• Proceedings of the Plant Resources Society of Korea Conference
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• 1999.10a
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• pp.1-45
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• 1999

To date many kinds of compounds have been obtained from plants kingdom as antineoplastic and anti-cancerous agents. However, there is no special type of compounds for ncancer therapy. Various types of substances are effective for various types of cancers and tumors: for instance, alkaloids, lignans, terpenes and steroids etc. Curcumol obtained from Curcuma aromatica was tested and noticed to be effective against cancer of the uterine cervix clinically Oridonin isolated from Rabdosia ssp.is now investigated for clinical trials in China. Moreover, camptothecine isolated from Camptotheca acuminata is also antineoplastic alkaloid, but is very toxic. Chemical modification has been tried to decrease its toxicity. This compound is now using as clinical agent. Harringtonin was investigated as an anticancerous drug in China. Taxol, a compound with a taxane ring isolated from the bark of Taxus brevifolia, has been demonstrated to have substantial anticancer activity in patients with solid tumors refractory standard chemotherapy. Supply of this drug has severely limited full exploration of its antineoplastic potential. Some efforts are continued in National Cancer Institute NCI) Washington for surveying various Taxus species for optimal taxol content, improvement in semi-synthesis from baccatin III, improvement in method of extraction, and development of alternative renewable resources. Further, there are many compounds which have been reported as antineoplastic agents. On the other hand, we have screened on higher plants collected in Japan, China, Korea, Southeast Asia and South America for antineoplastic activity, which has been done using Sarcoma 180 ascites in mice, P388 Iymphocytic leukemia in mice, Chinese hamster lung V-79 cells, P388 cells and nasopharynx carcinoma (KB) cells in our laboratory, as primary screening. In this meeting, I will present on antitumor and cytotoxic substances of the higher plants (Rubia cordifolia, Ailanfhus Vilmoriniana, Aster tataricus, Taxus cuspidata var. nana, Cephalotaxus harringtonia var drupacea, etc.) selected from above screening tests.

• Journal of Environmental Science International
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• v.16 no.10
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• pp.1139-1146
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• 2007

The vascular plants in the Mt. Manduk was listed 560 taxa composed of 110 families, 345 genera, 488 species, 1 subspecies, 67 varieties and 4 forms. Based on the list of the rare plants by the Forest Research Institute, 4 taxa were recorded in the studied areas; Lilium distichum (Preservation priority order; No. 159), Tricyrtis dilatata (No. 97), Aristolochia contorta (No. 151) and Prunus yedoensis (No. 110). Based on the list of Korean endemic plants, 12 taxa were recorded; Cephalotaxus koreana, Carex okamotoi, Lilium amabile, Populus tomentiglandulosa, Salix purpurea var. japonica, Pseudostellaria multiflora, Prunus yedoensis, Stewartia koreana, Forsythia koreana, Paulownia core ana, Weigela subsessilis and Aster koraiensis. Based on the list of approved for delivering overseas of plants, 7 taxa were recorded; Carex okamotoi, Lilium distichum, Aristolochia contorta, Vaccinium oldhami, Paulownia coreana, Asperula lasiantha and Saussurea seoulensis. Specific plants by floral region were total 32 taxa; Prunus yedoensis in class V, Wistaria floribunda in class IV, 5 taxa (Girardinia cuspidata, Spiraea salicifolia, Acer palmatum, Stewartia koreana, Asperula lasiantha) in class III, 3 taxa (Potentilla dickinsii, Viola tokubuchiana var. takedana and Caryopteris incana) in class II and 22 taxa (Pinus koraiensis, Hosta capitata, Chloranthus japonicus, Salix glandulosa, Juglans mandshurica, etc.) in class I. The naturalized plants in the surveyed sites were 14 families, 36 genera, 44 species, 2 varieties, 46 taxa and naturalization rate was 8.2% of all 560 taxa of vascular plants. Wild plants disturbing ecosystem like Ambrosia artemisiifolia var. elatior have been increasing. Therefore, continuous control and conservation measures are needed on the ecosystem of Mt. Manduk.

