• Journal of Korean Neurosurgical Society
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• v.67 no.5
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• pp.510-520
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• 2024

Objective : Parkinson's disease (PD) is one of the most prevalent neurodegenerative diseases, characterized by the loss of dopaminergic neurons in the substantia nigra pars compacta. The treatment of PD aims to alleviate motor symptoms by replacing the reduced endogenous dopamine. Currently, there are no disease-modifying agents for the treatment of PD. Zebrafish (Danio rerio) have emerged as an effective tool for new drug discovery and screening in the age of translational research. The neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is known to cause a similar loss of dopaminergic neurons in the human midbrain, with corresponding Parkinsonian symptoms. L-type calcium channels (LTCCs) have been implicated in the generation of mitochondrial oxidative stress, which underlies the pathogenesis of PD. Therefore, we investigated the neuro-restorative effect of LTCC inhibition in an MPTP-induced zebrafish PD model and suggested a possible drug candidate that might modify the progression of PD. Methods : All experiments were conducted using a line of transgenic zebrafish, Tg(dat:EGFP), in which green fluorescent protein (GFP) is expressed in dopaminergic neurons. The experimental groups were exposed to 500 μmol MPTP from 1 to 3 days post fertilization (dpf). The drug candidates : levodopa 1 mmol, nifedipine 10 μmol, nimodipine 3.5 μmol, diethylstilbestrol 0.3 μmol, luteolin 100 μmol, and calcitriol 0.25 μmol were exposed from 3 to 5 dpf. Locomotor activity was assessed by automated tracking and dopaminergic neurons were visualized in vivo by confocal microscopy. Results : Levodopa, nimodipine, diethylstilbestrol, and calcitriol had significant positive effects on the restoration of motor behavior, which was damaged by MPTP. Nimodipine and calcitriol have significant positive effects on the restoration of dopaminergic neurons, which were reduced by MPTP. Through locomotor analysis and dopaminergic neuron quantification, we identified the neuro-restorative effects of nimodipine and calcitriol in zebrafish MPTP-induced PD model. Conclusion : The present study identified the neuro-restorative effects of nimodipine and calcitriol in an MPTP-induced zebrafish model of PD. They restored dopaminergic neurons which were damaged due to the effects of MPTP and normalized the locomotor activity. LTCCs have potential pathological roles in neurodevelopmental and neurodegenerative disorders. Zebrafish are highly amenable to high-throughput drug screening and might, therefore, be a useful tool to work towards the identification of disease-modifying treatment for PD. Further studies including zebrafish genetic models to elucidate the mechanism of action of the disease-modifying candidate by investigating Ca2+ influx and mitochondrial function in dopaminergic neurons, are needed to reveal the pathogenesis of PD and develop disease-modifying treatments for PD.

• Food Science and Biotechnology
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• v.17 no.1
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• pp.118-122
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• 2008

The use of tartary buckwheat flour as a source of dietary rutin has been limited because of the enzymatic degradation of rutin during the dough-making process, which results in a bitter taste. A variety of pretreatment regimes, including heating, steaming, boiling, and extruding, were evaluated in relation to the inactivation of the rutin-degrading enzyme responsible for rutin loss and color change during dough-making. Steaming (120 see), boiling (90 see) buckwheat grains, or extruding (180 rpm/min at $140^{\circ}C$) the flour resulted in the retention of >85% of the original rutin and eliminated the bitter taste in the hydrated flours. In contrast, dry heating at $140^{\circ}C$ for 9 min or microwaving at 2,450 MHz for 3 min did not reduce the rutin loss, and the bitter taste remained. Unlike in the flour, the rutin degradation in water-soaked grains was insignificant at room temperature. Moreover, the samples treated by steaming, boiling, or extrusion were darker and more reddish in color.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• v.24 no.3
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• pp.270-277
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• 2013

In this paper, we propose a wideband ridge SIW(Ridge Substrate Integrated Waveguide)-to-SIW(Substrate Integrated Waveguide) transition. The proposed transition structure is designed to acquire a wide bandwidth by inserting through via holes at the regular interval for an impedance matching and an E-field mode matching method. The measurement results show a fractional bandwidth is 29.1 % at 20 dB return loss from the center frequency(11 GHz). The maximum insertion loss is 0.49 dB from 9.21 GHz to 12.41 GHz.

• Transactions of the Korean Society for Noise and Vibration Engineering
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• v.23 no.6
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• pp.553-562
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• 2013

Vehicle vibrations arise from engine and road surface excitations. The engine mount system of a passenger car sustains the engine weight and insulates the excitation force from the engine system. The dynamic properties of viscoelastic material used for the vehicle engine mounts have large variation due to environmental factors such as environmental temperature and humidity etc. The present study aims to investigate the variability of dynamic characteristics in rubber engine mounts considering both environmental temperature change and material model errors/uncertainty. The engine mounts for a passenger car were modeled using finite element method. Then, the dynamic stiffness variability of the engine mounts were estimated using Monte Carlo simulation method. In order to estimate the variations in the storage and loss moduli of the viscoelastic materials, the material properties of the synthetic rubber were expressed as a fractional-derivative model. Next, in order to simulate the uncertainty propagation of the dynamic stiffness for the engine mounts due to the storage and loss moduli variations, the Monte Carlo simulation was used. The Monte Carlo simulation results showed large variation of the engine-mount stiffness along frequency axis.

