• 한국소성가공학회:학술대회논문집
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• 한국소성가공학회 2007년도 춘계학술대회 논문집
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• pp.139-142
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• 2007

This study focuses on the manufacturing process of a magnesium alloy impeller used for the fuel cell car using the hot forging technology. The impeller has the very complicated shape with sharply curved blade and thus generally produced by mechanical machining or casting process. However, since these technologies give the high manufacturing cost or poor mechanical properties, the forging technology is required to make the high-quality impeller with the lower manufacturing cost. In order for production of the impeller by forging technology, the parametric studies using finite element analyses were carried out to find the optimal perform shape of impeller made of magnesium alloy AZ 31 and finally die design was proposed based on the simulation results.

• 대한기계학회논문집A
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• 제32권4호
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• pp.319-326
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• 2008

In this study, we investigate the deformation behavior of F.C.C. single crystals containing micro- or submicron-sized voids by using three dimensional finite element methods. The locally homogeneous constitutive model for the rate-dependent crystal plasticity is integrated based on the backward Euler method and implemented into a finite element program (ABAQUS) by means of user-defined subroutine (UMAT). The unit cell analysis has been investigated to study the effect of stress triaxiality and crystallographic orientations on the growth and coalescence of voids in F.C.C. single crystals.

• 한국소성가공학회:학술대회논문집
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• 한국소성가공학회 2001년도 추계학술대회 논문집
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• pp.186-189
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• 2001

The main method in micro-etching process, used in manufacturing semiconductors, electronic components, circuits, is Photo Masking method that exposes and develops on the photo-sensitivity solutions or films. This method enables one to process highly precisely, $\pm$0.03 mm in end line location area. But this has limits in a high speed / wide width process, difficulties in endless masking, and the problem of high price. We have developed the direct masking method to make use of Gravure printing, widely used in grocery packing sheet printing. We made cylinder tools to influence the masking quality by laser stream process. We have confirmed that the end line location accuracy in the line width of the product is improved from 0.12 mm to $\pm$0.07 mm level, after etching process.

• 한국소성가공학회:학술대회논문집
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• 한국소성가공학회 1995년도 춘계학술대회논문집
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• pp.90-106
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• 1995

The "O"S' BONDING make metallic and non-metalic crystal structures and form localized superconducting orbitals , which induce electrical conduction , semi-conduction, and superconduction. The orbitals are proced by Ampere's law, Faraday's law , Meissner effect, highcritical temperature of thecopper oxide layers. abnomal trans-membrane signal in cancer cell and plastic deformations bytwins and dislocations, In the case of alloying metals, the most deterimentla cases of electrical conduction are those of solid solution and intermetalic compound . The highest case for the hardness are also those of solid solution and intermetallic compound. It explains the contributions of the "O"S' BONDING for conduction bands and plastic deformation by twins and dislocations.ns and dislocations.

• 한국소성가공학회:학술대회논문집
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• 한국소성가공학회 2009년도 춘계학술대회 논문집
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• pp.180-184
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• 2009

A novel set of experimental test tooling for measuring pulling and holding forces for drawbeads on binders inclined at a wide range of angles is introduced. A mechanical design featuring a single load cell, a male-female draw bead set, translation and rotation degrees of freedom, and a screw-driven clamping system has been incorporated into a standard tensile test machine. On a real time basis, restraining and holding force data with respect to draw-in displacement may be directly downloaded into a PC for data processing. The proposed experimental system represents a significant breakthrough in drawbead simulation technology due to its relatively low cost, clever design, and versatility. The system is shown to yield excellent experimental data suitable for verifying theory and numerical model predictions.

• 한국소성가공학회:학술대회논문집
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• 한국소성가공학회 2005년도 춘계학술대회 논문집
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• pp.454-457
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• 2005

Voloxidizer for hot cell demonstration that handle spend fuel of high radiation virulence in limited space should become a small size and not scatter in its exit. This study determine optimum velocity of $U_3O_8$ using Newton-Raphson Method. We have conducted fortran programing on the Newton-Raphson Method, obtained a theory results and, predicted optimum velocity on the particle size distribution of $U_3O_8$. We have conducted experimentation using acrylic experimental device for verification of theory method, sampled and analyzed using the particle size analyzer In the results, we have found maximum $5\~7\%$ error rate in the comparative value of theory and experimentation. Optimum velocity and experimental results of $U_3O_8$ for scatter prevention have applied for design of demonstration voloxidizer, and produced operation condition of voloxidizer.

