• Korean Journal of Veterinary Research
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• v.49 no.1
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• pp.1-8
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• 2009

The ubiquitin-proteasome mediated protein degradation pathway plays an important role in regulating both cell proliferation and cell death. Proteasome inhibitors are well known to induce apoptosis in various human cancer cell lines. We investigated the effect of combined treatment with proteasome inhibitor and TRAIL, and a possible mechanism of the enhancing apoptosis by the both treatment, on TRAIL-resistant non-small cell lung cancer. A549 cells were exposed to the N-Acetyl-Leu-Leu-Norleu-al (ALLN) as a proteasome inhibitor and then treated with recombinant TRAIL protein. In A549 cells under proteasome inhibition conditions by pretreatment with ALLN, TRAIL treatment significantly decreased cell viability compared to that ALLN and TRAIL alone treatment. Also, the both treatment induced cell damage through DNA fragmentation and p53 expression. In addition, the combined treatment of both markedly increased caspase-8 activation, especially the exposure for 2 h, and Bax expression and induced the dissipation of mitochondrial transmembrane potential in A549 cells. Taken together, these findings showed that proteasome inhibition by ALLN enhanced TRAIL-induced apoptosis via DNA degradation by activated P53 and mitochondrial transmembrane potential loss by caspase-8 activation and bax expression. Therefore, our results suggest that proteasome inhibitor may be used a very effectively chemotherapeutic agent for the tumor treatment, especially TRAIL-resistant tumor cell.

• THE INTERNATIONAL COMMERCE & LAW REVIEW
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• v.37
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• pp.277-327
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• 2008

This paper is to provide for an analysis on the trade adjustment assistance program and the Case study affected by international trade and FTA. The paper offers a legal study on analysis about Korea's Trade Adjustment Assistance Law for the Manufacturing Industries, USA's TAA. and Japan's law for Industry revival. In general, USA's TAA measures are defined as assistance actions for business enterprises, farmers and manufacturing industries workers. We exclude farmers and fishermen under Korea's Trade Adjustment Assistance Law for the Manufacturing Industries's business enterprises and workers, but we give them the systemic supports under korea's special assistance law for the farmers and fishermen and so on after FTA. Especially this focuses on the trade adjustment assistance case about both Korea's agriculture-farmer assistance from FTA and USA's TAA from workers in layoffs of trade-impacted communities. Korea has provided TAA to the sphere of agriculture after special legislation in Korea-Chile helping closed orchard, modernizing high quality producing facility for agriculture competition, producing superior fruit saplings, and constructing the distribution center in the producing district. But for US-Korea FTA and rapid increase of import by FTA expansion, we must prepare such indemnity systems for loss as cash benefit and wider aids for closed farm. The USA's TAA program targets manufacturing workers affected by international trade, who may have fewer transferable skills and face greater challenges to reemployment than other dislocated workers. A large majority sought some assistance from their one-stop center. Relatively small numbers chose to enroll in training, but those who did it often used this opportunity to chart a new career path. Finally, we learned the importance of education and discipline from USA cases. The fast and accurate information providing can raise efficiencies. The infrastructure can maximize the effect of TAA. The effective application would help us get over difficulties of TAA at hand.

• Journal of the Institute of Electronics Engineers of Korea TC
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• v.49 no.7
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• pp.65-70
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• 2012

In this paper, a compact UWB (Ultra Wideband) BPF(Band-Pass Filter) with dual notched bands is proposed using a hybrid Composited Right-Left Handed (CRLH) and Defected Ground Structure (DGS). To avoid the interferences such as Wireless LAN (Center frequency: 2.4GHz and 5.8GHz), the CRLH is employed to obtain the dual notched bands and the DGS is used to obtain the wide stop-band above the pass-band. The fabricated filter has good performance and has more than 30dB rejection at the center frequency of 2.4 GHz and 5.8GHz. The dual notched bands are easily movable by changing the CRLH parameter. Also the insertion loss is less than 0.4dB in the lower pass-band and 0.7dB in the upper pass-band, and it has small group delay variation less than 0.6ns. The size of the fabricated filter is very compact (17mm*17mm).

