• 전기전자학회논문지
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• 제23권1호
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• pp.1-8
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• 2019

본 논문에서는 18650 원통형 NCA 리튬이온 배터리로 구성된 고출력 직렬 배터리로 다양한 C-rate의 전기적 특성을 테스트한다. 테스트를 통해 추출한 14S1P 배터리 팩의 방전 용량 데이터와 4S1P 배터리 팩의 EV cycle 데이터를 통해 C-rate의 변화에 따른 전기적 특성을 분석한다. 분석을 통해 얻은 데이터를 기반으로 C-rate에 따른 방전용량 실험의 셀 간 전압 편차와 EV cycle 실험의 셀 간 전압 편차를 다중선형회귀 모델로 추정하여 선형적인 특징을 가진 데이터와 비선형적인 특징을 가진 데이터에 대한 각각의 추정성능을 검증한다. 모델의 추정성능을 검증하기 위해 추정 데이터와 실제 데이터의 RMSE를 구해 알고리즘의 정확성을 평가한다. 논문의 결과는 14S1P 배터리 팩의 방전 용량의 셀 간 전압 불균형과 4S1P 배터리 팩의 EV cycle의 셀 간 전압 불균형 중 선형적인 데이터인 방전 용량의 셀 간 불균형 데이터의 추정 성능이 더 뛰어난 것을 검증하는데 기여한다.

• 한국자원식물학회:학술대회논문집
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• 한국자원식물학회 2018년도 추계학술대회
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• pp.31-31
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• 2018

Benign prostatic hyperplasia (BPH), which is the most common disorder in elderly men, involves androgenic hormone imbalance with chronic inflammation that causes imbalance between cell apoptosis and cell proliferation. As the root cause of the BPH remains unclear and synthetic drugs for treatment of BPH have undesirable side effects, the development of effective alternative medicines has been considered. Chinese Skullcap has been considered natural remedy to treat pyrexia, micturition disorder and inflammation. Although skullcap has effective properties on various diseases, the effects and molecular mechanism of Skullcap on BPH are not fully understood. Therefore, in this study, we evaluated the efficacy of Chinese Skullcap root extract (SRE) in testosterone-induced BPH rats. Compared with the untreated group, the SRE treatment group suppressed pathological alterations, such as prostate growth and increase in serum dihydrotestosterone and $5{\alpha}$-reductase levels. Furthermore, SRE significantly decreased the expression of androgen receptor and proliferating cell nuclear antigen. SRE also restored Bax/Bcl-2 balance. These effect of SRE was more prevalent than commercial $5{\alpha}$-reductase inhibitor, finasteride. Taken together, we propose that SRE suppresses abnormal androgen events in prostate tissue and inhibits the development of BPH by targeting inflammation- and apoptosis-related markers. These finding strengthens that SRE could be used as plant-based $5{\alpha}$-reductase inhibitory alternative.

• 대한약침학회지
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• 제18권1호
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• pp.19-26
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• 2015

Objectives: Quercetin, a flavonoid compound, has been reported to induce apoptosis in cancer cells, but its anti-inflammatory effects, which are also closely linked with apoptosis, if any, on non-small-cell lung cancer (NSCLC) have not so far been critically examined. In this study, we tried to determine if quercetin had any demonstrable anti-inflammatory potential, which also could significantly contribute to inducing apoptosis in a NSCLC cell line, A549. Methods: In this context, several assays, including cytotoxicity, flow cytometry and fluorimetry, were done. Gene expression was analyzed by using a western blot analysis. Results: Results revealed that quercetin could induce apoptosis in A549 cells through mitochondrial depolarization by causing an imbalance in B-cell lymphoma 2/Bcl2 Antagonist X (Bcl2/Bax) ratio and by down-regulating the interleukine-6/signal transducer and activator of transcription 3 (IL-6/STAT3) signaling pathway. An analysis of the data revealed that quercetin could block nuclear factor kappa-light-chain-enhancer of activated B cells (NF-${\kappa}B$) activity at early hours, which might cause a down-regulation of the IL-6 titer, and the IL-6 expression, in turn, could inhibit p-STAT3 expression. Down-regulation of both the STAT3 and the NF-${\kappa}B$ expressions might, therefore, cause down-regulation of Bcl2 activity because both are major upstream effectors of Bcl2. Alteration in Bcl2 responses might result in an imbalance in the Bcl2/Bax ratio, which could ultimately bring about mitochondria mediated apoptosis in A549 cells. Conclusion: Overall, the finding of this study indicates that a quercetin induced anti-inflammatory pathway in A549 cells appeared to make a significant contribution towards induction of apoptosis in NSCLC and, thus, may have a therapeutic use such as a strong apoptosis inducer in cancer cells.

• 대한기계학회논문집B
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• 제39권4호
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• pp.359-370
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• 2015

본 연구는 다양한 조건하에서 모세관력 불균형에 의해 구동되는 수평 표면 위의 액적 거동을 수치해석적으로 연구한 것이다. 액적 거동은 자체개발 코드(PowerCFD)를 사용하여 수치해석하였다. 수치해석에 사용된 코드는 보존적인 압력기반 유한체적방법에 기초한 비정렬 셀 중심 방법 및 VOF 방법에 체적포착법인 CICSAM을 채용하고 있다. 상세한 액적 거동이 다양한 초기 액적형상, 접촉각 및 표면장력(또는 Bond 수)의 조건하에서 얻어졌다. 또한 액적 이송 메커니즘이 액적 형상에 대한 수치해석 결과로부터 검토되었다.

