• Nuclear Engineering and Technology
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• 제39권4호
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• pp.313-326
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• 2007

In this paper, an algorithm to reconstruct two orthogonal images into a three-dimensional image is developed in order to measure the bubble size and volume in a two-phase boiling flow. The central-active contour model originally proposed by P. $Szczypi\'{n}ski$ and P. Strumillo is modified to reduce the dependence on the initial reference point and to increase the contour stability. The modified model is then applied to the algorithm to extract the object boundary. This improved central contour model could be applied to obscure objects using a variable threshold value. The extracted boundaries from each image are merged into a three-dimensional image through the developed algorithm. It is shown that the object reconstructed using the developed algorithm is very similar or identical to the real object. Various values such as volume and surface area are calculated for the reconstructed images and the developed algorithm is qualitatively verified using real images from rubber clay experiments and quantitatively verified by simulation using imaginary images. Finally, the developed algorithm is applied to measure the size and volume of vapor bubbles condensing in a subcooled boiling flow.

• 대한치과보철학회지
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• 제33권4호
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• pp.753-768
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• 1995

For accurate impression taking of dental patient and esthetic denture treatment of ednetulous patient, measuring between intraoral anatomic landmarks is useful.In this study the subjects selected at a random were two-jundred forty persons with a mean age 22.5(range 21-24) and were taken impression of by irreversible hydrocolloid impression material(Alginate). On the study model made by dental stone, each individual tray was made and final impresion was taken by border moilding. On final model measurings were performed with 3-dimensional measuring device and the values were analyzed by t-test The results is following : ABOUT THE MEASURED VALUES. 1. The width between maxillary right and left canine cusp tip was average 36.44mm(s.d. 2.48), man 36.67mm, woman 35.83mm(p<0.05). 2. The width between labial height of contour of maxillary right and left canine was average 40.08mm(s.d. 2.42), man 40.29mm, woman 39.52mm(p<0.05). 3. The width between mesio-lingual cusps of maxillary first molar was average 43.14mm(s.d. 3.33), man 43.56mm, woman 42.05mm(p<0.05). 4. The width between buccal alveolar ridge on axis of mesiolingual cusp of right and left maxillary first molar was average 64.89mm(s.d. 3.88), man 65.58mm, woman 62.92mm(p<0.05). 5. The width between buccal alveolar ridge on axis of mesiolingual cusp of right and left maxillary second molar was average 68.58mm(s.d. 3.91), man 69.29mm, woman 66.30mm (p<0.05). 6. The width between right and left hamular notch was average 49.80mm(s.d. 3.96), man 50.70mm, woman 48.20mm(p<0.05). 7. The length from labial heigth of contour of maxillary central incisor to center of incisive papilla was average 9.52mm(s.d. 1.18), man 9.46mm, woman 9.63mm(p>0.05). 8. The length from labial heigth of contour of maxillary central incisor to palatine fovea was average 53.27mm(s.d. 2.93), man 53.93mm, woman 52.08mm(p<0.05). 9. The center of incisive papilla ws located posterior to intercanine line at 0.40mm(s.d. 1.16), man 0.51mm, woman 0.11mm(p<0.05). 10. The height from incisal edge of maxillary central incisor to the labial vestibule was average 21.84mm(s.d. 1.38), man 22.01mm, woman 21.00mm(p<0.05). 11. The height from mesiolingual cusp of maxillary first molar to buccalvestible was average 17.45mm(s.d. 1.42), man 17.56mm, woman 17.08mm(p>0.05). 12. The height from hamular notch to standard occlusal plane was average 6.84mm(s.d. 1.06), man 6.91mm, woman 6.70mm(p>0.05). 13. The height from the deepest point of palatal vault to standard occlsalplane was average 19.95 mm(s.d. 2.03), man 20.19mm, woman 19.12mm(p<0.05). ABOUT THE ARCH FORM 1. The arch form was able to classify into four typr by the rate of the measured values. Each arch form distribution was that the 1 group had 32.46% the 2 group 2.19%, the 3 group 52.83%, the 4 group 12.72%. The sexual composition was that in 1 group man had 73.5%, woman 26.5%, in 2 group man had 40.0%, woman 60.0%, in 3 group man had 83.3%, woman 16.7%, and in 4 group man had 55.17%, woman 44.83%. 2. When canine cusp tip was marked as point O, the intersection point between labial height of contour of maxillary central incisor and intermaxillary suture as point A, height of contour of maxillary second molar buccal alveolar ridge as B point, ${\angle}$AOB was measured $133.8^{\circ}$for the 1 group, $133.0^{\circ}$for the 2 group, $132.3^{\circ}$for the 3 group, $128.9^{\circ}$for the 4 group.

