• 한국수자원학회논문집
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• 제37권4호
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• pp.305-314
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• 2004

온실기체의 증가에 따른 기후변화로 인해 유역에서의 물순환이 과거와는 다른 패턴을 보이고 있다. 그러나 현재의 수자원 계획 및 관리에는 기후변화의 영향이 포함되어 있지 않다. 이에 본 연구에서는 기후변화의 영향이 유역의 물순환에 어떻게 영향을 주는지를 검토하였다. 본 연구는 기존의 여러 가지 배증 $CO_2$상태의 GCM(General Circulation Model) 모의결과를 이용하여 기온 및 강수량 자료를 Markov 연쇄에 의해 모의발생 하였다. 또 강우-유출 모형을 이용하여 100년동안의 일단위 유출을 계산하였다. 그 결과 GCM 시나리오별로 연평균기온은 ＋3.2∼＋4.6$^{\circ}C$, 연평균강수량은 －7∼＋8%, 연평균유출은 －14 ∼ ＋7 % 그리고 기온 1$^{\circ}C$ 변화에 따른 잠재증발산량은 ＋3∼＋4 %의 변화를 보였다. 기후변화에 따른 영향의 평가는 GCM 모의결과에 크게 의지하지만 유황분석결과 기후변화에 따른 유출의 변동가능폭은 현재 상태보다 커질 것으로 예상된다.

• 대한안전경영과학회지
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• 제17권2호
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• pp.215-228
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• 2015

A creative innovation and an innovative problem-solving of industrial companies can be achieved by overcoming the challenges of technical and physical contradictions. The approaches to address conflicting and paradoxical problems, such as technical and physical contradictions have a crucial role in advancing the quality assessment for manufacturer and service provider. The term, technical contradiction, depicts the state that improvement of one ends of IFR (Ideal Final Result) leads to unfavorable condition of the other ends, and results in conflicting problem. Another type of contradictions that's discussed in this study is a physical contradiction which is due to two mutually opposing states of the means of ends, and gives paradoxical situation. By integrating the means-ends chain perspectives, the physical contradiction that is a specifically root-causes, "means", can be initially addressed to resolve the downstream problem of technical contradiction which represents a general and abstract goals, "ends". This research suggests IFR resolution processes to handle both physical contradiction of means and technical contradiction of ends by employing causal relationship with IFR, effects and causes. In summary, the study represents three major processes that resolve such contradictions are demonstrated as follows: 1) Derivation of causal and hierarchical relationship among IFR, ends and means by considering CAED (Cause-And-Effect Diagram) and LT (Logic Tree). 2) Identification of causal relationship between physical contradiction and technical contradiction by using TPCT (TRIZ Physical Contradiction Tree) and TCD (Technical Contradiction Diagram). 3) Application of integrated TRIZ principles by classifying 40 inventive principles into 4 general conditions of the separation principle of mutually opposite states in space, in time, based on conditions, and between the parts and the whole. In order to validate the proof of proposed IFR resolution processes, the analysis of the TRIZ case studies from National Quality Circle Contest in the years, 2011 to 2014 have been proposed. The suggested guidelines that are built based on TRIZ principles can uniquely enhance the process of quality innovation and assessment for quality practitioners.

• 한국환경보건학회:학술대회논문집
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• 한국환경보건학회 2005년도 국제학술대회
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• pp.306-310
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• 2005

Exposure to UVB radiation can cause diverse biological photodamage to skin. Eeb 761 and Korean red ginseng are the major and most effective natural drug against a variety of oxidative damage. But, the protective effects against UVB radiation have not been clearly identified. In this study, we investigated the protective effect of topical EGb 761 and Korean red ginseng on pigmentation by UVB radiation. Pro-inflammatory cytokines($IL-l{\beta}$, IL-6 and $TNF-{\alpha}$) and melanogenesis proteins(tyrosinase, TRP-1 and TRP-2) mRNA were measured by reverse transcription-polymerase chain reaction(RT-PCR) analysis. The in vivo protection against pigmentation was calculated using chromameter. The mRNA level of IL-lf and TNF-a were increased by UVB irradiation in treated and non-treated group, while no significant changes were observed in IL-6 level. Topical treatment with EGb 761 and Korean red ginseng remarkably reduced expression of tyrosinase, TRP-1 and TRP-2 in the non-irradiated and irradiated skin. Application of EGb 761 and Korean red ginseng significantly protected the WB-induced skin pigmentation and Korean red ginseng was more effective. Our study suggests that topical ECb761 and Korean red ginseng can regulate melanogenic proteins and protect UVB radiation on skin pigmentation.

