• 대한화장품학회지
• /
• 제41권2호
• /
• pp.135-141
• /
• 2015

세포 노쇠화(cell senescence)는 나이 듦에 따른 내인성 노화 및 질병들에서 나타날 수 있는 세포의 노화인자 발현, 세포분열 정지 등의 현상으로 일컬어진다. 피부세포의 경우, 노화 및 외부요인으로 인한 세포 노쇠화가 일어나 세포분열의 정지 및 기능 이상이 관찰되며 이는 피부노화를 가속화시키는 요인이 된다. 본 연구에서는, cordycepin을 이용하여 노화된 피부세포의 세포 노쇠화 억제 및 기능 향상을 유도하여 피부노화 개선의 가능성을 제시하였다. 사람에서 유래한 섬유아세포를 이용하여 세포의 ${\beta}$-galactosidase 활성 세포염색 결과, 많은 계대의 세포에서 발현이 높게 나타남을 알 수 있었다. 항산화 및 항염 효과가 알려진 cordycepin을 많은 계대의 세포에 처리하였을 때 ${\beta}$-galactosidase 활성이 확연히 떨어짐을 확인하였고 무혈청 배지 조건에서 많은 계대 세포의 증식 및 생존율을 높이는 결과를 보였으며 세포 노쇠화와 많은 연관성이 대두되고 있는 미토콘드리아의 기능관련 실험을 진행한 결과, 높은 ROS억제능이 나타났다. 본 연구를 통하여 노화된 사람 피부 섬유아세포에서의 cordycepin의 세포 노화 개선능을 알 수 있었으며, 피부 항노화소재로서의 가능성을 확인하였다.

• Journal of Preventive Medicine and Public Health
• /
• 제37권3호
• /
• pp.238-245
• /
• 2004

Objectives : This study was conducted to examine the smoking behaviors and the relationship between smoking and other health behaviors among medical students. Methods : A self-administrated questionnaire was administered to a sample of 1,775 students from four medical schools between April and May 2003. Due to the small number of female smokers, the characteristics of smoking behaviors were analyzed only for males. Results : A total of 1,367 students (920 males and 447 females) completed the questionnaires, with an overall response rate of 77.7%. The smoking rates for males and females were 31.5, and 2.2%, respectively. Among the male smokers, 70.7% smoked daily, and 39.0% smoked one pack or more per day. Male students on medical course were more likely to smoke daily, and one pack or more per day, than those on premedical course. Male daily smokers desired to quit smoking less than occasional smokers, and 65.0% of male daily smokers were not ready to quit compared with 37.8% of the occasional smokers. Among the male daily smokers, 29.6% were severely nicotine dependent. The most common reason for not to quit smoking among male smokers was 'no alternative stress coping method' (44.4%), followed by 'lack of will power' (25.4%), and 'no need to quit' (19.4%). Compared with male non-smokers, male smokers were more likely to drink alcohol more often and in larger amounts, take coffee more often, eat breakfast less regularly, and be overweight or obese. Conclusions : The results of this study suggest that many male medical students were serious smokers, especially those on medical course. It is necessary to install a smoking prevention program for pre-medical students, provide effective smoking cessation methods for smokers, teach positive stress coping methods, and make the school environment suitable for coping with stress.

• 한국융합학회논문지
• /
• 제6권2호
• /
• pp.13-18
• /
• 2015

본 연구의 목적은 소방공무원의 외상후 스트레스 장애의 원인을 파악하고 스트레스를 진단하기 위한 척도와 도구에 대한 고찰을 통해 위기상황 스트레스 관리 교육프로그램과 대책을 제안하고자 하는데 그 목적이 있다. 외상후 스트레스 장애는 침습 증상, 회피 증상, 인지와 기분의 부정적 변화, 과각성 증상을 특징을 포함한다. 트라우마의 기억은 외현 기억(explicit memory)과 암묵 기억(implicit memory)이 있다. 외현 기억은 의식적, 인지적, 서술적이며, 변연계 구조물 중 해마가 관여한다. 사건 당시 정보 처리는 억제적이며, 내러티브 언어구성을 갖는다. 암묵 기억은 무의식적, 정서적, 절차적이며, 몸이 기억을 한다. 관련된 변연계 구조물은 편도체이고 사건 당시 정보처리는 활성화되어 있고, 말로 표현할 수 없는 언어구성을 갖는다. 암묵 기억의 소거가 트라우마 치료에서 가장 중요하다. 위기상황 스트레스 관리(critical incident stress management, CISM)는 위기 상황으로 인해 발생되는 스트레스의 유해성을 감소시키고, 조절하기 위한 포괄적이고 체계적인 접근 방법이다. 결론적으로 CISM의 핵심적 목표는 외상후 스트레스 장애에 의한 심리적 상태의 종결이라고 할 수 있다. 본 연구는 외상후 스트레스 장애의 원인과 대처방법에 대한 문헌 고찰을 통해 소방공무원의 외상후 스트레스 장애 해소를 위한 교육프로그램 개발을 제안하고자 하였다.

