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Screening of Biogenic Amine Non-Producing Yeast and Optimization of Culture Conditions Using Statistical Method for Manufacturing Black Raspberry Wine (복분자 와인 제조를 위한 바이오제닉 아민 비생성 효모의 선별 및 통계학적 기법을 이용한 배양조건 최적화)

  • Yang, Hee-Jong;Jeong, Su-Ji;Jeong, Seong-Yeop;Heo, Ju-Hee;Jeong, Do-Youn
    • Journal of the Korean Society of Food Science and Nutrition
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    • v.44 no.4
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    • pp.592-601
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    • 2015
  • Rubus coreanus is known as Korean black raspberry, native to Korea, Japan, and China. Preliminary studies evaluating their potential for cancer treatment in mammalian test systems are ongoing. In recent years, interest has been renewed due to their high levels of anthocyanins. Anthocyanins in black raspberry are important due to their potential health benefits as dietary antioxidant, anti-inflammatory compound, and as a chemopreventive agent. In the present study, Saccharomyces cerevisiae BA29 was isolated from black raspberry fruit and fruit juice as a biogenic amine non-producing strain for manufacturing of black raspberry wine, after which we investigated its characteristics: biogenic amine-producing ability, cell growth ability, alcohol-fermentation ability, and resistance to alcohol, glucose, and sulfur dioxide. Based on preliminary experiments, we optimized culture medium compositions for improving dried cell weight of S. cerevisiae BA29 by response surface methodology (RSM) as a statistical method. Design for RSM used a central composite design, and molasses with the industrial applicability was used as a carbon source. Through statistical analysis, we obtained optimum values as follows: molasses 200 g/L, peptone 30 g/L, and yeast extract 40 g/L. For the model verification, we confirmed about 3-fold improvement of dried cell weight from 6.39 to 20.9167 g/L compared to basal yeast peptone dextrose medium. Finally, we manufactured black raspberry wine using S. cerevisiae BA29 and produced alcohol of 20.33%. In conclusion, S. cerevisiae isolated from black raspberry fruit and juices has a great potential in the fermentation of black raspberry wine.

A Study on the Expansion of Arbitration's Area of Coverage in Korea (한국중재의 영역확대 방안에 관한연구)

  • Kim, Suk-Chul
    • Journal of Arbitration Studies
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    • v.20 no.3
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    • pp.47-69
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    • 2010
  • From the review of Korean arbitration systems with the comparison of those of other countries, we can summarize some issues to be tackled as follows: First, Korean arbitration system started with the purpose of export promotion. This may be the main reason that various domestic disputes have not been resolved by arbitration. Second, the Korean Arbitration Law applies to private disputes. The Law's arbitration scope is wider than that of China and France, but narrower than that of the U.S.A. that encompasses a variety of disputes in the filed of consumer, labor, medical services, patents, etc. Third, active judges or public officials in Korea can not be arbitrator and there is no arbitration court. However, if chief judge allows the necessity, court's judges in the UK can be arbitrator with the mutual agreement of the parties and also arbitration system is operated in the court. Fourth, the Korean Commercial Arbitration Board(KCAB), the only representative institution for arbitration in Korea, is under the Ministry of Knowledge Economy(MKE). This makes it difficult for the KCAB to handle other disputes related to the Ministry of Health and Welfare, the Ministry of Strategy and Finance, the Ministry for Food, Agriculture, Forestry and Fisheries, the Ministry of Employment and Labor, etc. Fifth, as mentioned, the KCAB is the unique institution for arbitration by the Law in Korea, while other countries allow have a diversity of arbitration agencies such as maritime arbitration organization, consumer arbitration institution, arbitration court, etc. Therefore, we suggest some ideas to expand the arbitration's area of coverage in Korea as follows: First, there should be more active policies that promote various domestic disputes to be settled by the arbitration system. Second, it is quite needed to expand the scope of arbitration to cover many disputes in the fields of consumer, labor, medical service, advertising, fair trade, etc. Third, there should be discussions to allow court judges as arbitrator and to introduce the arbitration court. Fourth, the KCAB should strengthen its status and roles as general arbitration organization to overcome the limited scope of commercial disputes. For this, there should be the strong support and coordination among the MKE and other government agencies. Fifth, to reduce the burden of the court's complicated and expensive procedures, more efficient disputes resolution systems should be established on the basis of the parties' free will. Each central government agency should streamline the legal barriers to allow industrial organizations under its control to establish their own or joint arbitration system with the KCAB.

