• 제목/요약/키워드: Case-crossover design

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서울지역 대기오염이 호흡기계질환에 미치는 단기영향에 관한 환자교차연구 (Short-term Effect of Air Pollution on Respiratory Disease in Seoul : A Case-Crossover Study)

  • 이영주;이종태;신동천;임형준;조수헌;주영수
    • Journal of Preventive Medicine and Public Health
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    • 제34권3호
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    • pp.253-261
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    • 2001
  • Objectives : To evaluate the hypothesis that air pollution could increase emergency room visits for respiratory diseases, and if so, to quantify the strength of association between those. Methods : We compiled daily records of hospital emergency room visits for respiratory diseases in Seoul, from November 1. 1955 to October 31. 1996, by using medical utilization data of unscheduled visits. In addition, air quality and weather data for the same period was collected. And a case-crossover design was applied by adopting conditional logistic regression analysis to determine the relationship between air pollutants and emergency room visits for respiratory diseases. In particular, the control periods were chosen by a bidirectional paired matching technique 7, 14, and 21 days before and after the case periods. Results : Only ozone was associated with the increased number of emergency room visits for respiratory diseases. The relative risk according to a 30ppb increase of ozone concentration (24hr mean, lagged 1day) was 1.91(95% confidence interval = 1.78-2.05). Conclusion : There was a statistically significant association between the ambient ozone and daily emergency room visits for respiratory diseases.

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환자-교차 대조군 연구를 적용한 산업재해 발생의 단기적 영향 요인 (Transient Effects the Risk of Occupational Injuries as an Acute Events : a Case-crossover Study)

  • 정선아;원종욱;노재훈;이종태
    • Journal of Preventive Medicine and Public Health
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    • 제34권1호
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    • pp.35-40
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    • 2001
  • Objectives : To elucidate the transient effects on the risk of occupational injuries as acute events and establish so alternative proposal. Methods : The study population comprised a total of 302 workers randomly selected from applications for occupational injury compensation reported to the Inchon local labor office from January 1. 1999 to December 31. A case-crossover design, where each case serves its own control, was applied to this study. Through a telephone interview, workers provided useful data concerning five job related stressful events such as company transfer, work load change, overtime work, exchange duty, and work-part transfer. They were asked whether there were stressful events within a week of the occurrence of injury and the degree of stress. Exposure status from one year prior was used as control information. In the end, the data provided by 158 of selected persons was used for the analysis based on the quality of the data provided by the participants. A conditional logistic regression was used to discover the transient effects on the risk of occupational injuries as acute events. Results : The effects a company transfer and work load change on occupational injury was statistically significant on the risk of occupational Injuries as an acute event(RR=5.5, 95% CI=2.501-12.428; RR=3.1, 95% CI=1.963-5.017, respectively). Other stressful events were found to elevate the risk factor for the occurrence of occupational jujury, but were not significant. Conclusions : Our results suggested that transient stressful events elevated the risk factor for the occurrence of occupational injury.

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Genetic Algorithm을 이용한 상수관망의 최적설계: (II) -민감도 분석을 중심으로- (Optimal Design of Water Distribution Networks using the Genetic Algorithms:(II) -Sensitivity Analysis-)

  • 신현곤;박희경
    • 상하수도학회지
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    • 제12권2호
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    • pp.50-58
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    • 1998
  • Genetic Algorithm (GA) consists of selection, reproduction, crossover and mutation processes and many parameters including population size, generation number, the probability of crossover (Pc) and the probability of mutation (Pm). Determining values of the parameters is found critical in the whole optimization process and a sensitivity analysis with them seems mandatory. This paper tries to demonstrate such importance of sensitivity analysis of GA using an example water supply tunnel network of the New York City. For optimization of the network with GA, Pc and Pm vary from 0.5 to 0.9 by an increment of 0.1 and from 0.01 to 0.05 by an increment of 0.01, respectively, while fixing both the population size and the generation number to 100. This sensitivity analysis results in an optimum design of 22.3879 million dollars at the values of 0.8 and 0.01 for Pc and Pm, respectively. In addition, the probability of recombination (Pr) is introduced to check its applicability in the GA optimization of water distribution network. When Pr is 0.05 with the same values of Pc and Pm as above, the optimum design costs 20.9077 million dollars. This is lower than the cost of 22.3879 million dollars for the case of not using Pr by 6.6%. These results indicate that conducting a sensitivity analysis with parameter values and using Pr are useful in the optimization of WDN.

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행렬 표현 유전자 알고리즘을 이용한 퍼지 제어기의 설계 (A Design of Fuzzy Controllers Using Matrix Encoding Genetic Algorithm)

  • 김동일;차성민;강전배;권기호
    • 대한전자공학회:학술대회논문집
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    • 대한전자공학회 2001년도 하계종합학술대회 논문집(3)
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    • pp.153-156
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    • 2001
  • Fuzzy controllers also show good performance In case of the systems being nonlinear and difficult to solve. But these fuzzy controllers have problems which have to decide suitable rules and membership functions. In general we decide those using the heuristic methods or the experience of experts. Therefore, many researchers have applied genetic algorithms to make fuzzy rule automatically. In this paper, we suggest a new coding method and a new crossover method to maintain the good fuzzy rule base and the shape of membership