• The Korean Journal of Physiology
• /
• 제2권2호
• /
• pp.11-20
• /
• 1968

Maximal oxygen uptake was measured in thirty-three secondary school girls by means of the treadmill test. Eighteen middle school girls aged 14.0 (range: $13.0{\sim}15.9$) years and fifteen high school girls aged 16.9 (range: $16.0{\sim}18.0$) years served as subjects. Maximal treadmill run lasted for 2 minutes and 20 seconds and the expired air was collected in a Douglas bag through a J-valve during the last one minute period. In general, absolute values of various measurements in the high school girls were greater than those of the middle school girls. When values were expressed on the body weight or lean body weight basis, however, work capacity of middle school girls was superior to that of the high school girls. The detailed results are as follows: 1. In middle school girls maximal oxygen uptake was 1.78 l/min., 47.4 ml/kg body weight, 12.3 ml/cm body height, and 61.7ml/kg lean body mass. In high school girls maximal oxygen uptake was 1.93 l/min., 39.7ml/kg body weight, 12.3 ml/cm body height, and 51.2 ml/kg LBM. Although the absolute value of maximal oxygen uptake was greater in high school girls than in middle school girls, values expressed on the body weight basis showed the reverse trend, namely, values of the middle school girls was greater than those of the high school girls. 2. The ratio of maximal to resting oxygen uptake was 8.8 in the middle school girls and was 10.2 in the high school girls. 3. Maximal pulmonary ventilation in the middle school girls was 55.3 l/min. and 66.1 l/min. in the high school girls. The ratio of maximal to resting pulmonary ventilation was 10.2 in the middle school girls and 10.1 in the high school girls. 4. The correlation between body weight and maximal oxygen uptake was relatively high, namely, r=0.79 both in middle and high school girls. The correlation coefficient between body weight and maximal pulmonary ventilation was a little less that of between maximal oxygen uptake and showed a value of r=0.60 both in middle and high school girls. The lean body mass was a poor reference of maximal oxygen uptake or maximal pulmonary ventilation as compared to body weight. The correlation between maximal oxygen uptake and maximal pulmonary ventilation was high and the coefficient of correlation in middle school girls was 0.927 and in high school girls it was 0.856. 5. Maximal ventilation equivalent was 30.9 liters in middle school girls and 33.9 liters in high school girls. This indicated that no hyperventilation was induced during the maximal of oxygen uptake exercise period as related to the maximal oxygen uptake. 6. Heart rate reached to the peak value within 1.5 minutes after beginning of maximal oxygen uptake run and remained at the same peak plateau level throughout the entire running period. Heart rate decreased steeply on cessation of running and subsided slowly thereafter. The maximal heart rate was 184 beat/min. in middle school girls and 189 beat/min. in high school girls. 7. Maximal oxygen pulse was 9.4 in middle school girls and 9.9 ml/beat in high school girls.

• 대한약침학회지
• /
• 제18권1호
• /
• pp.79-85
• /
• 2015

Objectives: A vertebral compression fracture (VCF) is characterized by back pain and fracture of a vertebral body on spinal radiography. VCFs of the thoraco lumbar spine are common in the elderly. In general, appropriate analgesics should be prescribed to reduce pain and, thus, promote early mobilization. The ideal treatment approach for VCFs has not been determined. In Korea, acupuncture and herbal medication have been used to treat VCFs for many years. There is empirical evidence that acupuncture might benefit patients with a VCF. However, no randomized, controlled, clinical trials evaluating the efficacy and the safety of acupuncture for treating a VCF have been published. Therefore, we designed a randomized, controlled, pilot, clinical trial to obtain information for the design of a further full scale trial. Methods: A five week protocol for a randomized, controlled, pilot, clinical trial is presented. Fourteen patients will be recruited and randomly allocated to two groups: a control group receiving interlaminar epidural steroid injections once a week for three weeks, and an experimental group receiving interlaminar epidural steroid injections plus acupuncture treatment (three acupuncture sessions per week for three weeks, nine sessions in total). The primary outcomes will be the pain intensity (visual analogue scale and PainVision$^{TM}$ system). The secondary outcome measurements will be the answers on the short form McGill pain questionnaire and the oswestry disability index. Assessments will be made at baseline and at one, three, and five weeks. The last assessment (week five) will take place two weeks after treatment cessation. This study will provide both an indication of feasibility and a clinical foundation for a future large scale trial. The outcomes will provide additional resources for incorporating acupuncture into existing treatments, such as nonsteroidal anti-inflammatory medications, narcotics and vertebral augmentation. This article describes the protocol.