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Abiraterone for Treatment of Metastatic Castration-resistant Prostate Cancer: a Systematic Review and Meta-analysis

  • Zhou, Zhi-Rui;Liu, Shi-Xin;Zhang, Tian-Song;Xia, Jun;Li, Bo
    • Asian Pacific Journal of Cancer Prevention
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    • v.15 no.3
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    • pp.1313-1320
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    • 2014
  • Introduction: Although most prostate cancers initially respond to castration with luteinizing hormonereleasing analogues or bilateral orchiectomy, progression eventually occurs. Based on the exciting results of several randomized controlled trials (RCTs), it seems that patients with metastatic castration-resistant prostate cancer (mCRPC) might benefit more from treatment withabiraterone. Therefore we conducted a systematic review to evaluate the efficacy and toxicity of abiraterone in the treatment of mCRPC. Methods: Literature was searched from Embase, PubMed, Web of Science, and Cochrane Library up to July, 2013. Quality of the study was evaluated according to the Cochrane's risk of bias of randomized controlled trial (RCT) tool, then the Grading of Recommendations Assessment, Development and Evaluation (GRADE) System was used to rate the level of evidence. Stata 12.0 was used for statistical analysis. Summary data from RCTs comparing abiraterone plus prednisone versus placebo plus prednisone for mCRPC were meta-analyzed. Pooled hazard ratios (HRs) for overall survival (OS), radiographic progression-free survival (RPFS) and time to PSA progression (TTPP); Pooled risk ratios (RR) for PSA response rate, objective response rate and adverse event were calculated. Results: Ten trials were included in the systematic review; Data of 2,283 patients (1,343 abiraterone; 940 placebo) from two phase 3 trials: COU-AA-301 and COU-AA-302 were meta-analyzed. Compared with placebo, abiraterone significantly prolonged OS (HR, 0.74; 95% confidence interval [CI], 0.66 to 0.84), RPFS (HR, 0.59; 95% CI, 0.48 to 0.74) and time to PSA progression (HR, 0.55; 95% CI, 0.43 to 0.70); it also significantly increased PSA response rate (RR, 3.63; 95% CI, 1.72 to 7.65) and objective response rate (RR, 3.05; 95% CI, 1.51 to 6.15). This meta-analysis suggested that the adverse events caused by abiraterone are acceptable and can be controlled. Conclutios: Abiraterone significantly prolonged OS, RPFS and time to progression patients with mCRPC, regardless of prior chemotherapy or whether chemotherapy-na$\ddot{i}$ve, and no unexpected toxicity was evident. Abiraterone can serve as a new standard therapy for mCRPC.

Analysis of Changes in Rainfall Frequency Under Different Thresholds and Its Synoptic Pattern (절점기준에 따른 강우빈도 변화 및 종관기후학적 분석)

  • Kim, Tae-Jeong;Kwon, Hyun-Han
    • KSCE Journal of Civil and Environmental Engineering Research
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    • v.36 no.5
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    • pp.791-803
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    • 2016
  • Recently, frequency of extreme rainfall events in South Korea has been substantially increased due to the enhanced climate variability. Korea is prone to flooding due to being surrounded by mountains, along with high rainfall intensity during a short period. In the past three decades, an increase in the frequency of heavy rainfall events has been observed due to enhanced climate variability and climate change. This study aimed to analyze extreme rainfalls informed by their frequency of occurrences using a long-term rainfall data. In this respect, we developed a Poisson-Generalized Pareto Distribution (Poisson-GPD) based rainfall frequency method which allows us to simultaneously explore changes in the amount and exceedance probability of the extreme rainfall events defined by different thresholds. Additionally, this study utilized a Bayesian approach to better estimate both parameters and their uncertainties. We also investigated the synoptic patterns associated with the extreme events considered in this study. The results showed that the Poisson-GPD based design rainfalls were rather larger than those of based on the Gumbel distribution. It seems that the Poisson-GPD model offers a more reasonable explanation in the context of flood safety issue, by explicitly considering the changes in the frequency. Also, this study confirmed that low and high pressure system in the East China Sea and the central North Pacific, respectively, plays crucial roles in the development of the extreme rainfall in South Korea.

