• Journal of Korean Society of Coastal and Ocean Engineers
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• 제23권1호
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• pp.79-92
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• 2011

In this study, wave pressure of short-period gravity waves and tsunami acting on the upright section of the horizontal-slit type caisson placed on the impermeable or permeable seabed, which is a well-known permeable breakwater with a good wave controlling ability, are investigated via numerical simulations. Further, the permeable seabed was modeled as the porous media with porosity of 0.4. Using the numerical results, the effects of the seabed conditions on the wave pressure on the front wall and inside wall of the chamber have been studied. In the numerical simulations, short-period gravity waves and tsunami(solitary wave or bore) with the same amplitude to the gravity wave are considered. A numerical wave tank is used, which is able to consider a gas-liquid two-phase flow in the same calculation zone. Numerical results show that the wave pressure of the tsunami was 3~5 times higher than the short-period gravity waves acting on the front wall and it was 2~4 times higher than the short-period gravity waves acting on the inner wall.

• Journal of the Korean Vacuum Society
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• 제16권1호
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• pp.46-51
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• 2007

The HFMX((High Flux Macromolecular X-ray crystallography) beamline at Pohang Accelerator Laboratory uses beams from a multi-pole wiggler. Two horizontal and vertical slits relevant to high heat-load are installed at its front-end. In order to treat high heat-load with reducing beam scattering, the horizontal slit has two Glidcop blocks with a grazing incidence angle of $10^{\circ}$ of a grazing-incidence knife-edge configuration. The blocks adjust the slit gap by being translated along guides by two actuating bars, respectively. Water flowing through holes, drilled along the actuating bars, cools the heat-load of both blocks. The vortical slit has the same structure as the horizontal slit except its installation direction with respect to the vacuum chamber and its grazing incidence angle. By virtue of a pair of blocks translating on guides, no alignment between both blocks is required and the installed slits show stable operating performance. The cooling performance of the two slits has been also shown to be acceptable. In this paper, the detailed explanation for the design of the two slits is presented and their operating performance is discussed.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• 제29권1호
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• pp.50-60
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• 2018

In this paper, we developed a broadband multi-layered radome applicable for high-power applications. In this regard, we presented the wave propagation characteristics of the broadband multi-layered radome with the ABCD matrix and obtained the optimal thickness and the material constant for each layer by an optimization algorithm called "particle swarm optimization," implemented by a commercial numerical modeling tool. Further, we redesigned it in view of mechanical properties to reflect environmental conditions such as wind, snow, and ice. The power transmission property was reanalyzed based on the recalculated data of each layer's thickness to consider the limitations of the fabrication of a large structure. Under the condition of a peak electric field strength that is 10 dB above the critical electric field strength in air breakdown, we analyzed the air breakdown by radio frequency(RF) in the designed radome using the commercial full-wave electromagnetic tool. The radome was manufactured and tested by continuous wave(CW) RF small signal and large signal in an anechoic chamber. The test results showed good agreement with those attained by simulation.

• Journal of the Korea Academia-Industrial cooperation Society
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• 제17권3호
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• pp.661-667
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• 2016

This study evaluated the potential of methodology development of the helical type anchor for soft ground applications. The rotational penetration of the helix structure might make construction-steps easy without the soil spitting and reusable rods could reduce the material cost. Removal of the anchors would be simple as a construction, which can be named the removal anchor. The anchoring resistance after construction is strongly related to the number of helixes resulting in a concise design process. The investigation involved a chamber test with soft soils. In the test, a specially designed and fabricated helical anchor and torque-driver were used to obtain the maximum pull-out resistance of the anchor after rotational penetration. As a result of the tests, The rotational torque and pull-out resistance have a proportional relationship with the strength of the prepared soils. Within the range of the study, the torque of the anchor penetrating increased with increasing pull-out resistance.

