• Korean Journal of Clinical Pharmacy
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• v.31 no.2
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• pp.153-159
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• 2021

Background: With increasing economic evaluation studies on the treatment of or screening tools for liver diseases that cause hepatocellular carcinoma (HCC), interest in the analysis of the medical utilization and costs of HCC treatment is increasing. Therefore, we aimed to estimate the medical utilization and costs of HCC patients, and calculate the cost of main procedures for HCC treatment, including liver transplant (LT), hepatic resection (HR), radiofrequency ablation (RFA), and transarterial chemoembolization (TACE). Methods: We analyzed claim data from January to December 2018 from the Health Insurance and Review and Assessment Service-National Patient Sample (HIRA-NPS-2018) dataset, including data of patients diagnosed with HCC (Korean Standard Classification of Diseases code C22.0) who had at least one inpatient claim for HCC. Results: A total of 715 HCC patients were identified. In 2018, the yearly average medical cost per HCC patient was ₩18,460K (thousand), of which ₩14,870K was attributed to HCC. Among the total medical costs of HCC patients, the inpatient cost accounted for the largest portion of both the total medical and HCC-related costs. The major procedures of HCC treatment occurred most frequently in the order of TACE, RFA, HR, and LT. The average medical cost per treatment episode was the highest for LT (₩87,280K), followed by HR (₩10,026K), TACE (₩4,047K), and RFA (₩2,927K). Conclusion: By identifying the medical costs of HCC patients and the costs of the main procedures of HCC treatment, our results provide basic information that could be utilized for cost estimation in liver disease-related economic evaluation studies.

• Journal of the Korean Institute of Gas
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• v.25 no.1
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• pp.40-47
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• 2021

In this study, hazards of decomposition and explosion for tert-butylperoxymaleate(TBPM), an organic peroxide, were evaluated by using various equipment to determine the cause of a fire explosion accident. As a result of DSC analysis, the instantaneous power density of TBPM was 26,401 kW/ml, and the NFPA reactive index(Nr) was classified as 4. And the positive value of EP(explosive propagation) and SS(shock sensitivity) showed that the TBPM had a potential hazard of explosion. From the experimental results, the shock sensitivity and friction sensitivity was rated as class 4 and 5, respectively. In the pressure vessel test, TBPM was ranked USA-PVT No.4 and evaluated as a self-reactive substance. In the combustion rate test, TBPM had the combustion rate of 167 mm/sec and was evaluated as the flammable solid classification 2 in GHS.

• Journal of Korean Neurosurgical Society
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• v.64 no.3
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• pp.386-405
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• 2021

Recent advancements in basic research on the process of secondary neurulation and increased clinical experience with caudal spinal anomalies with associated abnormalities in the surrounding and distal structures shed light on further understanding of the pathoembryogenesis of the lesions and led to the new classification of these dysraphic entities. We summarized the changing concepts of lesions developed from the disordered secondary neurulation shown during the last decade. In addition, we suggested our new pathoembryogenetic explanations for a few entities based on the literature and the data from our previous animal research. Disordered secondary neurulation at each phase of development may cause corresponding lesions, such as failed junction with the primary neural tube (junctional neural tube defect and segmental spinal dysgenesis), dysgenesis or duplication of the caudal cell mass associated with disturbed activity of caudal mesenchymal tissue (caudal agenesis and caudal duplication syndrome), failed ingression of the primitive streak to the caudal cell mass (myelomeningocele), focal limited dorsal neuro-cutaneous nondisjunction (limited dorsal myeloschisis and congenital dermal sinus), neuro-mesenchymal adhesion (lumbosacral lipomatous malformation), and regression failure spectrum of the medullary cord (thickened filum and filar cyst, low-lying conus, retained medullary cord, terminal myelocele and terminal myelocystocele). It seems that almost every anomalous entity of the primary neural tube may occur in the area of secondary neurulation. Furthermore, the close association with the activity of caudal mesenchymal tissue in secondary neurulation involves a wider range of surrounding structures than in primary neurulation. Although the majority of the data are from animals, not from humans and many theories are still conjectural, these changing concepts of normal and disordered secondary neurulation will provoke further advancements in our management strategies as well as in the pathoembryogenetic understanding of anomalous lesions in this area.

