• Journal of the Korean Institute of Rural Architecture
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• v.12 no.2
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• pp.125-133
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• 2010

The advanced rural village development project started in 2005, and this project of purpose is improvement of housing environment and promotion of region activation. Researcher investigated about the advanced rural village development project of nine complex through field survey. The aim of this study is to be offered data of idyllic housing policy by examination actual conditions of study subject. Based on this study, mainly three results can be drawn as follows ; first, this project makes a great contributed to flow in population from urban to activate rural areas. Second, the project success depends on improvement an institution and planed, timely approach. Third, central government must plan network system with rural development project in political, and must support local government into political frame. The local government must consider a regional housing plan overall and must make an effort itself for the project success.

• Investigative Magnetic Resonance Imaging
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• v.26 no.2
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• pp.96-103
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• 2022

Purpose: The survival of organisms critically depends on avoidance responses to life-threatening stimuli. Information about dangerous situations needs to be remembered to produce defensive behavior. To investigate underlying brain regions to process information of danger, manganese-enhanced MRI (MEMRI) was used in olfactory fear-conditioned rats. Materials and Methods: Fear conditioning was conducted in male Sprague-Dawley rats. The animals received nasal injections of manganese chloride solution to monitor brain activation for olfactory information processing. Twenty-four hours after manganese injection, rats were exposed to electric foot shocks with odor cue for one hour. Control rats were exposed to the same odor cue without foot shocks. Forty-eight hours after the conditioning, rats were anesthetized and their brains were scanned with 9.4T MRI. Acquired images were processed and statistical analyses were performed using AFNI. Results: Manganese injection enhanced brain areas involved in olfactory information pathways in T1 weighted images. Rats that received foot shocks showed higher brain activation in the central nucleus of the amygdala, septum, primary motor cortex, and preoptic area. In contrast, control rats displayed greater signals in the orbital cortex and nucleus accumbens. Conclusion: Nasal delivery of manganese solution enhanced olfactory signal pathways in rats. Odor cue paired with foot shocks activated amygdala, the central brain region in fear, and related brain circuits. Use of MEMRI in fear conditioning provides a reliable monitoring technique of brain activation for fear learning.

• Biomolecules & Therapeutics
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• v.32 no.3
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• pp.309-318
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• 2024

Compared to other organs, the brain has limited antioxidant defenses. In particular, the hippocampus is the central region for learning and memory and is highly susceptible to oxidative stress. Glial cells are the most abundant cells in the brain, and sustained glial cell activation is critical to the neuroinflammation that aggravates neuropathology and neurotoxicity. Therefore, regulating glial cell activation is a promising neurotherapeutic treatment. Quinic acid (QA) and its derivatives possess anti-oxidant and anti-inflammatory properties. Although previous studies have evidenced QA's benefit on the brain, in vivo and in vitro analyses of its anti-oxidant and anti-inflammatory properties in glial cells have yet to be established. This study investigated QA's rescue effect in lipopolysaccharide (LPS)-induced behavior impairment. Orally administering QA restored social impairment and LPS-induced spatial and fear memory. In addition, QA inhibited proinflammatory mediator, oxidative stress marker, and mitogen-activated protein kinase (MAPK) activation in the LPS-injected hippocampus. QA inhibited nitrite release and extracellular signal-regulated kinase (ERK) phosphorylation in LPS-stimulated astrocytes. Collectively, QA restored impaired neuroinflammation-induced behavior by regulating proinflammatory mediator and ERK activation in astrocytes, demonstrating its potential as a therapeutic agent for neuroinflammation-induced brain disease treatments.

• The Bulletin of The Korean Astronomical Society
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• v.45 no.1
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• pp.30.2-31
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• 2020

We present the properties of circumnuclear gas associated with the AGN located in the center of Abell 1644-South. A1644-S is the main cluster in a merging system, which is also known for gas sloshing in its core as seen in X-ray. The X-ray emission of A1644-S shows a rapidly declining profile, indicating the presence of cooling gas flow. This flow of cool gas may fuel the supermassive black hole embedded in the brightest cluster galaxy, leading to the activation of the central AGN. Indeed, we find a parsec-scale bipolar jet feature in the center of A1644-S in our recent KaVA observation, which implies that its central AGN is likely to have been (re)powered quite recently. In order to verify the hypothesis that cooling gas flow in the cluster core can (re)activate the central AGN, we probe the cold gas properties of the central 1 kpc region of A1644-S using the archival VLA and ALMA data. Based on the spatially resolved morphology and kinematics of HI and CO gas, we challenge to identify inflow/outflow gas streams and clumps. We study the role of circumnuclear cool gas in fueling the centrally located cluster AGN in the cool-core environment. We also discuss how the feedback due to the (re)powered AGN affects the surrounding medium.

