• Journal of the Korean Chemical Society
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• v.43 no.6
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• pp.628-635
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• 1999

Direct preparative method of 2,6-diformyl-p-cresol and 2-hydroxy-3-hydroxy-5-methylbenzaldehyde from 2,6-bis(hydroxymethyl)-4-methylphenol using activated $Mn(IV)O_2$ was described. Hexadentate compartmental Iigands, $H_4L[A]\;and\; H_4L[B]$ were prepared by condensation reactions of 2-hydroxy-3-hydroxy methyl-5-methylbenzaldehyde with ethylenediamine and 1,3-diaminopropane respectively. By the reaction of macrocycle($H_4[20]DOTA$) with Ln(III) nitrate {Ln(III)=Pr, Sm, Cd, Dy }, discrete mononuclear Ln(III) complexes of the type $[Ln(H_2[20]DOTA)(ClO_4)(H_2O)]\;{\cdot}\;3H_2O$ were synthesized in the solid state. $[Ln([20]DOTA)(NO_3)(H_2O)](NO_3)_2\;{\cdot}\;xH_2O$ was placed in methanol for 2 days, and $[Ln([20]DOTA)(NO_3)(CH_3OH)]^{2+}$ was formed. The equilibrium constants(K) for the substitution of coordinated $CH_3OH$ in the Ln-[20]DOTA complexes by various auxiliary ligand, $L_a$(=salicylic acid, p-chlorobenzoic acid, benzoic acid, acetic acid, 4-bromophenol) were determined spectroscopically at 25$^{\circ}C$ and 0.1M $NaClO_4$. The K values calculated were in the order of salicylic acid > p-chlorobenzoic acid > benzoic acid > acetic acid > 4-bromophenol, while pKa of auxiliary ligands was in the opposite trend.

• Applied Biological Chemistry
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• v.44 no.2
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• pp.103-108
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• 2001

The objectives of this study were to investigate the contamination of the soils around the major roadsides in Seoul and to accumulate base-line data. Fifty topsoils ($0{\sim}5$ cm) and 48 subsoils ($20{\sim}50$ cm) were collected from 50 sampling sites near Manguro in Chungnanggu. The samples were air-dried, passed through 2-mm sieves, and analyzed to determine the physicochemical properties and the contents of heavy metals (Cd, Cu, Pb, Zn) and anions (Cl, $NO_3$, $SO_4$). Soil textures of top- and subsoils were mainly loamy sand and sandy loam, respectively. Average $_PH$ of top- and subsoil was approximately 7.5, much higher than that of the forest soils in Seoul. Average heavy metal contents were lower than the levels allowed by the Soil Environment Conservation Act of Korea, whereas much higher than those of the forest soils. Contents of some heavy metals were higher than the maximum allowed levels. Anion concentrations were also much higher than those of the forest soils. A careful management to prevent the aggravation of the present contamination level and the diffusion of contaminants is recommended.

• Korean Journal of Cleft Lip And Palate
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• v.5 no.1
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• pp.27-42
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• 2002

This study was designed to evaluate the morphology and the position of the mandible in the complete unilateral cleft lip and palate patients, Craniofacial skeletal morphology pattern was analyzed on the lateral cephalometric radiographs of the 50 subjects of complete unilateral cleft lip and palate, the 50 normal and 50 class III, Each group was divided into child and adult sub-groups, All the data were tested statistically. The results were as follows: I, In the comparison with the normal group, complete cleft group showed smaller angular, condylar length, clockwisely rotated mandible and larger NMe/SGo(p<0.01). 2, In the comparison with the class III group, the complete cleft group showed significantly smaller angular, condylar, ramal, body length of the mandible(p<0,01). 3. As for the position of the mandibular condyle to the cranial base, the class III group was the most anterior, the normal group was the most posterior and the complete cleft group was in the middle(p<0.05). 4. In the comparison with child group, the normal adult group showed smaller mandibular angle and mandibular plane angle, but not the other two groups. And the complete cleft group and the class III group showed the similar change. The normal and class III group showed increased XiCd/XiPog, but not the complete cleft group(p<0.01).

