• Journal of Construction Engineering and Project Management
• /
• v.9 no.4
• /
• pp.1-15
• /
• 2019

Since its adoption by the transportation sector in the early 1990s, partnering has been broadly used with the traditional delivery method by many agencies with significant reported benefits. During the same era, a number of transportation agencies (DOTs) started experimenting with a wide variety of alternative project delivery methods (APDMs) aimed at improving the delivery of highway construction projects. The effect of collaborative working strategies such as partnering, together with the APDMs have become somehow interrelated posing a potential challenge on how to effectively integrate partnering as a concept in the APDMs. The salient question has been if the collaborative nature of these APDMs has affected how partnering is being used by state DOTs. Through an extensive literature review, analysis of 32 CMGC RFPs/RFQs and review of three CMGC case studies, the study found that there is limited information in state DOT documents that show procedures on the usage of partnering with CMGC projects. Majority of DOTs are relying on the inherent nature of the CMGC contract to promote healthy collaborative practices and there is the need to consider partnering during preconstruction and construction separately to cater for any personnel change over. The study also revealed that partnering may become less important at the construction phase due to overlap between partnering and CMGC practices. In support of this finding, a CMGC partnering model was developed that can be adopted by DOTs. This paper contributes to both research and practice by expanding the existing knowledge on partnering on APDMs.

• BMB Reports
• /
• v.51 no.9
• /
• pp.450-455
• /
• 2018

Tamoxifen (TAM) is commonly used to treat estrogen receptor (ER)-positive breast cancer. Despite the remarkable benefits, resistance to TAM presents a serious therapeutic challenge. Since several HOX transcription factors have been proposed as strong candidates in the development of resistance to TAM therapy in breast cancer, we generated an in vitro model of acquired TAM resistance using ER-positive MCF7 breast cancer cells (MCF7-TAMR), and analyzed the expression pattern and epigenetic states of HOX genes. HOXB cluster genes were uniquely up-regulated in MCF7-TAMR cells. Survival analysis of in slico data showed the correlation of high expression of HOXB genes with poor response to TAM in ER-positive breast cancer patients treated with TAM. Gain- and loss-of-function experiments showed that the overexpression of multi HOXB genes in MCF7 renders cancer cells more resistant to TAM, whereas the knockdown restores TAM sensitivity. Furthermore, activation of HOXB genes in MCF7-TAMR was associated with histone modifications, particularly the gain of H3K9ac. These findings imply that the activation of HOXB genes mediate the development of TAM resistance, and represent a target for development of new strategies to prevent or reverse TAM resistance.

• Journal of Engineering Education Research
• /
• v.21 no.1
• /
• pp.27-36
• /
• 2018

This study aims to deduce operational implication of R-WeSET program through women students in science & engineering and companies's perception and assessment on the basis of NCS key competency. The significant results are as follows. Firstly, companies and women students in science & engineering share a similar perception on importance of NCS key competencies. The programs should be reviewed and improved for women students who are truly aware of companies' needs. Secondly, the main areas of NCS key competency that are poor in companies' perception are 'positive thinking & drive', 'creativity & challenge spirit', 'communication skills' and 'problem-solving skills'. To enhance these weak skills, activating the actual programs such as "Convergence Design Camp", "Field Adaptability Improvement" and developing the new communication program are required. Lastly, most of women students have attained the satisfying result from "Field Competency Reinforcement Program". Especially, "Industry Field Training" shared the great progresses on all skills of key competency, hence why the progressive model should be developed in the future. This study figures out who's the right person for the 4th Industrial Revolution era, producing a meaningful result in order to change in the higher education system of women students and to grow human resources who will contribute to the community and company.

• Journal of Microbiology and Biotechnology
• /
• v.10 no.6
• /
• pp.865-872
• /
• 2000

Helocobacter phylori is the major cause of gastritis, peptic ulcer, and a principal risk factor for gastric cancer. As the firs step towards a vaccine against H. pylori infection, Hy.pylori urease was expressed and purified as a recombinant apoenzyme (rUrease) in E. coli. In order to develop an effective immunization protocol using rUrease, the host immune responses were evaluated after the oral immunization of mice with rUrease preparations plus cholera toxin relative to various conditions, such as the physical nature of the antigen, the frequency of the booster immunization, the dose of the antigen, and the route of administration. The protective efficacy was assessed using a quantitative culture following an H. pylori SS1 challenge. It was demonstrated that rUrease, due to its particulated nature, was more superior than the UreB subunit as a vaccine antigen. The oral immunization of rUrease elicited significant systemic and secretory antibody responses, and activated predominantly Th2-type cellular responses. The bacterial colonization was significantly reduced (~100-fold) in those mice immunized with three or four weekly oran doses of rUrease plus cholera toxin (p<0.05), when compared to the non-immunized/challenged controls. The protection correlated well with the elicited secretory IgA level against rUrease, and these secretory antibody responses were highly dependent on the frequency of the booster immunization, yet unaffected by the dose of the antigen (25-200$\mu\textrm{g}$). These results demonstrate the remarkable potential of rUrease as a vaccine antigen, thereby strengthening the possibility of developing an H. pylori vaccine for humans.

