• Nuclear Engineering and Technology
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• 제36권4호
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• pp.346-356
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• 2004

14 Pressurized Water Reactors (PWR) in Korea use a remote monitoring system (RMS), which have been used in Korea since 1998. A Memorandum of Understanding on Remote Monitoring, based on Enhanced Cooperation on PWRs, was signed at the 10th Safeguards Review Meeting in October 2001 between the International Atomic Energy Agency (IAEA) and Ministry Of Science and Technology (MOST). Thereafter, all PWR power plants applied for remote monitoring systems. However, the existing method is high cost (involving expensive telephone costs). So, it was eventually applied to an Internet system for Remote Monitoring. According to the Internet-based Virtual Private Network (VPN) applied to Remote Monitoring, the Korea Atomic Energy Research Institute (KAERI) came to an agreement with the IAEA, using a Member State Support Program (MSSP). Phase I is a Lab test. Phase II is to apply it to a target power plant. Phase III is to apply it to all the power plants. This paper reports on the penetration testing of Phase I. Phase I involved both domestic testing and international testing. The target of the testing consisted of a Surveillance Digital Integrated System (SDIS) Server, IAEA Server and TCNC (Technology Center for Nuclear Control) Server. In each system, Virtual Private Network (VPN) system hardware was installed. The penetration of the three systems and the three VPNs was tested. The domestic test involved two hacking scenarios: hacking from the outside and hacking from the inside. The international test involved one scenario from the outside. The results of tests demonstrated that the VPN hardware provided a good defense against hacking. We verified that there was no invasion of the system (SDIS Server and VPN; TCNC Server and VPN; and IAEA Server and VPN) via penetration testing.

• 대한조선학회논문집
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• 제46권1호
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• pp.31-42
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• 2009

Common structural rule (CSR) doesn' t provide any other specific regulations for permanent means of access (PMA) platform structure in a cargo oil tank. The PMA platform is recommended to comply with scantling requirement of local support member. However, it leads to too conservative scantlings compared with actual loads imposed on the platform. This paper proposes a strength assessment procedure for the PMA structure based on a nonlinear ultimate strength. The ultimate strength is evaluated in a sufficiently conservative way. The first linear buckling mode is used as an initial imperfection shape and its magnitude is determined using the definitions of DNV PULS. Since the same imperfection mode as the failure mode of the ultimate limit state is assumed, it can accelerate the failure. Au ultimate strength capacity curve obtained from a series of nonlinear FE analysis is compared with actual stresses calculated by CSR cargo hold analysis.

• Bulletin of the Korean Chemical Society
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• 제29권2호
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• pp.381-388
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• 2008

An X-linked skeletal disorder, SEDT (spondyloepiphyseal dysplasia tarda) is a genetic disease characterized by a disproportionately short trunk and short stature caused by mutations in the SEDL gene. This gene is evolutionarily conserved from yeast to human. The yeast SEDL protein ortholog, Trs20p, has been isolated as a member of a large multi-protein complex called the transport protein particle (TRAPP), which is involved in endoplasmic reticulum (ER)-to-Golgi transport. The interaction between SEDL and partner proteins is important in order to understand the molecular mechanism of SEDL functions. We isolated several SEDL-binding proteins derived from rat cells by an immobilized GST-fusion method. Furthermore, the SEDL-homologue proteins were identified using motif based methods. Common motifs between SEDL-binding proteins and SEDL-homologue proteins were classified into seven types and 78 common motifs were revealed. Sequence similarities were contracted to seven types using phylogenetic trees. In general, types I-III and VI were classified as having the function of acetyl-CoA carboxylase, glycogen phosphorylase, isocitrate dehydrogenase, and enolase, respectively, and type IV was found to be functionally related to the GST protein. Types V and VII were found to contribute to TRAPP vesicle trafficking.

