• Bulletin of the Korean Chemical Society
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• 제28권8호
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• pp.1346-1352
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• 2007

This article presents an original work on kinetically studying the selective adsorption and recognition by molecularly imprinted polymer (MIP). With S-naproxen as template, the imprinted polymer was prepared. The result indicates that the prepared polymer shows a more complicated sorption toward S-naproxen than toward its enantiomer R-naproxen. The rate constant in the case of template appears to be a variable. There are also significant deviations from the idealized Langmuir model. Related information indicates that these, in logic, can be a result of biomimic structural and functional complements between imprint and the template, which makes the polymer capable of selectively recognizing the imprint species.

• 한국미생물·생명공학회지
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• 제46권4호
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• pp.430-433
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• 2018

Hepatitis B is a major health problem in China. However, little is known about the prevalence of hepatitis B virus (HBV) in Kaifeng, the major urban capital of Henan province, China. We found that HBV prevalence increased with age and that chronic HBV was predominant in adult males in Kaifeng. The HBV prevalence remained unchanged over a 5-year period for all age groups. Alarmingly, 25% of the population remained unvaccinated and potentially susceptible to future HBV infection. HBV immunization and health education initiatives should be carried out in this population to further reduce the overall prevalence of HBV.

• The Korean Journal of Physiology and Pharmacology
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• 제27권5호
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• pp.437-448
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• 2023

Diabetic ulcer is usually seen in people with uncontrolled blood sugar. Reportedly, many factors such as impaired glucose metabolism, and macrovascular and microvascular diseases caused angiogenesis disorders and delayed the healing of diabetic ulcers, thus affecting the body's metabolism, nutrition, and immune function. This study aimed to explore the effect of paeonol on skin wound healing in diabetic rats and the related mechanism. A rat model of diabetic ulcer was established. High glucose-treated mouse skin fibroblasts were co-cultured with M1 or M2-polarized macrophages treated with or without paeonol. H&E and Masson staining were used to reveal inflammatory cell infiltration and collagen deposition, respectively. Immunohistochemistry visualized the expression of Ki67, CD31, and vascular endothelial growth factor (VEGF). Western blot was used to detect interleukin (IL)-1β, tumor necrosis factor (TNF)-α, IL-4, IL-10, CD31, VEGFA, and collagen I/III. The expression of iNOS and arginase 1 was revealed by immunofluorescence staining. Paeonol treatment augmented collagen deposition and the expression of Ki67, CD31, VEGF, and macrophage M2 polarization markers (IL-4 and IL-10) and reduced wound area, inflammatory cell infiltration, and macrophage M1 polarization markers (IL-1β and TNF-α) in the ulcerated area. In vitro, paeonol treatment promoted M2-polarization and repressed M1-polarization in macrophages, thereby improving the repair of cell damage induced by high glucose. Paeonol accelerates the healing of diabetic ulcers by promoting M2 macrophage polarization and inhibiting M1 macrophage polarization.

• Asian Pacific Journal of Cancer Prevention
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• 제13권8호
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• pp.4031-4036
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• 2012

Background: The negative signaling provided by interactions of the co-inhibitory molecule, programmed death-1 (PD-1), and its ligands, B7-H1 (PD-L1) and B7-DC (PD-L2), is a critical mechanism contributing to tumor evasion; blockade of this pathway has been proven to enhance cytotoxic activity and mediate antitumor therapy. Here we evaluated the anti-tumor efficacy of AAV-mediated delivery of the extracellular domain of murine PD-1 (sPD-1) to a tumor site. Material and Methods: An rAAV vector was constructed in which the expression of sPD-1, a known negative regulator of TCR signals, is driven by human cytomegalovirus immediate early promoter (CMV-P), using a triple plasmid transfection system. Tumor-bearing mice were then treated with the AAV/sPD1 construct and expression of sPD-1 in tumor tissues was determined by semi quantitative RT-PCR, and tumor weights and cytotoxic activity of splenocytes were measured. Results: Analysis of tumor homogenates revealed sPD-1 mRNA to be significantly overexpressed in rAAV/sPD-1 treated mice as compared with control levels. Its use for local gene therapy at the inoculation site of H22 hepatoma cells could inhibit tumor growth, also enhancing lysis of tumor cells by lymphocytes stimulated specifically with an antigen. In addition, PD-1 was also found expressed on the surfaces of activated CD8+ T cells. Conclusion: This study confirmed that expression of the soluble extracellular domain of PD-1 molecule could reduce tumor microenvironment inhibitory effects on T cells and enhance cytotoxicity. This suggests that it might be a potential target for development of therapies to augment T-cell responses in patients with malignancies.