• Polymer(Korea)
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• v.37 no.5
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• pp.656-662
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• 2013

The flexible patterned cover film was made by a simple solution coating process using polymethyl methacrylate (PMMA) solution with glass beads. The effect of patterned cover film on the efficiency of solar cell has been investigated. It was found that the relative solar cell efficiency increased up to 3.4% with the incident light angle between $0-90^{\circ}$ by the sphere shape of glass bead coated on the film surface. This was understood that the loss of transmittance and scattering due to the light directional dependency on solar cell were minimized because the light entered glass beads normal to its surface regardless of incident light angle. The maximum relative solar cell efficiency was achieved when glass bead shape on the film is hemisphere and the relative efficiency increased with increasing the amount of glass bead on the film surface. However, too much glass beads on the film surface resulted in the lower relative solar cell efficiency due to the lowering of transmittance as well as the occurring of light interference.

• The KSFM Journal of Fluid Machinery
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• v.20 no.2
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• pp.53-62
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• 2017

In this paper, the effect of oil conditions in rotor dynamic behaviors of a FFRB (Fully-Floating Ring Bearing) is investigated. Through the characteristic of a FFRB has two films, it has several advantages such as less friction loss and better stability over a wide speed range. However, it is difficult to supply a oil to the inner film. Thus, turbocharger makers have been paid significant attention to the lubrication of a FFRB because of its importance. This work focuses on the influence of oil inlet pressure and temperature. The methodologies of computational simulation and experimental test were used to estimate the rotor dynamic behaviors. In experimental test, the single-scroll turbocharger for the 1.4L diesel engine was used. The results show that the oil inlet pressure and temperature will place considerable influence on the rotor response. Oil conditions affect RSR (Ring Speed Ratio) which is cause of sub-synchronous vibrations, which also cause of oil whirling and whip even a critical speed. At higher speed range, the phenomenon of self-excited vibrations which is cause of instability of fluid whirl is investigated through the orbit shapes that consist of small orbit and large amplitude orbit. It is shown that some performance of a FFRB can be controlled by the conditions of oil supply. Finally, it was revealed that the oil induced operating conditions will strongly affect the turbocharger rotor dynamics behaviors.

• Journal of Korean Medicine Rehabilitation
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• v.30 no.4
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• pp.89-103
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• 2020

Objectives This study has been conducted to verify frequently used herbs and herbal formulas to treat obesity in Korea during 2015 to 2019. Methods Publications related to treatment of obesity using herbal medicines from 2015 to 2019 were retrieved from 12 databases (PubMed, EMBASE, Scopus, China National Knowledge Infrastructure [CNKI], Koreanstudies Information Service System [KISS], National Digital Science Library [NDSL], Research Information Sharing Service [RISS], DBPIA, KMBASE, KoreaMed, KoreanTK, Oriental Medicine Advanced Searching Integrated System [OASIS]). Extracted articles were analyzed in terms of publication year, journal, and type of herbs. Results A total of 136 studies have been included in this study. 33 herbal formulaes and 129 herbs have been analyzed. Taeyeumjowui-tang was the most frequently studied herbal formulae and Ephedrae Herba was the most frequently studied herb. Ginseng Radix was the most frequently studied single herb in isolation from herbal formulae. Conclusions These results suggest that various herbs and herbal formulae can be used to treat obesity. Since this study includes every type of study, additional studies based on clinic are thought to be necessary.