• 한국재료학회지
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• 제15권8호
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• pp.536-542
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• 2005

Recently European Council(EU) published the RoHS(restriction of the use of certain hazardous substances in electrical and electronic equipment) which is prohibit the use of Pb, Hg, Cd, $Cr^{+6}$, PBB or PBDE in the electrical and electronic equipments. So EU member States shall ensure that, from 1 July 2006, new electrical and electronic equipment put on the market does not contain 6 hazardous substances. The one of the most important in electronics manufacturing process is soldering. Soldering process use the chemical substances which are applied in fluxing and cleaning processes and it can generate the malfunction of electronics caused by corrosion in the fields conditions. Therefore this study researched on the polarization and Tafel properties of Sn40Pb and Sn3.0Ag0.5Cu(SAC) solder based on the electrochemical theory. We prepared SnPb specimens which was aged in $150^{\circ}C,\;180^{\circ}C$ for 15 minutes ana Sn3.0Ag0.5Cu specimens that was aged in $180^{\circ}C,\;220^{\circ}C$ for 10 minutes. Experimental polarization curves were measured in distilled ionized water and $3.5 wt\%$, 1 mole NaCl electrolyte of $40^{\circ}C$, pH 7.5. Ag/AgCl and graphite were utilized by reference and counter electrode, respectively. To observe the electrochemical reaction, polarization test was conducted from -250 mV to +250 mV. From the polarization curves that were composed of anodic and cathodic curves, we obtained Tafel slop, reversible electrode potential(Ecorr) and exchange current density(Icorr). In these results, corrosion rate for two specimen were compared Sn3.0Ag0.5Cu with SnPb solders

• 한국해양바이오학회지
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• 제2권4호
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• pp.224-229
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• 2007

Muscle tissue expresses many muscle-specific genes, including myostatin (also known as GDF8) that is a member of the transforming growth factor-beta superfamily. Myostatin (MSTN) negatively regulates mammalian skeletal muscle growth and development by inhibiting myoblast proliferation. Mice and cattle possessing mutant MSTN alleles display a 'double muscling' phenotype characterized by extreme skeletal muscle hypertrophy and/or hyperplasia. In this study, we first have characterized partial cDNA of a MSTN gene from the muscle tissue in the F. chinensis and examined its expression pattern in various tissues. The partial MSTN gene (GenBank accession number EU 131093) in the F. chinensis was 1134 bp, encoding for 377 amino acids that showed 63-93% amino acid similarity to other vertebrate MSTNs, containing a conserved proteolytic cleavage site (RXRR) and conserved cysteine residues in the C-terminus. Based on a RT-PCR, the MSTN gene was expressed in the all tissues of F. chinensis used in this study.

• The Korean Journal of Physiology and Pharmacology
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• 제13권5호
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• pp.337-341
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• 2009

Signal transducer and activator of transcription 4 (STAT4), a STAT family member, mediates interleukin 12 (IL12) signal transduction. IL12 is known to be related to calorie-restricted status. In the central nervous system, IL12 also enhances the production of nitric oxide (NO), which regulates food intake. In this study, the expression of neuronal NO synthase (Nos1), which is also related to food intake, was investigated in the hypothalamic areas of Stat4 knockout (KO) mice using nicotinamide adenine dinucleotide phosphate-diaphorase (NADPH-d) histochemistry, a marker for neurons expressing Nos1 enzyme. Western blots were also performed to evaluate Nos1 and Fos expression. Wild-type Balb/c (WT group, n=10 male) and Stat4 KO mice (Stat4 KO group, n=8 male) were used. The body weight and daily food intake in the WT group were $22.4{\pm}0.3$ and 4.4 g per day, while those in the Stat4 KO group were $18.7{\pm}0.4$ and 1.8 g per day, respectively. Stat4 mice had lower body weight and food intake than Balb/c mice. Optical intensities of NADPH-d-positive neurons in the paraventricular nucleus (PVN) and lateral hypothalamic area (LHA) of the Stat4 KO group were significantly higher than those of the WT group. Western blotting analysis revealed that the hypothalamic Nos1 and Fos expression of the Stat4 KO group was up-regulated, compared to that in the WT group. These results suggest that Stat4 may be related to the regulation of food intake and expression of Nosl in the hypothalamus.