• 대한한의학회지
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• 제19권1호
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• pp.419-429
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• 1998

Poncirus trifoliata (L.) Raf (Rutaceae) fruits (PTFE) has been used for the treatment of allergic disease. IgE is normally one of the least abundant immunoglobulin (Ig) isotypes in the serum of both humans and several species of experimental animals: however a number of different stimuli can result in profound increases in IgE levels relative to other isotypes. In rodents, infection with many parasitic helminths can cause approximately 100-fold elevation in IgE within 2 wks. Immunization of mice with small amounts of protein antigens on alum also results in 10-fold to fold increase in total serum IgE, much of it specific for the immunizing antigen. In this experiment, I investigated the effect of an aqueous extract of Poncirus trifoliata (L.) Raf (Rutaceae) fruits (PTFE) on a in vivo and in vitro IgE production. PTFE dose-dependently inhibited the serum levels of IgE induced by antigens. The regulation of IgE synthesis is influenced by T cells and T cell derived factors. IL -4, a T cell-derived cytokine, has been shown to stimulate murine IgE synthesis both in vitro and in vivo. Current evidence suggests that IL-4 induces IgE synthesis in the mouse by stimulating H chain isotype switch. Lipopolysaccharide (LPS) plus IL-4 cause about l00-fold increase in IgE secretion by murine B cells. The effects of PTFE on the IL-4-dependent IgE response by mouse whole spleen cells were studied. Whole spleen cells were cultured for 7 days in the presence of LPS plus IL-4 and PTFE and the supernatants were assayed for IgE. IL-4 dependent IgE production of LPS-stimulated whole spleen cells was inhibited by PTFE. Moreover, in the present study using U266Bl human IgE-bearing B cells, I found that PTFE inhibited the production of IgE activated by LPS plus IL-4. These results indicate that PTFE have antiallergic activity by inhibition of IgE production from B cells.

• 분석과학
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• 제14권4호
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• pp.356-363
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• 2001

절삭폐수의 여과수 등에 많이 포함된 음이온 계면활성제의 정성 및 정량분석을 위한 기초연구로 SDS를 포함하는 완충용액에서의 음이온 계면활성제들의 거동을 알아보고 최적의 분석조건을 찾기 위한 실험을 수행하였다. SDS 미셀과의 상호작용 결과, 탄소수가 10이상인 카르복실레이트 혹은 술포네이트계 계면활성제는 SDS의 농도가 증가함에 따라, 겉보기 이동도가 크게 변하였다. 겉보기 이동도, 전기삼투 이동도 그리고 전기영동 이동도를 계산하여 비교한 결과, 이러한 겉보기 이동도의 변화는 주로 전기영동 이동도의 변화의 영향임을 알 수 있는 근거를 제시하였다.

• Toxicological Research
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• 제6권2호
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• pp.159-166
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• 1990

The ability of many toxigenic fungi to invade and develop in a wide variety of raw ingredients of human diet renders human exposure to mycotoxing very difficult to avoid. Most of the energy-rich commodities, such as cereal grains, oil seeds, tree nuts, and dehydrated fruits, are susceptible to mycotoxin contamination. Mycotoxins therefare have been recognized as an important class of hazardous substances in the human food chain. Although human exposure to mycotoxins is largely through ingestion, inhalation and skin contact may also be significant under conditions other than consumption of foods. Human ingestion of mycotoxins is due to consumption of contaminated dietary ingredients and the edible tissues and products of domestic animals that have been exposed to mycotoxins in moldy feed. Large scale acute human mycotoxicoses, such as ergotism in France, alimentary toxic aleukia in Russia, yellow rice syndrome in Japan, endemic nephropathy in Balkan countries, and acute aflatoxin poisonings in India and Taiwan, have been well documented, indicating that mycotoxicosis is a global problem. In some incidents, hundreds of victims were killed and many more became seriously ill. The mycotoxins that have been implicated in the etiology of these human diseases include aflatoxins, citreoviridin, cyclopiazonic acid, ergot alkaloids, moniliformin, ochratoxin A, trichothecenes, tenuazonic acid, and zearalenone. Among these, aflatoxins have been also implicated in the etiology of human primary liver cancer in those high-incidence countries in Africa and southeast Asia. It is well recognized that cause-effect relationship between mycotoxins and human diseases is very difficult to establish, especially for the cancer connection. Careful risk assessment must be performed to determine whether a mycotoxin indeed warrants costly regulatory actions.

