• 대한족부족관절학회지
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• 제4권2호
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• pp.83-86
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• 2000

A vascular necrosis of the talus has frequently been reported following trauma because talus has no muscle insertions, sixty percent of the surface of the talus is covered by hyaline cartilage, takes only a small area for entrance of a blood supply. Osteonecrosis is also associated with a variety of nontraumatic disorders. There are many indications for steroid usage, patient with rheumatoid arthritis, systemic lupus erythematosus, chronic obstructive pulmonary disease, and status- post renal or cardiac transplantation may be on long- term steroid usage, osteonecrosis may develop. A vascular necrosis of the talus secondary to chronic steroid usage is an unusual case. Delay in detection of osteonecrosis may lead to fragmentation and collapse of the talar body. When pain on range of motion is present and conservative treatment have been exhausted, surgical treatment is indicated, that is, fusion of the ankle joint. However it is important that conservative treatment may prevent its various sequelae with early diagnosis because steroid - treated patients have a more operative risk and increased risk for postoperative infection. We report a rare case of corticosteroid induced avascular necrosis of talus after cardiac transplantation.

• Childhood Kidney Diseases
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• 제20권2호
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• pp.83-87
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• 2016

Congenital chloride diarrhea (CLD) is a rare autosomal recessive disease that is difficult to diagnose. CLD requires early treatment to correct electrolyte imbalance and alkalosis and to prevent severe dehydration. Renal injury is clearly associated with defective electrolyte balance induced by CLD, particularly during the first months or years of life. A 7-year-old boy was diagnosed with CLD following detection of a homozygous mutation (c.2063-1G>T) in SLC26A3 at 6 months of age. During treatment with electrolyte supplements, mild proteinuria was detected at 8 months of age, and is still present. Renal biopsy showed the presence of focal renal dysplasia, with metaplastic cartilage and mononuclear cell infiltration, calcification, and fibrosis in the interstitium. Up to two-thirds of the glomeruli exhibited global obsolescence, mostly aggregated in the dysplastic area. In nondysplastic areas, the glomeruli were markedly increased in size and severely hypercellular, with increased mesangial matrix, and displayed segmental sclerosis. The marked glomerular hypertrophy with focal segmental glomerulosclerosis suggested a compensatory reaction to the severe nephron loss or glomerular obsolescence associated with renal dysplasia, with superimposed by CLD aggravating the tubulointerstitial damage.

• Biomaterials and Biomechanics in Bioengineering
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• 제3권3호
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• pp.141-155
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• 2016

Two-dimensional (2D) cell culture and in vivo cancer model systems have been used to understand cancer biology and develop drug delivery systems for cancer therapy. Although cell culture and in vivo model studies have provided critical contribution about disease mechanism, these models present important problems. 2D tissue culture models lack of three dimensional (3D) structure, while animal models are expensive, time consuming, and inadequate to reflect human tumor biology. Up to the present, scaffolds and 3D matrices have been used for many different clinical applications in regenerative medicine such as heart valves, corneal implants and artificial cartilage. While tissue engineering has focused on clinical applications in regenerative medicine, scaffolds can be used in in vitro tumor models to better understand tumor relapse and metastasis. Because 3D in vitro models can partially mimic the tumor microenvironment as follows. This review focuses on different scaffold production techniques and polymer types for tumor model applications in cancer tissue engineering and reports recent studies about in vitro 3D polymeric tumor models including breast, ewing sarcoma, pancreas, oral, prostate and brain cancers.

• 대한전기학회:학술대회논문집
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• 대한전기학회 2005년도 심포지엄 논문집 정보 및 제어부문
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• pp.51-53
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• 2005

Considerable noise is sometimes associated with degeneration of the hee joint surface. Such noise may indicate roughness or softening of the cartilage surfaces, and may be a useful index for early disease. In this study, we have evaluated arthritic pathology using the acoustical analysis of knee joint sounds. During sitting and standing periods, subjects' active knee flexion and extension were monitored. Fundamental frequency, mean amplitude of pitch, jitter and shimmer were analyzed according to the position and the joint angle. The result showed that the fundamental frequency of the 2nd patient group and standing position was higher than the others, and that the pitch of sounds changed unstably. These results suggest that an analysis of knee joint sound might assist non-invasive diagnosis of an articular pathology.

