• Asian-Australasian Journal of Animal Sciences
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• v.29 no.1
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• pp.36-42
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• 2016

Milk-related traits (milk yield, fat and protein) have been crucial to selection of Holstein. It is essential to find the current selection trends of Holstein. Despite this, uncovering the current trends of selection have been ignored in previous studies. We suggest a new formula to detect the current selection trends based on single nucleotide polymorphisms (SNP). This suggestion is based on the best linear unbiased prediction (BLUP) and the Fisher's fundamental theorem of natural selection both of which are trait-dependent. Fisher's theorem links the additive genetic variance to the selection coefficient. For Holstein milk production traits, we estimated the additive genetic variance using SNP effect from BLUP and selection coefficients based on genetic variance to search highly selective SNPs. Through these processes, we identified significantly selective SNPs. The number of genes containing highly selective SNPs with p-value <0.01 (nearly top 1% SNPs) in all traits and p-value <0.001 (nearly top 0.1%) in any traits was 14. They are phosphodiesterase 4B (PDE4B), serine/threonine kinase 40 (STK40), collagen, type XI, alpha 1 (COL11A1), ephrin-A1 (EFNA1), netrin 4 (NTN4), neuron specific gene family member 1 (NSG1), estrogen receptor 1 (ESR1), neurexin 3 (NRXN3), spectrin, beta, non-erythrocytic 1 (SPTBN1), ADP-ribosylation factor interacting protein 1 (ARFIP1), mutL homolog 1 (MLH1), transmembrane channel-like 7 (TMC7), carboxypeptidase X, member 2 (CPXM2) and ADAM metallopeptidase domain 12 (ADAM12). These genes may be important for future artificial selection trends. Also, we found that the SNP effect predicted from BLUP was the key factor to determine the expected current selection coefficient of SNP. Under Hardy-Weinberg equilibrium of SNP markers in current generation, the selection coefficient is equivalent to $2^*SNP$ effect.

• Journal of Life Science
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• v.25 no.1
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• pp.1-7
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• 2015

Cyclin D is a member of the cyclin protein family, which plays a critical role as a core member of the mammalian cell cycle machinery. D-type cyclins (D1, D2, and D3) bind to and activate the cyclin-dependent kinases 4 and 6, which can then phosphorylate the retinoblastoma tumor suppressor gene products. This phosphorylation in turn leads to release or derepression of E2F transcription factors that promote progression from the G1 to S phase of the cell cycle. Among the D-type cyclins, cyclin D3 encoded by the CCND3 gene is one of the least well studied. In the present study, we have investigated the biochemistry of the proteolytic mechanism that leads to loss of cyclin D3 protein. Treatment of human prostate carcinoma PC-3-M cells with lovastatin and actinomycin D resulted in a loss of cyclin D3 protein that was completely reversible by the peptide aldehyde calpain inhibitor, LLnL. Additionally, using inhibitors for various proteolytic systems, we show that degradation of cyclin D3 protein involves the $Ca^{2+}$-activated neutral protease calpain. Moreover, the half-life of cyclin D3 protein half-life increased by at least 10-fold in PC-3M cells in response to the calpain inhibitor. We have also demonstrated that the transient expression of the calpain inhibitor calpastatin increased cyclin D3 protein in serum-starved NIH 3T3 cells. These data suggested that the function of cyclin D3 is regulated by $Ca^{2+}$-dependent protease calpain.

• Korean Journal of Agricultural and Forest Meteorology
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• v.9 no.2
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• pp.109-120
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• 2007

The information on flowpath, storage, residence time, and interactions of water and carbon transport in a catchment is the prerequisite to the understanding and predicting of water and carbon cycling in the mountainous landscapes of Korea. In this paper, along with some up-to-date results, we present the principal methods that are currently used in HydroKorea and CarboKorea research to obtain such information. Various catchment hydrological processes have been examined on the basis of the water table fluctuations, the end-member mixing model, the cross correlation analysis, and cosmogenic radioactive isotope activity. In the Gwangneung catchment, the contribution of surface discharge was relatively large, and the changes in the amount, intensity and patterns of precipitation affected both the flowpath and the mean residence time of water. Particularly during the summer monsoon, changes in precipitation patterns and hydrological processes in the catchment influenced the carbon cycle such that the persistent precipitation increased the discharge of dissolved organic carbon (DOC) concentrated in the surface soil layer. The improved understanding of the hydrological processes presented in this report will enable a more realistic assessment of the effects of climate changes on the water resource management and on the carbon cycling in forest catchments.

