego-strength, and agreeableness, was met normal range in all the scale of SPFQ. Finally, each three groups were showed statistically significant differences in psychological adaptation scales(self-identity and resilience). We expected that these results contributed to explore the psychological and the political plans for North Korean female refugees' settlement in South Korea.

  • PDF

Relationship between Grain Size and Organic Carbon Content of Surface Sediments in the Major Estuarine Areas of Korea (국내 주요 하구역 표층퇴적물의 입도와 유기탄소 함량 관계)

  • BOO-KEUN KHIM;JU-YEON YANG;HYUK CHOI;KWANGKYU PARK;KYUNG HOON SHIN
    • The Sea:JOURNAL OF THE KOREAN SOCIETY OF OCEANOGRAPHY
    • /
    • v.28 no.4
    • /
    • pp.158-177
    • /
    • 2023
  • An estuary is a transitional water area that links the land and sea through rivers and streams, transporting various components from the land to the sea, which plays an important role in determining primary productivity in the coastal environment, and this coastal ecosystem captures a huge amount of carbon into biomass, known as blue carbon, which mitigates climate change as a potential carbon reservoir. This study examined the variation of mean grain size and organic carbon content of the surface sediments for 6 years and analyzed their relationship in the western and southern estuarine areas (Han River Estuary, Geum River Estuary, Yeongsan River Estuary, Seomjin River Estuary, and Nakdong River Estuary) and the East Sea upwelling area. During the sampling period (2015 to 2020), seasonal variation of both properties was not observed, because their variations might be controlled by diverse oceanographic environments and hydrographic conditions within each survey area. However, despite the synoptic problem of all samples, the positive relationship was obtained between the averages of mean grain size and organic carbon content, which clearly distinguishes each survey area. The unique positive relationship in all estuarine areas implies that the same process by sediment clay particles is important in the organic carbon accumulation. However, additional important factor may be expected in the organic carbon accumulation in the East Sea upwelling area. Further necessary data (sedimentation rate, dry bulk density etc) should be required for the estimation of carbon stock to evaluate the major estuaries in Korea as potential carbon reservoirs in the coastal environment.

Factors Associated With Post-Traumatic Growth in Patients With Cancer (암환자의 외상 후 성장에 영향을 미치는 요인)

  • Nam Pyo Lee;Jong Woo Kim;Myungjae Baik;Mi Ae Oh;A Ra Lee;Won Sub Kang
    • Korean Journal of Psychosomatic Medicine
    • /
    • v.31 no.2
    • /
    • pp.79-88
    • /
    • 2023
  • Objectives : Cancer diagnosis causes significant distress while it may also bring positive change: post-traumatic growth. This study was conducted to analyze factors that affect post-traumatic growth. Methods : Medical records of 52 cancer patients who received psychiatric treatment at a university hospital in Seoul were reviewed and the correlation between post-traumatic growth and following factors were analyzed: Resilience, Anxious thoughts and tendencies, Mindful attention awareness, Acceptance attitude Results : Using Multiple Generalized Linear model, a positive correlation was found between post-traumatic growth and resilience (B=1.45, p<0.0001), mindful attention awareness (B=0.58, p=0.0030) and acceptance attitude (B=1.29, p=0.0003), while anxious thoughts and tendencies (B=-0.84, p<0.0001) had negative association. Conclusions : Factors that have a positive impact on post-traumatic growth were resilience, mindful attention awareness, acceptance attitude and a factor with a negative impact was anxious thoughts and tendencies; Factors that impact post-traumatic growth need to be taken into account, when approaching the treatment of cancer patients.

Understanding of mind and social skills in adolescents (청소년의 마음이해 능력과 사회적 능력)

  • Hyeon Ok Choi;Hei Rhee Ghim
    • Korean Journal of Culture and Social Issue
    • /
    • v.14 no.1
    • /
    • pp.1-18
    • /
    • 2008
  • The present study was to investigate the developmental change of adolescent's theory of mind. In addition, the relations between theory of mind and the social competence were investigated. Sixty students in each the 6th and 8th grade group were participated in this study. Adolescents' understanding of mind were measured by four kinds of mindreading tasks; the second-order false belief tasks, understanding the ambiguous social behaviors tasks, understading the hidden meaning of a figurative statement tasks, and the "faux pas" tasks. Social skills were measured by social skill scales. Eighth graders performed better than the 6th graders on the understanding the ambiguous social behaviors tasks and faux pas tasks but not on the second-order false belief tasks and understanding the hidden meaning of figurative statement tasks. The results suggests that the mindreading ability continues to develop during the adolescence, especially the ability to interpret others' ambiguous social behaviors by reading their mental states and the ability to understand that a person says a faux pas it is due to a mistaken belief. In addition, the understanding the ambiguous social behaviors tasks was found to be the best task to predict social behaviors. The results suggests that the mindreading ability would be a significant explanatory factor on social competence.

  • PDF

The Effect of Korean version of Mindfulness-Based Stress Reduction Program on Chronic Pain of Workers. (한국형 마음 챙김 명상에 기반한 스트레스 감소 프로그램이 만성통증에 미치는 효과)

  • Susie Kim ;Sang-sub Ahn
    • Korean Journal of Culture and Social Issue
    • /
    • v.15 no.3
    • /
    • pp.359-375
    • /
    • 2009
  • This study developed a program that integrated MBSR-K and progressive muscular relaxation for the health and well-being of patients with chronic pain, and proved its effectiveness by studying 40 chronic pain patients. This program used nature of mind, body scanning meditation, breath meditation, mindfulness meditation, Hatha yoga and progressive muscular relaxation to ease chronic pain. Whenever negative feelings and emotions such as fear, anxiety, and pain occurred, the program focused on those emotions and observed the outcome. This program, which was based on the results of the preceding studies, was composed of eight courses. Major findings of the study are as follows: First, the meditation group that was composed of patients with chronic pain had significant decrease of physical symptoms compared to the control group. Second, to confirm the outstanding features of the participating patients with chronic pain that brought change in the effect of the program, characteristics of clients were analysed. Third, the program factor that influenced the effectiveness of the treatment process was evident when the training was performed twice a week rather than having once a week of training and second week for homework.

  • PDF