• Biomolecules & Therapeutics
• /
• v.24 no.3
• /
• pp.283-290
• /
• 2016

Oroxylum indicum has long been used in Asian traditional medicine to prevent and treat respiratory diseases, diabetes, diarrhea and other conditions. Oroxylin A is a flavone that is present in Oroxylum indicum and in Scutellaria baicalensis. Because the root extracts of both plants have been shown to have anti-allergic effects, the authors investigated whether oroxylin A is likely to have beneficial effects on allergic asthma using female Balb/c mice and rat RBL-2H3 mast cells. Antigen-induced degranulation was measured in vitro by measuring b-hexosaminidase activity. A murine ovalbumin-induced allergic asthma model was used to test the in vivo efficacy of oroxylin A. Sensitization and challenge of ovalbumin induced allergic asthma responses, the accumulations of eosinophils and Th2 cytokine levels in bronchoalveolar lavage fluid and lung tissues. Oroxylin A administration decreased numbers of inflammatory cells, especially eosinophils, and reduced the expression and secretion of Th2 cytokines, including IL-4 and IL-13, in lung tissues and bronchoalveolar lavage fluid. Histologic studies showed oroxylin A reduced inflammatory signs and mucin production in lungs. These findings provide evidence that oroxylin A has potential use as an anti-allergic therapeutic.

• Journal of Korea Game Society
• /
• v.5 no.1
• /
• pp.11-18
• /
• 2005

Recently, as one method of the game manipulation, physical interactive game is increasing, which controls the program by direct human movement. Tangible interface for physical interactive game implementation can control virtual model directly through real world object. A digital desk, one of the tangible interface, offers the interface that human can manipulate virtual object directly, by making projection screen on real world desk as computer display device. In this paper, we implement "Battle Region" game in the form of tangible interface, which can offer game users an efficient and amusing experiences by the use of physical interactive game. Traditional game cannot pursuit the diversity of game background contents but our game can do it through Map image projection. From this, game provider can supply the diversity of choice and users ran set up the difficulty of game. Therefore, our implemented game can offer users an efficient and amusing experiences by making game user's challenge and satisfaction maximum.

• Journal of Korean Library and Information Science Society
• /
• v.46 no.3
• /
• pp.119-140
• /
• 2015

The domestic and foreign standards of school libraries suggest that school library should be run to give useful and pleasant experiences to students. This study applies Csikszentmihalyi's 'flow theory' to analyze the relationships between students' flow experience and their satisfaction about school libraries use. The variables selected in this study are students' satisfaction, flow experience, library skill, challenge of library use, types of library use and students' learning styles. The research model is designed by using these 6 variables in this study. The data are collected from 293 students and analyzed by structural equation modeling. The results of this study are as follows: The entire casual relationships show that library skills influence in types of library use, types of library use affect students' learning styles and students' learning styles influence in satisfaction through flow. To improve students' satisfaction about school library use, this study proposes effective ways related to teacher librarians' role performances to expand students' flow experience and increase their library skills.

• Journal of Information Processing Systems
• /
• v.14 no.2
• /
• pp.322-345
• /
• 2018

Climate change has become a major challenge for sustainable development of human society. This study is an attempt to analyze existing literature to identify economic indicators that hamper the process of global warming. This paper includes case studies based on various countries to examine the nexus for environment and its relationship with Foreign Direct Investment, transportation, economic growth and energy consumption. Furthermore, the observations are analyzed from the perspective of China-Pakistan Economic Corridor (CPEC) and probable impact on carbon emission of Pakistan. A major portion of CPEC investment is allocated for transportation. However, it is evident that transportation sector is substantial emitter of carbon dioxide (CO2) gas. Unfortunately, there is no empirical work on the subject of CPEC and carbon emission for vehicular transportation. This paper infers that empirical results from various other countries are ambiguous and inconclusive. Moreover, the evidence for the pollution haven hypothesis and the halo effect hypothesis is limited in general and inapplicable for CPEC in particular. The major contribution of this study is the proposal of an energy efficient transportation model for reducing CO2 emission. In the end, the paper suggests strategies to climate researchers and policymakers for adaptation and mitigation of greenhouse gases (GHG).

• Journal of the Korean Operations Research and Management Science Society
• /
• v.38 no.4
• /
• pp.95-112
• /
• 2013

Information system (IS) security continues to present a challenge for firms. Especially, IT security accident is recently taking place successively in the financial sector. Thus, a comprehensive measure on this is demanded. A large part of a research on security relies upon technical design in nature and is restrictive in a consideration of person and organizational issue. To achieve a goal of firm security, it is possible with an effort of organizational management and supervision for maintaining the technical and procedural status. Based on a theory of accountability, we propose that the security countermeasures of organization lead to an increase in accountability and reduction in risk of IT security in a financial firm and further to firm performance like promotion in firm reliability. In addition, we investigate which difference a theoretical model shows by comparison between South Korean and American financial firms. As a result of analysis, it found that South Korea and America have significant difference, but that a measure on the financing IT security is important for both countries. We aim to enhance interpretability of a research on security by comparatively analysis between countries and conducting a study focus on specific firm called financial business. Our study suggest new theoretical framework to a research of security and provide guideline on design of security to financial firm.

• Transactions of the Korean Society of Mechanical Engineers B
• /
• v.35 no.7
• /
• pp.685-691
• /
• 2011

The aim of this study is to point out the uniqueness of Doppler optical coherence tomography (DOCT) for use in a probe station for (in vivo) visualization of microscale flow and structure and to maximize the effectiveness of DOCT by overcoming its limitations. Conventional DOCT produces images of only one of the velocity components that is parallel to the incident light. In this study, a multi-angle DOCT to quantify a velocity vector field is proposed; this is an extension from a velocity scalar field to a vector field. Quantifying an instantaneous three-dimensional velocity field in a pulsating flow is another challenge because of its limited frame rate. The in-vivo pulsating blood flow is measured by using an electrocardiogram-gated multi-angle DOCT in a hamster cheek pouch model. It is shown that the aliasing problem caused by a relatively low frame rate is resolved by using this method of measurement.