• BMB Reports
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• v.48 no.10
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• pp.583-588
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• 2015

Microtubule actin crosslinking factor 1 (MACF1), a widely expressed cytoskeletal linker, plays important roles in various cells by regulating cytoskeleton dynamics. However, its role in osteoblastic cells is not well understood. Based on our previous findings that the association of MACF1 with F-actin and microtubules in osteoblast-like cells was altered under magnetic force conditions, here, by adopting a stable MACF1-knockdown MC3T3-E1 osteoblastic cell line, we found that MACF1 knockdown induced large cells with a binuclear/multinuclear structure. Further, immunofluorescence staining showed disorganization of F-actin and microtubules in MACF1-knockdown cells. Cell counting revealed significant decrease of cell proliferation and cell cycle analysis showed an S phase cell cycle arrest in MACF1-knockdown cells. Moreover and interestingly, MACF1 knockdown showed a potential effect on cellular MTT reduction activity and mitochondrial content, suggesting an impact on cellular metabolic activity. These results together indicate an important role of MACF1 in regulating osteoblastic cell morphology and function.

• Publications of The Korean Astronomical Society
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• v.22 no.3
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• pp.75-81
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• 2007

In this study we present basic principles and features of RVI2CELL, a precise RV (radial velocity) estimation program to process stellar spectra obtained through iodine cell. RVI2CELL is very robust and fast program. The instrument profile can be modeled as a sum of Gaussian functions or a non-parametric arbitrary shape. The RV accuracy estimated by observation of a RV standard star Tau Ceti indicates about 9 m/s.

• Journal of Astronomy and Space Sciences
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• v.36 no.2
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• pp.69-74
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• 2019

Spacecraft requires sufficient power in orbit to perform its mission. So as to comply with system requirements, the sufficient power should be made by a solar cell array by photovoltaic power conversion. A life time of space program depends on its mission considering parts reliability and parts grade. Based on the mission life time, power equipment might be designed to meet specifications. In outer space, solar cell array might generate the dc power by photovoltaic conversion effects and GaInP/GaAs/Ge solar cells are used in this study. Space programs that require more than five years should select parts for high reliability applications. Therefore, reliability analysis for high reliability applications should be performed to check its fulfilment of the requirements. This program should also require more five years for its mission and we performed its analysis using parts count method (PCM) for its reliability. Finally, we performed reliability analysis and obtained quantitative figures found out 99.9%. In this study, we presented the reliability analysis of the 300 W GaInP/GaAs/Ge solar cell array.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.37A no.12
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• pp.1093-1105
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• 2012

We propose an interference space reuse (ISR) algorithm for the MU-MIMO design in 3-cell downlink interference channels. Also, we provide a strategy for the adoption of the ISR scheme in the cellular network. In the multicell interference channels, the cell edge users may undergo severe interferences and their signals should be protected from the interferers for reliable transmissions. However, the intra cell users do not only experience small interferences but also they require small transmission power for stable communication. We provide a vector design algorithm based on ISR, where intra cell users are served through reusing the cell edge users' interference space. The performance enhancement reaches 20% compared to the fractional frequency reuse (FFR) scheme combined with IA through the scheduling between the cell edge users and the intra cell users. Also, it can be used to enhance the cell edge throughput when the quality of service (QoS) requirements of the intra cell users are fixed.

• Korean Institute of Interior Design Journal
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• v.20 no.5
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• pp.23-33
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• 2011

Starting with 21st Century, the role of the design has been widened and designers began to regard the psychological and behavioral factors as main design considerations. These factors are the core elements especially in designing interactive space. This research proposed the user-centered design methodology for interactive space. It developed Programming Process for Supporting Interactive Behaviors. To compose the process, this research analyzed the influential factors on the interactivity and the results were applied on the process. This newly proposed Programming Process contains four basic stages which are 'Opportunity Identification Cell', 'Intersubject Cell', 'Interaction & Interface Cell', and 'Programming Solution Cell'. More detailed tasks are also specified for each stage. This research asserts that the design process for Interactive space should differ from the past design processes in the fact that it puts much more attention on systemizing the psychological and behavioral elements than before. Therefore the design process for Interactive space should be reinforced with the data related to these psychological and behavioral understandings. The Programming Process of this paper is an attempt to enlarge the roles of these data in designing interactive space, and thus it is an attempt to accommodate the contemporary user-centered design paradigm.