• Journal of the Korea Concrete Institute
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• v.28 no.6
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• pp.673-683
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• 2016

In recent years, frequent terror or military attack by explosion, impact, fire accidents have occurred. Particularly, World Trade Center collapse and US Department of Defense Pentagon attack on Sept. 11 of 2001. Also, nuclear power plant incident on Mar. 11 of 2011. These attacks and incidents were raised public concerns and anxiety of potential terrorist attacks on major infrastructures and structures. Therefore, the extreme loading researches were performed of prestressed concrete (PSC) member, which widely used for nuclear containment vessel and gas tank. In this paper, to evaluate the blast resistance capacity and its protective performance of bi-directional unbonded prestressed concrete member, blast tests were carried out on $1,400{\times}1,000{\times}300mm$ for reinforced concrete (RC), prestressed concrete without rebar (PSC), prestressed concrete with rebar (PSRC) specimens. The applied blast load was generated by the detonation of 55 lbs ANFO explosive charge at 1.0 m standoff distance. The data acquisitions not only included blast waves of incident pressure, reflected pressure, and impulse, but also included displacement, acceleration, and strains at steel, concrete, PS tendon. The results can be used as basic research references for related research areas, which include protective design and blast simulation under blast loading.

• Journal of the Korea Institute of Building Construction
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• v.17 no.3
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• pp.245-252
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• 2017

Recently, structures such as large retailers, outlets and warehouses have been increasing in accordance with changes in consumption patterns. Since these structures include ultra-flat slab members, they are thoroughly managed to control slab cracking by the plastic and drying shrinkage. In order to control the cracking of the slab member, a chemical crack reduction method is used. In particular, the use of the shrinkage reducing agent has been examined. However, domestic research results are limited. In this study, the shrinkage properties of concrete using shrinkage reducing agent and the drying shrinkage properties according to the mixing factors were investigated. The performance of domestic shrinkage reducing agent was appeared similar to that of overseas high-grade shrinkage reducing agent. As the shrinkage reducing agent usage increased, the drying shrinkage reduction effect increased. At the age of 100 days, the dry shrinkage rate of specimen with the shrinkage reducing agent of 1.5%was shown about half that of the specimen without the shrinkage reducing agent. The shrinkage reducing agent was gound to have no specific performance change for the use of the admixture.

• Journal of the Society of Disaster Information
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• v.15 no.4
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• pp.524-530
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• 2019

Purpose: In this paper, we construct a detailed three-dimensional interface element using a three-dimensional analysis program, and evaluate the composite behavior stability of the connector by applying physical properties such as the characteristics of general members and those of reinforced members Method: The analytical model uses solid elements, including non-linear material behavior, to complete the modeling of beam structures, circular flanges, bolting systems, etc. to the same dimensions as the design drawing, with each member assembled into one composite behavior linkage. In order to more effectively control the uniformity and mesh generation of other element type contact surfaces, the partitioning was performed. Modeled with 50 carbon steel materials. Results: It shows the displacement, deformation, and stress state of each load stage by the contact adjoining part, load loading part, fixed end part, and vulnerable anticipated part by member, and after displacement, deformation, The effect of the stress distribution was verified and the validity of the design was verified. Conclusion: Therefore, if the design support of the micro pile is determined based on this result, it is possible to identify the Vulnerable Parts of the composite behavior connector and the degree of reinforcement.

• Journal of Korean Foot and Ankle Society
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• v.25 no.4
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• pp.149-156
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• 2021

Purpose: Given the lack of definite evidence-based guidelines in clinical practice, there may be a wide variation in treatment protocols for osteochondral lesions of the talus (OLT). Based on the Korean Foot and Ankle Society (KFAS) member survey, this study aimed to report the current trends in the management of OLT. Materials and Methods: A web-based questionnaire containing 30 questions was sent to all KFAS members in September 2021. The questions were mainly related to clinical experience and preferences in diagnosis, conservative, and surgical treatments for patients with OLT. Answers with a prevalence of ≥50% of respondents were considered a tendency. Results: Sixty-two (11.3%) of the 550 surgeons queried responded to the survey. The responses to 9 (30.0%) of the total of 30 questions established a tendency. Answers exhibiting a tendency were as follows; additional diagnostic tools except for plain radiograph (magnetic resonance imaging), most common conservative treatment method (oral medication, rest), most important radiological factor in decision making for surgical treatment and method (size of the lesion, ankle instability, loose bodies), most important patient factors in decision making for surgical treatment and method (age, activity or occupation), infrequently requiring posterior arthroscopy (less than 3%), most common revision surgery for failed bone marrow stimulation procedure (osteochondral autograft transplantation [OAT]), not requiring additional procedure for donor site in OAT, the main reason for unsatisfactory result after OAT (persistent pain without radiological abnormality), no generalization of autologous chondrocyte implantation or chondrogenesis using stem cells. Conclusion: This study presents updated information on current trends in the management of OLT in Korea. Both consensus and variations in the approach to patients with OLT were revealed through this survey. Since recent biologic efforts to regenerate cartilage have been unsuccessful, further studies to identify clinical evidence would be needed.

