• Proceedings of the Korean Society of Broadcast Engineers Conference
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• 2009.01a
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• pp.211-216
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• 2009

As demands for high-definition television (HDTV) increase, the implementation of real-time decoding of high-definition (HD) video becomes an important issue. The data size for HD video is so large that real-time processing of the data is difficult to implement, especially with software. In order to implement a fast moving picture expert group-2 decoder for HDTV, we compose five scenarios that use parallel processing techniques such as data decomposition, task decomposition, and pipelining. Assuming the multi digital signal processor environments, we analyze each scenario in three aspects: decoding speed, L1 memory size, and bandwidth. By comparing the scenarios, we decide the most suitable cases for different situations. We simulate the scenarios in the dual-core and dual-central processing unit environment by using OpenMP and analyze the simulation results.

• BMB Reports
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• v.46 no.6
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• pp.295-304
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• 2013

Extracellular acidification occurs not only in pathological conditions such as inflammation and brain ischemia, but also in normal physiological conditions such as synaptic transmission. Acid-sensing ion channels (ASICs) can detect a broad range of physiological pH changes during pathological and synaptic cellular activities. ASICs are voltage-independent, proton-gated cation channels widely expressed throughout the central and peripheral nervous system. Activation of ASICs is involved in pain perception, synaptic plasticity, learning and memory, fear, ischemic neuronal injury, seizure termination, neuronal degeneration, and mechanosensation. Therefore, ASICs emerge as potential therapeutic targets for manipulating pain and neurological diseases. The activity of these channels can be regulated by many factors such as lactate, $Zn^{2+}$, and Phe-Met-Arg-Phe amide (FMRFamide)-like neuropeptides by interacting with the channel's large extracellular loop. ASICs are also modulated by G protein-coupled receptors such as CB1 cannabinoid receptors and 5-$HT_2$. This review focuses on the physiological roles of ASICs and the molecular mechanisms by which these channels are regulated.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.15 no.3
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• pp.1442-1447
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• 2014

This study examined the effect of the cold-warm color contrast of the learning-item on the learner's performance. To do this, experimental conditions were divided into three conditions: control condition, cold-warm contrast condition of background and figure, and cold-warm contrast condition of distracter and target. In addition, the OSPAN (operation span) task was used as the learning task. As a result, the rate of word recognition was higher in cold-warm contrast condition of distractor and target than any other condition. These results could be interpreted as enhancing effect.

• YAKHAK HOEJI
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• v.46 no.3
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• pp.185-191
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• 2002

Alzheimer's disease (AD) involves neuronal degeneration with impaired cholinergic transmission, particularly in areas of the brain associated with learning and memory. Several cholinesterase inhibitors are widely prescribed to ameliorate the cognitive deficits in AD patients. In an attempt to examine if tacrine and donepezil, two well-known cholinesterase inhibitors, exhibit additional pharmacological actions in primary cultured rat cortical cells, we investigated the effects on neuronal injuries induced by glutamate or N-methyl-D-aspartate (NMDA), $\beta$-amyloid fragment ( $A_{{beta}25-35)}$), and various oxidative insults. Both tacrine and donepezil did not significantly inhibit the excitotoxic neuronal damage induced by glutamate. However, tacrine inhibited the toxicity induced by NMDA in a concentration-dependent fashion. In addition, tacrine significantly inhibited the $A_{{beta}25-35)}$-induced neuronal injury at the concentration of 50 $\mu$M. In contrast, donepezil did not reduce the NMDA- nor $A_{{beta}25-35)}$-induced neuronal injury. Tacrine and donepezil had no effects on oxidative neuronal injuries in cultures nor on lipid peroxidation in vitro. These results suggest that, in addition to its anticholinesterase activity, the neuroprotective effects by tacrine against the NMDA- and $A_{{beta}25-35)$-induced toxicity may be beneficial for the treatment of AD. In contrast, the potent and selective inhibition of central acetylcholinesterase appears to be the major action mechanism of donepezil.

• Journal of Ginseng Research
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• v.31 no.3
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• pp.117-126
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• 2007

Ginseng, the root of Panax species, a well-known herbal medicine has been used as a traditional medicine for thousands of years and is now a popular and worldwide used natural medicine. Ginseng has been used primarily as a tonic to invigorate weak bodies to help the restoration of homeostasis in a wide range of pathological conditions such as cardiovascular diseases, cancer, immune deficiency and hepatotoxicity. Although conclusive clinical data in humans is still missing, recent research results have suggested that some of the active ingredients ginseng exert beneficial effects on central nervous system (CNS) disorders and neurodegenerative diseases, suggesting it could be used in treatment of psychotic disorders. Data from neural cell cultures and animal studies contribute to the understanding of these mechanisms that involve inhibitory effects on stress-induced corticosterone level increasing and modulating of neurontransmitters, reducing $Ca^{2+}$ over-influx, scavenging of free radicals and counteracting excitotoxicity. In this review, we focused on recently reported medicinal effects of ginseng and summarized the possibility of its applications on psychotic disorders.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2016.05a
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• pp.409-411
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• 2016

Salt and pepper noise is caused by various causes such as camera malfunction, storage media memory error, and transmission channel error. Representative filters to remove salt and pepper noise include SMF(standard median filter), CWMF(center weighted median filter), and AMF(adaptive median filter). However previous filters have inadequate noise removal characteristics in high density salt-and-pepper noise environment. Therefore the study suggested a composite filter which, through noise evaluation, preserves original pixels when the central pixel is non-noise, and uses spatial weighted value mask and median when there is noise.