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DC/DC 컨버터의 파라미터 변화를 고려한 구간분석법 기반 제어기 설계 (Interval-based Controller Design Considering Parameter Variations for DC/DC Converters)

  • 최성진
    • 제어로봇시스템학회논문지
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    • 제19권10호
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    • pp.879-885
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    • 2013
  • By performing interval analysis on the system transfer function, we propose an improved method of control loop design for a DC/DC converter. In conventional design methods, the effect of system parameter change due to the specified range of operating conditions and production tolerances in power components should be checked a posteriori, because this may result in a transfer function shift and performance degradation. In the proposed method, a possible parameter change is considered a priori in the design step in order that the desired crossover frequency and sufficient phase margin can be achieved even in the worst case condition. As an illustrative example, a buck dc/dc converter is designed by two different methods and performance comparisons are performed to verify the feasibility of the proposed scheme.

Estimation of the National Burden of Disease and Vulnerable Population Associated with Natural Disasters in Korea: Heavy Precipitation and Typhoon

  • Han, Hyun-Jin;Kim, Jong-Hun;Chung, Soo-Eun;Park, Jae-Hyun;Cheong, Hae-Kwan
    • Journal of Korean Medical Science
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    • 제33권49호
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    • pp.314.1-314.15
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    • 2018
  • Background: Despite its growing significance, studies on the burden of disease associated with natural disasters from the perspective of public health were few. This study aimed at estimating the national burden of disease associated with typhoons and torrential rains in Korea. Methods: During the period of 2002-2012, 11 typhoons and five torrential rains were selected. Mortality and morbidities were defined as accentual death, injury and injury-related infection, and mental health. Their incidences were estimated from National Health Insurance Service. Case-crossover design was used to define the disaster-related excess mortality and morbidity. Disability-adjusted life years (DALYs) were directly assessed from excess mortality and morbidity. Results: The burden of disease from typhoons increased with the intensity, with 107.7, 30.6, and 36.6 DALYs per 100,000 per event for strong, moderate, and weak typhoons, respectively. Burden of disease from torrential rains were 56.9, 52.8, and 26.4 DALYs per 100,000 per event for strong, moderate, and weak episodes, respectively. Mental disorders contributed more years lived with disability (YLDs) than did injuries in most cases, but the injury-induced YLDs associated with strong typhoon and torrential rain were higher than those of lower-intensity. The elderly was the most vulnerable to most types of disaster and storm intensities, and males younger than 65 years were more vulnerable to a strong torrential rain event. Conclusion: The intensity of torrential rain or typhoon was the strongest determinant of the burden of disease from natural disasters in Korea. Population vulnerable may vary depending on the nature and strength of the disasters.

정신과 연구에서 다양한 임상연구방법의 장단점 (Pros and Cons of Various Research Designs in Clinical Psychiatry)

  • 하라연;조현상
    • 생물정신의학
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    • 제19권4호
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    • pp.159-163
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    • 2012
  • An appropriate research design for hypotheses and purposes leads to a good quality of research results. In this review article, we summarized the types of research methods and described the characteristics of clinical trials. Research designs are categorized into observational studies and experimental ones, depending on data collecting methods. In an observational study, there are cross-sectional, cohort and case-control studies. Parallel groups design and crossover trial studies are representative designs in a randomized controlled trial study, a kind of experimental study. Clinical researchers should understand the characteristics of clinical research designs including advantages and disadvantages and choose the suitable design according to their study purposes and the nature of collected data or subjects.

Optimal design using genetic algorithm with nonlinear inelastic analysis

  • Kim, Seung-Eock;Ma, Sang-Soo
    • Steel and Composite Structures
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    • 제7권6호
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    • pp.421-440
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    • 2007
  • An optimal design method in cooperated with nonlinear inelastic analysis is presented. The proposed nonlinear inelastic method overcomes the difficulties due to incompatibility between the elastic global analysis and the limit state member design in the conventional LRFD method. The genetic algorithm used is a procedure based on Darwinian notions of survival of the fittest, where selection, crossover, and mutation operators are used to look for high performance ones among sections in the database. They are satisfied with the constraint functions and give the lightest weight to the structure. The objective function taken is the total weight of the steel structure and the constraint functions are load-carrying capacity, serviceability, and ductility requirement. Case studies of a planar portal frame, a space two-story frame, and a three-dimensional steel arch bridge are presented.

유전자 알고리즘을 이용한 비선형 비탄성 최적설계 (Nonlinear Inelastic Optimal Design Using Genetic Algorithm)

  • 마상수;김승억
    • 한국전산구조공학회:학술대회논문집
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    • 한국전산구조공학회 2003년도 가을 학술발표회 논문집
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    • pp.145-152
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    • 2003
  • An optimal design method in cooperated with nonlinear inelastic analysis method is presented. The proposed nonlinear inelastic method overcomes the difficulties due to incompatibility between the elastic global analysis and the limit state member design in the conventional LRFD method. The genetic algorithm uses a procedure based on Darwinian notions of survival of the fittest, where selection, crossover, and mutation operators are used among sections in the database to look for high performance ones. They satisfy the constraint functions and give the lightest weight to the structure. The objective function is set to the total weight of the steel structure and the constraint functions are load-carrying capacities, serviceability, and ductility requirement. Case studies of a three-dimensional frame and a three-dimensional steel arch bridge are presented.

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