• Journal of Ginseng Research
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• v.40 no.2
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• pp.196-202
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• 2016

Background: Ginsenoside Rd (GSRd), a main component of the root of Panax ginseng, exhibits anti-inflammation functions and decreases infarct size in many injuries and ischemia diseases such as focal cerebral ischemia. M1 Macrophages are regarded as one of the key inflammatory cells having functions for disease progression. Methods: To investigate the effect of GSRd on renal ischemia/reperfusion injury (IRI) and macrophage functional status, and their regulatory role on mouse polarized macrophages in vitro, GSRd (10-100 mg/kg) and vehicle were applied to mice 30 min before renal IRI modeling. Renal functions were reflected by blood serum creatinine and blood urea nitrogen level and histopathological examination. M1 polarized macrophages infiltration was identified by flow cytometry analysis and immunofluorescence staining with $CD11b^+$, $iNOS^+$/interleukin-12/tumor necrosis factor-${\alpha}$ labeling. For the in vitro study, GSRd ($10-100{\mu}g/mL$) and vehicle were added in the culture medium of M1 macrophages to assess their regulatory function on polarization phenotype. Results: In vivo data showed a protective role of GSRd at 50 mg/kg on Day 3. Serum level of serum creatinine and blood urea nitrogen significantly dropped compared with other groups. Reduced renal tissue damage and M1 macrophage infiltration showed on hematoxylin-eosin staining and flow cytometry and immunofluorescence staining confirmed this improvement. With GSRd administration, in vitro cultured M1 macrophages secreted less inflammatory cytokines such as interleukin-12 and tumor necrosis factor-${\alpha}$. Furthermore, macrophage polarization-related pancake-like morphology gradually changed along with increasing concentration of GSRd in the medium. Conclusion: These findings demonstrate that GSRd possess a protective function against renal ischemia/reperfusion injury via downregulating M1 macrophage polarization.

• Journal of Soil and Groundwater Environment
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• v.21 no.3
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• pp.6-13
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• 2016

The effect of blast oxygen furnace (BOF) slag used as filling materials on the soil environment was studied using column tests that simulated the flow of the BOF slag leachate through the soil layer. The Cu, Mn, Zn, Ni, and F contents of the leachate affected soil were similar to that of the controls (i.e., soils that were not affected by the leachate). The As, Cd, and Pb contents were lower in the leachate affected soils than the controls. The changes in these contaminants contents can be attributed to the interactions between anions such as alkalinity generating anions (e.g., CO₃²⁻, HCO₃⁻, OH⁻) or calcium ions with heavy metals or F, which consequently affected the fate of heavy metals and F in the leachate affected soils. The germination and growth of Spinapis alba in the soils affected by the leachate and the controls were also similar. However, the proportion of alkalophilic bacteria in the soils affected by the leachate significantly increased, and this can be explained by the increased soil pH due to the alkaline leachate. Overall, this study shows that the alkalinity of the BOF slag leachate, rather than the presence of heavy metals and F in the leachate, needs to be considered when the BOF slag is to be reused as structural filling materials.

• Proceedings of the Korea Technical Association of the Pulp and Paper Industry Conference
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• 2001.04a
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• pp.81-81
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• 2001

