• Journal of Electrical Engineering and Technology
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• v.7 no.6
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• pp.971-976
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• 2012

A 150 kJ compact capacitive pulsed power system (CCPPS) capable of delivering electrical energy into an electrothermal chemical (ETC) gun on a vehicle has been studied. The CCPPS provides pulsed electrical energy into a capillary plasma injector which generates plasma of tens of thousands $^{\circ}K$ in temperature and has a nonlinear resistance depending on the current. The design requirements of the CCPPS are as follows: the maximum power of 250 MW, the pulse width of about 0.6 ms, the volume of no more than 0.5 cubic meter, the efficiency of energy transfer over 80 % and the repetition rate of 4~5 times per minute. The constructed CCPPS is composed of four 37.5 kJ capacitor bank modules in parallel to make a trapezoid pulse shape and to satisfy the design requirements. Each module is designed to achieve high reliability, safety, efficiency and energy density to endure severe operating conditions. The results of the performance test on the CCPPS using a 120 mm ETC gun are described.

• Analytical Science and Technology
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• v.11 no.1
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• pp.36-41
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• 1998

A gas chromatography-mass spectrometry method for the determination of 5-fluorourasil in human plasma is described. The method involves a single extraction procedure with 10 ml of isopropanol-ether(20:80) solution and pentafluoro-benzylation. Samples were injected using an automatic injector, followed by separation on a nonpolar capillary column and detection with a mass selective detector(MSD). No endogeneous compounds were found to interfere. The detection limit, based upon an assayed plasma volume of 0.5, was 3 ng/ml. The extraction yield was found to be above 80%. Plasma 5-FU concentrations were determined by this method in about 500 plasma samples from cancer patients undergoing treatment with 5-FU. This method is suitable for monitoring of 5-FU in plasma of cancer patients.

• Journal of Pharmaceutical Investigation
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• v.22 no.3
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• pp.197-204
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• 1992

A gas chromatographic method using nitrogen phosphorous selective detection was developed for simultaneous determination of haloperidol and its metabolite, reduced haloperidol, in human plasma. Combelen was used as internal standard, The method involved extraction and trimethylsilylation followed by the injection of $2-4\;{\mu}l$ of benzene layer, which was used to dissolve the trimethylsilylated derivatives of haloperidol and reduced haloperidol, onto SE-54 column [5% phenyl methyl silica fused capillary column, $16m{\times}0.22\;mm$ $(I.D.){\times}0.33\;{\mu}m$ (coated thickness)]. The temperature of column oven was programmed from $200^{\circ}C\;to\;300^{\circ}C$ at the increase rate of $10^{\circ}C/min and also the temperatures of injector and detector were set at $300^{\circ}C$. Helium was used as carrier gas and its flow rate was maintained at 30 ml/min. The detection was conducted with nitrogen phosphorous selective detector. The retention times for combelen, reduced haloperidol and haloperidol were found to be 9.14, 9.75 and 9.99 min, respectively. The detection limits for haloperidol and reduced haloperidol in human plasma were both 0.2 ng/ml. The coefficients of variation of the intra-assay were generally low (below 9.8%). The mean absolute recoveries of added haloperidol and reduced haloperidol from plasma were 72% and 84%, respectively. No interferences from endogenous substances were found.