• Korean Journal of Environment and Ecology
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• v.21 no.5
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• pp.415-431
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• 2007

The native vascular plants, growing at the nature sabbatical application area, were classified & recorded as a total of 407 taxa, 83 families, 235 genera, 338 species, 3 subspecies, 54 varieties and 12 forms. The endangered wild plants were recorded as 2 taxa (Paeonia obovata and Lilium cernuum) and the Korean endemic plants were observed to exist in the formation of 21 taxa, 13 families, 19 genera, 15 species, 4 varieties and 2 forms including Cephalotaxus koreana, Pseudostellaria coreana, Aconitum pseudo-laeve, Clematis trichotoma, Geranium koreanum for. hirsutum, Thalictrum uchiyamai. The floristic special plants consist of 55 taxa, 35 families, 50 genera, 51 species, 4 varieties(Crypsinus hastatus, Cimicifuga heracleifolia, Paeonia obovata, Lilium cernuum and Gastrodia elata etc.). The naturalized plants comprise 10 taxa, 4 families, 10 genera, 9 species and 1 variety. The ratio of Urbanization and Naturalized Index was 3.51% and 2.46%, respectively. Life form spectra were displayed as H-R5-D4-e type.

• Korean Journal of Environment and Ecology
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• v.16 no.4
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• pp.359-386
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• 2003

The vascular plants in Baekdudaegan of the South Korea were recorded of 1,477 taxa; 126 families, 641 genus, 1,248 species, 3 subspecies, 204 varieties, 22 forma. From the floristic point of view, Jirisan, Backunsan and Duckyusan District in the Baekdudaegan belongs to the southern province in Korea, appeared to Cephalotaxus koreana, Lindera obtusiloba, Lindera erythrocarpa, Lindera glauca, Izex macropoda, Meliosma myriantha, Melisoma oldhami and Stewartia koreana. But on the top regions of these mountains more than 1,000m above the sea level were contained many alpine plants. And on the top regions and ridgeline parts of Duckyusan and Jirisan were the middle province, owing to Betula costata, Betula ermani, Ulmus laciniata, Isopyrum raddeanum, Hylomecon vemale, Viola diamantica, Vaccinium koreanum, Heloniopsis orientalis, Disporum ovale, Symplocarpus renifolius and Veronica arvensis. These results were epresented that plant species of the middle province moved to the South along the ridgeline of Baekdudaegan, on the other hand plants of southern province had biological niche of low ground according to go toward the North.

• Journal of the Korean Society of Environmental Restoration Technology
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• v.14 no.4
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• pp.25-40
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• 2011

The vascular plants in Jeokjabong, Bogil Island were listed 350 taxa composed of 89 families, 233 genera, 309 species, 1 subspecies, 36 varieties and 4 forms. Divided into woody plants were 142 taxa (40.6%) and herbaceous plants were 208 taxa (59.4%). Based on the list of rare and endangered species by Korea Forest Service and Korea National Arboretum, 3 taxa were recorded; Celtis choseniana, Asarum maculatum, Rubus sorbifolius, and endemic plants, 10 taxa were recorded; Asarum maculatum, Cephalotaxus koreana, Carpinus coreana, Celtis choseniana, Lespedeza maritima, Indigofera koreana, Dendropanax morbifera, Ligustrum quihoui var. latifolium, Weigela subsessilis, Carex okamotoi, and plant species subject to permission for taking abroad, 4 taxa were recorded; Celtis choseniana, Asarum maculatum, Vaccinium oldhami, Carex okamotoi. Based on the list of floristic regional indicator plants by Korean Ministry of Environment were total 64 taxa (18.3% of all 350 taxa of vascular plants); Ligustrum quihoui var. latifolium in class IV, 19 taxa (Stauntonia hexaphylla, Cinnamomum japonicum, Zanthoxylum ailanthoides, Daphniphyllum macropodum, Centella asiatica, Verbena officinalis, Mitchella undulata, etc.) in class III, 5 taxa (Potentilla dickinsii, Ostericum melanotilingia, Sanicula rubriflora, Caryopteris incana, Teucrium veronicoides) in class II and 39 taxa (Gleichenia dichotoma, Cyrtomium fortunei, Aphananthe aspera, Rubus hirsutus, Meliosma myriantha, Hedera rhombea, Ainsliaea apiculata, etc.) in class I. Based on the list of naturalized plants, 5 families, 17 genera, 20 taxa (Phytolacca americana, Lepidium virginicum, Robinia pseudo-acacia, Verbesina alternifolia, Lolium perenne, etc.) and naturalization rate was 5.7% of all 350 taxa of vascular plants. Hereafter natural ecosystem into disturbance on naturalized plants and legal protection species and rare and endangered species distribute in the Bogil Island, precision investigation after management counterplan of the monitoring a point of view be required.

