• Journal of the Korean Society of Combustion
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• v.8 no.1
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• pp.46-56
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• 2003

The present paper is concerned with the development of the computational biology in the past half century and its relationship with combustion. The modem computational biology is considered to be initiated by the work of Alan Turing on the morphogenesis in 1952. This paper first touches the life and scientific achievement of Alan Turing and his theory on the morphogenesis based on the reactive-diffusive instability, called the Turing instability. The theory of Turing instability was later extended to the nonlinear realm of the reactive-diffusive systems, which is discussed in the framework of the excitable media by using the Oregonator model. Then, combustion analogies of the Turing instability and excitable media are discussed for the cellular instability, pattern forming combustion phenomena and flame edge. Finally, the recent efforts on numerical simulations of biological systems, employing the detailed bio-chemical knietic mechanism is discussed along with the possibility of applying the numerical combustion techniques to the computational cell biology.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.20 no.6
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• pp.2046-2056
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• 1996

The constrained melting inside an isothermally heated horizontal cylinder has been repeatedly investigated in many studies only for the moderate Rayleigh numbers. This study extends the range of Rayleigh numbers to systematically investigate the transition during melting processes, especially focusing on the complex multi-cellular flow pattern and thermal instability. The enthalpy-porosity formulation, with appropriate source terms to account for the phase change, is employed. For low Rayleigh numbers, initially developed single-cell base flow keeps the flow stable. For moderate Rayleigh numbers, even small disturbances in balance between thermal buoyance force and viscous force result in branched flow structure. For high Rayleight numbers, Benard type convection is found to develop within a narrow gap between thee wall and the unmelted solid. The marginal Rayleigh number and the corresponding wave number are in excellent agreement with those from linear stability theory.

• International Journal of Oral Biology
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• v.47 no.2
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• pp.17-24
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• 2022

Preserving intact genetic material and delivering it to the next generation are the most significant tasks of living organisms. The integrity of DNA sequences is under constant threat from endogenous and exogenous factors. The accumulation of damaged or incompletely-repaired DNA can cause serious problems in cells, including cell death or cancer development. Various DNA damage detection systems and repair mechanisms have evolved at the cellular level. Although the mechanisms of these responses have been extensively studied, the global RNA expression profiles associated with genomic instability are not well-known. To detect global gene expression changes under different DNA damage and hypoxic conditions, we performed RNA-seq after treating human cervical cancer cells with ionizing radiation (IR), hydroxyurea, mitomycin C (MMC), or 1% O₂ (hypoxia). Results showed that the expression of 184-1037 genes was altered by each stimulus. We found that the expression of 51 genes changed under IR, MMC, and hypoxia. These findings revealed damage-specific genes that varied differently according to each stimulus and common genes that are universally altered in genetic instability.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.38 no.6
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• pp.493-500
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• 2014

Nonlinear characteristics of cellular counterflow diffusion flame near the radiative extinction limit at large Damk$\ddot{o}$hler number are numerically investigated. Lewis number is assumed to be 0.5 and flame evolution is calculated by imposing an infinitesimal disturbance to a one-dimensional(1-D) steady state flame. The early stage of nonlinear development is very similar to that predicted in a linear stability analysis. The disturbance with the wavenumber of the fastest growing mode emerges and grows gradually. Eventual, an alternating pattern of reacting and quenching stripes is developed. The cellular flame temperature is higher than that of 1-D flame because of the gain of the total enthalpy. As the Damk$\ddot{o}$hler number is further increased, the shape of the cell becomes circular to increase the surface area per unit reacting volume. The cellular flames do not extinguish but survive even above the 1-D steady state extinction condition.

• Proceedings of the Korean Society of Propulsion Engineers Conference
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• 2009.11a
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• pp.191-196
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• 2009

Experiments were conducted in a constant pressure combustion chamber using schlieren system to investigate the effects of carbon dioxide/nitrogen/helium diluents on cellular instabilities of syngas-air premixed flames at room temperature and elevated pressures. Laminar burning velocities and Markstein lengths were calculated by analyzing high-speed schlieren images at various diluent concentrations and equivalence ratios. Experimental results showed substantial reduction of the laminar burning velocities and of the Markstein lengths with the diluent additions in the fuel blends. Effective Lewis numbers of helium-diluted syngas-air flames increased but those of carbon dioxide- and nitrogen-diluted syngas-air flames decreased in increase of diluents in the reactant mixtures. With helium diluent, the propensity for cells formation was significantly diminished, whereas the cellular instabilities for carbon dioxide-diluted and nitrogen-diluted syngas-air flames were not suppressed.