• Journal of Contemporary Eastern Asia
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• 제17권2호
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• pp.237-253
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• 2018

In order to understand China's internet governance, this paper examined 1,931 Internet policies of China by bibliometric techniques. Specifically, the bibliometric techniques include simple document counting, co-word analysis, collaboration network analysis and citation analysis. The findings include: (1) China's Internet legislations mainly emphasized e-commerce and Internet governance, and, to some extent, neglected personal data protection; (2) China's Internet is under intensive multiple regulatory controls by central government. A large number of government agencies are involved in Internet policy-making. The Propaganda Department of the Central Committee of the Communist Party of China and the State Information Leading Group of the State Council, enforced fewer policy documents, but occupy higher positions in the Internet governance hierarchy; (3) China's Internet legislation system is primarily composed of industry-specific administrative rules, rather than laws or administrative regulations. Nevertheless, laws and administrative regulations received significantly more citations owing to their superior force. This paper also discussed current gaps in China's internet governance and how the country's internet policies are situated in the broader global context.

• 국제지역연구
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• 제16권2호
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• pp.121-146
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• 2012

본 논문의 목적은 오늘날 부상하고 있는 중국이 기존 패권국가인 미국에 대응해 국제사회에서 어떻게 자신의 영향력을 유지·확대하고 있는 가를 연구하는 것이다. 최근 중국의 영향력은 동아시아를 넘어서 중앙아시아로 확대되고 있는 추세이다. 중국은 소프트밸런싱 전략을 통해 미국을 견제하며 중앙아시아에 대한 자국의 영향력을 확대하고 있다. 본 연구는 최근 급속도로 발전하고 있는 중국과 중앙아시아의 관계를 대미 견제의 소프트밸런싱 이론을 적용해 분석하고자 한다. 본 논문에서는 중국의 중앙아시아에 대한 전략이 소프트밸런싱인지를 판단하기 위한 3가지 지표를 제시한다. 1) 도전국가는 지역적 또는 국제적 다자협력을 활용하여 패권국가의 외교적 비용을 높이거나 패권국을 견제하기 위한 전략을 제시한다. 2) 도전국가는 역내 국가들과의 경제협력을 강화하여 자국의 영향력을 증대하는 한편, 패권국의 경제적 영향력이 도전국가의 역내로 확대되는 것을 견제하고자 한다. 3) 도전국은 군사동맹보다는 역내 국가들과 연합을 통해 제한적인 군사훈련과 군비 증강, 영토의 부인의 방식으로 하나의 국가가 패권국가에 대응하여 초래할 수 있는 위험부담을 분산 또는 감소하고 패권국의 군사적 영향력이 역내로 확대되는 것을 견제하고자 한다. 이러한 지표를 통해 중국의 다극화 전략, 중앙아시아 지역의 국가들과의 경제협력과 에너지 협력 그리고 SCO 등 다자기구를 통한 중국과 중앙아시아 국가들 간의 군사안보 협력을 분석한다.

