• Tuberculosis and Respiratory Diseases
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• 제61권2호
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• pp.167-170
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• 2006

대퇴골 전이를 동반한 비소세포폐암 환자에서 전이 부위에 대한 방사선 치료 후 시행한 항암화학요법 도중, gemcitabine으로 인한 방사선 회귀 피부, 근육염이 발생하였다. 대퇴부의 부종, 발적과 통증 등은 스테로이드 사용 후 모두 사라졌으며, gemcitabine 투여를 중지한 이후 현재까지 재발이 없었다.

• 한국임상약학회지
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• 제24권3호
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• pp.213-218
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• 2014

Objectives: The aim of this study was to identify the causal relationship between use of levocetrizine or cetrizine, and liver injury, by comparing frequency and pattern of hepatotoxicity in levocetrizine or cetrizine prescribed patients. Methods: This is a retrospective observational study, using data retrieved from electronic medical record system. Among 1164 patients prescribed levocetrizine or cetrizine during study period (Jul, 2009 - Jun, 2010) at Seoul National University Hospital, 543 patients with more than 4- time liver function test (LFT) results were included in final analysis. Liver injury was defined as greater than 3 times elevated level of alanine aminotransferase or 2 times elevated level of alkaline phosphatase or total bilirubin, compared to upper limit of normal, in patient with normal liver function at baseline. The frequency and pattern of liver injury were assessed. Results: Incidence of liver injury in patients prescribed with levotcetrizine or cetrizine were 1.48% and 2.94%, respectively. With few exceptions, most injuries were shown to be hepatocellular type. Rapid recovery was observed after drug cessation and long term use tends to be associated with incidence of liver injury. In patient with digestive system disorder, rate of liver injury was significantly higher (p=0.011). Conclusion: The result of this study implies potential need of liver toxicity monitoring, especially in patients taking long term levecetrizine or cetrizine or in patient with digestive system disorder. However, prospective large scale observational study is needed to confirm liver injury associated with the use of levocetirizine or cetirizine.

• 지역사회간호학회지
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• 제5권1호
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• pp.5-29
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• 1994

In recent years, interests in health promotion have been stimulated by the epidemiological transition from infectious to chronic diseases as lead ing causes of death, the aging of the population, rapidly escalating health care costs, and epidemiologic findings linking individual risk to morbidity and mortality. It is not surprising that the workplace has been targeted as a promising setting for health promotion. In Korea, national attention to the opportunities for workplace health promotion began in the first 1990s. But there is no in depth study to identify the relating factors to the health promotion program in the workplace. The objective of this study is behavioral and physical characteristics to find that in crease the person's risk for a range of health problems and to analysis other characteristics to influence the degree of his/her intention to change health behavior. In addition, this study is purposed to present the process of planning health promotion program in the workplace. To accomplish these objectives, one workplaces was selected. And 363 employees in those workplaces were served as subjects for the study. Major findings in this study are as follows. (1) They have many risk factors such as smoking, drinking, lack of sleep, law rate of regular exercise, irregular eating, stress. (2) Some of the health risk factors such as smoking, drinking, and stress have the negative correlation to the intention to change. (3) Among cognitive and socio-environmental factors, significant predictors to the intention are attitude and social support. (4) In the cluster analysis to segment the target population in to homogeneous unit, three clusters of lifestyle are specified. (5) Smoking cessation and exercise program are planned for the risk group to change their behavior.

• 지역사회간호학회지
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• 제15권1호
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• pp.36-43
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• 2004

Purpose: The main objective of this study was to develop a continuing education program for school health nurses using the Internet, and evaluate the satisfaction of users. Method: A survey using a self reported questionnaire was done to identify areas where education is needed. A stratified random sampling method was employed to select 1.746 school health nurses and to receive the respondings from 584 school health nurses. The contents of the module for the education program were determined to be counseling and teaching techniques to meet health care needs related to sex, and cessation of smoking. The researchers wrote the educational content for the program, and the storyboards and illustrations appropriate to the module were constructed and the domain was registered. The web site was named 'www.healthyyouth.org'. Results: Three topics were identified where education is needed: youth and sex, youth and smoking, and counseling techniques for children, and programs were developed under the web site named. 'www.healthyyouth.org'. Over 90 percent of the respondents reported that the web site was useful and 100 percent reported that they would recommend the web site to other school health nurses. Conclusion: The web based program allowed school health nurses to study and improve their health care knowledge and skills. Since almost all schools in Korea have personal computers in the infirmary, accessibility to the program is excellent. Based on the results of this study, this type of education program will be a useful method for the continuing education of school health nurses.