• 한국기계가공학회지
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• 제12권2호
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• pp.68-74
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• 2013

In this paper, an average surface roughness, $R_a$, was measured by optical measurement and its mathematical model according to spindle speed and feedrate was obtained by least square method. Also, its result is compared and investigated with real measured average surface roughness. The optical measurement of surface roughness is performed by CLSM(confocal laser scanning microscope) and the captured HEI(height encoded image) data is used as an original data for the generation of average surface roughness and its mathematical plane or contour surface of surface roughness. Using this polynomial model with two independent variables, the behavior of an average surface roughness is investigated and analyzed with an experimental modeling of least square algorithm. And it can be used for the prediction of $R_a$ in different condition of machining.

• 한국염색가공학회지
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• 제21권5호
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• pp.41-50
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• 2009

Design of experiments (DoE) concept was successfully applied to determine the optimum processing conditions that yield maximum % exhaustion for berberine interaction with synthetic tanning agent pretreated polyamide substrates. The potential of synthetic tanning agent to provide anionic sites on the polyamide for berberine interaction which is cationic in nature was tested to increase the % exhaustion of berberine in this article. Experiments were designed according to Central Composite Rotatable Design (CCRD). The three factors for synthetic tanning agent pretreatment and two factors for berberine interaction each at five different levels, including central and axial points were considered. Experiments were conducted in a laboratory scale infra-red treatment instrument according to CCRD. For each response, second order polynomial models were developed using multiple linear regression analysis incorporating linear, interactions and squared effects of all variables and then optimized. The significance of the mathematical model developed was ascertained using Excel regression (solver) analysis module. Analysis of variance (ANOVA) was performed to check the adequacy and accuracy of the fitted models. The response surfaces and contour maps showing the interaction of process variables were constructed. Applying Monte Carlo simulation, response surface and contour plots, optimum operating conditions were found and at this optimum point, % exhaustion of 81% and 74% respectively for synthetic tanning agent pretreatment and berberine interaction were observed and subsequently the results were experimentally investigated.

• 한국식품저장유통학회지
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• 제10권3호
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• pp.320-325
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• 2003

대부분의 마는 건조분말제품으로 가공되고 있는데, 마를 다양한 가공품으로 개발하기 위한 방법의 하나로 삼투건조라는 전처리를 행하여 건조에 의한 품질손상을 억제하고 단맛으로 기호성을 높인 건조 마 제품을 얻을 수 있는 당절임 공정의 최적화를 시도하여 최적조건을 얻고자 하였다. 침지시간을 3-7시간, 온도는 20-6$0^{\circ}C$, 당농도는 30-70%로 하는 중심합성계획법으로 실험을 설계하여 최적화하였다. 이때의 종속변수로는 침지 후 수분함량, 당도, 색도, 그리고 동결건조후의 수분함량과 재수화율로 하여 분석한 결과 동결건조 후 수분함량에 대해서는 유의성이 없었다. 세 가지의 공정 변수 중 온도의 영향이 가정 적어 온도를 중심으로 고정한 후 침지시간과 당농도의 최적조건을 찾은 결과, 수분함량을 66-70%, 당도를 25-30%, L 75이상, a -2.1--2.4, b를 5이상 그리고 재수화율을 200-250을 제한 조건으로 하는 영역은 5.2-5.9시 간, 56-61%로 나타났다.

• 통합자연과학논문집
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• 제13권4호
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• pp.170-180
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• 2020

Abnormal regulation, hyperphosphorylation, and aggregation of the tau protein are the hallmark of several types of dementia, including Alzheimer's Disease. Increased activity of Glycogen Synthase Kinase-3β (GSK-3β) in the Central Nervous System (CNS), increased the tau hyperphosphorylation and caused the neurofibrillary tangles (NFTs) formation in the brain cells. Over the last two decades, numerous adenosine triphosphate (ATP) competitive inhibitors have been discovered that show inhibitory activity against GSK-3β. But these compounds exhibited off-target effects which motivated researchers to find new GSK-3β inhibitors. In the present study, we have collected the dataset of 31 C-Glycosylflavones derivatives that showed inhibitory activity against GSK-3β. Among the dataset, the most active compound was docked with the GSK-3β and molecular dynamics (MD) simulation was performed for 50 ns. Based on the 50 ns MD pose of the most active compound, the other dataset compounds were sketched, minimized, and aligned. The 3D-QSAR based Comparative Molecular Field Analysis (CoMFA) model was developed, which showed a reasonable value of q2=0.664 and r2=0.920. The contour maps generated based on the CoMFA model elaborated on the favorable substitutions at the R2 position. This study could assist in the future development of new GSK-3β inhibitors.

• 한국생산제조학회지
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• 제21권3호
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• pp.387-393
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• 2012

It is very difficult to determine suitable cutting conditions in order to obtain accurate cutting profiles because machining errors caused by tool deflection depend upon cutting conditions. In this study the relationship between real cutting profiles (inclined shapes and machining errors) and cutting conditions was modeled in order to fabricate draft angle on micro molds. CCD (Central Composite Design) of DOE (Design Of Experiment) and RSM (Response Surface Method) were applied in order to model the relationship between cutting conditions and machining errors. In order to use CCD the range of radial depth of cut was chosen by $10-90{\mu}m$ and the range of feedrate was chosen by 200-300mm/min, and 9 points of cutting conditions were chosen inside determined ranges. Then, actual cutting processes were carried out as respect to 9 points of cutting conditions, draft angles and real cutting profiles were measured on cutting profiles, each response surface function was determined by conducting response surface analysis and the functions were represented by 3-dimensional graphs, contour lines and $101{\times}101$ matrices. Consequently it is possible to determine suitable cutting conditions in order to obtain arbitrary given draft angles and cutting profiles by using modeling. To validate proposed approach in this study suitable cutting conditions were determined by modeling in order to obtain arbitrary given draft angle and cutting profile, and actual cutting processes were carried out. About 95% of good agreement between predicted and measured values was obtained.

