• Journal of Power System Engineering
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• v.14 no.3
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• pp.77-82
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• 2010

In general, the control valves are essential components in hydraulic systems. Structural changes within the valves remain a challenge because many parameters of valve tend to interact in terms of static and dynamic performance. Therefore, the valve characteristics is applied directly to the stability of hydraulic system. Inner structure of the valve which is used mainly in the industries is made up poppet type and spool type. This paper made a description of the method for numerical analysis and modeling of the valve with a built-in moving part of four-type. Based on the physical parameters of the valves, a numerical model of objected valve is developed using the bond graph method. It is to verified the results that the moving part of four-type has an effect on pressure and flow characteristics. Also, It is analyzed the results which has an effect on response characteristic by angular of poppet valve face and inertia variation of the valve with a built-in moving part. In the results, it is confirmed that the rising and settling time vary with the shape of moving part in valve.

• Korean Journal of Veterinary Research
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• v.47 no.1
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• pp.77-84
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• 2007

Helicobacter pylori (H. pylori) is an important bacterial pathogen that causes chronic gastritisand is associated with gastroduodenal ulcer disease, adenocarcinoma of the distal stomach, and gastricH. pylori infection associated with host agehave not been well-defined in human. To evaluate the difference in host susceptibility to infection in relationto age of acquisition of H. pylori infection, we designed an experiment involving inoculation of H. pyloriATC 43504 at different ages of Mongolian gerbils. H. pylori was inoculated at 5 weeks and 18 monthsof age, as representatives of early and late infection, respectively. Animals were sacrificed 1 week and 4weeks after challenge, and the stomach was removed from each animal for bacterial culture, histologicalexamination, and polymerase chain reaction test. 5 week-old gerbils revealed infection andmaintained continuously its infection until 4 weeks. However, old gerbils did not maintained H. pyloriinfection. These data suggest the insusceptibility of H. pylori in old Mongolian gerbils and the importanceof animal ages for successful animal experimental infection. Also, the results demonstrated that earlyinfection of H. pylori increases its host susceptibility, as compared to the case with later infection, possiblybecause of differences in host gastric mucosal factors and imunologic responses.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.6 no.3
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• pp.954-972
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• 2012

Content Delivery Networks (CDN) server loads that fluctuant necessitate CDN to improve its service scalability especially when the peak load exceeds its service capacity. The peer assisted scheme is widely used in improving CDN scalability. However, CDN operators do not want to lose profit by overusing it, which may lead to the CDN resource utilization reduced. Therefore, improving CDN scalability moderately and guarantying CDN resource utilization maximized is necessary. However, when and how to use the peer-assisted scheme to achieve such improvement remains a great challenge. In this paper, we propose a new method called Dynamic Moderate Peer-assisted Method (DMPM), which uses time series analysis to predict and decide when and how many server loads needs to offload. A novel peer-assisted mechanism based on the prediction designed, which can maximize the profit of the CDN operators without influencing scalability. Extensive evaluations based on an actual CDN load traces have shown the effectiveness of DMPM.

• International Journal of Aeronautical and Space Sciences
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• v.11 no.4
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• pp.326-337
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• 2010

This work addresses problems regarding trajectory planning for unmanned aerial vehicle sensors. Such sensors are used for taking measurements of large nonlinear systems. The sensor investigations presented here entails methods for improving estimations and predictions of large nonlinear systems. Thoroughly understanding the global system state typically requires probabilistic state estimation. Thus, in order to meet this requirement, the goal is to find trajectories such that the measurements along each trajectory minimize the expected error of the predicted state of the system. The considerable nonlinearity of the dynamics governing these systems necessitates the use of computationally costly Monte-Carlo estimation techniques, which are needed to update the state distribution over time. This computational burden renders planning to be infeasible since the search process must calculate the covariance of the posterior state estimate for each candidate path. To resolve this challenge, this work proposes to replace the computationally intensive numerical prediction process with an approximate covariance dynamics model learned using a nonlinear time-series regression. The use of autoregressive time-series featuring a regularized least squares algorithm facilitates the learning of accurate and efficient parametric models. The learned covariance dynamics are demonstrated to outperform other approximation strategies, such as linearization and partial ensemble propagation, when used for trajectory optimization, in terms of accuracy and speed, with examples of simplified weather forecasting.

• Parasites, Hosts and Diseases
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• v.44 no.1 s.137
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• pp.55-61
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• 2006

For treating Leishmania major infection in BALB/c mice, we used thalidomide in conjunction with glucantime. Groups of mice were challenged with $5{\time}10^3$ metacyclic promastigotes of L. major subcutaneously. A week after the challenge, drug treatment was started and continued for 12 days. Thalidomide was orally administrated 30 mg/kg/day and glucantime was administrated intraperitoneally (200 mg/kg/day). It was shown that the combined therapy is more effective than single therapies with each one of the drugs since the foot pad swelling in the group of mice received thalidomide and glucantime was significantly decreased (0.9 :t 0.2 mm) compared to mice treated with either glucantime, thalidomide, or carrier alone (1.2 :t 0.25, 1.4 :t 0.3, and 1.7 :t 0.27 mm, respectively). Cytokine study showed that the effect of thalidomide was not dependent on IL-12; however, it up-regulated IFN-yand down-regulated IL-10 production. Conclusively, thalidomide seems promising as a conjunctive therapy with antimony in murine model of visceral leishmaniasis.

