• 대한기계학회논문집A
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• 제35권7호
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• pp.745-751
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• 2011

입자강화 알루미늄 복합재의 강도를 계산하기 위하여 압밀 후 냉각할 때 일어나는 전위 펀칭을 유한요소로 모델링 하였다. 다양한 입자의 체적비에서 입자의 크기가 강도에 미치는 영향을 고려하기 위하여 강화 입자 주위에 변형률 구배 소성과 테일러 전위 모델을 적용하였다. 변형률 구배는, 구형 단위 셀이 냉각하는 동안 입자와 기지재의 열팽창계수 차이에 의한 전위 펀칭이 일어날 때 형성되는 등가소성변형률로부터 구하였다. 펀칭된 영역에 걸쳐 평균적으로 변형률 구배를 고려함으로써 항복 응력이 증가하는 것을 관찰하였다. 유한요소 해석을 활용하여 다양한 입자 크기와 체적비에 대하여 SiC 강화 알루미늄 356-T6 복합재의 축대칭 단위 셀의 인장시 강도의 변화를 예측하였다. 예측된 강도는 실험 데이터와 잘 일치하며, 입자 크기 의존 효과를 분명히 보인다.

• 한국소성가공학회:학술대회논문집
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• 한국소성가공학회 2008년도 추계학술대회 논문집
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• pp.422-425
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• 2008

Recently, electronic products and related parts are required to have thin thickness because of small form factor. To go with the trend, LGP(light guide plate) of LCD BLU(Liquid Crystal Display Back light unit: It is one of kernel parts of LCD) for cell phone has the thickness of 0.3 mm and the battery case of cell phone has 0.25 mm. Accordingly, high speed injection molding is required to make products which have thin thickness. High speed injection molding means that the resin is injected into the cavity at higher than normal speed avoiding short shot. In the case of hydro-mechanical high speed injection machine, it requires the design for hydraulic unit to make high injection speed and the design for control unit to control hydraulic unit. In the present paper, we concentrated on the molding stability of hydro-mechanical high speed injection machine to make an LGP of 0.3 mm thickness.

• 소성∙가공
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• 제20권3호
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• pp.193-205
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• 2011

Because of its rustproof property, stainless steel is widely used in kitchen appliances, building materials, electronics, chemical plants and automobile exhausts. In addition, the utilization of stainless steel for fuel cell application is growing. As the demand for this material increases, it is necessary to study the basic properties of stainless steel such as corrosion resistance, heat transfer, formability, cutting or shearing ability and weldability. In this article, the mechanical properties, formability and press forming performance of stainless steel are reviewed. Since temperature and strain rate affect the press forming performance of STS304(austenitic) stainless steel, the influence of these parameters on the plastic behavior should be investigated. Moreover, measures for the prevention of ridging of STS430(ferritic) and delayed fracture of STS430, which respectively appear during and after press forming, should be considered. Recently, stainless steel sheets with a thickness lower than 0.2 mm have been widely used in applications for mobile phone, digital camera and fuel cell separator. Therefore, there is a growing interest of studying the grain size effect and plasticity at the crystal scale in order to understand the anisotropic behavior and micro forming ability of thin sheets. This review paper was written with the objective of helping engineers and researchers to understand the forming characteristics of stainless steel and to establish standards in plastic forming techniques.

• 한국소성가공학회:학술대회논문집
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• 한국소성가공학회 2002년도 금형가공 심포지엄
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• pp.253-259
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• 2002

Micro cell structures with high aspect ratio were fabricated by injection molding method. The mold inserts had dimension $1.9cm\times8.3cm$ composed of a lot of micro posts and were fabricated by LIGA process. The size of the micro posts was $157{\mu}m\times157{\mu}m\times500{\mu}m$ and the gaps between two adjacent posts were $50{\mu}m$. Using Polymethylmethacrylate (PMMA) injection molding was performed. The key experimental variables were temperature, pressure, and time. By controlling these, good shaped mim cell structures with $50{\mu}m$ in wall thickness and $500{\mu}m$ in depth were obtained. In order to understand micro molding mechanism, shape changes of molded PMMA were studied with experimental variables. And the durability of mold insert was investigated, too. The results show that the most important factor in molding processes was the mold temperature that is closely related to the filling of the melt into the micro cavity. And the holding time before cooling showed a great effect on the quality of molded PMMA.

• 한국소성가공학회:학술대회논문집
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• 한국소성가공학회 2008년도 춘계학술대회 논문집
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• pp.247-251
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• 2008

This paper presents a micro air pump actuated by PZT actuator (synthetic jet actuator) for air supply for micro fuel cells. The synthetic jet actuators are usually created by a traditional PZT-driven actuator, which consists of a small cylindrical cavity, in/outlet channel and PZT diaphragms. To design the micro air pump, a numerical analysis has been conducted for flow characteristics with respect to various geometries. A prototype of the micro air pump, with a size of $mm{\times}mm{\times}mm$, was fabricated by PDMS replication process and was conducted performance test. To control the PZT actuator, we used the SP4423 micro chips that can be amplified input voltage to reduce the controller size and the power consumption. With a voltage of 3V at 100Hz, the air pump's pumping pressure is 600pa and its power consumption is only 0.1mW.