• 한국치위생학회지
• /
• 제20권3호
• /
• pp.313-324
• /
• 2020

Objectives: The aim of this study was to confirm the association among the health status, health behaviors, and periodontitis according to total, age and sex in cases of adult metabolic syndrome(MetS). Methods: This cross-sectional study used collected data from the 7^th Korea National Health and Nutrition Examination Survey (KNHANES) conducted from 2016 to 2018 with 3,394 adults with MetS aged 19-79 years. The complex samples logistic regression analysis confirmed the relevant factors for periodontitis. Results:Periodontitis was diagnosed in 43.6% of all MetS cases. Diabetes (Odds Ratio [OR]=1.554), abdominal obesity (OR=1.336), current smoking (OR=2.465), past smoking (OR=1.379), and not-using oral care products (OR=1.414) were associated with periodontitis in MetS. In the age of 19-39 years with MetS group, diabetes (OR=5.379), elevated blood pressure (OR=3.975), current smoking (OR=7.430), and not using oral care products (OR=3.356) were associated with periodontitis. In the 40-79 age group, diabetes (OR=1.398), abdominal obesity (OR=1.360), current smoking (OR=2.022), and not using oral care products (OR=1.416) were associated with periodontitis. In the male MetS group, current smoking (OR=3.119), past smoking (OR=1.625), and brushing teeth more than three times (OR=0.743) were associated with periodontitis. In the female MetS group, diabetes (OR=1.733), impaired fasting glucose (OR=1.434), abdominal obesity (OR=1.479), and not using oral care products (OR=1.992) were associated with periodontitis. Conclusions: Improvement in blood sugar control, obesity, smoking cessation, and oral health education, including how to use oral care products in all individuals with MetS may result in improved oral health. In addition, improvement in elevated blood pressure in the MetS group aged under 40 years, and brushing teeth more than three times a day in the male MetS group can reduce the risk of periodontitis. Therefore, public and oral health professionals should emphasize on the relationship between age and sex during the metabolic syndrome management program and share relevant information with patients.

• 한국산학기술학회논문지
• /
• 제14권3호
• /
• pp.1359-1366
• /
• 2013

본 연구는 중년기 남성 근로자의 흡연과 비흡연에 따른 혈압, 혈청지질치 및 비만지표와의 관계를 알아보고, 금연이 혈압, 혈청지질 및 비만도의 변화에 어느 정도 영향을 미치는 가를 검토하고자 시도하였다. 연구대상은 30~59세의 남성 근로자 2,172명이었으며, 조사항목으로는 피조사자들의 연령, 흡연상태, SBP와 DBP, TC, TG, HDL-C, LDL-C, 동맥경화지수(AI), BMI, 체지방률 및 허리둘레였다. 조사는 2011년 4월부터 7월까지의 기간 동안에 실시하였다. 연구결과, 각 조사항목의 평균치를 보면 수축기혈압과 확장기혈압은 비흡연군(흡연중단군 포함)에 비해 흡연군에서 유의하게 높았다. TC, TG, 동맥경화지수(AI)는 비흡연군에 비해 흡연군에서 유의하게 높은 반면, HDL-C는 비흡연군에 비해 흡연군에서 유의하게 낮았다. BMI는 흡연군에 비해 비흡연군에서 유의하게 높았다. 흡연상태에 따른 각 조사항목의 분포를 보면, 고혈압은 비흡연군에 비해 흡연군에서 유의하게 높았다. TC, TG 및 HDL-C의 비정상치는 비흡연군에 비해 흡연군에서 유의하게 높았으며, BMI에 의한 비만은 흡연군보다 비흡연군에서 유의하게 높았다. 연령을 조정한 상태에서의 비흡연군에 비해 흡연군에서 발생할 각 조사항목의 위험비를 보면, 고혈압 발생의 위험비는 3.59배, 고콜레스테롤혈증 발생의 위험비는 1.49배, 고중성지질혈증 발생의 위험비는 1.81배, 저HDL-콜레스테롤혈증 발생의 위험비는 1.58배, 고동맥경화지수 발생의 위험비는 1.27배 증가하였다. 위와 같은 결과를 볼 때 흡연은 고혈압과 고지혈증에 관계하고 있음을 시사한다.