• 지역사회간호학회지
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• 제19권1호
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• pp.57-65
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• 2008

Purpose: The purpose of this study is to assess the priorities of health promotion for older adults in the rural community. The study attempts to display demographic characteristics subjective health status and chronic diseases status of the older adults. Methods: We surveyed 384 senior residents in a community via face-to-face interviews in their homes, who were selected by proportional random sampling. We analysed the frequency, multiple responses and $X^2$ by SPSS 12.0K. Results: The mean of subjective health status was $54.04{\pm}21.69$ with a maximum of 100. Our study found that the high priorities in health promotion for older adults were prevention and management of hypertension and diabetes, strengthening of joint and muscles, cancer screening and physical exercise. Prevention of depression and social activities were low priorities. Strengthening of joints and muscles was a high priority among women while smoking cessation and social activities were high priorities of men. Conclusion: In conclusion, health promotion priorities of older adults differed by gender and subjective health status. Disease-related priorities received more attention than psycho-social health priorities. This study suggests comparing the priorities regionally and nationally.

• 보건교육건강증진학회지
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• 제24권1호
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• pp.1-16
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• 2007

Objctives: This study purposed to examine the intention to participate in the preventive program of depression of Internet user and to offer the baseline data for development of mental health promotion program. Methods: The internet survey was performed using a self-reported questionnaire on intention to participate in the preventive program of depression, depressive symptom(with Zung's SDS) and so forth from 1,000 internet user (aged $13{\sim}49$ years) via two web sites at Feb($1st{\sim}10th$), 2006. We analyzed the intention to participate in preventive program of depression and the factors related with that intention by depressive level. Results: In the normal group, the intention to participate in a preventive program of depression was influenced significantly by counselling experience(s) on depression(p<.001), and perceived control(p<.001) over the barriers to participation in the preventive program of depression, and marginally by gender. In the depressive group, the smoking habit revealed marginal effect(p=.051) and perceived control over the barriers to participation in the preventive program of depression influenced on that intention significantly(p<.001). Conclusion: Among internet users, especially the solutions of barriers to participate in the preventive program of depression is more important at the intervention program for prevention of depression. In the normal group, we need to consider the use of messages tailored by counselling experience(s) on depression. Some intervention program dealing with two subjects, smoking cessation and prevention of depression concurrently, will be appropriate for the depressive group.

• 성인간호학회지
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• 제22권2호
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• pp.190-199
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• 2010

Purpose: The purpose of this study was to determine the differences in the level of disease related knowledge, compliance of health behavior, and educational needs in relation to time (at discharge and 6 months after discharge) among patients underwent percutaneous coronary intervention (PCI). Methods: Data were collected from January 1, 2006 to September 30, 2006 and a total of 60 patients participated in the study. The survey was conducted in patients underwent PCI at the time of discharge right after discharge education was provided and at a follow up visit which was 6 months after discharge. Results: The level of disease related knowledge (p<.001), the compliance of health behavior (p<.001), educational need (p=.496), the sub-item of sexual life (p<.001), follow up (p<.001), diet (p=.021), stress (p<.001) in compliance of health behavior, and the sub-item of specific character of disease in educational needs (p=.015) were significantly different between discharge and 6 months after discharge. Conclusion: The results of this study suggested that further education should be provided to the patients underwent PCI regarding medication, smoking cessation, daily life and exercise at a time of 6 months after discharge in order to increase patient compliance of health behavior.