• Cross-Cultural Studies
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• v.22
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• pp.203-221
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• 2011

With the beginning of systemized research on Latin American region as a part of the third world in the mid-60s, Latin American regional studies in Korea acquired a steppingstone for development through the establishment of Hankook University of Foreign Studies Central & South American Regional Study, the creation of Central & South America Research Center, and Latin American Society established in the mid-80s. Latin American regional studies achieved quantitative and qualitative growth with the natioal globalization policy in the 90s, and research centers related to Latin America in Seoul National University, Pusan University of Foreign Studies, Dankook University, and Sunmoon University have contributed to the activation of regional studies. In spite of such achievements, Latin American regional studies, which have developed with 40 years of history, still possess problems that need to be solved. This study achieves qualitative analysis on theses published from 2000 to March 2001 in main Latin America regional study academic journals in Korea to analyze Latin American regional study trend of the recent 10 years in order to search measures for activating Latin American regional studies. Academic journals used in analysis include "Ibero America Research" of Seoul National University Research Center of Central & South America, Spain, "Central & South America Research" of Hankook University of Foreign Studies Research Center of Central & South America, "Ibero America Research" of Pusan University of Foreign Studies Central & South America Center, and "Latin America Research" published by Latin American Society. According to analysis on publication ratio of published theses according to field, it was presented that culture and politics fields occupied the highest ratio. Social and cultural fields, the elementary studies of regional research which have previously presented a weak research tendency, have achieved noticeable development during the past 10 years. According to analysis on researched nations, Latin America regional study was weighted in particular nations, and nations of economic size and political influence within region were selected as main subjects of research. Furthermore, several nations were not researched at all. For the last 10 years, the depth and width of the Latin America regional study had been decided by the degree of political, economic, social, and cultural significance occupied by the nation. It can be said that studies based on overall understanding on regional countries of Latin America have been relatively weak in individual nation study. Furthermore, studies that separate issues to achieve analysis based on the awareness theory of individual branches can be regarded dominant among studies based on entire Latin America. These studies still possess limitations in failing to deviate from the outline of particular region and topic.

• YAKHAK HOEJI
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• v.41 no.2
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• pp.247-254
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• 1997

The proteinase-activated receptor (PAR-2) belongs to the family of seven transmembrane region receptors, like the thrombin receptor, it is activated by specific proteolytic clea vage of its extracellular amino terminus and a synthetic peptide (SLIGRL). The earthworm protein fraction (EPF) extracted from Lumbricus rubellus elicted dose- and endothelium-dependent relaxations in phenylephrine-contracted rat thoracic aorta, whereas heat inactivated EPF (0.5 ${\mu}g$ /ml) had no effect. In the presence of the nitric oxide synthase inhibitor NG-methyl-L-arginine (1.8 micro M), EPF (0.5 ${\mu}g$ /ml)-induced relaxations were partially inhibited. Furthermore, EPF (0.5 ${\mu}g$ /ml) dramatically caused relaxation of thrombin-desenstized rat thoracic aorta. These results indicate that EPF activates PAR-2 in vascular endothelial cell. Intravenous injection of EPF (20 mg/kg, bolus) into anesthetized rats produced a marked depressor response. EPF (0 ~ 80 ${\mu}g$ /ml, gradient) was very effective on increasing of perfusion volume in rabbit ear vessel preparations. These results imply the usefulness of EPF as a vascular smooth muscle relaxant and indicate that the activation of PAR-2 may be a mechanism of EPF on hemokinetic improvement.