• Plant Resources
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• v.3 no.1
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• pp.1-45
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• 2000

To date many kinds of compounds have been obtained from plants kingdom as antineoplastic and anti-cancerous agents. However, there is no special type of compounds for cancer therapy. Various types of substances are effective for various types of cancers and tumors: for instance, alkaloids. lignans, terpenes and steroids etc. Curcumol obtained from Curcuma aromatica was tested and noticed to be effective against cancer of the uterine cervix clinically. Oridonin isolated from Rabdosia ssp. is now investigate for clinical trials in China. Moreover camptothecine isolated from Camptotheca acuminata is also antineoplastic alkaloid, but is very toxic. Chemical modification has been tried to decrease its toxicity This compound is now using as clinical agent. Harringtonin was investigated as an anticancerous drug in China. Taxol, a compound with a taxane ring isolated from the bark of Taxus brevifotia. has been demonstrated to have substantial anticancer activity in patients with solid tumors refractory standard chemotherapy. Supply of this drug has severely limited full exploration of its antineoplastic potential Some efforts are continued in National Cancer Institute(NCI) Washington for surveying various Taxus species for optimal taxol content, improvement in semi-synthesis from baccatin 111, improvement in method of extraction, and development of alternative renewable resources. Further, there are many compounds which have been reported as antineoplastic agents. On the other hand, we have screened on higher plants collected In Japan, China, Korea. Southeast Asia and South America for antineoplastic activity, which has been done using Sarcoma 180 ascites in mice, P388 Iymphocytic leukemia In mice, Chinese hamster lung V-79 cells, P388 cells and nasopharynx carcinoma(KB) cells in our laboratory, as primary screening. In this meeting, 1 will present on antitumor and cytotoxic substances of the higher plants(Rubis cordifolia, Ailanthus vilmoriniana, Aster tataricus, Taxus cuspidata var. nana, Cephalotaxus harringtonia var. drupacea, etc.) selected from above screening tests.

• Proceedings of the Plant Resources Society of Korea Conference
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• 2019.10a
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• pp.60-60
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• 2019

개비자나무[Cephalotaxus harringtonia (Knight ex Forbes) K. Koch]와 비자나무[Torreya nucifera (L.) Siebold & Zucc.]의 3년생 실생묘를 유리온실에 재배하면서 실험재료로 사용하였다. 실내의 광량을 측정하여 10, 50, 100 및 200 PPFD (${\mu}mol{\cdot}m^{-2}{\cdot}s^{-1}$)로 설정하였다. 광량을 제외한 광주기(12/12 h), 온도($25{\pm}1^{\circ}C$), 습도($55{\pm}3%$) 및 관수(1회/3일)주기를 일정하게 유지시킨 밀실에서 8주간 재배하였다. 유리온실에서 재배중인 식물과 광량별 처리구의 초장, 줄기직경, 엽수, 엽장, 엽폭, 엽록소함량(SPAD) 및 광화학반응을 평가하였다. 개비자나무의 생육결과, 모든 광량조건에서 줄기직경과 엽록소함량이 증가하는 경향을 보였으며, 초장, 엽폭의 경우 대조구와 유의한 차이가 없었다. 스트레스지수(Fm/Fo), 최대양자수율(Fv/Fm) 및 광계II 성능지수(Pi_Abs)는 대조구에 비해 모든 광량에서 증가하는 경향을 나타냈다. 10 PPFD의 광량을 제외한 처리구에서 재배된 비자나무의 초장, 줄기직경, 엽장, 엽폭은 대조구와 유사한 경향을 나타냈다. 한편, 엽수와 엽록소함량은 대조구에 비해 우수하였다. Fm/Fo, Fv/Fm, Pi_Abs 및 비광학적 에너지의 손실(DIo/RC)은 모든 광량처리구에서 대조구에 비해 유의적으로 높은 측정값을 나타냈다.

