• Analytical Science and Technology
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• v.32 no.5
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• pp.185-195
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• 2019

Over the past decades, chiral switch of the proton pump inhibitors (PPIs) has been received widespread attention in therapeutic advantages as well as pharmaceutical analysis. In present study, the influence of cyclodextrins (CDs) on the chiral separation of four common PPIs (lansoprazole, omeprazole, pantoprazole, and rabeprazole) was investigated. The results demonstrated that capillary electrophoresis (CE) with dual CDs as a chiral selector system is a possible and promising method for the enantioseparation of these PPIs. Rabeprazole, which is the most challenging and acid-labile candidate among four PPIs, was selected for further development of the technique. To optimize CE condition, the effects of capillary parameters and background electrolytes on the enantioseparation were investigated. Finally, the best chiral separation was acheived by using sulfobutyl ether-${\beta}$-CD, and ${\gamma}$-CD as dual chiral selectors. The developed CE method not only provided the effective chiral separation but also showed the good stability of rabeprazole. The proposed method was successfully validated according to the International Conference on Harmonization guideline and effectively applied to determine rabeprazole enantiomers in commercial rabeprazole tablets, with recoveries ranging from 97.17 % to 103.29 % of the label content.

• Korean Journal of Air-Conditioning and Refrigeration Engineering
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• v.11 no.4
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• pp.499-510
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• 1999

A computer program was developed for simulating performance(capacity, power consumption and etc.) of air-conditioners using compressor, fin-tube heat exchanger and capillary tube. The program consists of five modules, condenser, evaporator, compressor, capillary tube simulation modules and properties modules of refrigerant and moist air, The present program is focused on R22 only, however can be easily extended for other refrigerants such as R407C and R410A just by adding property modules. The compressor simulation module utilizes performance maps supplied by manufacturers-map-based model. The condenser and evaporator simulation modules are modeled using tube-by-tube method. Simulation results(capacity and power consumption) were compared with calorimeter test results of actual air-conditioners of window and split types, where more than 82% of the data lied within ${\pm}5$% of the predicted results.

• Journal of Korean Society for Atmospheric Environment
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• v.22 no.E1
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• pp.27-34
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• 2006

Although the importance of size-resolved raindrops study has been known, it has not been popularized up to the present. In the present study, an attempt was made to generalize the size-resolved raindrops study by a combination of the frozen raindrop collection method and a commercially available high-performance capillary electrophoresis (HPCE). Samplings were carried out at Kyoto, Japan in October 2002. The inorganic ions (chloride, nitrate, sulphate, calcium, ammonium, sodium, magnesium, potassium) in size classified raindrop samples were successfully analyzed by HPCE with good repeatability. To assure the accuracy and precision of HPCE data, t-test was conducted with paired analytical data, which were experimentally constructed by analyzing standard solutions with HPCE and IC, respectively. T-test showed that there is no notable difference between the concentrations determined by the two analytical methods. Every ionic concentration in both cation and anion was found to be strong raindrop size dependence. Though there was slight increase of sodium and sulphate concentrations between 0.85 mm and 1.15 mm raindrop radius, it showed a strong decrease for every ionic component with increasing droplet radius. The combination of the frozen raindrop collection method and a commercially available HPCE can meet the need of size-resolved raindrops study.

• Archives of Pharmacal Research
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• v.24 no.6
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• pp.601-606
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• 2001

A simple assay method of recombinant human epidermal growth factor (rhEGF) in a pharmaceutical preparation was studied and validated by capillary electrophoresis (CE) using micellar electrokinetic chromatography (MEKC) techniques. Factors affecting the migration behavior and separation performances of the peptide; type of buffers pH, butler concentration, and concentration of sodium dodecyl sulfates (SDS) were investigated to optimize the analytical performance. CE was performed using running buffers 50.0 mM borate (pH 8.5) containing 12.5 mM SDS at 20 $mutextrm{V}$ of the applied voltage. Calibration curves for the rhEGF showed good linearity (r>0.999) over the wide dynamic range from 1.25 to $100{\mu\textrm{g}}/ml$. Sample analysis was performed by using standard addition method to eliminate the matrix effects of dosage vehicle. This method is assumed to be useful for quality control (QC) of various forms of pharmaceutical products of the peptide.

• Journal of Advanced Marine Engineering and Technology
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• v.33 no.8
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• pp.1144-1151
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• 2009

Refrigeration systems can be incorporated with non-adiabatic capillary tubes to improve their efficiency. The non-adiabatic capillary tube is constructed by joining the capillary tube with suction pipe to allow heat transfer between them, which is called capillary tube-suction line heat exchanger(SLHX). There are various joining methods and they may influence the characteristics of the refrigeration cycle. The present work aims to analyze the effect of widely-used two joining methods on the refrigeration cycle. The results show that soldered SLHX has much less thermal resistance than tapered SLHX but slightly outperforms in terms of coefficient of performance(COP) and cooling capacity. The soldered SLHX increased COP and cooling capacity of a refrigerator by 5.09% and 14.77% while the tapered SLHX did by 5.05% and 14.75%, respectively.

