• Asian Pacific Journal of Cancer Prevention
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• v.16 no.5
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• pp.1677-1682
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• 2015

Cancer progression is attained by uncontrolled cell division and metastasis. Increase in tumor size triggers different vascular channel formation to address cell nutritional demands. These channels are responsible for transferring of nutrients and gaseous to the cancer cells. Cancer vascularization is regulated by numerous factors including vascular endothelial growth factors (VEGFs). These factors play an important role during embryonic development. Members included in this group are VEGFA, VEGFB, VEGFC, PIGF and VEGFD which markedly influence cellular growth and apoptosis. Being freely diffusible these proteins act in both autocrine and paracrine fashions. In this review, genetic characterization these molecules and their putative role in cancer staging has been elaborated. Prognostic significance of these molecules along with different stages of cancer has also been summarized. Brief outline of ongoing efforts to target hot spot target sites against these VEGFs and their cognate limitations for therapeutic implications are also highlighted.

• East Asian Journal of Business Economics (EAJBE)
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• v.2 no.2
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• pp.58-67
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• 2014

If we compare the GDP per Capita for the last 20 years between Philippines and other ASEAN countries, Philippines remains in the lowest on GDP per Capita. This paper is trying to find out the possible reasons for the low growth rate of the GDP per Capita in the Philippines. 53 years data from the World Bank are used explore the relationships between the GDP per Capita and eight economic indicators to run three time series models and one to one regression. Three indicators, namely, consumer price index, gross capital formation as a percentage of GDP and population are remarked with possible contribution to the low growth rate of the GDP per capita of the Philippines.

• Journal of Life Science
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• v.29 no.1
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• pp.90-96
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• 2019

The objective of this study was to evaluate the potential of Diospyros malabarica stem extract, a natural materials, in oral health material. With this aim in mind, thin layer chromatography (TLC), TLC-bioautography, high-performance liquid chromatography (HPLC), electrospray ionization-mass spectrometry (ESI-MS), scanning electron microscopy (SEM), and real-time qPCR were performed. The antibacterial activity of D. malabarica stem extract against Streptococcus mutans KCTC3065 was confirmed in an n-hexane fraction with low polarity. The molecular weight of the antibacterial compound was estimated to be 188 by ESI-MS analysis. The inhibitory effects of the extract on biofilm formation and gene expression related to biofilm formation of S. mutans were determined by SEM and real-time PCR analysis. The extract inhibited the formation of S. mutans biofilms at D. malabarica stem extract concentrations of 1 mg/ml, as shown by SEM. The real-time PCR analysis showed that the expression of the gtfC gene, which is associated with biofilm formation, was significantly decreased in a dose-dependent manner. Based on the above results, it can be concluded that D. malabarica stem extracts, a natural materials, can be used in oral health products to suppress the formation of biofilms by inhibiting tooth adhesion of S. mutans, a causative agent of dental caries.

• International Journal of Computer Science & Network Security
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• v.22 no.1
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• pp.340-346
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• 2022

The article examines the formation of the scientific paradigm of transformation of the potential-forming space of the regional economy under the influence of intellectual and innovative determinants. Based on the study of different scientific views on the nature and properties of potential-forming space through the study of approaches to understanding the concept of "space" clarified the complexity and multifaceted nature of the phenomenon and found that its characteristics are relevant to the industrial development model. It is revealed that the leading modern trends related to the spread of globalization and regionalization, rapid development of information and communication technologies, diffusion of innovations accompany the transition from industrial to post-industrial development and its development, which leads to new development: changes production, nature and relations between business entities, etc. It is proved that under such conditions, the region as a key element of the economic system, acquires a leading role in achieving sustainable and balanced development. These processes significantly affect the potential-forming space of the regional economy under the influence of intellectual and innovative determinants, leading to the need for its transformation and change in accordance with modern realities, which is reflected in thorough research on the formation of scientific paradigm based on the formation of its theoretical foundations and methodological basis. This study reveals the essence, role, functions, structure, process of formation of the scientific paradigm of transformation of the potential-forming space of the regional economy under the influence of intellectual and innovative determinants. It is proved that the formation of the modern scientific paradigm of transformation of the potential-forming space of the regional economy under the influence of intellectual and innovative determinants occurs in the context of building a post-industrial model of development, accompanied by consideration of the region as a spatial object territories from the physical plane to the spatial environment in which the development of human capital, innovation and self-development of the region. Taking into account the above, the article outlines the prerequisites and factors of formation of the scientific paradigm of transformation of the potential-forming space of the regional economy under the influence of intellectual and innovative determinants.

