• Biomolecules & Therapeutics
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• v.23 no.1
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• pp.31-38
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• 2015

Histone acetylation plays a critical role in the regulation of transcription by altering the structure of chromatin, and it may influence the resistance of some tumor cells to tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) by regulating the gene expression of components of the TRAIL signaling pathway. In this study, we investigated the effects and molecular mechanisms of trichostatin A (TSA), a histone deacetylase inhibitor, in sensitizing TRAIL-induced apoptosis in Caki human renal carcinoma cells. Our results indicate that nontoxic concentrations of TSA substantially enhance TRAIL-induced apoptosis compared with treatment with either agent alone. Cotreatment with TSA and TRAIL effectively induced cleavage of Bid and loss of mitochondrial membrane potential (MMP), which was associated with the activation of caspases (-3, -8, and -9) and degradation of poly (ADP-ribose) polymerase (PARP), contributing toward the sensitization to TRAIL. Combined treatment with TSA and TRAIL significantly reduced the levels of the cellular Fas-associated death domain (FADD)-like interleukin-$1{\beta}$-converting enzyme (FLICE) inhibitory protein (c-FLIP), whereas those of death receptor (DR) 4, DR5, and FADD remained unchanged. The synergistic effect of TAS and TRAIL was perfectly attenuated in c-$FLIP_L$-overexpressing Caki cells. Taken together, the present study demonstrates that down-regulation of c-FLIP contributes to TSA-facilitated TRAIL-induced apoptosis, amplifying the death receptor, as well as mitochondria-mediated apoptotic signaling pathways.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.18 no.5
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• pp.1215-1223
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• 2014

In multi-hop wireless networks, a message transmission path is set up on demand by a route discovery step, where a shortest path is used in general. The shortest path, however, normally uses the nodes near the center area, which causes a high traffic load in that area and reduces the message transmission reliability. We propose a stable routing protocol considering the remaining energy of nodes. Our protocol uses ETX as a link performance estimator and tries to avoid the nodes with smaller energy. By doing this, we can reduce the route failure probability and packet loss. We have evaluated the performance of the proposed protocol using QualNet and compared with AODV and MRFR protocols. The simulation result shows that our protocol has a similar performance as MRFR in terms of end-to-end message reception ratio, average message delay and delay jitter, but outperforms MRFR in terms of traffic load distribution.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• v.22 no.12
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• pp.1086-1096
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• 2011

In this paper, we present the trisection band-pass filter with a transmission zero at 2.63 GHz, which has a center frequency of 2.44 GHz, relative bandwidth of 5 %, and return loss of 18 dB, based on a multi-port ElectroMagnetic simulation. The coupling matrix for the trisection filter is calculated and this filter is transformed into band-pass filter prototype through a lossless 2-port circuit transformation. The J-inverter values and slope parameters of each individual resonator are computed using an EM simulation Y-parameters of the filter with multi port. The dimensions of desired filter are determined by matching the computed J-inverter and susceptance slope parameters to those of the prototype band-pass filter. Undesired cross-couplings are found to occur which does not appear in the prototype trisection filter. To overcome the problem of undesired couplings, the filter was optimized to satisfy the same frequency response of prototype filter. The validity of the proposed design method was verified through the implementation of the designed and optimized filter.

• Tribology and Lubricants
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• v.28 no.1
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• pp.12-18
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• 2012

This application study of a swash-plate type axial piston pump was concerned about the lubrication characteristics between cylinder barrel and valve plate which are the main rotating body and its opposite sliding part respectively. A computer simulation was implemented to assess bearing and sealing functions of the fluid film between cylinder barrel and valve plate. A numerical algorithm was developed to facilitate simultaneous calculations of dynamic cylinder pressure, 3 degree-of-freedom barrel motions considering inertia effect, and fluid film pressure assuming full fluid film lubrication regime. Central clearance, tilt angle, and azimuth angle of the rotating body were calculated for each time step. Surface waviness was found to be an influential factor due to the small fluid film thickness which can appear in flat land bearings. Five surface lays which can form on the lubrication surface in accordance with machining process were defined and analyzed using the simulation tool. Oil leakage flow and frictional torque in the fluid film between cylinder barrel and valve plate were also calculated to discuss in the viewpoint of energy loss. The simulation results showed that in actual sliding conditions proper surface non-flatness can make a positive effect on the energy efficiency and reliability of the thrust bearing.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.13 no.10
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• pp.4801-4806
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• 2012

There are still problems have to solve for safety of driving comparing to the upgraded convenience of advanced vehicle. Most traffic accident is by uncareful driving cause of interface operations which are directive reasons of it in controlling the complicate multimedia device. According to interesting in smart automobile, various approaches for safe driving have been studied. The current multimedia interface embedded in vehicle is lacking the safety due to loss the sense and operation capacity by instantaneous view movement. In this paper, we propose a safe dialing system for safe driving to control dial and search dictionary by hand-gesture. The proposed system improved the user convenience and safety in automobile operation using intuitive gesture and TTS(Text to Speech).

