• Natural Product Sciences
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• 제29권1호
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• pp.31-37
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• 2023

In this study, we investigated the efficacy of Celtis choseniana Nakai (C. choseniana) as complementary herbal medicine to ameliorate androgenic alopecia (AGA). The effects of C. choseniana on AGA were evaluated using testosterone propionate-induced AGA mouse model and dihydrotestosterone-treated human hair follicle dermal papilla cells. In vivo, C. choseniana treatment deactivated androgen signaling by reducing the concentration of serum dihydrotestosterone level and expressions of 5α-reductase 2 and androgen receptor. Next, C. choseniana treatment increased the hair regrowth rate. Histological studies demonstrated that C. choseniana induced the anagen phase in testosterone propionate-induced AGA mouse model. Cellular proliferation was promoted by C. choseniana treatment via increasing the expression of proliferation factors, such as proliferating cell nuclear antigen and cyclin D1. Furthermore, C. choseniana treatment increased the expression of proteins related to the Wnt/β-catenin signaling pathway. In addition, dickkopf-1, a Wnt inhibitor, was downregulated with C. choseniana treatment. Likewise, C. choseniana treatment promoted cellular proliferation in vitro. This study demonstrated the inhibitory effect of C. choseniana on androgen-induced AGA. Moreover, C. choseniana induced activation of Wnt/β-catenin signaling, resulting in prolonged anagen and cellular proliferation. Therefore, we suggest that C. choseniana can be used as a therapeutic agent to alleviate AGA.

• 한국환경생태학회지
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• 제25권4호
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• pp.498-515
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• 2011

2008년 3월부터 10월까지 총 7회에 걸쳐 주왕산국립공원 일대의 식물상을 조사하였다. 주왕산국립공원지역에서 확인된 환경부 지정 멸종위기야생식물종은 둥근잎꿩의비름, 망개나무, 깽깽이풀, 노랑무늬붓꽃과 가시오갈피나무, 솔나리, 연잎꿩의다리 7분류군 이었으며, 식물구계학적 특정식물종은 총 88분류군으로 V등급에 해당하는 분류군은 깽깽이풀, 망개나무, 솔나리 등 8과 9분류군, IV등급에 해당하는 분류군은 승마, 회리바람꽃, 돌마타리 등의 4과 5분류군, III등급에 해당하는 분류군은 애기석위, 가침박달, 등칡 등 16과 18분류군, 2등급으로는 백작약, 나도바람꽃, 개불알꽃 등의 14과 18분류군, 1등급은 늦고사리삼, 홀아비꽃대, 백선 등 30과 38분류군이 확인되었다. 한국 고유 식물종은 호랑버들, 검팽나무, 할미밀망, 노랑갈퀴, 정영엉겅퀴 등의 총 15분류군이 확인되었다. 귀화식물은 닭의덩굴, 나도닭의덩굴, 다닥냉이, 족제비싸리, 컴프리, 수박풀 등의 총 21분류군으로 조사되었다.