• Journal of Astronomy and Space Sciences
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• v.32 no.1
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• pp.81-89
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• 2015

In this paper, we describe the development of a bioreactor for a cell-culture experiment on the International Space Station (ISS). The bioreactor is an experimental device for culturing mouse muscle cells in a microgravity environment. The purpose of the experiment was to assess the impact of microgravity on the muscles to address the possibility of long-term human residence in space. After investigation of previously developed bioreactors, and analysis of the requirements for microgravity cell culture experiments, a bioreactor design is herein proposed that is able to automatically culture 32 samples simultaneously. This reactor design is capable of automatic control of temperature, humidity, and culture-medium injection rate; and satisfies the interface requirements of the ISS. Since bioreactors are vulnerable to cell contamination, the medium-circulation modules were designed to be a completely replaceable, in order to reuse the bioreactor after each experiment. The bioreactor control system is designed to circulate culture media to 32 culture chambers at a maximum speed of 1 ml/min, to maintain the temperature of the reactor at $36{\pm}1^{\circ}C$, and to keep the relative humidity of the reactor above 70%. Because bubbles in the culture media negatively affect cell culture, a de-bubbler unit was provided to eliminate such bubbles. A working model of the reactor was built according to the new design, to verify its performance, and was used to perform a cell culture experiment that confirmed the feasibility of this device.

• Bulletin of the Korean Space Science Society
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• 2008.10a
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• pp.33.3-34
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• 2008

As an activity of building Korean Space Weather Prediction Center (KSWPC), we has studied of radiation effect on the spacecraft components. High energy charged particles trapped by geomagnetic field in the region named Van Allen Belt can move to low altitude along magnetic field and threaten even low altitude spacecraft. Space Radiation can cause equipment failures and on occasions can even destroy operations of satellites in orbit. Sun sensors aboard Science and Technology Satellite (STSAT-1) was designed to detect sun light with silicon solar cells which performance was degraded during satellite operation. In this study, we try to identify which particle contribute to the solar cell degradation with ground based radiation facilities. We measured the short circuit current after bombarding electrons and protons on the solar cells same as STSAT-1 sun sensors. Also we estimated particle flux on the STSAT-1 orbit with analyzing NOAA POES particle data. Our result clearly shows STSAT-1 solar cell degradation was caused by energetic protons which energy is about 700 keV to 1.5 MeV. Our result can be applied to estimate solar cell conditions of other satellites.

• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.37 no.10
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• pp.1017-1026
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• 2009

The solar cell system operates by facing the sun-light. Minor cracks, static discharge, and thermal shock that can happen during production/testing phase can lead to degradation in performance during operation, since solar cells are exposed to extreme thermal/mechanical environment in space. In order to detect small cracks and internal damages in the solar cells due to thermal shocks, which are the core units of a solar cell system, expensive equipment, complicated test process, and much time are required. Therefore, a qualitative method for easily and quickly testing the 'health' of solar cell functionality is required. This dissertation describes a theoretical and technical grounds for quickly and easily evaluating the health of solar cells using electroluminescence effect of Gallium-Arsenide solar cells that are most widely used by spacecrafts in recent years. Also described in the dissertation is the technical issues and constraining factors for applying the proposed method to actual space-rated solar cell systems.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• v.50 no.1
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• pp.56-59
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• 2024

There are very few case reports of the diagnosis and management of concurrent oral cavity and parapharyngeal space tumors. We present a case involving a 49-year-old female who presented with oral cavity squamous cell carcinoma confirmed by biopsy. Initial diagnostic workup revealed a concurrent parapharyngeal mass. Diagnostic studies and surgical therapy were tailored to account for both pathological entities. The patient was treated with a combination of surgery and adjuvant therapy. The surgical strategy was designed to address both lesions simultaneously. One year post-surgery, the patient had good response to therapy with no evidence of persistent or recurrent disease. This report discusses the outcome and treatment of a rare case of concurrent squamous cell carcinoma with a complicating parapharyngeal space tumor. It explores the diagnostic process, comprehensive workup, and the surgical management.

• Korean Institute of Interior Design Journal
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• no.34
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• pp.106-113
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• 2002

Certosa, a representative Monastic Architecture of Renaissance era, has been well preserved. And it has worked as a symbol of the space form & style revealed by monad, sell, arcade and court, which are characteristic of a monastery. A court is divided into large court and small one, and it connects each units and each sells through the annex with clarifying each space identities. And arcade and pillar is not only to derive a unitary space from entire space, but also to try openness and extension applying a different height in spite of physical closure of style. Especially planned by monad and cell, the routine space of monks, a structure of rational space is a yardstick of moderation and frugality, showing affluent space which occupy essential areas without extra space. And the space appears self-sufficiency, honest poverty, and affluence with order and eternity based on elementary principles of the Cartusio order in composition and plan of the space. Keeping strong linking with entire sells in the monastery, Each sell symbolizes entire sells, and the inverse is the same. And it is the universe advocating eternity and it is also a small city which provides the monks with accurate modules and scales in the very recluse space.