• Journal of Korean Neurosurgical Society
• /
• v.55 no.2
• /
• pp.69-72
• /
• 2014

Objective : There was no abundance of data on the use of anticoagulant in patients with previous high risk of thromboembolic conditions under a newly developed intracranial hemorrhage in Korean society. The purpose of this study was to evaluate the safety of discontinuance and suggest the proper time period for discontinuance of anticoagulant among these patients. Methods : We reviewed the medical records of 19 patients who took anticoagulant because of thromboembolic problems and were admitted to our department with newly developed anticoagulation associated intracranial hemorrhage (AAICH), and stopped taking medicine due to concern of rebleeding from January 2008 to December 2012. Analysis of the incidence of thromboembolic complications and proper withdrawal time of anticoagulant was performed using the Kaplan-Meier method. Results : Our patients showed high risk for thromboembolic complication. The $CHA_2DS_2$-VASc score ranged from two to five. Thromboembolic complication occurred in eight (42.1%) out of 19 patients without restarting anticoagulant since the initial hemorrhage. Among them, three patients (37.5%) died from direct thromboembolic complications. Mean time to outbreak of thromboembolic complication was $21.38{\pm}14.89$ days (range, 8-56 days). The probability of thromboembolic complications at 7, 14, and 30 days since cessation of anticoagulation was 0.00, 10.53, and 38.49%, respectively. Conclusion : Short term discontinuance of anticoagulant within seven days in patients with AAICH who are at high embolic risk ($CHA_2DS_2$-VASc score >2) appears to be relatively safe in Korean people. However, prolonged cessation (more than seven days) may result in increased incidence of catastrophic thromboembolic complications.

• Biomolecules & Therapeutics
• /
• v.21 no.5
• /
• pp.371-380
• /
• 2013

Doxorubicin is still main drug in chemotherapy with limitation of use due to adverse drug reaction. Increased oxidative stress and alteration of nitric oxide control have been involved in cardiotoxicity of doxorubicin (DOX). A Disintegrin And Metalloproteinase (ADAMs) are transmembrane ectoproteases to regulate cell-cell and cell-matrix interactions, but role in cardiac disease is unclear. The aim of this study was to determine whether DOX activates peroxynitrite and ADAM 10 and thus ADAM and matrix metalloproteinase (MMP) induce cardiac remodeling in DOX-induced cardiomyopathy. Adult male Sprague-Dawley rats were subjected to cardiomyopathy by DOX (6 times of 2.5 mg/kg DOX over 2-weeks), and were randomized as four groups. Then followed by 3, 5, 7, and 14 days after cessation of DOX injection. DOX-injected animals significantly decreased left ventricular fractional shortening compared with control by M-mode echocardiography. The expressions of cardiac nitrotyrosine by immunohistochemistry were significant increased, and persisted for 2 weeks following the last injection. The expression of eNOS was increased by 1.9 times (p<0.05), and iNOS was marked increased in DOX-heart compared with control (p<0.001). Compared to control rats, cardiac ADAM10- and MMP 9- protein expressions increased by 20 times, and active/total MMP 9 proteolytic activity showed increase tendency at day 14 after cessation of DOX injection (n=10, each group). DOX-treated $H_9C_2$ cell showed increased ADAM10 protein expression with dose-dependency (p<0.01) and morphometric changes showed the increase of ventricular interstitial, nonvascular collagen deposition. These data suggest that activation of cardiac peroxynitrite with increased iNOS expression and ADAM 10-dependent MMP 9 expression may be a molecular mechanism that contributes to left ventricular remodeling in DOXinduced cardiomyopathy.

• The Journal of the Korea Contents Association
• /
• v.17 no.7
• /
• pp.622-633
• /
• 2017

The study was conducted to compare the factors affecting smoking quit attempts according to the amounts of smoking in adolescent smoker. The data were derived from the 12th Korea youth risk behavior web-based survey 2016 in Korea and analyzed using the IBM SPSS statistics version 21.0 software package considering complex samples analysis. The subjects were 4,012 adolescents smokers, Of these, 78.4% of the general smoker who smoke less than 10 cigarettes a day and 21.6% of the heavy smoker who smoke more than 10 cigarettes a day. As a logistic regression, vigorous physical activity, depression, smoking initiation time, friends smoking, smoking cessation education, and non-smoking promotion were associated with significantly smoking quit attempts in general smoker, vigorous physical activity, friends smoking, smoking cessation education, and non-smoking promotion were associated with significantly smoking quit attempts in heavy smoker. Based on the results, they were taken a baseline data for developing adapted smoking quit education program which were succeed effectively in adolescent smokers.

