• Journal of the Korean Data and Information Science Society
• /
• 제23권6호
• /
• pp.1271-1277
• /
• 2012

In this paper, we propose an estimation method of the parameter in an exponential distribution based on a progressive Type I interval censored sample with semi-missing observation. The maximum likelihood estimator (MLE) of the parameter in the exponential distribution cannot be obtained explicitly because the intervals are not equal in length under the progressive Type I interval censored sample with semi-missing data. To obtain the MLE of the parameter for the sampling scheme, we propose a method by which progressive Type I interval censored sample with semi-missing data is converted to the progressive Type II interval censored sample. Consequently, the estimation procedures in the progressive Type II interval censored sample can be applied and we obtain the MLE of the parameter and survival function. It will be shown that the obtained estimators have good performance in terms of the mean square error (MSE) and mean integrated square error (MISE).

• Communications for Statistical Applications and Methods
• /
• 제7권1호
• /
• pp.245-256
• /
• 2000

Large sample properties of Life-Table estimator are discussed for interval censored bivariate survival data. We restrict out attention to the situation where response times within pairs are not distinguishable and the univariate survival distribution is the same for any individual within any pair.

• Communications for Statistical Applications and Methods
• /
• 제23권4호
• /
• pp.343-353
• /
• 2016

In doubly-censored data, an originating event time and a terminating event time are interval-censored. In certain analyses of such data, a researcher might be interested in the elapsed time between the originating and terminating events as well as regression modeling with risk factors. Therefore, in this study, we introduce a model evaluation method to measure the predictive ability of a model based on negative predictive values. We use a semiparametric estimate of the predictive accuracy to provide a simple and flexible method for model evaluation of doubly-censored survival outcomes. Additionally, we used simulation studies and tested data from a prostate cancer trial to illustrate the practical advantages of our approach. We believe that this method could be widely used to build prediction models or nomograms.

• 응용통계연구
• /
• 제25권3호
• /
• pp.423-434
• /
• 2012

A two-sample test for equality of survival distribution is one of the important issues in survival analysis, especially for clinical and epidemiological research. With interval censored data, some testing methods have been developed. This study introduces some testing methods and compares them under various situations through simulation study. Based on simulation result, it provides some useful information on choosing the most appropriate testing method in a given situation.

• 응용통계연구
• /
• 제23권3호
• /
• pp.521-531
• /
• 2010

구간중도절단은 중도절단의 가장 일반적인 개념으로 구간중도절단자료는 의학 및 역학분야의 연구에서 흔히 관찰된다. 본 연구에서는 구간중도절단의 상황에서 생존함수와 중간생존시간을 추정하는 방법으로 평균대치법과 자기일치법을 비교 연구하고, 실제 자료로 혈우병환자에서 선천성면역결핍바이러스 감염시점을 추정하였다. 또한 구간중도절단자료를 생성하는 새로운 방법을 제시하였으며, 생성된 구간중도절단자료를 이용한 모의실험을 통하여 두 추정치에 대한 다양한 비교연구를 시행하였다. 구간중도절단자료에서 생존함수와 중간생존시간을 추정할 경우 중도절단율이 크지 않다면 평균대치법이 자기일치법보다 더 우수한 추정치로 판명되었다.

• Genomics & Informatics
• /
• 제17권4호
• /
• pp.41.1-41.12
• /
• 2019

Survival analysis mainly deals with the time to event, including death, onset of disease, and bankruptcy. The common characteristic of survival analysis is that it contains "censored" data, in which the time to event cannot be completely observed, but instead represents the lower bound of the time to event. Only the occurrence of either time to event or censoring time is observed. Many traditional statistical methods have been effectively used for analyzing survival data with censored observations. However, with the development of high-throughput technologies for producing "omics" data, more advanced statistical methods, such as regularization, should be required to construct the predictive survival model with high-dimensional genomic data. Furthermore, machine learning approaches have been adapted for survival analysis, to fit nonlinear and complex interaction effects between predictors, and achieve more accurate prediction of individual survival probability. Presently, since most clinicians and medical researchers can easily assess statistical programs for analyzing survival data, a review article is helpful for understanding statistical methods used in survival analysis. We review traditional survival methods and regularization methods, with various penalty functions, for the analysis of high-dimensional genomics, and describe machine learning techniques that have been adapted to survival analysis.

• Communications for Statistical Applications and Methods
• /
• 제15권6호
• /
• pp.969-976
• /
• 2008

Mixed linear models have been widely used in various correlated data including multivariate survival data. In this paper we extend hierarchical-likelihood(h-likelihood) approach for mixed linear models with right censored data to that for left censored data. We also allow a general random-effect structure and propose the estimation procedure. The proposed method is illustrated using a numerical data set and is also compared with marginal likelihood method.

• 한국통계학회:학술대회논문집
• /
• 한국통계학회 2004년도 학술발표논문집
• /
• pp.237-241
• /
• 2004

In standard time-to-event or survival analysis, the occurrence times of the event of interest are observed exactly or are right-censored. However in certain situations such as the AIDS data, the incubation period which is the time between HIV infection time and the diagnosis of AIDS is usually doubly censored. That is the HIV infection time Is interval censored and also the time of the diagnosis of AIDS is right censored. In this paper, we Impute the Interval censored infection time using the conditional mean imputation and estimate the coefficient factor of the regression analysis for the incubation period using Gibbs sampler. We applied parametric and semi-parametric methods for the analysis of the Incubation period and compared the results.

• 응용통계연구
• /
• 제24권5호
• /
• pp.871-881
• /
• 2011

In this paper we propose a logistic regression method to estimate the survival function and the median survival time in interval-censored data. The proposed method is motivated by the data augmentation technique with no sacrifice in augmenting data. In addition, we develop a cross validation criterion to determine the size of data augmentation. We compare the proposed estimator with other existing methods such as the parametric method, the single point imputation method, and the nonparametric maximum likelihood estimator through extensive numerical studies to show that the proposed estimator performs better than others in the sense of the mean squared error. An illustrative example based on a real data set is given.

• Journal of the Korean Data and Information Science Society
• /
• 제24권1호
• /
• pp.201-209
• /
• 2013

For censored regression, it is often the case that some input variables are not important, while some input variables are more important than others. We propose a novel algorithm for selecting such important input variables for censored kernel regression, which is based on the penalized regression with the weighted quadratic loss function for the censored data, where the weight is computed from the empirical survival function of the censoring variable. We employ the weighted version of ANOVA decomposition kernels to choose optimal subset of important input variables. Experimental results are then presented which indicate the performance of the proposed variable selection method.