• Applied Biological Chemistry
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• v.51 no.2
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• pp.124-128
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• 2008

Cell proliferation inhibitory effects of homoharringtonine (HHT), an active drug substance in Cephalotaxus koreana, against blood cancer cell line K562 were evaluated. In addition, in vivo chronic toxicity test with mouse was carried out. When K562 cell line was treated everyday for 9, 6, 3 days, $IC_{50}$ values of HHT were determined as 0.27, 0.37, and 1.10 mM respectively. The anticancer activity of HHT was comparable to adriamycin, a known anticancer drug compound for blood cancer treatment. in vivo chronic toxicity test of the HHT, the number of red blood cell (RBC) showed no significant difference. From the analysis of the liver-functional enzymes in blood, all of liver damage related enzymes such as glutamate-oxalate-transferase (GOT), glutamate-pyruvate-transferase (GPT), cholesterol (Chol) and alkaline phosphatase (ALP) showed no significant change. However, from the histologic test, a neutrophil of the band type in liver tissue was observed.

• Korean Journal of Plant Resources
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• v.20 no.2
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• pp.133-144
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• 2007

The vascular plants at the Wolmyung Park was listed 479 taxa: 105 families, 317 genera, 417 species, 1 subspecies, 55 varieties and 6 forms. 479 taxa listed consists of 291 taxa of edible plants (60.8%), 335 taxa of medicinal plants (69.9%), 234 taxa of ornamental plants (48.9%) and 243 taxa of the others (50.7%). Based on the list of the rare plants by the Forest Research Institute, 4 taxa were recorded in the investigated areas; Aristolochia contorta (Preservation priority order, No. 151), Magnolia kobus (No. 187), Prunus yedoensis (No. 110), Berchemia racemesa (No. 67) and based on the list of Korean endemic plants, 9 taxa were recorded; Cephalotaxus koreana, Carex okamotoi, Populus tomentiglandulosa, Prunus yedoensis, Forsythia koreana, Asperula lasiantha, Weigela subsessilis, Adenophora triphylla var. hirsuta, Aster koraiensis. Specific plant species by floral region were total 31 taxa; Prunus yedoensis, Berchemia racemosa in class V, Magnolia kobus, Wistaria floribunda in class IV, 4 taxa (Spiraea salicifolia, Acer palmatum, Asperula lasiantha, etc.) in class III, Caryopteris incana in class II, 22 taxa (Clematis patens, Orixa japonica, Euscaphis japonica, Grewia biloba var. parviflora, etc.) in class I. The naturalized plants in this site were 14 families, 35 genera, 44 species, 2 varieties, 46 taxa and naturalization rate was 9.6% of all 479 taxa vascular plants.

• Journal of Korean Society of Forest Science
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• v.70 no.1
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• pp.17-27
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• 1985

Through the study of the physiognomical vegetation, the vertical distribution, the distribution of forest community and the flora of the woody plants on the south facing slope of Mt. Pal-Gong, the results obtained were summarized as follows. The forest of Pinus densiflora was dominant in the region of below 750m above the sea level, the mixed forest of conifer and broad-leaved trees in the region of 750m to 950m and the pure forest of deciduous broad-leaved trees in the region of above 950m. Pinus densiflora and Quercus mongolica were dominant for the upper-story trees, Acer pseudo-sieboldianum and Carpinus laxiflora for the mid-story trees, Lespedeza maximowiczii, Sasa purpurascens, Rhododendron mucronulatum and Rhododendron schlippenbachii for the under-story trees. Among seventeen forest communities, Cephalotaxus koreana, Populus davidiana and Alnus hirsuta var. sibirica were considered remarkable communities on the south facing slope of Mt. Pal-Gong. The woody plants growing on Mt. Pal-Gong are composed of 59 families, 7 subfamilies, 122 genera, 178 species, 29 varieties and 10 formae. Populus davidiana, Alnus hirsuta var. sibirica and Rubus phoenicolasius were collected newly in this study.