• Safety and Health at Work
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• v.13 no.2
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• pp.227-234
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• 2022

Background and Purpose: In 2021, lung cancer in school food workers was first recognized as an occupational cancer. The classification of the carcinogenicity of cooking fumes by International Agency for Research on Cancer (IARC) was based on Chinese epidemiological data. This study aimed to determine the hazard levels of school cooking fumes in Korea. Materials and Methods: Based on public school cafeterias in one area, 25 locations were selected for the survey according to the number per school type, ventilation states, and environmental pre-assessments of cafeterias. Two inside cooking areas using a heat source and one outside cooking area were selected as control measurement points. Measurements of CO, CO₂, polycyclic aromatic hydrocarbons (PAHs), and total volatile organic compounds (TVOCs), including benzene, formaldehyde, and particulate matter (PM10, PM2.5, PM1, respectively), were taken. The concentrations and patterns of each substance in the kitchens were compared with the outdoor air quality. Result: Known carcinogens, such as the concentrations of PAHs, formaldehyde, TVOC (benzene), and particulate matter in school cooking fumes, were all detected at similar or slightly higher levels than those found outside. Additionally, substances were detected at relatively low concentrations compared to the Chinese cooking fumes reported in the literature. However, the short-term exposure to high concentrations of CO (or composite exposure with CO₂) and PM2.5 in this study were shown. Conclusion: The school cooking fumes in South Korea was a relatively less harmful than Chinese cooking fumes, however short-term, high exposure of toxic substances can cause a critical health effect.

• Korean Chemical Engineering Research
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• v.60 no.2
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• pp.223-228
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• 2022

In chemical processes, unintended faults can make serious accidents. To tackle them, proper fault diagnosis models should be designed to identify the root cause of faults. To design a fault diagnosis model, a process and its data should be analyzed. However, most previous researches in the field of fault diagnosis just handle the data set of benchmark processes simulated on commercial programs. It indicates that it is really hard to get fresh data sets on real processes. In this study, real faulty conditions of an industrial polystyrene process are tested. In this process, a runaway reaction occurred and this caused a large loss since operators were late aware of the occurrence of this accident. To design a proper fault diagnosis model, we analyzed this process and a real accident data set. At first, a mode classification model based on support vector machine (SVM) was trained and principal component analysis (PCA) model for each mode was constructed under normal operation conditions. The results show that a proposed model can quickly diagnose the occurrence of a fault and they indicate that this model is able to reduce the potential loss.

• The Korean Journal of Applied Statistics
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• v.35 no.5
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• pp.593-601
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• 2022

We call "fruad" the cases that are not frequently occurring but cause significant losses. Fraud detection is commonly encountered in various applications, including wafer production in the semiconductor industry. It is not trivial to directly extend the standard binary classification methods to the fraud detection context because the misclassification cost is much higher than the normal class. In this article, we propose the functional fraud detection support vector machine (F²DSVM) that extends the fraud detection support vector machine (FDSVM) to handle functional covariates. The proposed method seeks a classifier for a function predictor that achieves optimal performance while achieving the desired sensitivity level. F²DSVM, like the conventional SVM, has piece-wise linear solution paths, allowing us to develop an efficient algorithm to recover entire solution paths, resulting in significantly improved computational efficiency. Finally, we apply the proposed F²DSVM to the defective wafer detection problem and assess its potential applicability.