초지 공정은 wire, roll, pump등의 회전체로 이루어진 공정이 거의 대부분이기 때문에 주기적으로 변동하는 성분들이 많고, QCS(Quality Control System) 및 DCS(Distributed Co n ntrol System)상에 서 의 자동 Control Logic에 의 한 불안정 (Fluctuation)요소도 내 재 되 어 있 어 이에 대한 분석이 필요하다. 이러한 주기적인 변동은 제품의 여러 물성(평량, 두께, 광택 도등) 에 영향을 미치게 되어 품질의 균일성이나 프로파일에 영향을 미치게 된다. 따라서 공정상이나 품질에서 주기적으로 변동하는 성분을 추출하여 공정 각 성분과 연관을 시키변 품질에 나타나는 주기적 성분의 요인이 어느 부분에서 기인하는 지를 직접적으로 찾아낼 수 있고 이의 개선을 통해 품질의 균일성 및 프로파일 향상을 꾀할 수 있다. 본 연구에서는 Air padded type 헤드박스 초지기에서 DAQ(Data Acquisition) System 을 이용하여 각 공정별로 MD(Machine Direction)방향으로의 변동을 측정하고 제품의 물성 변동과 비교하였다. DAQ System은 각 공정상의 전기적 신호를 높은 주파수 영역까지 다채널로 동시에 받 아 들일 수 있는 장치로 이 시스템을 활용하여 공정상의 Machine chest 농도, Stock box 유량 및 레벨, Fan pump RPM, Cleaner압력, Screen압력, H!B압력 및 레벨, Silo level등 공 정요소의 변동상태와 상호영향을 분석하였다. 이러한 공정 각 요소의 변동과 MD 방향의 제품 물성 값(Tapio, Paper Variation Analyzer에 대한 비교 분석결과 제품 평량에서 주기적인 변동성분을 확인할 수 있었고 이중 큰 비 중을 차지하는 것이 fνB 레벨 변동주기와 일치하는 것을 찾아낼 수 있었다. 이에 근거하여 D DCS system의 control 요소인 튜닝 parameter(P,I 값)들을 미 세 조정 하여 제 품의 MD방향 평량 변동 진폭을 기존 수준의 30% 수준으로 감소시킬 수 있었다. 그 결과 COV(표준편차/ 평량)값을 0.8-1.2%에서 0.6-0.8%수준으로 낮출 수 있었고 이에 따라 CD (Cross Direction) 방향의 제품 Profile도 함께 개선되는 효과를 거둘 수 있었다.

• Publications of The Korean Astronomical Society
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• v.11 no.1
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• pp.1-26
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• 1996

We have built a near-infrared imaging camera with a PtSi array detector manufactured by the Mitsubishi Company. The PtSi detector is sensitive in the wavelength range 1 to $5{\mu}m$. Quantum efficiency of PtSi is much lower than that of InSb and HgCdTe types. However, the PtSi array has advantages over the latter ones: (i)The read-out noise is very low; (ii)the characteristics of the array elements arc uniform and stable; (iii)it is not difficult to make a large PtSi array; and (iv) consequently the price is affordably low. The array used consists of $512{\times}512$ pixels and its size is $10.2\;mm{\times}13.3\;mm$. The filter wheel of the camera is equipped with J, H, K filters, and an aluminum plate for measuring the dark noise. The dewar is cooled with liquid nitrogen. We have adopted a method of installing the clock pattern and the observing softwares in the RAM, which Gill he easily used for other systems. We have developed a software with a pull-down menu for operating the camera and data acquisition. The camera has been tested by observing $\delta$ Orionis.

• Journal of the Korean Institute of Electrical and Electronic Material Engineers
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• v.15 no.5
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• pp.435-440
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• 2002

In this study, we have investigated photo-induced changes of optical energy gap( $E_{OP)}$ and photoluminescence (PL) in amorphous ($\alpha$-) S $e_{100-x}$G $e_{x}$ (x=5, 25 and 33) thin films prepared by conventional thermal evaporation method. In the $\alpha$-S $e_{100-x}$G $e_{x}$ thin film, the $E_{OP}$ is obtained by a linear extrapolation of the ($\alpha$hν)$^{\frac{1}{2}}$ versus hν plot to the energy axis using the optical absorption coefficient ($\alpha$) calculated from the extinction coefficient k measured in the wavelength range of 290~900nm. Although the values of $\Delta$ $E_{OP}$ are very different, all films exhibit photo-induced photo-darkening (PD) effect that is a red shift of $E_{OP}$ . In particular, $\Delta$ $E_{OP}$ in $\alpha$-S $e_{75}$ G $e_{25}$ thin film exhibits the largest value (i, e., $\Delta$ $E^{OP}$ ~40meV for $\alpha$-S $e_{95}$ G $e_{5}$ , $\Delta$ $E_{OP}$ ~200meV for $\alpha$-S $e_{75}$ G $e_{25}$ , $\Delta$ $E_{OP}$ ~130meV for $\alpha$-S $e_{67}$ G $e_{33}$ ). PL spectra in $\alpha$-SeGe by hν$_{HeCd}$ have no-Stokes shift (SS) and show a tendency dependent on both composition and illumination time. We explain the energy-induced phenomena such as the PD and thermal bleaching, the native charged-defect generation and the no-SS PL, etc..the PD and thermal bleaching, the native charged-defect generation and the no-SS PL, etc..tc..