• Asian Pacific Journal of Cancer Prevention
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• 제17권1호
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• pp.73-80
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• 2016

Colorectal cancer is a very prevalent diagnosed cancer. The current study was performed in order to examine the role of BRAE (Basella rubra aqueous extract) in regulating aberrant crypt foci (ACF) formation, cell proliferation and inhibition of apoptosis in a colon carcinogenesis model in male Wistar rats. Rats were randomly allocated into six groups. Group I served as control, and group II acted as a drug control administered BRAE (250mg/kg b.w.) orally for 30 weeks. Rats in group III-VI were given subcutaneous injections of DMH (25mg/kg b.w. weekly) for 15 weeks to initiate colon carcinogenesis. Those in group IV and VI were administered BRAE along with DMH injections. Rats in group V were administered with BRAE after cessation of DMH injection. After 30 weeks of experimental period colons were obtained from experimental groups and analyzed for ACF incidence, argyrophilic nucleolar organizing region-associated proteins (AgNOR) count, histopathological and immunohistochemical changes. Only in DMH exposed groups were ACF and AgNOR numbers increased. Administration of BRAE appreciably decreased the numbers of ACF and AgNOR in BRAE treated groups. Histopathological findings revealed a high level of dysplastic changes with decreased number of goblet cells found only in only DMH injected rats. Administration of BRAE in treated group rats reversed these changes. Expression markers for cell proliferation (PCNA and Ki67) were elevated in DMH treated rats, but reduced with BRAE treatement. This expression was reversed with apoptosis markers (p53 and Caspase-3). Thus the results results of the present study were found to be significant and confirmed the potential efficacy of BRAE against colon carcinogenesis.

• Asian Pacific Journal of Cancer Prevention
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• 제16권13호
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• pp.5433-5438
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• 2015

Background: Systemic chemotherapy for patients with metastatic gastric cancer (MGC) is generally palliative, although some patients experience long-term survival after treatment. Thus, we identified clinical characteristics that are associated with long-term survival of patients with MGC after palliative chemotherapy. Materials and Methods: We retrospectively reviewed 514 MGC patients who received systemic chemotherapy at our institution from 2001 to 2008. To identify clinical predictors of survival beyond 2 years, multivariate logistic regression analyses were performed, and 5-year survival rates were estimated among MGC patients following chemotherapy. Results: Among 514 patients, 96 (19%) and 16 (3%) survived beyond 2 and 5 years, respectively, and performance status of 0 or 1 (odds ratio [OR]=3.39; p=0.01), previous gastrectomy (OR=1.86; p=0.01), single metastatic site (OR=1.80; p=0.03), and normal alkaline phosphatase levels (OR=2.81; p<0.01) were identified as independent predictors of long-term survival. Of the 16 5-year survivors, six were alive at the end of the study and showed no evidence of disease despite cessation of chemotherapy. Conclusions: The present data demonstrate distinct clinical characteristics that are associated with long-term survival of MGC patients, and indicated that palliative chemotherapy can be curative in highly selected patients.

• Asian Pacific Journal of Cancer Prevention
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• 제16권1호
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• pp.139-144
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• 2015

Background: The work force in industries are at risk of developing unduly high rates of health and behaviour related problems including abuse of alcohol, betel nut and cigarette (alcohol, betel nut and cigarette consumption). This study describes the relationships between alcohol, betel nut and cigarette consumption and health promoting behaviour among industrial workers. Materials and Methods: A cross sectional survey was conducted on workers in various industries of Ghaziabad city with concerned authority permission. A sample size of 732 workers was calculated based on pilot study. Through Simple random sampling 732 workers in 20 to 50 years age group with informed consent were interviewed through structured, pretested, validated questionnaire in vernacular language by one calibrated investigator. Data on socio demography, alcohol, betel nut and cigarette consumption pattern and health behaviour were collected. The association between health promoting behaviour and alcohol, betel nut and cigarette consumption was analysed by Logistic regression and Chi-square test through SPSS 16 at p<0.05 and 95%CI as significant. Results: Total prevalence of alcohol, betel nut and cigarette consumption in study population was 88%. The prevalence of individual alcohol, betel nut and cigarette consumption were 82%, 68% and 79% respectively. Combined alcohol, betel nut and cigarette prevalence in study population was 58%. Alcohol and cigarette users were significantly higher (p<0.001) in 30 to 40 years age group with lower level of education having poor attitude towards health promoting behaviour, poor oral hygiene practices and rare indulgence in regular physical exercise. Conclusions: This study stimulate further research on exploring methods to prevent initiation of health risk behaviour and promote healthy behaviour with cessation help for the current alcohol, betel nut and cigarette users.