• 국제물리치료학회지
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• 제1권2호
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• pp.91-98
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• 2010

This study is intended to examine the motor skill learning and treadmill exercise on motor performance and synaptic plasticity in the cerebellar injured rats by harmaline. Experiment groups were divided into four groups and assigned 15 rats to each group. Group I was a normal control group(induced by saline); Group II was a experimental control group(cerebellar injured by harmaline); Group III was a group of motor skill learning after cerebellar injured by harmaline; Group IV was a group of treadmill exercise after cerebellar injured by harmaline. In motor performance test, the outcome of group II was significantly lower than the group III, IV(especially group III)(p<.001). In histological finding, the experimental groups were destroy of dendrities and nucleus of cerebellar neurons. Group III, IV were decreased in degeneration of cerebellar neurons(especially group III). In immunohistochemistric response of synaptophysin in cerebellar cortex, experimental groups were decreased than group I. Group III's expression of synaptophysin was more increased than group II, IV. In electron microscopy finding, the experimental groups were degenerated of Purkinje cell. These result suggest that improved motor performance by motor skill learning after harmaline induced is associated with dynamically altered expression of synaptophysin in cerebellar cortex and that is related with synaptic plasticity.

• BMB Reports
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• 제52권3호
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• pp.214-219
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• 2019

The role of tumor-proximal factors in tumor plasticity during chemoresistance and metastasis following chemotherapy is well studied. However, the role of endothelial cell (EC) derived paracrine factors in tumor plasticity, their effect on chemotherapeutic outcome, and the mechanism by which these paracrine factors modulate the tumor microenvironment are not well understood. In this study, we report a novel mechanism by which endothelial miR-125a and let-7e-mediated regulation of interleukin-6 (IL-6) signaling can manipulate vasculogenic mimicry (VM) formation of MDA-MB-231 breast cancer cells. We found that endothelial IL-6 levels were significantly higher in response to cisplatin treatment, whereas levels of IL-6 upon cisplatin exposure remained unchanged in MDA-MB-231 breast cancer cells. We additionally found an inverse correlation between IL-6 and miR-125a/let-7e expression levels in cisplatin treated ECs. Interestingly, IL-6, IL-6 receptor (IL-6R), and signal transducer and activator of transcription 3 (STAT3) genes in the IL-6 pathway are closely regulated by miR-125a and let-7e, which directly target its 3' untranslated region. Functional analyses revealed that endothelial miR-125a and let-7e inhibit IL-6-induced adhesion of monocytes to ECs. Furthermore, conditioned medium from cisplatin treated ECs induced a significantly higher formation of VM in MDA-MB-231 breast cancer cells as compared to that from intact ECs; this effect of cisplatin treatment was abrogated by concurrent overexpression of miR-125a and let-7e. Overall, this study reveals a novel EC-tumor cell crosstalk mediated by the endothelial miR-125a/let-7e-IL-6 signaling axis, which might improve chemosensitivity and provide potential therapeutic targets for the treatment of cancer.

• 소성∙가공
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• 제11권8호
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• pp.701-709
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• 2002

Aluminium foam material is highly porous material, which has the complicated cellular structure defined by randomly distributed pores in metallic matrix. This structure gives the characteristic properties which cannot be achieved by any other conventional processes. As the properties of aluminium foam material significantly depend on its porosity, a desired profile of properties can be tailored by changing the foam density. But various defects lead to undesirable effects on the mechanical properties. Mechanical properties are dependent on cell sizes and aspect ratios. Therefore, this paper presents the effects of various processing parameters of various parameters on the mechanical properties. For the sake of this, combined stirring was used to fabricate aluminum foam materials by the parameters. Compression and bending tests were performed to investigate the effects of cell sizes and aspect ratios on the mechanical properties.

• IMMUNE NETWORK
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• 제23권1호
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• pp.4.1-4.15
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• 2023

Th cells, which orchestrate immune responses to various pathogens, differentiate from naive CD4 T cells into several subsets that stimulate and regulate immune responses against various types of pathogens, as well as a variety of immune-related diseases. Decades of research have revealed that the fate decision processes are controlled by cytokines, cytokine receptor signaling, and master transcription factors that drive the differentiation programs. Since the Th1 and Th2 paradigm was proposed, many subsets have been added to the list. In this review, I will summarize these events, including the fate decision processes, subset functions, transcriptional regulation, metabolic regulation, and plasticity and heterogeneity. I will also introduce current topics of interest.