Clinical Study of Tumor Angiogenesis and Perfusion Imaging Using Multi-slice Spiral Computed Tomography for Breast Cancer

  • Xu, Na;Lei, Zhen;Li, Xiao-Long;Zhang, Jun;Li, Chen;Feng, Guo-Quan;Li, Di-Nuo;Liu, Jing-Yi;Wei, Qiang;Bian, Ting-Ting;Zou, Tian-Yu
    • Asian Pacific Journal of Cancer Prevention
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    • v.14 no.1
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    • pp.429-433
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    • 2013
  • Objectives: To explore the correlation between multi-slice spiral CT (MSCT) perfusion parameters and the expression of vascular endothelial growth factor (VEGF) as well as matrix metalloproteinase-2 (MMP-2) in breast cancer. Methods: Forty five breast cancer patients and 16 patients with benign breast tumor, both confirmed by pathology examination, were enrolled. All underwent MSCT perfusion imaging to obtain perfusion maps and data for parameters including blood flow (BF), blood volume (BV) and permeability surface (PS). Cancer patients did not receive treatment prior to surgery. The expression of VEGF and MMP-2 were examined with both immunohistochemistry and Western blotting. Results: The levels of VEGF and MMP-2 by immunohistochemistry were significantly higher in the breast cancer group (P < 0.01) than the benign tumor group. Relative OD values from Western blotting were also higher in cancer cases (P < 0.05). Similarly, the mean MSCT perfusion parameters (BF, BV, PS) were significantly higher in the breast cancer group (P < 0.01), BF and BV positively correlating with VEGF expression (r = 0.878 and 0.809 respectively, P < 0.01); PS and VEGF and MMP-2 expression were also positively correlated (r= 0.860, 0.786 respectively, P < 0.01). Conclusion: There is a correlation between breast cancer MSCT perfusion parameters and VEGF andMMP-2 expression, which might be useful for detection of breast lesions, qualitative diagnosis of breast cancer, and evaluation of breast cancer treatment.

Overexpression of Phospholipase A2 Group IIA in Esophageal Squamous Cell Carcinoma and Association with Cyclooxygenase-2 Expression

  • Zhai, Yan-Chun;Dong, Bin;Wei, Wen-Qiang;He, Yan;Li, Xin-Qing;Cormier, Robert T.;Wang, Wei;Liu, Fen
    • Asian Pacific Journal of Cancer Prevention
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    • v.15 no.21
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    • pp.9417-9421
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    • 2014
  • Background: Esophageal cancer is one of the most frequently occurring malignancies and the seventh leading cause of cancer-related deaths in the world. The esophageal squamous cell carcinoma (ESCC) is the most common histological type of esophageal cancer worldwide. Materials and Methods: Our goal in this study was to detect phospholipase A2 Group IIA (PLA2G2A) and cyclooxygenase-2 (COX-2) immuno-expression in ESCC in a high-risk population in China. Results: Positive expression of PLA2G2A protein was observed in 57.2% (166/290) of the cases, while COX-2 was found in 257 of 290 samples (88.6%), both PLA2G2A and COX-2 being expressed in 153 cases (52.8%), with a significant agreement (Kappa=0.091, p=0.031).Overexpression of PLA2G2A was significantly correlated with the depth of invasion (p=0.001). Co-expression of PLA2G2A and COX-2 not only significantly correlated with the depth of invasion (p=0.004) but also with TNM stage (p=0.04). Conclusions: Our results showed that in patients with ESCC, PLA2G2A overexpression and PLA2G2A co-expression with COX-2 is significantly correlated with advanced stage. The biological role and pathophysiologic regulation of PLA2G2A and COX-2 overexpression in ESCC deserve further investigation.

Astragaloside IV Prevents Obesity-Associated Hypertension by Improving Pro-Inflammatory Reaction and Leptin Resistance

