• Proceedings of the Korean Society of Precision Engineering Conference
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• 2001.04a
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• pp.393-397
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• 2001

This paper addresses an Intelligent Agent-based Open Architecture Cell Controller for Intelligent Manufacturing System(IMS). With an Intelligent Agent approach, the IMS will be a independent, autonomous, distributed system and achieve a adaptability to change of manufacturing environment. As the development methodology of Open Architecture Cell Controller, an object-oriented modeling technique is employed for building models associated with IMS operation, such as resource model, product model, and control model. Intelligent Agent-based Open Architecture Cell Controller consists of two kinds of dependant agents, that are the active agent and the coordinator agent. The Active agent is contributed to control components of IMS in real-time. The coordinator agent has great role in scheduling and planning of IMS. It communicates with other active agents to get information about status on system and generates the next optimal task through the making-decision logic and dispatch it to other active agent.

• 제어로봇시스템학회:학술대회논문집
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• 2003.10a
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• pp.2457-2460
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• 2003

There is a great demand to manipulate biological cell autonomously since biologist should spend much time to obtain skillful manipulation techniques. For this purpose, we propose a cell chip to control, carry, fix and locate the cell. In this paper, we focus on the cell rotator to rotate individual biological cell based on a micro fluidics technology. The cell rotator consists of injection hole and rotation well to rotate a biological cell properly. Under the variation of flow rate in injection hole, the angular velocity of a biological cell is evaluated to find the feasibility of the proposed rotation method. As a practical experiment, Zebrafish egg is employed. Based on this research, we find the possibility of non-contact rotation way that can highly reduce the damage of the biological cell during manipulation. To realize an autonomous biological cell manipulation, a cell chip with manipulation well and micro channel in this research will be utilized effectively in near future.

• Journal of IKEEE
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• v.16 no.2
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• pp.81-85
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• 2012

In this paper, we analyze the effect of mobility management method to the data rate of moving users when pico-cell which uses the same frequency bandwidth as that of macro-cell is overlaid over macro-cell. From this analysis, we show that the data rate which is available to the moving user depends on the method of mobility management and relative location of the overlaid pico-cell over macro-cell in the network.

• Microbiology and Biotechnology Letters
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• v.38 no.2
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• pp.124-128
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• 2010

Vaccines, especially for viruses, have been produced from egg-based manufacturing process. The method is simple and easy to set up the manufacturing process. However, the method has many problems in quality control, limit of manufacturing capacity, and ethical issues. Over the last decade, an alternative method, which manufactures vaccines using cell culture-based system, has received great attention to overcome the problems in egg-based vaccine production. This article examines current status and perspectives of cell culture-based vaccine production.

• Journal of Korea Spatial Information System Society
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• v.6 no.2 s.12
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• pp.23-37
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• 2004

Location Based Services(LBSs) in mobile environments become very popular recently. For efficient LBSs, spatial database management systems must need a spatial indexing scheme such as R-trees in order to manage the huge spatial database. However, it may need unnecessary disk accesses since it needs to access objects which are not actually concerned to user's location-based queries. In this paper, to support the location-based queries efficiently, we propose a CLR-tree(Cell Leveling R-tree) in which a dynamic cell is built up within the minimum bounding rectangle of R-trees' node. The cell level of nodes is compared with the query's cell level in location-based query processing and determines the minimum search space. Also, we propose the insertion, split, deletion, and search algorithms for CRL-trees. From the experimental results, we see that a CLR-tree is able to decrease $5{\sim}20%$ of disk accesses from those of R-trees. So, a CLR-tree can be used for fast accessing spatial objects to user's location-based queries in LBSs.

• Geophysics and Geophysical Exploration
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• v.22 no.2
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• pp.56-61
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• 2019

In this paper, we studied efficient modeling strategies when we simulate the 3D time-domain acoustic wave propagation using a cell-based finite difference method which can handle the variations of both P-wave velocity and density. The standard finite difference method assigns physical properties such as velocities of elastic waves and density to grid points; on the other hand, the cell-based finite difference method assigns physical properties to cells between grid points. The cell-based finite difference method uses average physical properties of adjacent cells to calculate the finite difference equation centered at a grid point. This feature increases the computational cost of the cell-based finite difference method compared to the standard finite different method. In this study, we used additional memory to mitigate the computational overburden and thus reduced the calculation time by more than 30 %. Furthermore, we were able to enhance the performance of the modeling on several media with limited density variations by using the cell-based and standard finite difference methods together.