• 한국주거학회논문집
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• 제11권1호
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• pp.125-135
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• 2000

Recently, the space organization of Korean-Chinese houses is different from that of other territories. The vast land of China, coming from different hometown in Korean peninsula, and the different hometown in Korean peninsula, and the different procedure of settlement seem to make the different space organization of Chinese-Korean single family housing at the urban area in Liaoning Province.The characteristics of the Korean-Chinese space organization of single family housing at the urban area in Liaoning Province are as follows;i)Three types of space organization are central kitchen type, central corridors types, and central living room type. ii)The central kitchen type is mainly in old urban housing, after 1980's, the central corridor type appears in single family housing, and central living room type appears 1990's.iii) It seems that the main reason to change the space organization are fuel, system of heating, influence of Korea housing. Especially, Korean-Chinese like central living room type that is suitable for sit down living style. This central living room type supposes to be used as popular space organization in urban housing.

• 대한지리학회지
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• 제38권4호
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• pp.591-609
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• 2003

본 연구는 중국 철도망의 구조와 철도여객 및 화물 유동에 대한 분석을 통하여 중국 도시 네트워크의 특징과 변화를 밝히는 것을 주요 목적으로 하였다. 중국 도시의 접근성은 허난성을 중심으로 한 중부지역이 가장 높고 주변으로 향할수록 접근성이 떨어진다. 도시 네트워크의 중심은 중부지역에서 동부지역으로 이동하였으며, 3개의 남북방향 축과 주요 도시들의 지역 중심성은 여전하지만 그들의 영향권은 확대되고 중심성도 분산되었다. 도시 네트워크의 계층구조는 3단계로 구분할 수 있는데 1단계 계층에서 대부분의 영향권은 도시 성(자치구) 범위를 크게 벗어나지 않았고, 2단계 계층에서는 대부분의 지역에서 영향권 교차현상이 나타났으며 선형 패턴이 더욱 뚜렷하였다. 3단계에서는 5대 영향권으로 구분되었다.

• 한국자원리싸이클링학회:학술대회논문집
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• 한국자원리싸이클링학회 1993년도 EARTH 발표논문초록
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• pp.7.1-7
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• 1993

• Asian Pacific Journal of Cancer Prevention
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• 제16권14호
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• pp.5675-5679
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• 2015

Background: Low-risk human papillomavirus (LR-HPV) infection is the main cause of genital warts. LRHPV genotypes 6 and 11 are associated with genital warts, but there have only been a few published studies about the genotype-specific prevalence of HPV in genital warts in China. The objective of our study was to assess the prevalence of HPV genotypes for clinical cases involving both men and women and to evaluate the potential benefit of a quadrivalent (genotypes 6, 11, 16, and 18) HPV vaccine in eastern Guangdong province of China. Materials and Methods: A total of 696 eligible patients with genital warts were enrolled during the period Aug 2009 through Oct 2014. Specimens were collected from genital warts, the HPV GenoArray test was used for HPV detection and genotyping, which could detect 21 HPV genotypes, including genotypes 6, 11, 16, and 18. Results: Among the 696 cases, 675 samples were successfully genotyped. The median age of patients was 32.1 years (range, 16-67 years). The most prevalent genotypes were HPV-6 (285/675, 42.2%), HPV-11 (265/675, 39.3%), HPV-52 (52/675, 7.7%), HPV-16 (51/675, 7.56%), HPV-81 (50/675, 7.40%) and HPV-58 (37/675, 5.48%). Low-risk genotypes predominated, with a prevalence of 96.59%. The cumulative prevalence of genotypes 6 and 11 was 78.7% (531/675), the cumulative prevalence of genotypes 16 and 18 was 11.6% (78/675), and the cumulative prevalence of genotypes 6, 11, 16, and 18 was 82.5% (557/675). Conclusions: Our results provide strong evidence that, in eastern Guangdong, different from Western countries, the most prevalent low risk HPV genotypes in patients with genital warts are 6, 11 and 81. The quadrivalent HPV vaccine could prevent 82.5% of genital warts in eastern Guangdong.