• 센서학회지
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• 제19권6호
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• pp.449-455
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• 2010

Implantable middle ear hearing devices(IMEHDs) have being actively studied to overcome the problems of conventional hearing aids. Vibration transducer, an output devices of IMEHDs, is attached on the ossicular chain and transmits mechanical vibration to cochlea. This approach allows us to hear more clear sound because mechanical vibration is effective to transfer high frequency acoustics, but occurs some problems such as fatigue accumulation to ossicular chian and reduction of vibration displacement caused by mass loading effect. Recently, many studies for the round window stimulation are announced, because it does not cause such problems. It have been studied by older transducers designed for attaching on ossicular chain. In this paper, we proposed a new electromagnetic transducer which consists of two magnets, three coils and a vibration membrane. The magnet assembly, magnet coupled in opposite direction, were placed in the center of three coils, and the optimum length of each coil generating maximum vibrational force was calculated by finite element analysis(FEA). The transducer was implemented as the calculated length of each coil, and measured vibration displacement. From the results, it is verified the vibration displacement can be improved by optimizing the length of coils.

• 한국환경복원기술학회지
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• 제20권4호
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• pp.1-13
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• 2017

The purpose of this study is to analyze a term of decade of water quality data of the Mulgum intake station on the Nakdong river(dam) to find the cause of algal blooms and to set an alternative to prevent artificial lake water pollution. Our study shows that water quality changes have regular periodic regularity and there was a certain correlation between specific analytical items. According to the analysis results of each factor, the decline in precipitation was not the main reason for algal blooms. TP concentration had a slight effect on Chl-a concentration but was not a limiting nutrient of a bloom. TN concentration had a strong correlation with Chl-a and strongly negative correlation with temperature, but was not a bloom's limiting nutrient, and was only a dependent variable. As the temperature was negatively correlated with the Chl-a concentration, it is found that the aspect of the ecological influence of the temperature was the most important factor of the phytoplankton concentration change. The N/P ratio lies under a power function with a high degree of reliability by the TP concentration, and the phenomenon appeared to be the same as the results of two other comparative areas. This result confirms that TN is dependent on TP and the biota in the lake that TN is a dependent variable whose concentration is determined by TP it. In conclusion, the increase in lake bloom is the result of a food chain change, and it is necessary to control the ecosystem by the food chain in the lake in order to reduce the lake's bloom. In particular, it is important to keep the benthic ecosystem as wide as possible in the aerobic state.

• EDISON SW 활용 경진대회 논문집
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• 제4회(2015년)
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• pp.14-23
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• 2015

Alzheimer's disease is one of the most common types of degenerative dementia. As a considerable cause of Alzheimer's disease, neurotoxic plaques composed of 39 to 42 residue-long amyloid beta($A{\beta}$) fibrils have been found in the patient's brain in large quantity. A previous study found that erythrosine B (ER), a red color food dye approved by FDA, inhibits the formation of amyloid beta fibril structures. Here, in an attempt to elucidate the inhibition mechanism, we performed molecular dynamics simulations to demonstrate the conformational change of $A{\beta}40$ induced by 2 ERs in atomistic detail. During the simulation, the ERs bound to the surfaces of both N-terminus and C-terminus regions of $A{\beta}40$ rapidly. The observed stacking of the ERs and the aromatic side chains near the N-terminus region suggests a possible inhibition mechanism in which disturbing the inter-chain stacking of PHEs destabilizes beta-sheet enriched in amyloid beta fibrils. The bound ERs block water molecules and thereby help stabilizing alpha helical structure at the main chain of C-terminus and interrupt the formation of the salt-bridge ASP23-LYS28 at the same time. Our findings can help better understanding of the current and upcoming treatment studies for Alzheimer's disease by suggesting inhibition mechanism of ER on the conformational transition of $A{\beta}40$ at the molecular level.

• 산업경영시스템학회지
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• 제28권2호
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• pp.18-26
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• 2005

The balanced scorecard(BSC) overcomes the limit of traditional financial statement that focuses on only financial performance. BSC is widely used in government and industry because of the clear representation of the relationship and logic between the key performance indicators(KPI) of 4 perspectives - financial, customer, internal process, and loaming and growth. However, traditional BSC does not consider evaluating the difference between the results measured by BSC. By using relatively small number of inputs and outputs In comparing decision-making units, data envelopment analysis(DEA) can aggregate multiple performance measures. In this research, we propose a methodology named CDB(Combined DEA and BSC) to evaluate the performance of organization considering financial and non-financial perspectives. CDB uses KPI of cause-and-effect relationship on BSC as inputs and outputs of DEA method. In addition, this research proposes a method of converting the KPI of BSC to the input and output variables of DEA, and enhancing discrimination power using the limit number of variables. We illustrate the methodology by giving an example of evaluating aquisition-unit efficiency in a supply chain.