• Proceedings of the KIEE Conference
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• 2003.11c
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• pp.563-566
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• 2003

We have designed the power control unit which belongs to the power cabinet and controls the power supplied to Control Rod Drive Mechanism(CRDM) as a digital system based on Digital Signal Processor(DSP). The power control unit dualized as the form of Master/Slave has had its increased reality. The Central Process Unit(CPU) board of a power control unit possesses two Digital Signal Processors(DSPs) of the control DSP for performing the tasks of power control and system monitoring and the communication of the Control DSP and the Communication DSP. To accomplish the functions requested in the power control unit effectively, we have installed Field Programmable Gate Arrays(FPGAS) on the CPU board and have FPGAs perform the memory mapping, the generation of each chip selection signal, the giving and receiving of the signals between the power controllers dualized, the fault detection and the generation of the firing signals.

• The Korean Journal of Archival Studies
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• no.10
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• pp.27-62
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• 2004

As the penetration of information technology into everyday life is accelerated day by day, virtually all kinds of human representation of knowledge and arts are produced and distributed in the digital form. It is problematic, however, because digital objects are so volatile that it is not easy to keep them in fixed form. The fatal fragility makes it extremely tricky to preserve the digital heritage of our time for the next generation. The present paper aims to introduce current endeavors made at the international and the national levels and to provide with suggestions for Korean national strategy of digital preservation. It starts with reviewing the global trends of digital archiving and long-term preservation, focusing on standardization, preservation strategies and current experiments and projects being conducted for preserving various digital objects. It then sketches national strategies of several leading countries. Based on the sketch, twofold suggestions for Korean national strategy are proposed: establishing a central coordinating agency and accommodating the digital preservation issue in the legislative and regulatory framework for the information society. The paper concludes with the necessity of cooperation among heritage organizations, including libraries, archives, museums. They should cooperate with each other because they have traditionally been trusted with the custodianship of collective memory of humankind and the digital heritage cannot be passed onto the next generation without their endeavor. They should also work together because any single institution, or any single nation could cover what it takes to complete the task of long-term preservation of our digital heritage.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.13 no.7
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• pp.3599-3619
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• 2019

In human activity recognition system both static and motion information play crucial role for efficient and competitive results. Most of the existing methods are insufficient to extract video features and unable to investigate the level of contribution of both (Static and Motion) components. Our work highlights this problem and proposes Static-Motion fused features descriptor (SMFD), which intelligently leverages both static and motion features in the form of descriptor. First, static features are learned by two-stream 3D convolutional neural network. Second, trajectories are extracted by tracking key points and only those trajectories have been selected which are located in central region of the original video frame in order to to reduce irrelevant background trajectories as well computational complexity. Then, shape and motion descriptors are obtained along with key points by using SIFT flow. Next, cholesky transformation is introduced to fuse static and motion feature vectors to guarantee the equal contribution of all descriptors. Finally, Long Short-Term Memory (LSTM) network is utilized to discover long-term temporal dependencies and final prediction. To confirm the effectiveness of the proposed approach, extensive experiments have been conducted on three well-known datasets i.e. UCF101, HMDB51 and YouTube. Findings shows that the resulting recognition system is on par with state-of-the-art methods.

• Biomedical Science Letters
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• v.27 no.4
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• pp.208-215
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• 2021

The purpose of this study was to explain the pathology of Alzheimer's disease (AD) and to investigate the correlation between AD and microRNA. AD is the most common type of dementia, accounting for about 80% of all types of dementia, causing dysfunction in various daily activities such as memory loss, cognitive impairment, and behavioral impairment. The typical pathology of AD is explained by the accumulation of beta-amyloid peptide plaques and neurofibrillary tangles containing hyperphosphorylated tau protein. On the other hand, microRNA is small non-coding RNA 22~23 nucleotides in length that binds to the 3' untranslated region of messenger RNA to inhibit gene expression. Many reports explain that microRNAs found in circulating biofluids are abundant in the central nervous system, are involved in the pathogenic mechanism of AD, and act as important factors for early diagnosis and therapeutic agents of AD. Therefore, this paper aims to clarify the correlation between AD and microRNA. In this review, the basic mechanism of miRNAs is described, and the regulation of miRNAs in the pathological processes of AD are highlighted. Furthermore, we suggest that miRNA-based system in development of therapeutic and diagnostic agents of AD can be a promising tool.