• 제목/요약/키워드: Case-control analysis

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Meta-analysis of the CYP1A2 -163C>A Polymorphism and Lung Cancer Risk

  • Deng, Sheng-Qiong;Zeng, Xian-Tao;Wang, Yun;Ke, Qing;Xu, Qiong-Li
    • Asian Pacific Journal of Cancer Prevention
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    • 제14권5호
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    • pp.3155-3158
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    • 2013
  • Many published studies have concerned associations between the CYP1A2 -163 C>A polymorphism and risk of lung cancer, but the results have been inconsistent. Therefore, we performed a meta-analysis to obtain a more precise estimate. We searched the PubMed database up to March 1, 2013 for relevant cohort and case-control studies. Supplementary search was conducted manually by searching the references of the included studies and relevant meta-analyses. A meta-analysis was performed using RevMan 5.2 software for calculation of pooled odds ratios (ORs) and relevant 95% confidence intervals (CIs) after data extraction. Finally, seven case-control studies and one nested case-control study involving 1,675 lung cancer patients and 2,393 controls were included. The meta-analysis showed that there was no association of CYP1A2 -163 C>A polymorphism with risk of lung cancer overall [(OR=0.89, 95%CI= 0.74-1.07) for C vs. A; (OR=0.73, 95%CI= 0.50-1.07) for AA vs. CC ; (OR=0.82, 95%CI= 0.62-1.09) for AC vs. CC; (OR=0.79, 95%CI= 0.58-1.07) for (AC+AA) vs. CC; and (OR=0.87, 95%CI= 0.67-1.13) for AA vs. (CC+AC)]. Subgroup analysis indicated that there was an associationbetween CYP1A2 -163C>A polymorphism and lung cancer risk for population-based controls, a trend risk for SCCL (squamous cell carcinoma of lung) and Caucasians. These results suggested that -163 C>A polymorphism is likely to be associated with risk of lung cancer compared with population-based controls.

Risk Factors of Breast Cancer in Kyzylorda Oblast of Kazakhstan: a Case-Control Study

  • Toleutay, Ulpan;Reznik, Vitaly;Kalmatayeva, Zhanna;Smigelskas, Kastytis
    • Asian Pacific Journal of Cancer Prevention
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    • 제14권10호
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    • pp.5961-5964
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    • 2013
  • Background: Breast cancer in Kazakhstan and its Kyzylorda oblast is the most prevalent cancer in women and features increasing trends of incidence. The aim of study was to reveal risk factors for breast cancer among women of Kyzylorda oblast of Kazakhstan. Materials and Methods: A hospital-based case-control study was conducted at Kyzylorda oblast Oncology Center, including 114 cases of breast cancer and 196 controls. Binary logistic regression analysis was performed. Results: Social and behavioral risk factors for breast cancer were evaluated, among which unfavorable living conditions, chronic stress, unilateral breastfeeding, breastfeeding less than 3 months and over 2 years, abortions, and hereditary predisposition were found to be related with increased breast cancer risk. Breastfeeding for 6-24 months was found to be protective. Conclusions: The findings may have significant impact on activity planning aimed towards breast cancer reduction among women in Kazakhstan.

굴뚝효과와 공학적분석에 의한 부속실 가압시스템 설계 - 사례를 중심으로 - (Design for Pressurizing System about Vestibule by Stack Effect & Engineering Analysis - Focused on Case Study -)

  • 김용광
    • 한국화재소방학회논문지
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    • 제23권4호
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    • pp.145-153
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    • 2009
  • 화재안전기준 NFSC 501A에 의하면 몇 가지 제연구역 선정방법이 있지만, 특별피난계단 부속실만을 단독으로 제연하는 경우가 보편화 되고 있다. 그러나 여기에는 상당한 문제점이 있다. 저자의 책임 감리현장도 다른 많은 유사 현장과 같이 부속실만 단독제연하는 것으로 설계되어 있다. 그 설계내용에서 몇 가지 문제점을 도출하고, 이를 해소하기 위한 대안으로 굴뚝효과를 고려한 공학적 분석방법에 의한 "계단실 및 그 부속실을 동시에 제연하는 것"으로 설계 변경하는 것이 가장 적합하다는 결론을 얻었다.