  • Jiang, Ping;Ma, Dufang;Wang, Xue;Wang, Yongcheng;Bi, Yuxin;Yang, Jinlong;Wang, Xuebing;Li, Xiao
    • Molecules and Cells
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    • v.41 no.3
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    • pp.244-255
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    • 2018
  • Low-grade pro-inflammatory state and leptin resistance are important underlying mechanisms that contribute to obesity-associated hypertension. We tested the hypothesis that Astragaloside IV (As IV), known to counteract obesity and hypertension, could prevent obesity-associated hypertension by inhibiting pro-inflammatory reaction and leptin resistance. High-fat diet (HFD) induced obese rats were randomly assigned to three groups: the HFD control group (HF con group), As IV group, and the As IV + ${\alpha}$-bungaratoxin (${\alpha}-BGT$) group (As IV+${\alpha}-BGT$ group). As IV ($20mg{\cdot}Kg^{-1}{\cdot}d^{-1}$) was administrated to rats for 6 weeks via daily oral gavage. Body weight and blood pressure were continuously measured, and NE levels in the plasma and renal cortex was evaluated to reflect the sympathetic activity. The expressions of leptin receptor (LepRb) mRNA, phosphorylated signal transducer and activator of transcription-3 (p-STAT3), phosphorylated phosphatidylinositol 3-kinase (p-PI3K), suppressor of cytokine signaling 3 (SOCS3) mRNA, and protein-tyrosine phosphatase 1B (PTP1B) mRNA, pro-opiomelanocortin (POMC) mRNA and neuropeptide Y (NPY) mRNA were measured by Western blot or qRT-PCR to evaluate the hypothalamic leptin sensitivity. Additionally, we measured the protein or mRNA levels of ${\alpha}7nAChR$, inhibitor of nuclear factor ${\kappa}B$ kinase subunit ${\beta}/nuclear$ factor ${\kappa}B$ ($IKK{\beta}/NF-KB$) and pro-inflammatory cytokines ($IL-1{\beta}$ and $TNF-{\alpha}$) in hypothalamus and adipose tissue to reflect the anti-inflammatory effects of As IV through upregulating expression of ${\alpha}7nAChR$. We found that As IV prevented body weight gain and adipose accumulation, and also improved metabolic disorders in HFD rats. Furthermore, As IV decreased BP and HR, as well as NE levels in blood and renal tissue. In the hypothalamus, As IV alleviated leptin resistance as evidenced by the increased p-STAT3, LepRb mRNA and POMC mRNA, and decreased p-PI3K, SOCS3 mRNA, and PTP1B mRNA. The effects of As IV on leptin sensitivity were related in part to the up-regulated ${\alpha}7nAchR$ and suppressed $IKK{\beta}/NF-KB$ signaling and pro-inflammatory cytokines in the hypothalamus and adipose tissue, since co-administration of ${\alpha}7nAChR$ selective antagonist ${\alpha}-BGT$ could weaken the improved effect of As IV on central leptin resistance. Our study suggested that As IV could efficiently prevent obesityassociated hypertension through inhibiting inflammatory reaction and improving leptin resistance; furthermore, these effects of As IV was partly related to the increased ${\alpha}7nAchR$ expression.

Pu-erh Tea Powder Preventive Effects on Cisplatin-Induced Liver Oxidative Damage in Wistar Rats

  • Zheng, Xiao-Nan;Wang, Xiao-Wen;Li, Li-Ya;Xu, Zi-Wei;Huang, Hsin-Yi;Zhao, Jin-Sheng;Zhang, Duo;Yin, Xu;Sheng, Jun;Tang, Jin-Tian
    • Asian Pacific Journal of Cancer Prevention
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    • v.15 no.17
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    • pp.7389-7394
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    • 2014
  • Background: Chemotherapy is one of the major means for control of malignancies, with cisplatin (CDDP) as one of the main agents, widely used for the treatment of various malignant solid tumors. However, prevention of hepatotoxicity from cisplatin is one of the urgent issues in cancer chemotherapy. In this study, we aimed to investigate the effects of pu-erh tea on hepatotoxicity through body weight and tissue antioxidant parameters like, liver coefficient, serum alanine aminotransferase (ALT), serum aspartate aminotransferase (AST), superoxide dismutase (SOD), glutathione peroxidase (GSH-PX), malondialdehyde(MDA) and glutathione (GSH) levels, and light microscopic evaluation by histological findings. Materials and Methods: The rats were randomly divided into five groups: Control (n=10), cisplatin (3 mg/kg p.i., n=10), cisplatin+pu-erh (0.32 g/kg/day i.g., n=10), cisplatin+pu-erh (0.8 g/kg/day i.g., n=10) and cisplatin+pu-erh (1.6 g/kg/day i.g., n=10). Pu-erh tea powder was administrated for 31 consecutive days. The rats were sacrificed at the end on the second day after a single dose of cisplatin treatment for measuring indices. Results: Pu-erh tea powder exhibited a protective effect by decreasing MDA and GSH and increasing the SOD and GSH-PX levels and GSH-PX/MDA ratio in camparison with the control group. Besides, pu-erh tea was also able to alleviate the pathological damage to some extent. Conclusion: Pu-erh tea powder is protective against cisplatin-induced liver oxidative damages, especially at the medium dosage (0.8 g/kg/d).