• Journal of Microbiology and Biotechnology
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• 제6권6호
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• pp.445-450
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• 1996

Gelatinase A is a member of the matrix metalloproteinases that play an important role in cancer invasion and metastasis. In the course of screening gelatinase A inhibitors from microbial sources, a fungal strain PT-262 showed a strong inhibitory activity. The strain was identified as Chaunopycnis alba on the basis of its morphological characteristics. The inhibitor was isolated from acetone extract of mycelial cake by sequential chromatographies on MCI-gel, Sephadex LH-20, and a reverse-phase HPLC column. The purified inhibitor was identified as pyridoxatin by its physico-chemical properties and spectroscopic analysis. Pyridoxatin is not a peptide analog and has cyclic hydroxamic acid moiety. It inhibited activated gelatinase A with an $IC_{50}$ value of 15.2 ${\mu}M$ using fluorescent synthetic peptide. It also had a strong cytotoxicity against human cancer cell lines in vitro. Furthermore, this compound inhibited DNA synthesis with an $IC_{50}$ value of 2.92 ${\mu}M$ in PC-3 prostate cancer cells by [$^3H$]thymidine incorporation assay.

• 임상간호연구
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• 제21권1호
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• pp.53-66
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• 2015

Purpose: The purpose of this study was to investigate the status of organizational nursing service for foreign patients in tertiary hospitals in order to build up a database for nursing care policy development for foreign patients. Methods: The subjects of this study were nursing managers or department managers of international care center in 36 tertiary hospitals nationwide. Questionnaires were consisted of the items measuring the details of and evaluations for nursing care for foreign patients within the given organizations and any organizational support for culturally competent care. The data from 35 hospitals out of 36 were analyzed finally. Results: The organizational nursing service for foreign patients was rated 6.49 points out of 10. Organizational support for culturally competent care was 2.61 points out of 4. Challenges to improving nursing care for foreign patients were listed such as developing interpreter services and international care units without accompanying by a family member, improving nursing staffs' attitudes and behaviors for providing culturally competent care, and preparing various medical documents using multiple languages. Conclusion: In order to improve nursing care for foreign patients in tertiary hospitals, we need to be more aware of cultural knowledge and sensitivity toward the care needs of foreign patients.

• 한국임상약학회지
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• 제28권2호
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• pp.138-145
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• 2018

Background: Presently, a multidisciplinary team of doctors, pharmacists, nurses, and dietitians provides patient education to impart information on chemotherapy. However, studies on multidisciplinary education satisfaction are inadequate. In this study, we aimed to contribute to the improvement of quality of multidisciplinary education counseling for patients with cancer by developing a satisfaction questionnaire and analyzing the satisfaction survey. Methods: A questionnaire was developed by an expert group, and the responses were recorded using the 5-point Likert scale. After conducting a pre-test, factor analysis was performed to evaluate validity. The reliability of the questionnaire was measured by Cronbach's alpha coefficient. A satisfaction survey was conducted by self-administration method. Results: Based on the results of factor analysis, factors can be divided into two parts: "overall education" and "each team member's education" (total 14 questions). The construct validity and reliability of the questionnaire are sufficiently high. Fifty-one patients took the survey between January 2, 2018 and January 20, 2018. Twenty-six (51%) patients responded that they were "very satisfied" and 22 (43.1%) patients responded that they were "satisfied". Conclusion: By developing a questionnaire on multidisciplinary education counseling for patients with cancer, it is possible to perform evaluation and research of cancer patient education. This study will contribute to the management and improvement of quality of multidisciplinary education.

• 콘크리트학회논문집
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• 제25권2호
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• pp.195-200
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• 2013

이 연구에서는 기존의 수화열저감 공법에서 문제가 되었던 시공성, 공기, 공사비용 등의 효율성을 높이기 위해 새로운 매스 콘크리트의 온도균열 발생 저감시스템을 개발하였다. 이 시스템은 매스 콘크리트에 발생하는 온도균열을 제어하기 위해서 타설 예정 매스 콘크리트 구조체 중심부와 표면부에 온도센서를 매립한 후 콘크리트를 타설하고, 온도제어시스템을 통해 내 외부 온도차이가 균열제어 기준 온도를 초과하면 온도차를 그 이하가 될 수 있도록 자동으로 구조체 표면에 적정온도의 양생수를 공급하여 온도균열 발생을 제어하는 양생 자동화 시스템이다. 이 시스템의 타당성을 검토하기 위해서 mock-up 테스트를 실시하였으며, 이 시스템의 우수성을 확인할 수 있었다.