• Journal of Korean Tunnelling and Underground Space Association
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• v.25 no.2
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• pp.43-63
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• 2023

With the concentration of the population in the city center and the saturation of the structures on the ground, the development of the underground structures becomes important and the construction of an adjoining tunnel that can reduce the overall problems is respected. In addition, it is necessary to apply the reinforcement construction method for the pillar part of the adjacent tunnel that can secure stability, economy and workability of the site. In this study, the tunnel pillar reinforcement method using prestress and grouting was reviewed. There are various reinforcement methods that can compensate for the problems of the side tunnel, but as the tunnel pillar construction method using prestress and grouting is judged to be excellent in field applicability, stability and economic feasibility, theoretical and numerical analysis of the actual behavior mechanism are conducted. Numerical analysis is divided into PC stranded wire + steel pipe reinforcement grouting + prestress (Case 1), pillar part tie bolt reinforcement (Case 2), pillar part non-reinforcement (Case 3) under the same ground conditions, and the maximum value of the celling displacement, internal displacement, and member force, the stability was confirmed. Through numerical analysis, it was confirmed that Case 1 which reinforced the PC stranded wire, was the best construction method and if it is verified and supplemented through field experiments later, it will be possible to derive superior results in terms of displacement control and member force than the currently applied reinforcement method was judged.

• Journal of the Korean Geosynthetics Society
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• v.22 no.1
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• pp.53-66
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• 2023

In this study, the results of the elasto-plastic beam analysis, finite element analysis and optimization design of the steel pipe sheet pile applied as an earth retaining wall under the deep excavation were presented. Through this study, it was found that the high-strength and sea resistant steel pipe has high allowable stress, excellent structural properties, favorable corrosion, and high utilization as an earth retaining wall, and the C-Y type joint has significantly improved the tensile strength and stiffness compared to the traditional P-P type. In addition, it was investigated that even if the leak or defect of the wall occurs during construction, it has the advantage of being able to be repaired reliably through welding and overlapping. In the case of steel pipe wall, they were evaluated as the best in views of the deep excavation due to the large allowable bending stress and deformation flexibility for the same horizontal displacement than CIP or slurry wall. Elasto-plastic and finite element analysis were conducted in consideration of ground excavation under large-scale earth pressure (uneven pressure), and the results were compared with each other. Quantitative maximum value were found to be similar between the two methods for each item, such as excavation behavior, wall displacement, or member force, and both analysis method were found to be applicable in design for steel pipe sheet pile wall. Finally, it was found that economical design was possible when determining the thinnest filling method with concrete rather than the thickest hollow shape in the same diameter, and the depth (the embedded length through normality evaluation) without rapidly change in displacement and member force.

• 한국노년학
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• v.31 no.4
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• pp.999-1014
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• 2011

The purpose of this study is to examine the effects of long-term care insurance(macro-system) on family relationship(micro-system)s' change based on ecosystems theory. Data come from the second(2007) and the fourth(2009) Korean Welfare Panel Study(KWPS). Experimental group is the beneficiary using long-term care insurance and the member of household in their households, and control group is the non-beneficiary not using long-term care insurance and the member of household in their households. The main findings of difference-in-difference model analysis are as follows. First, the ecosystems theory is a theory examining the correlation between long-term care insurance and family relationship. Second, the effects of long-term care insurance is not income effect but independent effect. This result shows that the meaning of family has faded away and family relationship has been weaken and that long-term care insurance has not complete characteristics as a social insurance. Thus, system reforms of long-term care insurance is highly needed for system comprehensiveness, coverage, adequacy, and service accessibility and is changed into family-friendly social policy.