• Genomics & Informatics
• /
• v.17 no.3
• /
• pp.29.1-29.8
• /
• 2019

The Wellcome Trust Case Control Consortium (WTCCC) study was a large genome-wide association study that aimed to identify common variants associated with seven diseases. That study combined two control datasets (58C and UK Blood Services) as shared controls. Prior to using the combined controls, the WTCCC performed analyses to show that the genomic content of the control datasets was not significantly different. Recently, the analysis of human leukocyte antigen (HLA) genes has become prevalent due to the development of HLA imputation technology. In this project, we extended the between-control homogeneity analysis of the WTCCC to HLA. We imputed HLA information in the WTCCC control dataset and showed that the HLA content was not significantly different between the two control datasets, suggesting that the combined controls can be used as controls for HLA fine-mapping analysis based on HLA imputation.

• Genomics & Informatics
• /
• v.3 no.1
• /
• pp.1-7
• /
• 2005

Case-control studies are widely used for disease gene mapping using individual genotyping data. However, analyses of large samples are often impractical due to the expense of individual genotyping. The use of DNA pooling can significantly reduce the number of genotyping reactions required; hence reducing the cost of large-scale case-control association studies. Here, we discuss the design and analysis of DNA pooling genetic association studies.

• The Transactions of the Korean Institute of Electrical Engineers D
• /
• v.53 no.7
• /
• pp.501-508
• /
• 2004

In this paper, a coordinated scheduling algorithm is proposed to reduce end-to-end delay in distributed control of systems. For the algorithm, the analysis of practical end-to-end delay in the worst case is performed priory with considering implementation of the systems. The end-to-end delay is composed of the delay caused by multi-task scheduling of operating systems, the delay caused by network communications, and the delay caused by asynchronous timing between operating systems and network communications. Through some simulation tests based on CAN(Controller Area Network), the proposed worst case end-to-end delay analysis is validated. Through the simulation tests, it is also shown that a real-time distributed control system designed to existing worst case delay cannot guarantee end-to-end time constraints. With the analysis, a coordinated scheduling algorithm is proposed here. The coordinated scheduling algorithm is focused on the reduction of the delay caused by asynchronous timing between operating systems and network communications. Online deadline assignment strategy is proposed for the scheduling. The performance enhancement of the distributed control systems by the scheduling algorithm is shown through simulation tests.

• Journal of Institute of Control, Robotics and Systems
• /
• v.5 no.6
• /
• pp.734-743
• /
• 1999

In this paper, a real-time communication method using a PICNET-NP(Plant instrumentation and Control Network for Nuclear Power plant) is proposed with an analysis of the control network requirements of DCS(Distributed Control System) in nuclear power plants. The method satisfies deadline in case of worst data traffics by considering aperiodic and periodic real-time data and others. In addition, the method was used to analyze the data characteristics of the DCS in existing nuclear power plant. The result shows that use of this method meets the response time requirement(100ms).

• Proceedings of the KIEE Conference
• /
• 2009.04b
• /
• pp.180-182
• /
• 2009

As a train control system becomes a large scale and complex, it is necessary to control rigorously the system requirements specification of the train control system at the early phase. This paper describes Use Cases and activity diagrams of ATS functions requirements in the train control system. Basic functions of the train control system refers to IEC 62290-land are suggested. And the basic functions includes train operation without a driver. It is anticipated that this paper will be helpful for the analysis of ATS functions, ATO functions and EI function in the train control system.

• Transactions of the Korean Society of Mechanical Engineers B
• /
• v.31 no.6 s.261
• /
• pp.522-530
• /
• 2007

The practical studies on the method of particle contamination control for yield enhancement in the cleanroom were carried out. The method of the contamination control was proposed, which are composed of data collection, data analysis, improvement action, verification, and implement control. The partition check method and the composition analysis for data collection and data analysis were respectively used in the main board and the cellular phone module production lines. And these methods were evaluated by the variation of yield loss between before and after improvement action. In case that the partition check method was applied, the critical process step was selected and yield loss reduction through improvement actions was observed. While in case that the composition analysis was applied, the critical sources were selected and yield loss reduction through improvement actions was also investigated. From these results, it is concluded that the partition check and the composition analysis are effective solutions for particle contamination control in the cleanroom production lines.

• Advances in concrete construction
• /
• v.14 no.1
• /
• pp.57-70
• /
• 2022

The spiral case concrete (SCC) used in the underground powerhouse of large hydropower stations is complex, difficult to pour, and has high requirements for temperature control and crack prevention. In this study, based on the closed-loop control theory of "multi-source sensing, real analysis, and intelligent control", a new intelligent cooling control system (ICCS) suitable for the SCC is developed and is further applied to the Wudongde large-scale underground powerhouse. By employing the site monitoring data, numerical simulation, and field investigation, the temperature control quality of the SCC is evaluated. The results show that the target temperature control curve can be accurately tracked, and the temperature control indicators such as the maximum temperature can meet the design requirements by adopting the ICCS. Moreover, the numerical results and site investigation indicate that a safety factor of the spiral case structure was sure, and no cracking was found in the concrete blocks, by which the effectiveness of the system for improving the quality of temperature control of the SCC is verified. Finally, an intelligent cooling control procedure suitable for the SCC is proposed, which can provide a reference for improving the design and construction level for similar projects.

• Transactions of the Korean Society of Automotive Engineers
• /
• v.13 no.1
• /
• pp.194-203
• /
• 2005

The process of guaranteeing that a distributed real-time control system will meet its timing constraints, is referred to as schedulability analysis. However, schedulability analysis algorithm cannot be simply used to analyze the system because of complex calculations of algorithm. It is difficult for control engineer to understand the algorithm because it was developed in a software engineer's position. In this paper we introduce a Response-time Analysis Tool(RAT) which provides easy way far system designer to analyze the system by encapsulating calculation complexity. Based on the RAT, control engineer can verify whether all real-time tasks and messages in a system will be completed by their deadline in the system design phase.

• Asian Pacific Journal of Cancer Prevention
• /
• v.13 no.6
• /
• pp.2459-2465
• /
• 2012

Background: Numbers of epidemiological studies assessing residential radon exposure and risk of lung cancer have yielded inconsistent results. Methods: We therefore performed a meta-analysis of relevant published case-control studies searched in the PubMed database through July 2011 to examine the association. The combined odds ratio (OR) were calculated using fixed- or random-effects models. Subgroup and dose-response analyses were also performed. Results: We identified 22 case-control studies of residential radon and lung cancer risk involving 13,380 cases and 21,102 controls. The combined OR of lung cancer for the highest with the lowest exposure was 1.29 (95% CI 1.10-1.51). Dose-response analysis showed that every 100 Bq/$m^3$ increment in residential radon exposure was associated with a significant 7% increase in lung cancer risk. Subgroup analysis displayed a more pronounced association in the studies conducted in Europe. Studies restricted to female or non-smokers demonstrated weakened associations between exposure and lung cancer. Conclusions: This meta-analysis provides new evidence supporting the conclusion that residential exposure to radon can significantly increase the risk of lung cancer in a dose-response manner.

• 제어로봇시스템학회:학술대회논문집
• /
• 2001.10a
• /
• pp.62.1-62
• /
• 2001

This paper suggests an inverse optimal PID control design method for the trajectory tracking case of mechanical systems. Also, simple coarse/fine performance tuning laws are suggested based on the analysis for performance limitation of inverse optimal PID controller. Experimental results for a robot manipulator show the validity of our analysis for the performance tuning methods.