• 한국학교ㆍ지역보건교육학회지
• /
• 제6권
• /
• pp.35-48
• /
• 2005

The age of the very first smoking is a significant indicator of life-long health status. Smoking prevention intervention was actively conducted based in middle and high schools with the support of the Korean Act for Health Promotion since 1998. These governmental supports became large and various smoking prevention programs were developed and conducted in diverse standards and perspectives. This study made a comprehensive descriptive literature review on smoking prevention educational programs for youth in Korea to identify the intervention quality and effectiveness of them for future smoking prevention program development. A total of 28 peer-reviewed journal articles published between May, 1995 and May 2005 (for the last 10 years) were finally included in this review process. The study participants should be adolescences in middle or high schools in Korea and the intervention types of the review studies should be smoking prevention or cessation educational programs. The outcomes of the reviewed studies were reanalyzed by the participants' characteristics, theory basement, evaluation design, intervention period, evaluation outcomes, and program effectiveness Most smoking intervention programs were not specified by sex and smoking status. Largely most intervention programs focused on male students although female students' smoking percent is increasing including both smokers and nonsmokers. Based on the school grades, the large percents of smoking intervention were conducted to the first grade of middle school and the first grade of high school. Almost 70% of the reviewed studies did not apply any health behavior change theories and the Transtheoretical model and social cognitive theory were utilized in 7 studies among the last reviewed 30%. The theory-based intervention studies had greater effectiveness than the non-theory based studies. More than 90% had quasi-experimental evaluation design and the effectiveness of the non-experimental designed study seemed over estimated than the quasi-experimental or experimental designed studies. More than 60% of the reviewed studies made their education for less than j days, over a short period and the evaluation factors were knowledge and attitude in general which can be obtained in short intervention period. Therefore, smoking intervention programs for youth in Korea need to be modified in terms of research design such as the intervention period, intervention-evaluation design, theory-based approach, and population-focused intervention specification.

• Journal of Korean Neurosurgical Society
• /
• 제30권sup1호
• /
• pp.120-123
• /
• 2001

1988년 1월부터 1997년 12월까지 본 교실에 내원하여 뇌수막종으로 진단받고 수술요법을 실시한 87례 중, 완전제거 후 재발한 경우와 부분적 절제후 방사선 치료를 받은 4례를 대상으로 hydroxyurea를 이용해 치료한 결과를 분석하였다. 남자가 1례, 여자가 3례이었으며 연령 분포는 23세에서 55세였다. 조직학적으로 3례가 meningothelial type이었으며 1례는 angiomatous type이었다. 3례에서 소뇌교각부에 발생하였으며 1례에서 해면정맥동에 발생하였다. 모든 환자들은 수술적 치료를 시행받았으며 3례의 환자에서 방사선 치료를 시행하였다. Hydroxyurea를 20mg/kg/day용량으로 투여하였으며 평균 추적관찰기간은 34개월이었다. 치료기간중 4례에서 종양이 줄어든 예는 없었으나 종양이 성장하지는 않았다. 삼차신경통 증상이 있던 1례는 증상 호전 되었으며 수술적 치료를 3차례 받았던 1례에서 두개골절제부위에 팽창되어 있던 뇌는 축소되어 두개강내로 복귀되었다. 혈액학적 부작용으로 백혈구 수치가 1례에서 감소되었으나 2주정도 복용을 중단한 후 다시 수치는 회복되었고 다른 심각한 부작용은 나타나지 않았다. 저자들은 뇌수막종 환자중, 수술후 재발한 경우와 불완전 제거를 시행한 경우 보조적 치료방법으로 hydroxyurea의 사용하여 종양크기의 감소는 없었으나 성장을 억제할 수 있었으며 앞으로 오랜 기간 추적관찰과 많은 증례에 대한 분석을 함으로써 뇌수막종 치료의 보조 방법으로 hydroxyurea를 이용할 수 있을 것으로 생각된다.

• 한국환경과학회지
• /
• 제28권11호
• /
• pp.907-915
• /
• 2019

This study aims to identify the most tolerant species under salinity stress from amongst Asteraceae and Poaceae. The seeds of six species were exposed to different concentrations of $CaCl_2$ (0, 9, 18, 45, 90 mM) and NaCl (0, 17, 34, 85, 170 mM), and germination was measured once every two days. The results indicated that percent germination of the six species of Asteraceae and Poaceae seeds were affected differently by changes in salinity concentration. Seed germination was reduced as salinity levels increase, and longer mean germination times correlated to lower percent germination and earlier germination cessation. Both Asteraceae and Poaceae seeds had the highest germination rates at 18 mM $CaCl_2$ and 34 mM NaCl, and seed germination and growth were severely reduced at salinities greater than 90 mM $CaCl_2$ and 170 mM NaCl. In the seeds of Poaceae, salt resistance was strong in the order of Miscanthus sinensis Andersson, Pennisetum alopecuroides (L.) Spreng., and Phragmites communis Trin. In the seeds of Asteraceae, salt resistance was strong in the order of Dendranthema zawadskii var. latilobum (Maxim.) Kitam, Aster yomena (Kitam.) Honda, and Dendranthema boreale (Makino) Ling ex Kitam.. Overall, the germination rate was higher in Asteraceae than in Poaceae. This study demonstrated that Dendranthema zawadskii var. latilobum (Maxim.) Kitam. is the most tolerant species and that a relationship exists between the salt tolerance of percent germination and the mean germination time in the leaves.