• 산업경영시스템학회지
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• 제46권3호
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• pp.139-147
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• 2023

The metal bush assembling process is a process of inserting and compressing a metal bush that serves to reduce the occurrence of noise and stable compression in the rotating section. In the metal bush assembly process, the head diameter defect and placement defect of the metal bush occur due to metal bush omission, non-pressing, and poor press-fitting. Among these causes of defects, it is intended to prevent defects due to omission of the metal bush by using signals from sensors attached to the facility. In particular, a metal bush omission is predicted through various data mining techniques using left load cell value, right load cell value, current, and voltage as independent variables. In the case of metal bush omission defect, it is difficult to get defect data, resulting in data imbalance. Data imbalance refers to a case where there is a large difference in the number of data belonging to each class, which can be a problem when performing classification prediction. In order to solve the problem caused by data imbalance, oversampling and composite sampling techniques were applied in this study. In addition, simulated annealing was applied for optimization of parameters related to sampling and hyper-parameters of data mining techniques used for bush omission prediction. In this study, the metal bush omission was predicted using the actual data of M manufacturing company, and the classification performance was examined. All applied techniques showed excellent results, and in particular, the proposed methods, the method of mixing Random Forest and SA, and the method of mixing MLP and SA, showed better results.

• Environmental Analysis Health and Toxicology
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• 제19권3호
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• pp.251-259
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• 2004

Xenoestrogens are chemicals with diverse structure that mimic estrogen. Bisphenol A, a monomer of polycarbonate and epoxy resins, has been detected in canned food and human saliva. Bisphenol A stimulate cell proliferation and induce expression of estrogen -response genes in vitro. The purpose of the this study was to evaluate cell proliferation of bisphenol A in the presence of a rat liver 59 mix contaning cytochrome P450 enzymes and Cu (II). The fragmentation of intact DNA, a parameter of apoptotic cell death, was evaluated quantitatively by diphenylamine reaction method. Bisphenol A induced apoptotic cell death in a dose-dependent manner The effect of radical scavenger on the apoptotic cell death induced bisphenol A was investigated. The DNA fragmentation induced by bisphenol A was significantly inhibited by addition of radical scavenger to the culture medium. This indicated that elevated oxidative stress caused by imbalance between the production and removal of free radicals occurred in cells. Taken together, these results suggest that free radical reacts with Cu (II) leading oxidative stress.

• 전기학회논문지
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• 제58권9호
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• pp.1706-1713
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• 2009

In this paper, a parallel operation algorithm for high power PEMFC generation systems is proposed. According to increasing the capacity of fuel cell systems with several fuel cell stacks, the different dynamic characteristics of each fuel cell stack effect on imbalance of load sharing and current distribution, so that a robust parallel operation algorithm is desired. Therefore, a power-sharing technique is developed and explained in order to design an optimal distributed PEMFC generation system. In addition, an optimal controller design procedure for the proposed parallel operation algorithm is introduced, along with informative simulations and experimental results.

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제8권10호
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• pp.3394-3408
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• 2014

Conventional mobile state (MS) and base station (BS) association based on average signal strength often results in imbalance of cell load which may require more powerful processor at BSs and degrades the perceived transmission rate of MSs. To deal with this problem, a Markov decision process (MDP) for load balancing in a multi-cell system with multi-carriers is formulated. To solve the problem, exploiting Sarsa algorithm of on-line learning type [12], ${\alpha}$-controllable load balancing algorithm is proposed. It is designed to control tradeoff between the cell load deviation of BSs and the perceived transmission rates of MSs. We also propose an ${\varepsilon}$-differential soft greedy policy for on-line learning which is proven to be asymptotically convergent to the optimal greedy policy under some condition. Simulation results verify that the ${\alpha}$-controllable load balancing algorithm controls the behavior of the algorithm depending on the choice of ${\alpha}$. It is shown to be very efficient in balancing cell loads of BSs with low ${\alpha}$.

• 전력전자학회논문지
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• 제24권4호
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• pp.279-285
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• 2019

This study proposes an enhanced switching pattern that can improve energy transfer efficiency in an active cell-balancing circuit using a multiwinding transformer. This balancing circuit performs cell balancing by transferring energy stored in a specific cell with high energy to another cell containing low energy through a multiwinding transformer. The circuit operates in flyback and buck-boost modes in accordance with the energy transfer path. In the conventional flyback mode, the leakage inductance of the transformer and the stray inductance component of winding can transfer energy to an undesired path during the balancing operation. This case results in cell imbalance during the cell-balancing process, which reduces the energy transfer efficiency. An enhanced switching pattern that can effectively perform cell balancing by minimizing the amount of energy transferred to the nontarget cells due to the leakage inductance components in the flyback mode is proposed. Energy transfer efficiency and balancing speed can be significantly improved using the proposed switching pattern compared with that using the conventional switching pattern. The performance improvements are verified by experiments using a 1 W prototype cell-balancing circuit.

• 한국세라믹학회지
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• 제51권4호
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• pp.289-294
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• 2014

The stability of a solid oxide fuel cell (SOFC) stack is strongly dependent on the magnitude and profile of the internal chemical potential of the solid electrolyte. If the internal partial pressure is too high, the electrolyte can be delaminated from the electrodes. The formation of high internal pressure is attributed to a negative cell voltage, and this phenomenon can occur in a bad cell (with higher resistance) in a stack. This fact implies that the internal chemical potential plays an important role in determining the lifetime of a stack. In the present work, we fabricate planar type anode-supported cells ($25cm^2$) with a bi-layer electrolyte (with locally increased electronic conduction at the anode side) to prevent high internal pressure, and we test the fabricated cells under a negative voltage condition. The results indicate that the addition of electronic conduction in the electrolyte can effectively depress internal pressure and improve the cell stability.