• The Korean Journal of Physiology and Pharmacology
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• 제24권2호
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• pp.129-135
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• 2020

SHP2 is an unusual protein phosphatase that functions as an activator for several signaling pathways, including the RAS pathway, while most other phosphatases suppress their downstream signaling cascades. The physiological and pathophysiological roles of SHP2 have been extensively studied in the field of cancer research. Mutations in the PTPN11 gene which encodes SHP2 are also highly associated with developmental disorders, such as Noonan syndrome (NS), and cognitive deficits including learning disabilities are common among NS patients. However, the molecular and cellular mechanism by which SHP2 is involved in cognitive functions is not well understood. Recent studies using SHP2 mutant mice or pharmacological inhibitors have shown that SHP2 plays critical role in learning and memory and synaptic plasticity. Here, we review the recent studies demonstrating that SHP2 is involved in synaptic plasticity, and learning and memory, by the regulation of the expression and/or function of glutamate receptors. We suggest that each cell type may have distinct paths connecting the dots between SHP2 and glutamate receptors, and these paths may also change with aging.

• BMB Reports
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• 제53권11호
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• pp.551-564
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• 2020

Proper development of the nervous system is critical for its function, and deficits in neural development have been implicated in many brain disorders. A precise and predictable developmental schedule requires highly coordinated gene expression programs that orchestrate the dynamics of the developing brain. Especially, recent discoveries have been showing that various mRNA chemical modifications can affect RNA metabolism including decay, transport, splicing, and translation in cell type- and tissue-specific manner, leading to the emergence of the field of epitranscriptomics. Moreover, accumulating evidences showed that certain types of RNA modifications are predominantly found in the developing brain and their dysregulation disrupts not only the developmental processes, but also neuronal activities, suggesting that epitranscriptomic mechanisms play critical post-transcriptional regulatory roles in development of the brain and etiology of brain disorders. Here, we review recent advances in our understanding of molecular regulation on transcriptome plasticity by RNA modifications in neurodevelopment and how alterations in these RNA regulatory programs lead to human brain disorders.

• BMB Reports
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• 제48권11호
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• pp.599-608
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• 2015

Regeneration, a process of reconstitution of the entire tissue, occurs throughout life in the olfactory epithelium (OE). Regeneration of OE consists of several stages: proliferation of progenitors, cell fate determination between neuronal and non-neuronal lineages, their differentiation and maturation. How the differentiated cell types that comprise the OE are regenerated, is one of the central questions in olfactory developmental neurobiology. The past decade has witnessed considerable progress regarding the regulation of transcription factors (TFs) involved in the remarkable regenerative potential of OE. Here, we review current state of knowledge of the transcriptional regulatory networks that are powerful modulators of the acquisition and maintenance of developmental stages during regeneration in the OE. Advance in our understanding of regeneration will not only shed light on the basic principles of adult plasticity of cell identity, but may also lead to new approaches for using stem cells and reprogramming after injury or degenerative neurological diseases.

• Journal of Yeungnam Medical Science
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• 제26권1호
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• pp.1-14
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• 2009

Human bone marrow-derived mesenchymal stem cells (MSCs) are a rare population of undifferentiated cells that have the capacity of self renewal and the ability to differentiate into mesodermal phenotypes, including osteocytes, chondrocytes, and adipocytes in vitro. Recently, MSCs have been shown to reside within the connective tissue of most organs, and their surface phenotype has been well analyzed. Many reports showed that transplanted MSCs enhanced regeneration as well as functional improvement of damaged organs and tissues. The wide differentiation plasticity of MSCs was expected to contribute to their demonstrated efficacy in a wide variety of experimental animal models and in human clinical trials. However, new findings suggest that the ability of MSCs to alter the tissue microenvironment via secretion of soluble factors may contribute more significantly than their capacity for differentiation in tissue repair. This review describes what is known about the cellular characteristics and differentiation potential of MSCs, which represent a promising stem cell population for further applications in regenerative medicine.

• 한국소성가공학회:학술대회논문집
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• 한국소성가공학회 2007년도 춘계학술대회 논문집
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• pp.139-142
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• 2007

This study focuses on the manufacturing process of a magnesium alloy impeller used for the fuel cell car using the hot forging technology. The impeller has the very complicated shape with sharply curved blade and thus generally produced by mechanical machining or casting process. However, since these technologies give the high manufacturing cost or poor mechanical properties, the forging technology is required to make the high-quality impeller with the lower manufacturing cost. In order for production of the impeller by forging technology, the parametric studies using finite element analyses were carried out to find the optimal perform shape of impeller made of magnesium alloy AZ 31 and finally die design was proposed based on the simulation results.