주파수 해석을 이용한 유도전동기의 고장 검출 및 분류 (Frequency analysis based fault detection and isolation of induction motors)

  • 신필재;이인수;전기준
    • 제어로봇시스템학회:학술대회논문집
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    • 제어로봇시스템학회 1996년도 한국자동제어학술회의논문집(국내학술편); 포항공과대학교, 포항; 24-26 Oct. 1996
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    • pp.702-705
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    • 1996
  • Recently, induction motors are used more widely because of their low cost and simple structure. Therefore, the importance of fault detection and isolation of induction motors significantly increases. In most case the line current is used for fault detection and isolation. But in case that an induction motor has an inverter for control, it distorts the information of faulty state included in the line current. This paper proposes a new method for fault detection and isolation of induction motors that is speed controlled by the inverter using frequency analysis of the reference current instead of the line current for fault detection and isolation.

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자기베어링지지 연삭기 추축계의 고속 회전시 런아웃 적응제어 (Adaptive Runout Control of Magnetically Suspended High Speed Grinder Spindle)

  • 노승국;경진호;박종권;최언돈
    • 한국정밀공학회:학술대회논문집
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    • 한국정밀공학회 1997년도 추계학술대회 논문집
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    • pp.52-55
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    • 1997
  • In this paper, the case study of reducing rotational errors is done for a grinding spindle with an active magnetic bearing system. The rotational errors acting on the magnetic bearing spindle are due to mass unbalance of rotor, runout, grinding excitation and unmodeled nonlinear dynamics of electromagnets. For the most case, the electrical runout of sensor target is big even in well-finished surface; this runout can cause a rotation error amplified by feedback control system. The adaptive feedforward method based on LMS algorithm is discussed to compensate this kind of runout effects, and investigated its effectiveness by numerical simulation and experimental analysis. The rotor orbit size in both bearings is reduced about to 5 pin due to lX rejection by feedforward control up to 50, 000 rpm.

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Analysis of Packet Transmission Probability under Flooding Routing

  • 홍정식;이창훈;이해상
    • 한국국방경영분석학회지
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    • 제18권2호
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    • pp.126-139
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    • 1992
  • In this paper, the computational problems of packet transmission probability (PTP) in a computer communication network (CCN) under flooding routing are investigated. To avoid a congestion under this routing, two control methods are considerd, i. e., copy storage control and hop count control. Problems of PTP under flooding routings with these two control methods are respectively shown to be equivalent to those of source-to-terminal reliability(STR) with an exception for a case of hop count control where the hop count is less than the length of the longest path. For this exceptional case, an efficient computational algorithm for PTP is developed. This algorithm is proposed as an efficient tool for the determination of hop count which satisfies a given reliability constraint. A numerical example illustrates a proposed algorithm.

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흡연과 중풍발생의 상관관계에 관한 환자-대조군 연구 (The Analysis of Relation between Cigarette Smoking and Stroke; case-control study)