• Korean Journal of Food Science and Technology
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• v.37 no.4
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• pp.513-518
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• 2005

Capillary electrophoresis (CE) method was developed to determine (+)-catechin and (-)-epicatechin contents in grape seed ethanol extract. CE separation was achieved using 100 mM phosphate and borate buffer at pH 6.0 as background electrolyte and fused silica capillary with 50 microns x 375 microns O.D. (effective length 20.0cm) maintained at $25^{\circ}C$. The applied voltage was 10kV, and detection was performed by DAD at 210 nm, Two catechins were well separated within 6 min with repeatability of <0.8% RSD for migration time and <2.0% RSD for peak area, and correlation coefficients higher than 0.994 were obtained from 58.0 to 174.0 mg/L with detection limit of 0.035 mg/L. Separated compounds were successfully determined. CE method was easy to handle and showed good reproducibility. CE method was compared with conventional coloring and HPLC methods, and main advantages of CE method were low amount of sample required, simple pre-sample treatment, good recovery rate, and short analysis time.

• Proceedings of the Korean Society for Agricultural Machinery Conference
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• 2000.11c
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• pp.662-669
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• 2000

Based on the viscous flow characteristics of gas through capillary tube, a simple and low cost system was developed for controlling gas concentration for use in C.A experiments. The gas flow rate through capillary tube had a linear relationship with pressure, $(length)^{-1}$ and $(radius)^4$ of capillary tube, which agreed well with Hagen-Poiseuille's law. The developed system could control the gas concentration in storage chamber within ${\pm}0.3%$ deviation compared to the preset concentration. The required time for producing target gas concentration in storage chamber was exactly predicted by the model used in this study, and it required much longer time than the calculated time which divided the volume of chamber by flow rate. Therefore, for producing target gas concentration as quickly as possible, it needs to supply higher flow rate of gas during the initial stage of experiment when gas concentration in storage chamber has not reached at target value. It appeared that the developed system was very useful for C.A experiments. Because one could decide a desired flow rate by the prediction model, control flow rate freely and easily by changing pressure in the pressure-regulating chamber and the accuracy was high.

• Journal of the Korean Society for Precision Engineering
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• v.14 no.8
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• pp.130-136
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• 1997

For compensating the error motion of hydrostatic guideways, we introduce a way that the clearance of table is actively controlled corresponding to the amount of error with the variable capillary. The structure and the theoretical design method of active controlled capillary using piezo actuator, named ACC, are proposed in this paper. Basic characteristics such as the maximum controllable range, micro step response and available dynamic bandwidth are tested for confirmation of structural suitability of ACC, and these characteristics are also tested on the table mounted with ACC for verifying the availability. The experimental result showed that by the use of ACC, the error motion within 2.7 .mu. m of a hydrostatic guideway can be compensated with the resolution of 2.7nm, 1/100 contollable range, and the frequency bandwidth of 5.5 Hz. From these results, it is confirmed that the ACC is very effective to improve the motion accuracy of high or ultra precision hydrostatic guideways.

• Korean Journal of Air-Conditioning and Refrigeration Engineering
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• v.17 no.9
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• pp.873-881
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• 2005

In this study, we made RFC, RCC and NCC according to the method by which polypropylene capillary tube was adopted, and evaluated cooling performance of each system through model experiments. We also investigated an applicability of the combined use of radiant cooling and dehumidification system. The results are as follows: In case of normal cooling load, RFC and RCC maintained set temperature without a condensation. But, in case of peak cooling load, RFC and RCC resulted in the lack of cooling performance and caused a condensation at the radiation surface. Consequently, the only use of polypropylene capillary tube is considered not to be enough for cooling in real application. Using the combination of a dehumidification and radiant cooling system maintained the set temperature without a condensation. NCC kept the set temperature at anytime without a condensation. It is more economic than packaged air-conditioner system due to the cooling effect of the floor surface.

• 한국정보디스플레이학회:학술대회논문집
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• 2002.08a
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• pp.1088-1090
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• 2002

In this study, a new processing route of barrier ribs for the plasma display panels was attempted. A slurry containing ceramic powders for the barrier ribs, binder, hardener, and other additives, was molded into a PDMS mold by capillary infiltration process. The molded slurry was cured prior to mold removal. It was demonstrated that the process can fabricate successfully the cell type barrier ribs of PDP.