• Transactions of the Korean Society of Automotive Engineers
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• v.19 no.1
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• pp.139-146
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• 2011

In present study, it aims to compare the noise and vibration characteristics between magnesium alloy and steel hood panel. The AZ31 magnesium hood panel was fabricated through warm forming process, and the noise and vibration characteristics between both hood panels was compared through the measurement of engine radiation noise and transmission loss, as well as FRF on modal analysis. The sound insulation performance of magnesium alloy was wholly superior to that of steel hood panel, even though the transmission loss of magnesium alloy is lower than that of steel due to mass effect primarily. The FRF characteristics on modal analysis indicates that the resonance frequency of magnesium hood panel is remarkably increased to higher value than that of steel hood panel. The radiation and interior noise of magnesium panel even without acoustic hood insulation were remarkably lower than those of steel hood panel with acoustic insulation, in particular, at a range below 4,000 rpm.

• The Journal of The Korea Institute of Intelligent Transport Systems
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• v.12 no.6
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• pp.37-43
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• 2013

In this paper, an UWB (Ultra Wide Band) band-pass filter with open stubs using SIR (Stepped Impedance Resonator) structure is presented. The proposed band pass filter (BPF) has SIR structure instead of open stubs for UWB application with low insertion loss. The bandwidth of the proposed BPF is 103 % at the center frequency of 5.8GHz and the insertion and return losses are 0.17dB and 13.1dB, respectively. Also, the entire size of the proposed band-pass filter is $21.6{\times}17.8mm^2$.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• v.12 no.2
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• pp.165-175
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• 2001

In this paper, it is analyzed lumped element isolators analytically by the analysis program using scattering matrixes including ferrite saturation magnetization, external direct current magnetic field and strip line length and width, designed and experimented the small isolator of mobile phone. The simulation results show that the characteristics of the isolator are affected by external R, C, length and width of strip line and ferrite width and saturation magnetization sensitivity. We proposed the isolator specification applied cellular and PCS mobile phones, experimented the isolator for cellular mobile phones. From the experimented result, isolation and return loss are measured below 20 dB, insertion loss is below 0.7 dB, bandwidth is about 44 MHz at center frequency 836.5 KHz. The implemented isolator has better performances than the conventional one.

• The Journal of The Korea Institute of Intelligent Transport Systems
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• v.4 no.3 s.8
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• pp.73-78
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• 2005

In this paper, a bandpass filter with excellent cut off characteristic due to transmission zero using bypass coupling capacitor and with superior harmonic characteristic by interdigital capacitor is suggested. The measurement results for SIR bandpass filter with bypass coupling capacitor and interdigital capacitor show that the insertion loss is less than 1.9 dB and the return loss is better than 15.4 dB with 4.2 % bandwidth at the center frequency of 5.78 GHz.

• Journal of Biomedical Engineering Research
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• v.28 no.6
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• pp.732-743
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• 2007

Background noise is one of the major complaints of not only hearing impaired persons but also normal listeners. This paper describes the results of two experiments in which speech recognition performance was determined for listeners with normal hearing and sensorineural hearing loss in noise environment. First, we compared speech enhancement algorithms by evaluation speech recognition ability in various speech-to-noise ratios and types of noise. Next, speech enhancement algorithms by reducing background noise were presented and evaluated to improve speech intelligibility for sensorineural hearing impairment listeners. We tested three noise reduction methods using single-microphone, such as spectrum subtraction and companding, Wiener filter method, and maximum likelihood envelop estimation. Their responses in background noise were investigated and compared with those by the speech enhancement algorithm that presented in this paper. The methods improved speech recognition test score for the sensorineural hearing impaired listeners, but not for normal listeners. The results suggest the speech enhancement algorithm with the loudness compression can improve speech intelligibility for listeners with sensorineural hearing loss.

• The Journal of Advanced Prosthodontics
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• v.7 no.3
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• pp.207-213
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• 2015

PURPOSE. The purpose of this study was to examine the abutment screw stability of screw- and cement-retained implant-supported dental prosthesis (SCP) after simulated cement washout as well as the stability of SCP cements after complete loosening of abutment screws. MATERIALS AND METHODS. Thirty-six titanium CAD/CAM-made implant prostheses were fabricated on two implants placed in the resin models. Each prosthesis is a two-unit SCP: one screw-retained and the other cemented. After evaluating the passive fit of each prosthesis, all implant prostheses were randomly divided into 3 groups: screwed and cemented SCP (Control), screwed and non-cemented SCP (Group 1), unscrewed and cemented SCP (Group 2). Each prosthesis in Control and Group 1 was screwed and/or cemented, and the preloading reverse torque value (RTV) was evaluated. SCP in Group 2 was screwed and cemented, and then unscrewed (RTV=0) after the cement was set. After cyclic loading was applied, the postloading RTV was measured. RTV loss and decementation ratios were calculated for statistical analysis. RESULTS. There was no significant difference in RTV loss ratio between Control and Group 1 (P=.16). No decemented prosthesis was found among Control and Group 2. CONCLUSION. Within the limits of this in vitro study, the stabilities of SCP abutment screws and cement were not significantly changed after simulated cement washout or screw loosening.