  • 양대진;배종면;이경섭;조기호;김영석;배형섭
    • 대한한의학회지
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    • 제22권4호
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    • pp.69-78
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    • 2001
  • Objectives : It is known that cigarette smoking is associated with increased risk of both thrombotic and hemorrhagic stroke. However, in Korea, especially in the academic world of Korean Medicine, there is a lack of study about the relation between cigarette smoking and stroke. We carried out a case-control study to clarify the relation between cigarette smoking and stroke. Method : We interviewed 441 stroke patients (236 men, 205 women) as a case group and 432 non-stroke patients (208 men, 224 women) as a control group. We investigated the smoking pattern of all patients and stroke-subtype of the case group. Smoking pattern is classed into two (Class I), four (Class II) and five groups (Class III). Class I consists of current non-smokers and current smokers. Class II consists of non-smokers, former smokers, current light smokers and current heavy smokers. Class III consists of never smoked, secondhand smokers, former smokers, Current light smokers and current heavy smokers. Stroke-subtype consists of cerebral infarction and cerebral hemorrhage. Results : The percentage of current smokers of case group is higher significantly than that of control group. The number of cigarettes smoked per day is associated positively with the risk of stroke. According to our study, generally cigarette smoking is related with ischemic stroke. The percentage of secondhand smokers of the case group is lower than that of the control group. According to our study, characteristically secondhand smoking is associated with hemorrhagic stroke. Conclusions : From the above results we found that cigarette smoking is an important risk factor of stroke - especially cerebral infarction - and the number of cigarettes smoked per day is associated positively with the risk of stroke. Characteristically according to our study, secondhand smoking is associated with hemorrhagic stroke. Overall we conclude that cigarette smoking may be an important preventable factor for stroke.

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CAN을 이용한 차체 네트웍 시스템에 대한 Holistic 스케줄링 해석 (Holistic Scheduling Analysis of a CAN based Body Network System)

  • 신민석;이우택;선우명호
    • 한국자동차공학회논문집
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    • 제10권5호
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    • pp.114-120
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    • 2002
  • In a distributed real-time control system, it is essential to confirm the timing behavior of all tasks because these tasks of each real-time controller have to finish their processes within the specified time intervals called a deadline. In order to satisfy this objective, the timing analysis of a distributed real-time system such as shcedulability test must be performed during the system design phase. In this study, a simple application of CAN fur a vehicle body network system is formulated to apply to a holistic scheduling analysis, and the worst-case execution time (WCET) and the worst-case end-to-end response time (WCRT) are evaluated in the point of holistic system view.

제조 공정상 랜덤 특성을 고려한 IC 최악조건 해석 (IC Worst Case Analysis Considered Random Fluctuations on Fabrication Process)

  • 박상봉;박노경;전흥우;문대철;차균현
    • 대한전자공학회논문지
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    • 제25권6호
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    • pp.637-646
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    • 1988
  • The CMOS physical parameters are extracted using by processing models in fabrication steps, processing parameters, fabrication disturbances, control parameters. Statistical CMOS process and device simulator is proposed to evaluate the effect of inherent fluctuations in IC fabrication. Using this simulator, we perform worst case analysis in terms of statistically independent disturbances and compare this proposed method to Monte Carlo method, previous Worst Case method. And simulation results with this proposed method are more accurate than the past worst case analysis. This package is written in C language and runs on a IBM PC AT(OPUS).

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뇌졸중 위험지표로서의 전해질 수치에 대한 환자;대조군 연구 (Case-Control Study on Electrolytes as a Risk Factor of Stroke)

  • 김민지;강경원;유병찬;최선미;강지선;문승희;이재휘;김윤식;설인찬
    • 동의생리병리학회지
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    • 제22권4호
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    • pp.968-974
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    • 2008
  • This study was aimed to investigate the electrolytes and its relationship with acute stroke patients in each stroke type by case-control study. 217 patients with first-ever acute stroke within 2 weeks as the case group(Cases), 146 people without four major risk factors(hypertension, diabetes mellitus, hyperlipidema and ischemic heart disease) as the healthy control group(Normals), and 160 people as the general control group(Controls) were recruited at the Stroke Medical Center in Daejeon University Oriental Medicine Hospital from july 2005 to march 2007 for this case-control study. We analyzed the odds ratio of electrolytes in binary logistic analysis and evaluated each stroke type and general characteristics such as age, sex etc. The level of sodium(Na+) and potassium(K+) were significantly lower in LAA, SVO type of ischemic stroke and hemorrhagic stroke. But the level of chloride(Cl-) had no significant relation with stroke occurance. In this study we demonstrated that low sodium(Na+) and potassium(K+) have an influence on stoke occurance than chloride(Cl-). And we think that the electrolytes must be considered in risk factors of ischemic stroke in Korean and more prospective studies are needed.