• Journal of Korean Physical Therapy Science
• /
• v.2 no.2
• /
• pp.465-479
• /
• 1995

We randomly assigned 61 healthy subjects(male 14, female 47) to compare the experimental pain threshold and skin temperature between high mode TENS and burst mode TENS. In this study, 61 subjects were divided into three groups ; high mode TENS(n=20), burst mode TENS (n=20), and control group(n=21). Experimental pain thresholds and skin temperatures were measured before, immediately after cessation of stimulation, and at 30 minutes post stimulation. Stimulation was applied to the dorsal surface of the forearm(L14, LI10). Pain thresholds were measured by chronaxie meter. Skin temperature were measured by electrical digital thermometer. The results are as follows ; 1. There were no statistical difference in the pain threshold and skin temperature at before TENS stimulation among the three groups(p>0.05). 2. The pain threshold and skin temperature in burst mode TENS group was significantly higher and longer effect than that in high mode TENS group and control group(p<0.01). 3. The pain threshold in burst mode TENS group decreased to prestimulation levels by 30 minutes poststimulation. 4. The skin temperature in burst mode TENS group decreased to prestimulation levels by 20 minutes poststimulation. 5. The skin temperature was significantly difference among three group at immediately after, and at 30 minutes poststimulation and the skin temperature in burst mode TENS group was significantely higher than that in two groups(p<0.001). 6. The increasing rate of pain threshold in high mode TENS group after immediately cassation of stimulation was 24.3%(p<0.001). 7. The increasing rate of pain threshold in burst mode TENS group after immediately cessation of stimulation was 93.5% (p<0.001).

• Asian Pacific Journal of Cancer Prevention
• /
• v.15 no.1
• /
• pp.229-237
• /
• 2014

Background: Dentists are typically the first professionals who are approached to treat ailments within the oral cavity. Therefore they should be well-equipped in detecting suspicious lesions during routine clinical practice. This study determined the levels of knowledge on early signs and risk factors associated with oral cancer and identified which factors influenced dentist participation in prevention and early detection of oral cancer. Materials and Methods: A survey on dentists' knowledge and their practices in prevention and early detection of oral cancer was conducted using a 26-item self-administered questionnaire. Results and Conclusions: A response rate of 41.7% was achieved. The level of knowledge on early signs and risk habits associated with oral cancer was high and the majority reported to have conducted opportunistic screening and advised patients on risk habit cessation. Factors that influenced the dentist in practising prevention and early detection of oral cancer were continuous education on oral cancer, age, nature of practice and recent graduation. Notably, dentists were receptive to further training in the area of oral cancer detection and cessation of risk habits. Taken together, the study demonstrated that the dental clinic is a good avenue to conduct programs on opportunistic screening, and continuous education in these areas is necessary to adequately equip dentists in running these programs. Further, this study also highlighted knowledge deficits and practice shortcomings which will help in planning and developing programs that further encourage better participation of dentists in prevention and early detection of oral cancer.

• The Journal of the Korea Contents Association
• /
• v.20 no.7
• /
• pp.547-559
• /
• 2020

Social Networking Service (SNS) is a part of our daily lives, with their positive and negative impacts. This study investigates SNS fatigue in men and women of different cultural backgrounds as well as the relationship between SNS fatigue and the intentions to cease SNS activities. The study results show that during SNS activities, women are more concerned for their reputation; participants with East Asian cultural backgrounds experience burdens with respect to relationships, and participants with Western cultural backgrounds experience fatigue with respect to privacy concerns. No statistical significance was identified between SNS fatigue and the intentions to cease SNS activity; although people experienced fatigue, they did not desire to stop SNS use. This study reveals that culture and gender impacts SNS fatigue, and few people quit SNS despite the fatigue.

• The Journal of the Korea Contents Association
• /
• v.20 no.7
• /
• pp.118-126
• /
• 2020

The purpose of the study is to analyze the relationship between the warning picture on a cigarette pack and non-smoking attempt, which is expected to contribute to the negative perception of smoking as a research subject about smoking adolescents. An online survey data of the Youth Health Behavior in 2018 has been used, and 3,722 adolescents who are currently smokers were selected for the study. For the measurement of variables, demographic sociology, health-related, and smoking-related factors have been revised, and multivariate binomial logistic regression analysis has been performed. The perception rate of cigarette warning pictures among adolescents who smoke currently is 84.7%, and among them, the attempt rate to quit smoking is 72.8%. As a result of the multivariate binomial logistic regression analysis, there is a meaningful relationship between adolescent smokers' attempts to quit smoking and whether they perceived cigarette pack warning pictures, and school grade year, academic performance, stress perception, and ease of purchasing cigarettes have been also expressed as meaningful variables. To be based on the result, it is necessary to manufacture to design a cigarette pack warning picture that can be easily recognized by smoking adolescents in the future.