• Journal of Ginseng Research
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• v.32 no.4
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• pp.315-323
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• 2008

In the previous studies, we isolated the compound K rich fractions (CKRF) and showed that CKRF inhibited Toll-like receptor (TLR) 4- or TLR9-induced inflammatory signaling. To extend our previous studies,1) we investigated the molecular mechanisms of CKRF in the TLR4-associated signaling via nuclear factor (NF)-${\kappa}B$, and in vivo role of CKRF for induction of tolerance in lipopolysaccharide (LPS)-induced septic shock. In murine bone marrow-dervied macrophages, CKRF significantly inhibited the induction of mRNA expression of proinflammatory mediators such as tumor necrosis factor-${\alpha}$, interleukin-6, cyclooxygenase-2, and inducible nitric oxide synthase. In addition, CKRF significantly attenuated the transcriptional activities of TLR4/LPS-induced NF-${\kappa}B$. Nuclear translocation of NF-${\kappa}B$ in response to LPS stimulation was significantly abrogated by pre-treatment with CKRF. Furthermore, CKRF inhibited the recruitment of p65 to the interferon-sensitive response element flanking region in response to LPS. Finally, oral administration of CKRF significantly protected mice from Gram-negative bacterial LPS-induced lethal shock and inhibited systemic inflammatory cytokine levels. Together, these results demonstrate that CKRF modulates the TLR4-dependent NF-${\kappa}B$ activation, and suggest a therapeutic role for Gram-negative septic shock.

• International conference on construction engineering and project management
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• 2015.10a
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• pp.468-471
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• 2015

The study aims to identify the degree and types of spatial decline in Eup/Myun units within Chungcheong region in South Korea to contribute to the efforts being made to diagnose the rural decline and the potentials. To this end, we analyzed 27 Sis and Guns to identify the degree of decline and potentials of rural areas in Chungcheong region. We also carried out the diagnosis and K-Means Clustering on 274 Eups and Myuns, the smallest administrative units, to figure out the types and characteristics of the rural recessions. According to the results of the clustering analysis carried out on the 166 Eups and Myuns, there were five outstanding clusters. They were; areas with housing deterioration (29), areas with poor economic foundation (16), areas with poor accessibility to central areas (42), areas with poor residential environment (51) and areas with aged population (28). The findings and results of the present study are likely to serve as a basis for the design and enforcement of forthcoming rural area activation policies. Also, it would be highly recommended that a more comprehensive diagnosis is taken from a community-level perspective and policy suggestions and strategies tailored for rural communities are further discussed.

• Nuclear Engineering and Technology
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• v.54 no.8
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• pp.3043-3050
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• 2022

In Korea, all nuclear power plants (NPPs) participate in annual performance tests including in vivo measurements using the FastScan, a stand type whole body counter (WBC), manufactured by Canberra. In 2018, all Korean NPPs satisfied the testing criterion, the root mean square error (RMSE) ≤ 0.25, for the whole body configuration, but three NPPs which participated in an additional lung configuration test in the fission and activation product category did not meet the criterion. Due to the low resolution of the FastScan NaI(Tl) detectors, the conventional peak analysis (PA) method of the FastScan did not show sufficient performance to meet the criterion in the presence of interfering radioisotopes (RIs), ¹³⁴Cs and ¹³⁷Cs. In this study, we developed an artificial neural network (ANN) to improve the performance of the FastScan in the lung configuration. All of the RMSE values derived by the ANN satisfied the criterion, even though the photopeaks of ¹³⁴Cs and ¹³⁷Cs interfered with those of the analytes or the analyte photopeaks were located in a low-energy region below 300 keV. Since the ANN performed better than the PA method, it would be expected to be a promising approach to improve the accuracy and precision of in vivo FastScan measurement for the lung configuration.

• Journal of the Economic Geographical Society of Korea
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• v.20 no.1
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• pp.105-120
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• 2017

Chung-ju enterprise city was selected as a model enterprise city in 2005, and the city is planned to finish the construction in 2020. The main purpose of this study is to suggest the developing strategy and activation plan for Chung-ju enterprise city based on the enterprise city of developed countries. Chung-ju enterprise city will grow into well-being self-sufficient city due to the cutting edge knowledge, industry-centered cluster which is the new growth industry of Chungchungbuk-do and the surrounding excellent nature. For the success of Chung-ju enterprise city, the cooperation between developing agents such as companies, universities, local government, and central government is important. The leading companies and researching facilities should be attracted as well. Also, non-profit exclusive organization must be installed. The successful development of Chung-ju enterprise city means the success of balanced region development policy which will solve overpopulation of capital region and unbalance of Korea.