• Journal of the Korean Society of Visualization
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• v.11 no.1
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• pp.22-27
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• 2013

An investigation into the influence of ultrasonic standing wave on the structural behavior of propane/air premixed flame has been made to get a clue to the combustion reaction acceleration and combustion instability. Visualization technique utilizing the Schlieren photography was employed for the observation of structural variation of the flame reaction zone. Evolutionary characteristics of the flame front were caught by the high-speed Schlieren image, through which local flame velocity of the moving front were analyzed in detail.

• Journal of the Korean Home Economics Association
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• v.42 no.9
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• pp.135-147
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• 2004

The purposes of this study were to investigate the actual conditions and deal with the psychological characteristics of adolescent cellular phone addicts through the Minnesota Multiphase Personality Inventory (MMPI). The subjects of this study were 407 senior high school students (male 185, female 222) in 2nd grade in Daegu. The cellular phone addiction inventory (CPAI) was designed on the basis of an interview process, referring to the Young's Internet Addiction Self Diagnosis Scale. SPSS version 10.0 was employed for data analysis. The mean score of the adolescent addict group was significantly higher than the non-addict group in Scale Pd, Pa, Pt, Sc and Ma. This result indicates that the cellular phone addict group is likely to suffer from more serious pathological disorders than the non-addict group. The rate of addictive adolescents was significantly higher in the addict group than in the non-addict group in psychological problematic score ranges in Scale Sc (Schizophrenia) and Ma (Hypomania). The study result suggests that adolescents who addictively use a cellular phone will be more likely to show immaturity, instability, impulsive personality, excessive activities, and escapism.

• Journal of the Korean Society of Combustion
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• v.1 no.1
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• pp.51-55
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• 1996

An experimental investigation has been made with the objective of studying the limits of equivalence ratio on mixing enhancement in a tone excited jet flame. The jet is pulsed by means of a loudspeaker-driven cavity and rich flames(${\phi}>1.5$) are used. The excitation frequency is chosen for the resonant frequency identified as a pipe resonance due to acoustic excitation. Methane, propane and butane are used to examine the effect of mixture property on the limit of equivalence ratio. Mixing is always enhanced in a methane/air flame as the excitation intensity increases. Constant lower limits of equivalence ratio for mixing enhancement are present in cases of propane/air and butane/air flames irrespective of mean mixture velocities. The equivalence ratio limits are also found to be related to the flame instability ; the lower Le, the higher the limit of equivalence ratio. Under the equivalence ratio limits, cellular flames are generated as the excitation intensity increases. The amplitude of oscillating velocity for generating a cellular flame in the equivalence ratio limit is proportional to a mean mixture velocity irrespective of fuels.

• Childhood Kidney Diseases
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• v.12 no.1
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• pp.11-22
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• 2008

Telomeres consist of tandem guanine-thymine(G-T) repeats in most eukaryotic chromosomes. Human telomeres are predominantly linear, double stranded DNA as they ended in 30-200 nucleotides(bases,b) 3'-overhangs. In DNA replication, removal of the terminal RNA primer from the lagging strand results in a 3'-overhang of uncopied DNA. This is because of bidirectional DNA replication and specificity of unidirectional DNA polymerase. After the replication, parental and daughter DNA strands have unequal lengths due to a combination of the end-replication problem and end-processing events. The gradual chromosome shortening is observed in most somatic cells and eventually leads to cellular senescence. Telomere shortening could be a molecular clock that signals the replicative senescence. The shortening of telomeric ends of human chromosomes, leading to sudden growth arrest, triggers DNA instability as biological switches. In addition, telomere dysfunction may cause chronic allograft nephropathy or kidney cancers. The renal cell carcinoma(RCC) in women may be less aggressive and have less genomic instability than in man. Younger patients with telomere dysfunction are at a higher risk for RCC than older patients. Thus, telomeres maintain the integrity of the genome and are involved in cellular aging and cancer. By studying the telomeric DNA, we may characterize the genetic determinants in diseases and discover the tools in molecular medicine.

• Molecules and Cells
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• v.38 no.9
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• pp.750-758
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• 2015

Genomic instability and altered metabolism are key features of most cancers. Recent studies suggest that metabolic reprogramming is part of a systematic response to cellular DNA damage. Thus, defining the molecules that fine-tune metabolism in response to DNA damage will enhance our understanding of molecular mechanisms of tumorigenesis and have profound implications for the development of strategies for cancer therapy. Sirtuins have been established as critical regulators in cellular homeostasis and physiology. Here, we review the emerging data revealing a pivotal function of sirtuins in genome maintenance and cell metabolism, and highlight current advances about the phenotypic consequences of defects in these critical regulators in tumorigenesis. While many questions should be addressed about the regulation and context-dependent functions of sirtuins, it appears clear that sirtuins may provide a promising, exciting new avenue for cancer therapy.