The Climatological Characteristics of the Landfall Typhoons on North Korea (북한에 상륙한 태풍의 기후학적 특성)

  • Ahn, Suk-Hee;Kim, Baek-Jo;Park, So-Yeon;Park, Gil-Un
    • Atmosphere
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    • v.20 no.3
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    • pp.239-246
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    • 2010
  • In this study, the climatological characteristics of the landfall typhoons on North Korea are surveyed to estimate the frequency, the intensity, the track, and their damage. The data for the period of 1951-2008 are used from both RSMC (Regional Specialized Meteorological Center) Tokyo Typhoon Center and NCEP/NCAR (National Centers for Environmental Prediction/National Center for Atmospheric Research), EM-DAT (Emergency Events Database). There are the ten highest frequencies from 1961 to 1965 and is one frequency for the period of both 1966-1979 and 1976-1980 respectively. Even if a clear trend on the frequency of typhoon is not defined, it is noticeable the intensity has been weak since the frequency of TS (Tropical Storm) decreased. In order to figure out both the characteristic of intensity and the relation between the typhoon track and the expansion of North Pacific High (NPH), Typhoon's tracks are classified into three types as follows: (I) landing on the west coast of North Korea through the mainland of China, (II) landing on the west coast of North Korea, (III) landing on a central/eastern part of the Korean peninsula through South Korea. More often than not, the characteristic of Type (I) is the case of a landfall after it becomes extratropical cyclone. Type(II) and Type(III) show a landfall as TS grade, by comparision. On the relation between the typhoon's track and the expansion of NPH analyzed, Type (I) shows the westward expansion while both Type (II) and Type (III) show the northward expansion and development of NPH. This means the intensity of a typhoon landfall on North Korea is variable depending on the development of NPH. Finally, only two cases are found among total five cases in EM-DAT, reportedly that North Korea was damaged. And therefore, the damage by the wind of Prapiroon (the $12^{th}$ typhoon, 2000) and heavy rainfall with Rusa (the $15^{th}$ typhoon, 2002) landing on North Korea was analyzed. Moreover, it is estimated both Prapiroon and Rusa have done badly damaged to North Korea as the economical losses of as much as six billion and five hundred-thousand US dollar, respectively.

A Numerical Study on the Wintertime Upwind flow of the Yellow Sen in an Idealized Basin

  • Kyung, Tae-Jung;Park, Chang-Wook;Oh, Im-Sang;Lee, Ho-Jin;Kang, Hyoun-Woo
    • Journal of the korean society of oceanography
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    • v.37 no.3
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    • pp.91-107
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    • 2002
  • The wintertime upwind flow in the Yellow Sea has been investigated through a series of two-dimensional numerical experiments in an idealized basin. A total of 10 experiments have been carried out to examine the effects of wind forcing, bottom friction and the presence of oceanic currents sweeping the shelf of the East China Sea. A spatially uniform steady and periodic wind stresses are considered along with comparison of linear and quadratic formulations. The wind-driven flow in the absence of oceanic current has been computed using Proudman open boundary condition (POBC), while the wind-driven current in the presence of oceanic current has been computed using Flather’s radiation condition (FOBC). The oceanic currents to be prescribed at the open boundary have been simulated by specifying uniform sea level gradients across the Taiwan Strait and the eastern ECS shelf, Calculations show that, as seen in Lee et al. (2000), oceanic flow little penetrates into the Yellow Sea in the absence of wind forcing unless a unrealistically low rate of bottom frictional dissipation is assumed. Both steady and time-periodic wind stresses invoke the upwind flow along the central trough of the Yellow Sea, independently of the presence of the oceanic current. The presence of oceanic currents very marginally alters the north-south gradient of the sea surface elevation in the Yellow Sea. Changes in the intensity and direction of the wind-induced mean upwind flow are hardly noticeable in the Yellow Sea but are found to be significant near Cheju Island where the gradient is reduced and therewith contribution of Ekman transport increases. In case of steady wind forcing circulation patterns such as two gyres on the slope sides, a cyclonic gyre on the western slope and an anticyclonic gyre on the eastern slope persist and the upwind flow composes part of the cyclonic gyre in the Yellow Sea. While in case of the time-periodic wind stress the appearance and disappearance of the patterns are repeated according to the time variation of the wind stress and the upwind flow accordingly varies with phase delay, mostly intensifying near the time when the wind forcing is approximately near the middle of the decaying stage.