• Maxillofacial Plastic and Reconstructive Surgery
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• 제27권1호
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• pp.9-15
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• 2005

The objective of this study is screening the shear stress related proteins in chondrocytes using twodimensional electrophresis and MALDI-TOF. C-28/I2 cell line were grown. The fluid-induced shear stress(FISS) was applied using a cone viscometer at a rotational velocity of 80rpm for periods of 12 hours. Control cultures were tested under identical conditions without mechanical load application. Collected samples were used for the two-dimensional electrophoresis and MALDI-TOF. The identified proteins were calcyclin, RPE-spondin, interleukin-2, extracellular signal regulated kinase (ERK), lamin B2, porA protein, and RET-ELE1 protein. All of them showed a decreased expression. In conclusion, seven proteins were identified as a shear stress related proteins in chondrocytes. As the destruction of articular cartilage is one of main pathogenesis of TMJ internal derangement, this study will give useful information for the understanding of the molecular aspect of TMJ disease.

• 구강회복응용과학지
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• 제25권3호
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• pp.237-242
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• 2009

악관절부위의 활액성 연골종증은 매우 드물기 때문에 확진하기 까지 종종 몇 개월 몇 년이 걸리도 한다. 활액성 연골종증은 드문 양성 병소로 활액 내 수 많은 연골성, 골연골성 결정과 관절강내의 소성체가 형성되는 질환으로 관절강 내에 소성체를 형성하는 활액막의 연골성 변성으로 정의할 수 있다. 본 증례에서 29세 여자 환자로 저작시 동통을 주소로 내원하였다. 방사선 소견상 상관절강내에 석회화된 소성체가 발견이 되었다 치료는 석회된 소성체와 활액막 일부를 제거하였다. 술 후에 환자의 저작시의 동통이 완전히 사라졌다. 현재 아무런 재발 증상을 보이지 않고 있다.

• 대한두경부종양학회지
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• 제34권1호
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• pp.55-58
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• 2018

Auricular endochondral pseudocyst is a very rare, benign intracartilaginous cystic lesion which most commonly presents as a cystic mass in the anterior plane of the auricle. We present a case report of a 48-year-old man with a fluctuating lesion of 3 week's duration on the left auricle, with no specific history of trauma or disease. Initial incisional drainage revealed an abundance of serous fluid, which quickly recurred. Surgical removal of the hypertrophic perichondrium forming the pseudocyst anterior wall and ear cartilage curettage was carried out with intraoperative absolute alcohol sclerotherapy, followed by compression dressings. The auricle healed uneventfully, with a good final cosmetic result and no recurrence within a 6-month follow-up period. We report this unusual case as the first in Korean plastic surgery with a review of the literature.

• 대한정형외과 초음파학회지
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• 제1권2호
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• pp.94-111
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• 2008

전통적으로 슬관절 질병은 주로 방사선 촬영과 자기 공명 영상에 근거하여 진단과 치료를 하고 있다. 그러나 방사선 진단은 골 내부의 변화에는 좋은 영상을 가져다 주지만 연부 조직의 영상은 잘 볼 수 없는 단점이 있고 외래 진료실에서 실시간으로 할 수 없는 단점이 있다. 또 자기 공명 영상은 고가이고 역시 실시간으로 볼 수 없으며 정적인 정보만 제공한다. 초음파는 동적인 영상을 실시간으로 외래 진료실에서 즉시 볼 수 있고 비용이 저렴하며 동적 영상을 제공하고 연조직 영상을 잘 보여준다. 슬관절에서는 연조직 및 골 표면의 변화까지 관찰이 가능하므로 진단에 중요한 역할을 한다. 이 글에서는 정상적인 구조물의 초음파 영상과 병적 소견을 방사선 또는 자기 공명 영상 소견과 연계하여 소개하고 그 용도의 개략적인 것들을 설명하였다.

• Tuberculosis and Respiratory Diseases
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• 제40권4호
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• pp.431-435
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• 1993

저자들은 호흡곤란으로 내원한 환자에서 외이, 눈, 코, 기관과 기관지를 침범한 재발성 다발성 연골염 1예를 경험하였기에 이를 보고한다.

• Journal of Chest Surgery
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• 제29권11호
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• pp.1263-1266
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• 1996

단국대학교병원 흉부외과에서는 좌전하행지 기시부부터 95% 이상 협착을 보이는 단일혈관질환 1례에서 체외순환없이 제한적 전흉부 개흉으로 좌측내유동맥을 박리하여 박동심장하에서 관상동맥우회술을 성공적으로 시행하였기에 보고하는 바이다.