• Biomolecules & Therapeutics
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• v.16 no.4
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• pp.299-305
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• 2008

Active cardiovascular anaphylactic response was induced in ovalbumin-sensitized, pithed Sprague-Dawley and Wistar rats. On intravenous administration of the antigen, ovalbumin, marked tachycardia and pressor responses were immediately elicited. Thereafter, a delayed long-lasting severe hypotensive response was observed. These anaphylactic cardiovascular responses were maximal 2-3 weeks after the sensitization, and the response was slightly diminished 6 weeks after sensitization. The immediate pressor response was blocked by a non-selective serotonin antagonist methysergide at a dose-dependent manner, but not by histamine receptor antagonists mepyramine (pyrilamine) or cimetidine. The delayed hypotension was reduced either by histamine $H_1$ receptor antagonist mepyramine or $H_2$ receptor antagonist cimetidine, both in a dose-dependent manner. The tachycardic response was not influenced by serotonin or histamine receptor antagonists examined in this study. Differently from the cardiovascular responses, there was no observable bronchial contraction in Sprague-Dawley rat trachea in contrast to Wistar rat where the trachea contracted to in vitro antigen challenge. The cardiovascular anaphylactic model seems to be useful for studying cardiovascular events that occur exclusively in peripheral heart-blood vessel systems. The involvement of two major anaphylactic mediators, serotonin and histamine, is partially demonstrated.

• Journal of Animal Science and Technology
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• v.62 no.3
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• pp.348-355
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• 2020

Cyclophosphamide, a cytotoxic anticancer agent, induces immunosuppression and has several adverse effects. N-acetylcysteine alleviates oxidative stress, liver injury, and intestinal tissue damage. The present study examined whether N-acetylcysteine modulates the adverse effects of cyclophosphamide in pigs. Miniature pigs (n = 15) were used as an experimental model to evaluate the effects of N-acetylcysteine treatment on immune reactions, liver injury, and oxidative stress after cyclophosphamide challenge. Corn-soybean meal based dietary treatments were as follows: control diet with either saline injection, cyclophosphamide injection, or 0.5% N-acetylcysteine and cyclophosphamide injection. N-acetylcysteine increased the number of immune cells and decreased TNF-α production after cyclophosphamide injection and decreased TNF-α, IFN-γ, NF-κB, and IL-8 expression and increased IL-10 expression in peripheral blood mononuclear cells. Serum levels of alanine transaminase and aspartate aminotransferase decreased, superoxide dismutase activity increased, and malondialdehyde activity decreased following N-acetylcysteine treatment after cyclophosphamide injection. N-acetylcysteine decreases immunosuppression, liver injury, and oxidative stress in cyclophosphamide-challenged miniature pigs. The present study suggests that N-acetylcysteine has therapeutic application in livestock for modulating immune reactions, liver injury, and oxidative stress.

• Proceeding of EDISON Challenge
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• 2017.03a
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• pp.270-281
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• 2017

In this paper, a vibratory disturbance to the rotor system generated by gyroscopic precession through helicopter rotor is examined. Also, active vibration reduction method is designed and simulated by designing feedback controller. For this purpose, structural analysis is carried out using EDISON's geometric exact beam program which can analyze the rotor with the cantilever condition. And the aeroelastic analysis is performed by coupling it with the simple aerodynamic model. In order to obtain the real-time structural response, the EDISON program analysis results were modeled by nonlinear equations and the Newton-Raphson method was used for the trim analysis.

• Proceeding of EDISON Challenge
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• 2017.03a
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• pp.194-203
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• 2017

The center of percussion(COP) is the point of an extended massive object attached to a pivot where a perpendicular impact will produce no reactive shock at the pivot. COP is an important concept in the field of vibration and dynamics. In vibration, COP causes reduction of vibration and in dynamics, it brings about maximum speed of an object. Many studies about COP are still in progress. However most of the researches have typically focused on the method of mathematical and numerical anlalysis. In this paper, impact analysis was proved by the mechanical energy method using EDISON co-rotational plane beam transient analysis program. The result expressed in acceleration was the relative magnitude of the impulse, which was the indicator of COP. Then, these results were compared with the reference thesis results for exact consequences. Additionally, parametric study of COP was conducted.

• Journal of the Korean Society of Clothing and Textiles
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• v.26 no.11
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• pp.1627-1637
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• 2002

The objective of this study is to analyze the images of basic bodice apparel displayed on the PC monitor connected to digital camera, and to suggest a more efficient alternative method that enables the expert judge to evaluate the subject both traditional method and displayed images on the computer. Appearance evaluation has traditionally been assessed using subjective method dependent upon expertjudges' senses with the naked eye after direct observation of a living model. This research faces the new challenge focusing on the sensory evaluation of appearance for basic apparel patterns, which can overcome the space and time limitations of the traditional feet methods. A total fifteen basic bodice garment (3 types of $pattern\;{\times}\;5$ subject) were constructed with same fabrics. The appearance evaluation items consist of lg questions of upper torso. The image takes font, back and side view of the dressed subject with three different situations. Data was analyzed using percentiles, standard deviation T-test and ANOVA. Taken together, the present result of appearance evaluation through digital camera image shows that there is a significant difference ($p{\leq}.001$) in the response to the placement of the neckline, the waist & shoulder dart, the general ease of the bust & waist area, the side seam, the perpendicular of the waist hem and general acceptability between the above three different situations; the image in the condition of greenish yellow background with front light showed the highest score through all questions. These results depend on the kind of background colors with the light.