• Journal of Conservation Science
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• 제30권4호
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• pp.457-466
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• 2014

Rigorous analysis was performed to identify the structure and materials of the murals to study techniques used on mural tombs of ancient Daegaya era(6th century). The murals were painted by applying mortar on the walls and the ceiling after building a stone chamber and creating ground layers on mortar layers. Mud was applied on most of the mortar layers on four sides of the walls except the ceiling. Sand was not used in mortar but was made of materials with pure calcium substances. In addition, shells in irregular sizes with incomplete calcination were mixed; and the mortar's white powder was inferred as lime obtained by calcination of oyster shells. Kaolinite($Al_2Si_2O_5(OH)_4$) was used in the ground layer, Cinnabar(HgS) was used for red pigment, Malachite($Cu_2CO_3(OH)_2$) for green and Lead white($PbCO_3{\cdot}Pb(OH)_2$) for white. Mud plaster was applied on the mortar and was composed thinly and densely using clayey of particle size smaller than that of medium sand. It was assumed that the finishing was for repair after long time had passed since the mortar layer came off. Using lime made with oyster shells as mortar is unprecedented in ancient Korean mural tombs and its durability was very poor, suggesting that Gaya's mortar production technique was relatively behind compared to that of Koguryo's in the same era.

• Asian Pacific Journal of Cancer Prevention
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• 제14권1호
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• pp.201-208
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• 2013

Objective: To investigate changes in the invasive capacity of gastric cancer cells in vitro after expression inhibition of T lymphoma invasion and metastasis inducing factor 1 (Tiam 1) and underlying mechanisms. Methods: Using adhesion selection, two subpopulations with high ($M_H$) or low ($M_L$) invasive capacity were separated from the human gastric cancer cell line MKN-45 ($M_0$). Tiam 1 antisense oligodeoxynucleotide (ASODN) was transfected into $M_H$ cells with liposomes, and expression of Tiam 1 mRNA and protein was determined by RT-PCR and quantitative cellular-ELISA. Changes in the cytoskeleton, invasive capacity in vitro and expression of ras-related $C_3$ botulinum toxin substrate 1 (Rac 1), integrin ${\beta}1$ and matrix metalloproteinase 2 (MMP 2) between Tiam 1 ASODN transfected $M_H$ cells and non-transfected cells were observed by HE staining, cytoskeletal protein staining, scanning electron microscopy, Boyden chamber tests and cyto-immunohistochemistry. Results: A positive correlation existed between the expression level of Tiam l mRNA or protein and the invasion capacity of gastric cancer cells. After ASODN treatment ($0.43{\mu}M$ for 48 h), Tiam 1 mRNA transcription and protein expression in $M_H$ cells were decreased by 80% and 24% respectively (P < 0.05), compared with untreated controls, while invasive capacity in vitro was suppressed by 60% (P < 0.05). Morphologic and ultrastructural observation also showed that ASODN-treated $M_H$ cells exhibited smooth surfaces with obviously reduced filopodia and microspikes, which resembled $M_0$ and $M_L$ cells. Additionally, cytoskeletal distribution dramatically altered from disorder to regularity with reduced long filament-like structure, projections, pseudopodia on cell surface, and with decreased acitn-bodies in cytoplasm. After Tiam 1 ASODN treatment, the expression of Rac 1 and Integrin ${\beta}1$ in $M_H$ cells was not affected (P > 0.05), but that of MMP 2 in $M_H$ cells was significantly inhibited compared with untreated cells (P < 0.05). Conclusion: Over-expression of Tiam-1 contributes to the invasive phenotype of gastric cancer cells. Inhibition of Tiam 1 expression could impair the invasive capacity of gastric cancer cells through modulating reconstruction of the cytoskeleton and regulating expression of MMP 2.

• Journal of the Korean Recycled Construction Resources Institute
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• 제1권3호
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• pp.225-232
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• 2013

The inorganic insulating material was fabricated with quartzite, ordinary portland cement(OPC), lime, anhydrous gypsum and foaming agent by hydrothermal reaction. The inorganic insulating material was fabricated by using autoclave chamber under high-temperature and high-pressure. The inorganic insulating material is a porous lightweight concrete. Because of its porous structure, properties of inorganic insulating material were light-weight and high-heat insulation property. Properties of fabricated inorganic insulating material were $0.26g/cm^3$ in specific gravity, 0.4MPa in compressive strength and 0.064W/mK in thermal conductivity. In this study, the inorganic insulating material was fabricated and analyzed at different size of quartzite/OPC, various foaming reagent and functional additives to improve the properties. Consequently, polydimethylsiloxane can improve density and thermal conductivity. Especially, polydimethylsiloxane showed excellent improvement in compressive strength.