• Journal of the Korea Academia-Industrial cooperation Society
• /
• v.16 no.3
• /
• pp.2109-2116
• /
• 2015

This study aimed to identify the influencing factors on nicotine dependency of middle school smokers and to provide the basic data for the effective smoking cessation program. Data were collected from May 3 to July 26 in 2013 by self-reported questionnaires. The subjects of this study were 202 middle school smokers in D city. For data analysis, SPSS 18.0 and AMOS 18.0 was used to calculate Percentage, mean, Standard deviation, ANOVA, Scheffe test, Pearson's correlation coefficient and Path analysis. The results showed that smoking reinforced factors, social environment factors, self-efficacy and impulsivity were significantly influenced on the nicotine dependency directly and indirectly. Therefore, it is necessary to include intervention of smoking reinforced factors, social environment factors, self-efficacy and impulsivity to develop smoking cessation program for smoking in middle school students.

• Asian Pacific Journal of Cancer Prevention
• /
• v.14 no.3
• /
• pp.1931-1935
• /
• 2013

Background: This study was undertaken to identify the socio-demographic determinants of quit attempts among smokers and smokeless tobacco users to identify correlates of tobacco cessation behaviour in India Materials and Methods: This was a cross-sectional study for the outcome of quit attempts made by current tobacco users in last 12 months in twelve districts in two states. Simple and multivariable logistic regression analysis was used to obtain the odds ratios (ORs) of socio-demographic variables (age, gender, education, occupation, socio-economic status, community, area, type of family) and tobacco user status (smoker/smokeless). Results: In the combined analysis, a smoker had higher predicted probability of attempting quitting (OR-1.41,CI 1.14-1.90), in comparison to a smokeless tobacco user and a tobacco user in the state of Gujarat was less likely to attempt quitting than a user in Andhra Pradesh (OR-0.60, CI 0.47-0.78). The probability of making a quit attempt was higher among tobacco users who were more educated (OR-1.40, CI 1.04-1.94), having a higher socio-economic status (SES) (OR-2.39, CI 1.54-3.69), and belonging to non-agricultural labourer occupational group (OR-1.90, CI 1.29-2.78). The effects were maintained even after adjusting for all other variables. In disaggregated analysis, findings were similar except in smokeless as a separate group, education level was not significantly associated with quit attempts and with lower odds (OR-0.91, CI 0.58-1.42). Conclusions: This is one of the first studies to provide useful insight into potential determinants for quit attempts of tobacco users in India including smokeless tobacco users, exploring the socio-demographic patterning of correlates of quit attempts.

• Asian Pacific Journal of Cancer Prevention
• /
• v.13 no.12
• /
• pp.5959-5963
• /
• 2012

Background: The term 'hardcore' has been applied to use of smoking tobacco and generally referred to as the inability or unwillingness of regular smokers to quit. The component constructs of hardcore except nicotine dependence are product neutral. With the use of 'time to first chew' as a measure of nicotine dependence, hardcore definition can be extended to characterize smokeless tobacco users. Hardcore users respond less to tobacco cessation interventions, and are prone to tobacco induced diseases including cancer. Thus identifying hardcore users would help in estimate the burden of high risk population for tobacco induced diseases. Smokeless tobacco use is predominant and accounts for more than 50% of oral cancer in India. Hence, hardcore chewing information could be used for planning of tobacco and cancer control interventions. The objective of this study was to assess the prevalence and associated factors of hardcore smokeless tobacco use in India. Materials and Methods: Global Adult Tobacco Survey (GATS)-India 2010 data were analyzed to quantify hardcore smokeless tobacco use in India with following five criteria: (1) current daily smokeless tobacco use; (2) no quit attempt in the past 12 months of survey or last quit attempt of less than 24 hours duration; (3) no intention to quit in next 12 months or not interested in quitting; (4) time to first use of smokeless tobacco product within 30 minutes of waking up; and (5) knowledge of smokeless tobacco hazards. Results: The number of hardcore smokeless tobacco users among adult Indians is estimated to be 5% (39.5 million). This group comprises 23.2% of daily smokeless tobacco users. The population prevalence varied from 1.4-9.1% across different national regions of India. Logistic regression modeling indicated age, education and employment status to be the major predictors of hardcore smokeless tobacco use in India. Conclusions: The presence of a huge number (39.5 million) of hardcore smokeless tobacco users is a challenge to tobacco control and cancer prevention in India. There is an unmet need for a universal tobacco cessation programme and intensification of anti-tobacco education in communities.