• Analytical Science and Technology
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• v.34 no.6
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• pp.275-283
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• 2021

This study presents the development of cell-based microfluidic chips for the performance of acute eye irritation tests due to chemicals and examined some of their applications. Microfluidic chips were fabricated by photolithography and soft lithography, and they had three compartments with different areas for cell culture. Rabbit corneal epithelial cells were used for the eye irritation test. The death of cells cultured inside the chip was monitored at regular time intervals after treatment with an aqueous solution of chemicals, and the cell death rate constants were calculated based on the viability curve. The performance of the microfluidic chip was verified by examining the effects of cell-cell junctions, cell-substrate adhesion, and initial cell numbers compared to cell death rates. Eye irritation tests were performed at various concentrations of an aqueous solution of sodium dodecyl sulfate (SDS), a standard substance for the eye irritant test. The cells were exposed to the SDS aqueous solution for 300 s, and the resulting eye irritation was assessed by cell viability. Finally, the equation for calculating the toxicity score (TS) was derived based on the weighting factor for each compartment in the chip. The cell-based microfluidic chip developed in this study may be used for eye irritation tests from chemicals used in cosmetics and pharmaceuticals.

• BMB Reports
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• v.55 no.6
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• pp.267-274
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• 2022

Molecular imaging is used to improve the disease diagnosis, prognosis, monitoring of treatment in living subjects. Numerous molecular targets have been developed for various cellular and molecular processes in genetic, metabolic, proteomic, and cellular biologic level. Molecular imaging modalities such as Optical Imaging, Magnetic Resonance Imaging (MRI), Positron Emission Tomography (PET), Single Photon Emission Computed Tomography (SPECT), and Computed Tomography (CT) can be used to visualize anatomic, genetic, biochemical, and physiologic changes in vivo. For in vivo cell imaging, certain cells such as cancer cells, immune cells, stem cells could be labeled by direct and indirect labeling methods to monitor cell migration, cell activity, and cell effects in cell-based therapy. In case of cancer, it could be used to investigate biological processes such as cancer metastasis and to analyze the drug treatment process. In addition, transplanted stem cells and immune cells in cell-based therapy could be visualized and tracked to confirm the fate, activity, and function of cells. In conventional molecular imaging, cells can be monitored in vivo in bulk non-invasively with optical imaging, MRI, PET, and SPECT imaging. However, single cell imaging in vivo has been a great challenge due to an extremely high sensitive detection of single cell. Recently, there has been great attention for in vivo single cell imaging due to the development of single cell study. In vivo single imaging could analyze the survival or death, movement direction, and characteristics of a single cell in live subjects. In this article, we reviewed basic principle of in vivo molecular imaging and introduced recent studies for in vivo single cell imaging based on the concept of in vivo molecular imaging.

• Journal of Electrical Engineering and Technology
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• v.12 no.1
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• pp.29-38
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• 2017

This paper presents a study on the state-of-charge (SOC) reference based active cell balancing in real-time. The optimal references of SOC are determined by using the proposed active cell balancing system with the bidirectional DC/DC converters via the dual active bridge (DAB) type. Then, the energies between cells can be balanced by the power flow control of DAB based bidirectional DC/DC converters. That is, it provides the effective management of battery by transferring energy from the strong cell to the weak one until the cell voltages are equalized to the same level and therefore improving the additional charging capacity of battery. In particular, the cell aging of battery and power loss caused from energy transfer are considered. The performances of proposed active cell balancing system are evaluated by an electromagnetic transient program (EMTP) simulation. Then, the experimental prototype is implemented in hardware to verify the usefulness of proposed system.

• Journal of Hydrogen and New Energy
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• v.20 no.2
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• pp.104-115
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• 2009

In case of residential fuel cell system, it is significant to stably supply heat and power to a house with high efficiency and low cost for the successful commercialization. In this paper, the control strategy analysis has been performed to minimize the total cost including capital and operating cost of the residential fuel cell system. The proposed analysis methodology is based on the simulator including the efficiency models as well as the cost data for fuel cell components. The load control strategy is the key factor to decide the system efficiency and thus the cost analysis is performed when the fuel cell system is operated for several different load control logics. Additionally, annual efficiency of the system based on the seasonal load data is calculated since system efficiency is changeable according to the electric and heat demand change. As a result, the hybrid load control combined electricity oriented control and heat oriented control has the most economical operation.