• Archives of Craniofacial Surgery
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• v.23 no.5
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• pp.205-210
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• 2022

Background: Nasal bone fractures are the most common type of facial bone fracture, but are under-studied in adults above 65 years of age. Therefore, we investigated the epidemiology and patterns of nasal bone fractures among older adults in comparison to different age groups. Methods: This retrospective study included 2,321 nasal bone fracture patients who underwent surgery at our hospital from January 2010 to December 2017. The patients were classified by age as preschoolers, school-age children, young and middle-aged adults, and the elderly. We performed pairwise comparisons between elderly patients and each other age group in terms of sex, cause of injury, and fracture type. Results: The 2,321 nasal bone fracture patients included 76 elderly patients (50 men [65.8%] and 26 women [34.2%]). In these patients, the two most common injury causes were falling or slipping down (n= 39; 51.3%) and road traffic accidents (n= 19; 25.0%). According to the Stranc and Robertson classification, the most common force vector was lateral, and plane 2 fractures with lateral forces predominated. Conclusion: The elderly showed similar patterns of nasal bone fractures to those observed in young and middle-aged adults, but significant differences from preschoolers (in the injury vector and plane of fracture) and from school-age children (in the sex ratio and plane of fracture). However, elderly patients presented significantly different epidemiological characteristics compared to the other three groups. Therefore, it is necessary to improve the quality of life of the elderly and prepare for the upcoming super-aged society by taking steps to reduce the incidence and severity of fractures. Possible options for doing so include strengthening individual-level safety factors and expanding the social safety net for the elderly.

• Journal of IKEEE
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• v.26 no.4
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• pp.596-601
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• 2022

The application of the EGR system is increasing according to the recent trend of conversion to green-ships. EGR blower, one of the core parts of the EGR, consists of aerodynamic system and e-motor and inverter and etc. For the e-motor, a permanent magnet type synchronous motor with high energy density and excellent efficiency is applied recently. Small and medium-sized enterprises trying to develop the e-motors, however, for marine inverters mostly developed by global advanced companies due to the rigid classification certification and technical difficulties. One of disadvantage of universal inverters is that when optimal control fails, it is difficult to find the cause from user's point of view. Therefore, in this study, optimal controllers(Current vector contol and Tracking observer) for SPMSM for EGR blower was designed and verified to analyze the causes of failure of optimal control of universal inverter.

• Journal of the Korean Wood Science and Technology
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• v.31 no.2
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• pp.52-57
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• 2003

This research is to collect, classify and identify the insects boring tunnels into wood or damaging wooden frame structure. Intensive insect collections have been carried at the historical local schools annexed to the confucian shrine from March to September 2001. Ten species of Coleoptera, 15 species of Hymenoptera, 6 species of Hemiptera, 4 species of Ditera and 1 species of Demaptera were recorded. Most species of Coleoptera and Hymenoptera have the manducatory apparatus in the mouth-part that cause severe damage in wood, and showed the highest population among the genera recorded. Further research should be considered on the identification of wood demage insects at the species level among present collection and their mechanism of wood demage in the wood.

• Journal of Soil and Groundwater Environment
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• v.27 no.6
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• pp.22-36
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• 2022

Water resources in Jeju Island are dependent virtually entirely on groundwater. For groundwater resources, drought damage can cause environmental and economic losses because it progresses slowly and occurs for a long time in a large area. Therefore, this study quantitatively evaluated groundwater level fluctuations using principal component and cluster analyses for 42 monitoring wells in Jeju Island, and further identified the types of groundwater fluctuations caused by drought. As a result of principal component analysis for the monthly average groundwater level during 2005-2019 and the daily average groundwater level during the dry season, it was found that the first three principal components account for most of the variance 74.5-93.5% of the total data. In the cluster analysis using these three principal components, most of wells belong to Cluster 1, and seasonal characteristics have a significant impact on groundwater fluctuations. However, wells belonging to Cluster 2 with high factor loadings of components 2 and 3 affected by groundwater pumping, tide levels, and nearby surface water are mainly distributed on the west coast. Based on these results, it is expected that groundwater in the western area will be more vulnerable to saltwater intrusion and groundwater depletion caused by drought.