• Informatization Policy
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• v.19 no.2
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• pp.3-20
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• 2012

This study examines the trend and issues of sociological studies of social network service(SNS). For this purpose, the studies were classified into three types. The first type of study concerns spatial characteristics of SNS. It deals with the impact of such SNS usage on individual attitudes and behaviors. The second type of the study focuses on the formation process of interrelationship among users. It is based on sociological concepts such as trust and social capital. The last type of study emphasizes the impact of SNS on society. The study includes the issues of social movement and political participation. In the future study of SNS, more diverse sociological subjects, such as social integration, exclusion, public welfare, and affective support need to be dealt with.

• STI Policy Review
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• v.8 no.1
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• pp.113-156
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• 2017

Although technological progress is considered a key element for economic growth and development of a country, strong empirical evidence in this regard is not available yet. Therefore, to establish the empirical link between technology progress and economic development, it is advisable to carry out a time series analysis. In this regard, the Technology Achievement Index (TAI) of 100 top economies has been developed to examine the position of countries' technological progress for the 21 years spanning 1995 to 2015. Countries have been ranked on their TAI which is based on four pillars; technology creation, diffusion of older innovations, diffusion of recent innovations, and development of human skills. As well, this current study re-calculates the Humane Development Index (HDI) of 100 top economies for the 21 years from 1995 to 2015. Ranking of countries' HDI values reflects three dimensions: A long lifespan (life expectancy index), knowledge (Education Index) and a decent standard of living (Gross National Income Index, or GNI). The Standard Deviation (SD) technique has been used to investigate the technological gap between individual countries and groups of countries or regions. For a more meaningful assessment, technological gaps from the maximum achievement value (i.e., one of the countries under study) are presented as well. To investigate the impact of technological progress on economic development, this study introduces a model in which the HDI is used as the dependent variable and the TAI and Gross Capital Formation (GCF) are used as independent variables. The HDI, TAI and GCF are used in this model as proxy variables for economic development, technological progress and capital respectively. Econometric techniques have been used to show the impact of technological progress on economic development. The results show that long-term associations exist between technology progress and economic development; the impact of technology progress on economic development is 13.2% while the impact is 4.3% higher in eight selected East South Asian countries, at 13.5%, than in eight selected highly developed countries (9.2%).

• The Southeast Asian review
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• v.24 no.2
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• pp.35-79
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• 2014

This study examines the measures for the activation and the growth of intra-regional trade in Southeast Asia taking a look at the four dimensions of tariff rates, non-tariff barriers, trade facilitations, and trade infrastructures. Utilizing a gravity model, we performed empirical analysis and discussed the policy implications with the priorities to implement. To expand the intra-regional trade in Southeast Asia it would be necessary to enhance the level of trade facilitations and provide trade infrastructures, such as ports and airports as well as cutting the tariff rates and eliminating the non-trade barriers. In particular, in the case of exports of ASEAN6 to ASEAN6 the infrastructure is the important factor. Also, in the case of the exports of ASEAN6 to CLMV(Cambodia, Laos, Myanmar, and Vietnam), it is expected that eliminating non-tariff barriers and enhancing trade facilitations may play important roles in the progress of intra-regional trade. These results may provide the important implications for Southeast Asian countries, which are trying to promote intra-regional trade ahead of the constitution of ASEAN Economic Community by 2015. Southeast Asian countries could be evaluated to achieve a certain level of trade liberalization and economic integration through the formation of AFTA. But in order for Southeast Asia to develop to advanced economic integrated region it requires mutual cooperations and policy harmonizations among regional countries. Also, for the elimination of non-tariff barriers, promoting trade facilitations, and providing infrastructures, the administrative, legal, and institutional measures would have to be fulfilled in advance. In addition, capital investment for constructing infrastructures would be necessary to realize the intra-regional trade expansion. However, to achieve the goal, it would require a large capital investment and highly mandated policy considerations and harmonizations among Southeast Asian countries in terms of further trade liberalization and economic integration.