• Korean Journal of Health Education and Promotion
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• v.20 no.1
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• pp.203-218
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• 2003

In aging Korean society, many elderly people have difficulty in the areas of health, economic insecurity, role-loss(both work & spouse), loneliness, and family conflicts. Above all, retirement from work is one of the most important stressful life events having influences an elderly's persons economic & social activities, mental state, health status, and Lifelong educational programs could help the aged cope with these situations in later life. Health and social welfare are commonly recognized as an important value of life. They also have an effect on each other. Most people agree that the promotion of health and social welfare is to take a short-cut toward achieving well-being. Thus we need to develop a substantially integrated program of lifelong education, before and after retirement, for the promotion of health and welfare. Universities have the advantage of practicing lifelong educational programs because they have more material, intellectual, and human resources than any other educational facilities. As a result, the purposed of this study is to suggest life-long educational programs for promoting both health conditions and the level of social welfare by utilizing an aging center affiliated with a university. Specifically, the developmental courses of pre-retirement, learning in retirement, elder-hostels, and the connection between pre and post-retirement educational programs are proposed in this study.

• Journal of the Korean Institute of Gas
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• v.16 no.2
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• pp.60-66
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• 2012

With diversification of research and development activity according to fusion of state-of-the-art technology, potential hazard and risk factors in new forms have been increased in the laboratories. Also, as there are many cases where the experimental condition is extremely high/low temperature and pressure, many many accidents producing loss of life and/or injuries occur due to the extreme condition. In this study, The common fact questionnaire as the survey tool for the establishment of the accident prevention countermeasure in laboratory have been developed to safety security of the laboratory workers. The current status of chemical materials and the realization of important on laboratory safety management using the questionnaire investigated by an electronic mail and visiting survey in the laboratories and universities. The collected data was analyzed with Excel program and it can be utilized as basic data for accident prevention in laboratories.

• Korean Institute of Interior Design Journal
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• v.17 no.2
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• pp.111-121
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• 2008

In recent years, Korean population aged 65 and over has grown faster(7.2% in 2000, 14.4% projected in 2018 and 20.0% in 2026) than the other age groups and average life expectancy has increased from 65.8 years in 1980 to 75.9 years in 2000. The Aging Simulation Center(ASC) was built for people to give educational chance for further understanding of the elderly and the environment for the aged. People are able to recognize the changes including hearing loss, vision changes, and changes in the ability to touch and move after experiencing the simulated daily life of older persons. In general, ASC is composed of residential setting area and exhibition area of daily commodities for the elderly and care person. Currently, there are four ASCs in Korea. The purpose of this study is to evaluate the characteristics of space design and design elements of ASCs and to suggest design implementation for better residential environment for the elderly. For the research purpose, design characteristics such as floor plans and spatial design elements of three ASCs were analyzed and compared. As a whole, space design of three ASCs was almost same without distinguished characteristics. The major finding of this study indicates that the ASC is considerably helpful environment to understand aging. However, some of design elements such as lighting should be supplemented for safety issue. It is recommended for future design of ASC to include exterior space including outdoor stairs, paths and roads and so on. In addition, reception and preparation area should be arranged with universally designed furniture.

• Bulletin of the Korean Chemical Society
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• v.32 no.10
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• pp.3675-3681
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• 2011

Fusarium oxysporum, an important pathogen that mainly causes vascular or fusarium wilt disease which leads to economic loss. Disruption of gene encoding a heterotrimeric G-protein-${\beta}$-subunit (FGB1), led to decreased intracellular cAMP levels, reduced pathogenicity, colony morphology, and germination. The plant defense protein, Nicotiana alata defensin (NaD1) displays potent antifungal activity against a variety of agronomically important filamentous fungi. In this paper, we performed a molecular modeling and docking studies to find vital amino acids which can interact with various antifungal compounds using Discovery Studio v2.5 and GRAMMX, respectively. The docking results from FGB1-NaD1 and FGB1-antifungal complexes, revealed the vital amino acids such as His64, Trp65, Ser194, Leu195, Gln237, Phe238, Val324 and Asn326, and suggested that the anidulafungin is a the good antifungal compound.The predicted interaction can greatly assist in understanding structural insights for studying the pathogen and host-component interactions.