• Publications of The Korean Astronomical Society
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• v.27 no.4
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• pp.117-122
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• 2012

The interstellar dust grains are formed and supplied to interstellar space from asymptotic giant branch (AGB) stars or supernova remnants, and become constituents of the star- and planet-formation processes that lead to the next generation of stars. Both a qualitative, and a compositional study of this cycle are essential to understanding the origin of the pre-solar grains, the missing sources of the interstellar material, and the chemical evolution of our Galaxy. The AKARI/MIR all-sky survey was performed with two mid-infrared photometric bands centered at 9 and $18{\mu}m$. These data have advantages in detecting carbonaceous and silicate circumstellar dust of AGB stars, and the interstellar polycyclic aromatic hydrocarbons separately from large grains of amorphous silicate. By using the AKARI/MIR All-Sky point source catalogue, we surveyed C-rich and O-rich AGB stars in our Galaxy, which are the dominant suppliers of carbonaceous and silicate grains, respectively. The C-rich stars are uniformly distributed across the Galactic disk, whereas O-rich stars are concentrated toward the Galactic center, following the metallicity gradient of the interstellar medium, and are presumably affected by the environment of their birth place. We will compare the distributions of the dust suppliers with the distributions of the interstellar grains themselves by using the AKARI/MIR All-Sky diffuse maps. To enable discussions on the faint diffuse interstellar radiation, we are developing an accurate AKARI/MIR All-Sky diffuse map by correcting artifacts such as the ionising radiation effects, scattered light from the moon, and stray light from bright sources.

• Journal of Forest and Environmental Science
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• v.29 no.1
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• pp.58-70
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• 2013

Iriai an Indigenous forest management system in Japan from the viewpoint of "common pool resources" was a success resilient institution and resulted with sustainable production system and environmental conservation. This study was conducted in Osawa of the Nagano prefecture through group discussions, field observations and an in-depth field survey. Osawa Property Ward Forest is managed under the concept very much similarly to traditional "Iriai". This study firstly examined the changes of collective forest management system in terms of awareness and interest in forest management; forest management activities; role of forest; and collection of forest products. Then it analyzed the current threats for collective forest management have been identified as: land abandonment due to loss of benefits and lack of active community participation; deterioration of forest environment particularly the micro-climate and aesthetic values; conflict with local government authorities restraining the use of money in property ward forest and conflict with outsiders on damping of the garbage. Community cantered forestry management rules; livelihood contribution; protection of environment; local initiatives for protection and economic activities are the prevailing opportunities for collective forest management. The main requirements for revitalization of collective forest management are explained as local reciprocity; imposition of community based forest rules; encouraging local innovations; and building partnerships with stakeholders. Collective forest management system addresses the limitations of conventional forestry models, which had invalidated traditional 'iriai' institutions, and key to restoring sustainable use of forest and environmental resources. Cross-institutional collaborations together with responsibilities of local communities would ensure the revitalization of forest resources.

• Asian Pacific Journal of Cancer Prevention
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• v.13 no.11
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• pp.5445-5450
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• 2012

Although benign uterine leiomyomata (LMA) is the most common reproductive tumor in premenopausal women, its etiology is largely unknown. We aimed in the present study to demonstrate the potential role of environmental factors with estrogenic activity in tumor etiology by focusing on the role of aryl hydrocarbon receptor (AhR) which mediates the effects of many environmental endocrine disruptors and contributes to the loss of normal ovarian function in polluted environments. This case-control study aimed to compare the interactions between AhR and lifestyle factors in a clinical setting for the first time among 138 newly diagnosed LMA patients and 138 normal controls who lived in Tehran and Mashhad, respectively, during the last 10 years. To conduct immunohistochemical studies using appropriate monoclonal antibodies, 30 cases were selected retrospectively from 2009-2011 from the pathology departments of two university hospitals in Tehran. Although the levels of sex steroid receptors were similar in adjacent myometrium and uterine leiomyomas of all cases, AhR was significantly overexpressed (p=0.034, OR=1.667) in uterine LMA and this overexpression was correlated with living in Tehran [(p=0.04, OR=16 (1.216-210.58)], smoking[P=0.04, OR=2.085 (1.29-3.371)], living near polycyclic aromative hydrocarbon producing companies [p=0.007, OR=2.22 (1.256-3.926)] and eating grilled meat [p=0.042, OR=1.28 (1.92-3.842)]. Our study contributes to the understanding of the effects of EDCs on AhR levels as well as women's health and points out possible risk factors for the development and growth of uterine LMA. It seems that the development of LMA could be the result of interactions between hormonal and environmental factors.

• Journal of the Microelectronics and Packaging Society
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• v.17 no.4
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• pp.19-26
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• 2010

We found that saturated water vapor pressure is the most dominant stress factor for the degradation phenomenon in the package for high-power phosphor-converted white light emitting diode (high power LED). Also, we proved that saturated water vapor pressure is effective acceleration stress of LED package degradation from an acceleration life test. Test conditions were $121^{\circ}C$, 100% R.H., and max. 168 h storage with and without 350 mA. The accelerating tests in both conditions cause optical power loss, reduction of spectrum intensity, device leakage current, and thermal resistance in the package. Also, dark brown color and pore induced by hygro-mechanical stress partially contribute to the degradation of LED package. From these results, we have known that the saturated water vapor pressure stress is adequate as the acceleration stress for shortening life test time of LED packages.

• The Journal of the Institute of Internet, Broadcasting and Communication
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• v.15 no.4
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• pp.105-117
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• 2015

In this paper, we consider 19 cells with the two tiers for polar-rectangular coordinates (PRCs) and provide the cell edge performance of cellular networks based on distance from cell center i.e., BS (base station). When FFR is applied(or adopted) to cell edge, it is expected that BS cooperation, or a coordinated multipoint (CoMP) multiple access strategy will further improve the system performance. We proposed a new method to evaluate the sum rate capacity of the MIMO DC of multicell system. We improve the performance of cell edge users for intercell interference cancelation in cooperative downlink multicell systems. Simulation results show that the proposed scheme outperforms the reference schemes, in terms of cell edge SINR (signal-to-interference-noise ratio) with a minimal impact on the network path loss exponent. We show 13 dB improvements in cell-edge SINR by using reuse of three relative to reuse of one. BS cooperation has been proposed to mitigate the cell edge effect.