• The Journal of Asian Finance, Economics and Business
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• v.8 no.3
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• pp.751-761
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• 2021

The Vietnamese economy is a developing country that has brought many opportunities and challenges for the banking system. Commercial banks have developed strongly from quality to quantity, which plays a vital role in developing the economy. They play an important role in capital formation, which is essential for the economic development of a country. They provide financial services to the general public and businesses, ensuring economic and social stability and sustainable growth of the economy. Therefore, the relationship between bank depth and economic growth is of importance in research. This paper used a VAR (Vector Autoregressive Models) estimator for time series data models. The data is collected quarterly from the first quarter of the year 2000 to 2020. The study uses the VAR model to examine the causal relationships of economic growth, growth in money supply expansion, private sector capital requirement, and banks' domestic credit. The results indicate a general short-run relationship between banking sector depth and economic growth with a positive connection, but in the long term, the relationship between these variables can be reversed because of other macro factors. The findings show the two-way causal relationship between GDP growth and banking depth factors. This research contributes to policy-making by underlining the banking sector depth determinants when setting regulations and policies to develop the banking sector.

• Journal of East-Asian Urban History
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• v.2 no.2
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• pp.235-271
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• 2020

Tainan was the capital of Taiwan and was the largest commercial city in Taiwan with a significant number of ports. However, after the end of the Qing era, the functions of the capital and major ports were shifted to Taipei and Kaohsiung, thus leading Tainan to lose its position. This article focuses on festivals in the city. The Qing dynasty administrative agency set up a local government that grouped multiple villages based on the religious beliefs which were closely related to the concept of the urban space as the primary temple. Mazu is an object of worship that attracted the attention of city residents from the Taisho era to the colonial era. At the Mazu temple in Tainan, which has acquired a new mystery, a Mazu festival was conducted with Mazu patrols. This festival was conducted from 1915 to 1937, when it was canceled due to the temple reorganization movement. At the festival, multiple participating groups used to compete to earn the luxury of running the pavilions. The procession ran through the north side of the city on the first day and the south side of the city on the second day. During this festival, in addition to going around the villages of the old city, a touring route was planned for the procession to pass through major landmarks related to the colonial administration and the Ginza-dori Shopping Street, which was newly created during the Taisho era. Therefore, this procession was unique because it ensured that people could explore the old and new streets that were transformed through urban remodeling during the colonial period. Moreover, passing through the licensed quarters called Shin-machi, which was relocated through urban remodeling by the administrative agency, allowed people to visualize the urban structure of colonial Taiwan. Tainan city was renewed through remodeling during the colonial period, thus leading to the formation of a new commercial area. The spirit of the people in Tainan city can be gauged based on the fact that the festival was financially and religiously supported by the merchants who promoted it. The restoration of Mazu during the colonial period indicates the restoration of urban commerce in Tainan, which had fallen from its position as the primary port city in Taiwan since the end of the Qing period. Therefore, it can be considered to represent the restoration of the city.

• Journal of the Economic Geographical Society of Korea
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• v.27 no.2
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• pp.95-119
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• 2024

While several recent studies have investigated the spatial distribution of entrepreneurship within the Seoul metropolitan area, they have not thoroughly examined the relationship between the industrial composition and spatial distribution of entrepreneurial clusters. To address this gap, this study initially identified entrepreneurial clusters through hotspot analysis using Getis-Ord Gi* with venture capital investment data from 2021. Subsequently, to analyze the industrial composition of the identified clusters, we measured not only their industrial diversity and specialization, but also the share of software and non-software industries. Additionally, we examined the government policies related to the formation of the clusters. As a result, we identified fourteen prominent entrepreneurial clusters within the Seoul metro area and revealed that the clusters located closer to the city centers exhibited higher levels of industrial diversity and a greater share of software industries. Conversely, clusters situated farther from the city centers demonstrated a higher share of non-software industries. Furthermore, we found that government policies affect the industrial specialization of suburban clusters. Nevertheless, we observed several exceptions that diverged from the general trends due to policy interventions. These findings underscore that formulating policies for entrepreneurial clusters in metropolitan areas should be based on these insights.