• The Korean Journal of Nuclear Medicine Technology
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• v.13 no.3
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• pp.147-151
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• 2009

Purpose: 2-[$^{18}F$]Fluoro-2-deoxy-D-glucose ([$^{18}F$]FDG) particularly plays as a important role in Positron Emission Tomography (PET) imaging in nuclear medicine. Domestic [$^{18}F$]FDG auto synthesizers are installed in Seoul National University Bundang Hospital (SNUBH) at June 2008, these modules were known that it's synthetic yields were guaranteed in average $45{\pm}5%$ so far. To improve yields and convenience of domestic [$^{18}F$]FDG auto synthesizer, numerous trials in reaction time, base concentration, pressure and temperature were performed to increase [$^{18}F$]FDG yields. Materials and Methods: Several synthetic factors (temperature, time and pressure) and shortcoming were corrected based on many evaporation test. Syringe dispensing of tetra-butylammonium bicarbonate (TBAB) was replaced with micro pipette to prepare tetrabutyl ammonium fluoride salt ([$^{18}F$]TBAF). Troublesome refill of liquid nitrogen every 2 hours which was used to protect vacuum system was changed to charcoal cartridge, base guard filter. To monitor the volume of delivered $[^{18}O]OH_2$ from cyclotron by surveillance camera, we set up the volumetric vial on the cover of the module. In addition to, the recovery vial was added in [$^{18}F$]FDG production system to recover [$^{18}F$]FDG loss due to the leak of valve ($V_{13,14}$) in [$^{18}F$]FDG purification process. Results: When we used micro pipette for adding TBAB ($30\;{\mu}L$ in 12% $H_2O$ in acetonitrile), this quantitative dispensation has enabled to improve $5.5{\pm}1.7%$ residual fluorine-18 activity in fluorine separation cartridge compared to syringe adding. Besides, the synthetic yields of [$^{18}F$]FDG has increased $58{\pm}2.6%$ (n=19), $58{\pm}2.9%$ (n=14), $60%{\pm}2.5%$ (n=17) for 3 months. The life cycle of charcoal cartridge and base vacuum was 3 months prior to filling liquid nitrogen every 2 hours and additional side separator can prevent pump corrosion by organic solvent. After setting of volumetric indicator vial, the operator can easily monitor the total volume of irradiated $[^{18}O]OH_2$ from cyclotron. The recovery vial can be used for the stabilizer when an irregular [$^{18}F$]FDG loss was generated by the leak of valves ($V_{13,14}$). Conclusions: We has optimized appropriate synthetic conditions (temperature, time, pressure) in domestic [$^{18}F$]FDG auto synthesizer. In addition to, the remodeling with several accessories improve yields of domestic [$^{18}F$]FDG auto synthesizer with reliable reproducibility.

• Industrial Engineering and Management Systems
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• v.10 no.2
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• pp.161-169
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• 2011

In seeking further efficiency in production preparation, it is common to examine assembly sequences using digital manufacturing. The assembly sequences affect the product evaluation, so it is necessary to test several assembly sequences before actual production. However, because selection and testing of assembly sequences depends on the operator's personal experience and intuition, only a small number of assembly sequences are actually tested. Nevertheless, there is a systematic method for generating assembly sequences using a contact-related figure. However, the larger the number of parts, the larger the number of assembly sequences geometric becomes. The purpose of this study is to establish a systematic method of generating efficient assembly sequences regardless of the number of parts. To generate such assembly sequences selectively, a "Tournament Tree," which shows the structure of an assembly sequence, is formulated. Applying the method to assembly sequences of a water valve, good assembly sequences with the same structure as the Tournament Tree are identified. The structure of such a Tournament Tree tends to have fewer steps than the others. As a test, the structure is then applied for a drum cartridge with 38 parts. In all the assembly sequences generated from the contact-related figures, the best assembly sequence is generated by using the Tournament Tree.

• Journal of Korean Society on Water Environment
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• v.31 no.5
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• pp.523-532
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• 2015

Hydrocyclone is widely used in industry, for its simple design, high capacity, low maintenance and low operational cost. The objective of this study is to develop hydrocyclone coagulation and filtration system. The system is made of hydrocyclone ballasted coagulation with polyaluminium chloride silicate (PACS) and upflow filter to treat micro particles in urban storm runoff. Roadside sediment particles (< $200{\mu}m$) was mixed with tap water to make various turbid suspensions to simulate urban storm runoff. The filter cartridge was filled with polyethylene media system and ran 1hr per everyday and total operation time were 8.19hrs and backwashing everyday after end of operation. The operation condition of flowrate was $8.2{\sim}11.9m^3/day$ (mean $10.1m^3/day$) and surface overflow rate (SOR) based on filter surface area was $45.5{\sim}65.9m^3/m^2/day$ (mean $55.7m^3/m^2/day$). The range of PACS dosage concentration was 14.0~31.5 mg/L. As the results of operation, the range of removal efficiency of turbidity, SS were 81.0~95.8% (mean 89.5%) 81.8~99.0% (mean 91.4%), respectively. An increase of filtration basin retention time brought on increased of removal efficiency of turbidity and SS, and increase of SOR brought on decreased of removal efficiency. During the first flush in urban area, storm runoff have an high concentration of SS (200~600 mg/L) and the filtration bed becomes clogged and decreased of removal efficiency. Backwashing begins when the drainage pipe valve at the filtration tank bottom is completely open (backwashing stage 1). Backwashing stage 2 was using air bubbles and water jet washing the media for 5 mins and open the drainage valve. After backwashing stage 1, 2, 61.83~64.04%, 18.53~27.51% of SS loading was discharged from filtration tank, respectively. Discharged SS loading from effluent was 7.12~14.79% and the range of residual SS loading in fliter was 2.26~5.00%. The backwashing effects for turbidity, SS were 89.5%, 91.4%, respectively. The hydrocyclone coagulation and filtration with backwashing system, which came out to solve the problems of the costly exchange filter media, and low efficiency of removing micro particles of filter type nonpoint treatment devices, is considered as an alternative system.