• Journal of the korean academy of Pediatric Dentistry
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• 제47권4호
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• pp.406-415
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• 2020

Silver diamine fluoride (SDF) is an effective and efficient agent for arresting dental caries. It can be useful in treating children with behavioral or medical limitations. The purpose of this study was to evaluate the antimicrobial effect of SDF by using salivary biofilm. Pellicle-like saliva coated structure was prepared by using unstimulated saliva. For developing cariogenic biofilm, Streptococcus mutans was added to the mixture of pooled saliva and inoculated into a saliva coated glass or chamber. SDF was applied to cariogenic biofilm to evaluate the antimicrobial effect of SDF. As time passed, total bacteria and S. mutans were reduced after application of SDF (p < 0.000). Confocal laser scanning microscope also showed the increment of the ratio of dead cell. As a result of experiment using enamel and dentin of primary teeth, it was confirmed that the growth of cariogenic biofilm was inhibited when the SDF was treated (p = 0.029 each). This study showed excellent anti-microbial effect of SDF. And anti-caries effect in clinical practice can be expected.

• The Journal of Internal Korean Medicine
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• 제25권3호
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• pp.461-472
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• 2004

Objectives : For the screening of neuroprotective effects of medicinal herbs, the complex system of animal models suffer some disadvantages in controlling critical parameters such as blood pressure and body temperature. Additionally, application of drugs to the appropriate brain area sometimes is difficult, due to poor permeability though the blood brain barrier, and so potential protective effects might be masked. Methods : Organotypic hippocampal slice culture (OHSC) method has the advantages of being relatively easy to prepare and of maintaining the general structure, including tissue integrity and the connections between cells. Drugs can easily be applied and neuronal damage can easily be quantified by using tissues and culture media. This study demonstrates neuroprotective effects of Puerariae radix (葛根, PR), Salviae miltiorrhizae radix (丹蔘, SR), Rhei rhizoma (大黃, RR), and Bupleuri radix (柴胡, BR). These were screenedand compared to MK-801, antagonist of NMDA receptors, by using OHSC of 1 week-old Sprague-Dawley rats. Oxygen/glucose deprivation (OGD) were conducted in an anaerobic chamber $(85%\;N_2,\;10%\;CO_2\;and\;5%\;H_2)$ in a deoxygenated glucose-free medium for 60 minutes. Water extracts of each herbs were treated to culture media with $5\;{\mu}g/ml$ for 48 hours. Results : Neuronal cell death in the cultures was monitored by densitometric measurements of the cellular uptake of propidium iodide (PI). PI fluorescence images were obtained at 48 hours after the OGD and medicinal herb treatment. Also TUNEL-positive cells in the CAI and DG regions and LDH concentrations in culture media were measured at 48 hours after the OGD. According to measured data, MK-801, PR, SR and BR demonstrated significant neuroprotective effect against excessive neuronal cell death and apoptosis induced by the OGD insult. Especially, PR revealed similar neuroprotective effect to MK-801 and RR demonstrated weak neuroprotective effect. Conclusions : These results suggest that OHSC can be a suitable method for screening of neuroprotective effects of medicinal herbs. (This work was supported by the research program of Dongguk University and Grant 01-PJ9-PG1-01CO03-0003 from Ministry of Health & Welfare.)

• Journal of the Korean Society of Radiology
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• 제9권7호
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• pp.433-438
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• 2015

To evaluate the radiation exposure level based on radiation workers' locations in dental radiography, the radiation dose rate in the radiographic room, lead glass, and operation system was measured. To that end, various devices were used, such as a Standard(Max-GLS, Shinhung), a panorama (PCH-2500, Vatech), a cephalometric radiography (PCH-2500), and a cone beam CT (PHT-30LFO, Vatech), as well as a PM1405 equipment as a radiation meter. Radiography conditions were set the same as the factors used in the clinical setting. As the result, the cone beam CT turned out the highest with 98 uSv and the standard showed the lowest level with 0.4 uSv/h. The panorama was measured to be higher than the Cephalo due to its different focus mode. On the lead glass surface and in the operation stand, the oral radiography device, panoramic, and Cephalo all were measured below the recording level. However, the cone beam CT was measured to have the leakage dose. Thus, radiation involved workers should be equipped with appropriate protection tools and reduce radiography time as much as possible. In addition, the structure of the radiation chamber should be also designed efficiently. Dental radiography has continued to grow in recent years, so it is necessary take appropriate protection measures for patients and radiation workers.