• The Korea Journal of Herbology
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• v.36 no.1
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• pp.1-8
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• 2021

Objective : Citri Unshius Pericarpium (Citrus unshiu peel) has been used in Korean medicine to treat indigestion, vomiting, coughing and phlegm. This study investigated the hepatoprotective effect of ethanol extract of Citrus unshiu peel (CEE) in cadmium (CdCl2)-treated mouse model. Methods : CEE was dissolved in water and administered orally to mice once a day for 7 consecutive days. The mice were then exposed to a single intraperitoneal (i.p.) injection of cadmium (4 mg/kg body weight) to induce acute hepatotoxicity. At the end of the experiment, blood and liver tissue samples were collected, analyzed for alanine aminotransferase (ALT), aspartate aminotransferase (AST), and histopathological evaluation. Liver damage was assessed as the percentage of degenerative areas of the hepatic parenchyma, the number of degenerative hepatocytes, and the number of infiltrated inflammatory cells. Results : In cadmium-treated rats, pretreatment with CEE significantly reduced the serum ALT and AST levels associated with liver damage. Histopathologically, CEE prevented degenerative changes on the hepatic tissues including confluent necrosis, congestions and infiltration of inflammatory cells. CEE also reduced the elevation of oxidative stress markers (nitrotyrosine and 4-hydroxynonenal) and apoptosis markers (cleaved caspase-3 and cleaved PARP) positive cells. PARP protein expression in liver tissue was also restored by CEE. Conclusion : This study showed that CEE exerted antioxidant and anti-apoptotic effects against cadmium-induced liver injury. Thus, it can be concluded that CEE can be used to prevent liver damage caused by cadmium.

• Korean Journal of Environmental Agriculture
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• v.13 no.3
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• pp.321-337
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• 1994

The garbage from the dwelling houses was composted in two kinds of small composter in laboratory to investigate the possibility of garbage composting. They were general small composters. One (type 1) was insullated but the other (type 2) was not. Because it was found that type 2 was not available for composting under our meteorological conditions through winter experiment, only type 1 was tested in spring and summer. The experiment was performed for 8 weeks in each season. The seasonal variation of several compounds in compost was evaluated and discussed. The result summarized belows are those taken at the end of the experiment, if the time was not specified. 1) The maximum temperature was $58^{\circ}C$ in spring, $57^{\circ}C$ in summer and $41^{\circ}C$ in winter. This temperature was enough to destroy the pathogen except for winter. 2) The mass was reduced to average 62.5% and the volume reduction was avergae 74%. 3) The density was estimated as 0.7kg/l in spring, 0.8kg/l in summer and 1.1kg/l in winter. 4) The water content was not much changed for composting periods. It had 75.6% in spring and 76.6% in summer and winter. 5) There was a great seasonal difference in pH value. It was reached to pH 6.13 in spring, pH 8.62 in summer and pH 4.75 in winter. 6) The faster organic matter was decomposed, the greater ash content was increased. Cellulose and lignin content were increased, but hemicellulose content was reduced during composting period. 7) Nitrogen contents were in the range of 3.1-5.6% and especially high in summer. After ammonium nitrogen contents were increased at the early stage of composting period, they were decreased. The maximum ammonium nitrogen content was 3,243mg/kg after 2 weeks in winter, 6,053mg/kg after 3 weeks in spring and 30,828mg/kg after 6 weeks in summer. C/N-ratios were not much changed. Nitrification occurred actively in spring and summer. 8) The contents of volatile and higher fatty acids were increased in early stage of composting and reduced after that. The maximum content of total fatty acid was 10.1% after 2 weeks in winter, 5.8% after 2 weeks in spring and 15.7% after 4 weeks in summer. 9) The contents of inorganic compounds were not accumulated as composting was proceeded. They were in the range of 0.9-4.4% $P_2O_5$, 1.6-2.9% $K_2O$, 2.4-4.6% CaO and 0.30-0.80% MgO. 10) CN and heavy metal contents did not show any tendency. They were in the range of 0.11-28.99mg/kg CN, 24-166mg/kg Zn, 5-129mg/kg Cu, 0.8-14.3mg/kg Cd, 7-42mg/kg Pb, ND-30mg/kg Cr and $ND-132.16\;{\mu}g/kg$ Hg.