• 한국식품저장유통학회지
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• 제10권3호
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• pp.314-319
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• 2003

가지의 수출 경쟁력 향상을 위한 한 방안으로 수출용 가지품종인 축양품종을 염가공품으로 개발하기 위하여 염절임 공정을 최적화하였다. 염절임 시간, 절임온도, 염농도를 독립변수로 하고 절임 후 수분함량, 염도, 표면과 내부의 색도 등을 종속변수로 하여, 중심합성계획법으로 실험을 설계하여 최적조건을 얻고자 하였다. 수립된 이차회귀모형으로 예측식을 수립할 수 있었으며 특히 수분함량이나 염도, 표면과 내부의 L과 b 값에 대하여 높은 적합도를 보여 최적조건을 수립하기 위한 제한 변수로 선정하였다. 염농도를 중심점(30%)에서 고정시켜서 얻은 절임시간과 온도는 각각 5.5-6.5일과 13-17$^{\circ}C$였으며, 이때의 종속변수의 제한 요건으로는 수분함량 84%이하, 염도 14%이하 표면 L 값 10-20, b값 0 이하, 내부 L 값은 70-75, b 값이 16-18이었다.

• Environmental Engineering Research
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• 제15권2호
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• pp.63-70
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• 2010

In this study, the response surface method and experimental design were applied as an alternative to conventional methods for the optimization of coagulation tests. A central composite design, with 4 axial points, 4 factorial points and 5 replicates at the center point were used to build a model for predicting and optimizing the coagulation process. Mathematical model equations were derived by computer simulation programming with a least squares method using the Minitab 15 software. In these equations, the removal efficiencies of turbidity and total organic carbon (TOC) were expressed as second-order functions of two factors, such as alum dose and coagulation pH. Statistical checks (ANOVA table, $R^2$ and $R^2_{adj}$ value, model lack of fit test, and p value) indicated that the model was adequate for representing the experimental data. The p values showed that the quadratic effects of alum dose and coagulation pH were highly significant. In other words, these two factors had an important impact on the turbidity and TOC of treated water. To gain a better understanding of the two variables for optimal coagulation performance, the model was presented as both 3-D response surface and 2-D contour graphs. As a compromise for the simultaneously removal of maximum amounts of 92.5% turbidity and 39.5% TOC, the optimum conditions were found with 44 mg/L alum at pH 7.6. The predicted response from the model showed close agreement with the experimental data ($R^2$ values of 90.63% and 91.43% for turbidity removal and TOC removal, respectively), which demonstrates the effectiveness of this approach in achieving good predictions, while minimizing the number of experiments required.

• 공업화학
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• 제32권6호
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• pp.621-626
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• 2021

MOF-801 합성공정의 최적화를 위해 순차적인 실험 계획법을 이용하였다. 먼저 screening을 위한 완전 2-요인 설계와 이후 반응표면 분석법 중에 하나인 중심합성 계획법을 연속적으로 사용하였다. 두 가지 반응변수인 MOF-801의 결정화도와 BET 비표면적 중에 실험계획법에 보다 적합한 변수를 선택하기 위하여 fumaric acid, dimethylformamide (DMF) 및 formic acid의 몰비를 이용한 2³ 요인 설계법을 수행하였다. MINITAB 19 소프트웨어에 따라 설계된 8번의 MOF-801 합성 실험을 수행한 이후 XRD 분석 및 질소흡착법을 이용하여 특성분석을 수행하였다. 두 가지 반응변수 중 결정화도의 R²이 0.999로 BET 비표면적보다 실험계획법에 보다 적합하였다. 분산 분석(ANOVA)을 통해 fumaric acid와 formic acid의 몰 비가 MOF-801의 결정화도를 결정하는 주요 인자임을 확인하였다. response optimization과 두 인자의 contour plot을 통해 최적의 몰비는 ZrOCl₂·8H₂O : fumaric acid : DMF : formic acid = 1 : 1: 39 : 35로 추정되었다. 이후 합성반응 공정의 최적화를 위해 도출된 전구체의 몰 비 조건에서 합성 기간과 온도에 대한 박스-벤켄설계법을 수행하였다. 설계된 9번의 합성실험을 통해 도출된 결과를 2차 모델 방정식을 이용하여 계산하였다. 이를 이용하여 MOF-801의 최대 결정화도는 합성시간 7.8 h 그리고 합성온도 123 ℃의 조건에서 얻을 수 있음을 예측하였다.